Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2009540913', 'doi': 'https://doi.org/10.1074/jbc.m109.080457', 'title': 'Biochemical and Biological Characterization of a New Oxidized Avidin with Enhanced Tissue Binding Properties', 'display_name': 'Biochemical and Biological Characterization of a New Oxidized Avidin with Enhanced Tissue Binding Properties', 'publication_year': 2010, 'publication_date': '2010-01-26', 'ids': {'openalex': 'https://openalex.org/W2009540913', 'doi': 'https://doi.org/10.1074/jbc.m109.080457', 'mag': '2009540913', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20100839', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2838329'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m109.080457', 'pdf_url': 'http://www.jbc.org/article/S0021925820873050/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820873050/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005059994', 'display_name': 'Antonio Verdoliva', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Antonio Verdoliva', 'raw_affiliation_strings': ['Research and Development Department, Tecnogen S.p.A., Piana di Monte Verna, 81013 Caserta'], 'affiliations': [{'raw_affiliation_string': 'Research and Development Department, Tecnogen S.p.A., Piana di Monte Verna, 81013 Caserta', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038926662', 'display_name': 'Piero Bellofiore', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Piero Bellofiore', 'raw_affiliation_strings': ['Research and Development Department, Tecnogen S.p.A., Piana di Monte Verna, 81013 Caserta'], 'affiliations': [{'raw_affiliation_string': 'Research and Development Department, Tecnogen S.p.A., Piana di Monte Verna, 81013 Caserta', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113593109', 'display_name': 'Vincenzo Rivieccio', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Vincenzo Rivieccio', 'raw_affiliation_strings': ['Research and Development Department, Tecnogen S.p.A., Piana di Monte Verna, 81013 Caserta'], 'affiliations': [{'raw_affiliation_string': 'Research and Development Department, Tecnogen S.p.A., Piana di Monte Verna, 81013 Caserta', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032291641', 'display_name': 'Sergio Catello', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Sergio Catello', 'raw_affiliation_strings': ['Research and Development Department, Tecnogen S.p.A., Piana di Monte Verna, 81013 Caserta'], 'affiliations': [{'raw_affiliation_string': 'Research and Development Department, Tecnogen S.p.A., Piana di Monte Verna, 81013 Caserta', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103453128', 'display_name': 'Maurizio Colombo', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Maurizio Colombo', 'raw_affiliation_strings': ['Research and Development Department, Tecnogen S.p.A., Piana di Monte Verna, 81013 Caserta'], 'affiliations': [{'raw_affiliation_string': 'Research and Development Department, Tecnogen S.p.A., Piana di Monte Verna, 81013 Caserta', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010097454', 'display_name': 'Claudio Albertoni', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210131844', 'display_name': 'Sigma Tau (Italy)', 'ror': 'https://ror.org/03bxtpd68', 'country_code': 'IT', 'type': 'company', 'lineage': ['https://openalex.org/I4210131844']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Claudio Albertoni', 'raw_affiliation_strings': ['Research and Development Department, Sigma-Tau S.p.A., Pomezia, 00040 Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Research and Development Department, Sigma-Tau S.p.A., Pomezia, 00040 Rome, Italy', 'institution_ids': ['https://openalex.org/I4210131844']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011237039', 'display_name': 'Antonio Rosi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210131844', 'display_name': 'Sigma Tau (Italy)', 'ror': 'https://ror.org/03bxtpd68', 'country_code': 'IT', 'type': 'company', 'lineage': ['https://openalex.org/I4210131844']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Antonio Rosi', 'raw_affiliation_strings': ['Research and Development Department, Sigma-Tau S.p.A., Pomezia, 00040 Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Research and Development Department, Sigma-Tau S.p.A., Pomezia, 00040 Rome, Italy', 'institution_ids': ['https://openalex.org/I4210131844']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041018718', 'display_name': 'Barbara Leoni', 'orcid': 'https://orcid.org/0000-0001-9448-9457'}, 'institutions': [{'id': 'https://openalex.org/I4210131844', 'display_name': 'Sigma Tau (Italy)', 'ror': 'https://ror.org/03bxtpd68', 'country_code': 'IT', 'type': 'company', 'lineage': ['https://openalex.org/I4210131844']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Barbara Leoni', 'raw_affiliation_strings': ['Research and Development Department, Sigma-Tau S.p.A., Pomezia, 00040 Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Research and Development Department, Sigma-Tau S.p.A., Pomezia, 00040 Rome, Italy', 'institution_ids': ['https://openalex.org/I4210131844']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076593115', 'display_name': 'Anna Maria Anastasi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210131844', 'display_name': 'Sigma Tau (Italy)', 'ror': 'https://ror.org/03bxtpd68', 'country_code': 'IT', 'type': 'company', 'lineage': ['https://openalex.org/I4210131844']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Anna Maria Anastasi', 'raw_affiliation_strings': ['Research and Development Department, Sigma-Tau S.p.A., Pomezia, 00040 Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Research and Development Department, Sigma-Tau S.p.A., Pomezia, 00040 Rome, Italy', 'institution_ids': ['https://openalex.org/I4210131844']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5026780110', 'display_name': 'Rita De Santis', 'orcid': 'https://orcid.org/0000-0002-5037-0611'}, 'institutions': [{'id': 'https://openalex.org/I4210131844', 'display_name': 'Sigma Tau (Italy)', 'ror': 'https://ror.org/03bxtpd68', 'country_code': 'IT', 'type': 'company', 'lineage': ['https://openalex.org/I4210131844']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Rita De Santis', 'raw_affiliation_strings': ['Research and Development Department, Sigma-Tau S.p.A., Pomezia, 00040 Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Research and Development Department, Sigma-Tau S.p.A., Pomezia, 00040 Rome, Italy', 'institution_ids': ['https://openalex.org/I4210131844']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 1.254, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.799734, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '285', 'issue': '12', 'first_page': '9090', 'last_page': '9099'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13127', 'display_name': 'Biotin and Related Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13127', 'display_name': 'Biotin and Related Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11440', 'display_name': 'Click Chemistry and Applications', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10277', 'display_name': 'Vitamin D Research Studies', 'score': 0.9868, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/avidin', 'display_name': 'Avidin', 'score': 0.98684716}, {'id': 'https://openalex.org/keywords/isothermal-titration-calorimetry', 'display_name': 'Isothermal Titration Calorimetry', 'score': 0.5709124}, {'id': 'https://openalex.org/keywords/streptavidin', 'display_name': 'Streptavidin', 'score': 0.49858737}], 'concepts': [{'id': 'https://openalex.org/C176406525', 'wikidata': 'https://www.wikidata.org/wiki/Q24775166', 'display_name': 'Avidin', 'level': 3, 'score': 0.98684716}, {'id': 'https://openalex.org/C204628709', 'wikidata': 'https://www.wikidata.org/wiki/Q864854', 'display_name': 'Biotinylation', 'level': 2, 'score': 0.87622154}, {'id': 'https://openalex.org/C2778204606', 'wikidata': 'https://www.wikidata.org/wiki/Q181354', 'display_name': 'Biotin', 'level': 2, 'score': 0.6847941}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6216212}, {'id': 'https://openalex.org/C156911925', 'wikidata': 'https://www.wikidata.org/wiki/Q643384', 'display_name': 'Isothermal titration calorimetry', 'level': 2, 'score': 0.5709124}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5699347}, {'id': 'https://openalex.org/C2776190903', 'wikidata': 'https://www.wikidata.org/wiki/Q421817', 'display_name': 'Streptavidin', 'level': 3, 'score': 0.49858737}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.40277264}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.14893094}], 'mesh': [{'descriptor_ui': 'D001360', 'descriptor_name': 'Avidin', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D001671', 'descriptor_name': 'Biochemistry', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000447', 'descriptor_name': 'Aldehydes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000447', 'descriptor_name': 'Aldehydes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001360', 'descriptor_name': 'Avidin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001671', 'descriptor_name': 'Biochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019921', 'descriptor_name': 'Biotinylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019921', 'descriptor_name': 'Biotinylation', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D002645', 'descriptor_name': 'Chickens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005434', 'descriptor_name': 'Flow Cytometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010100', 'descriptor_name': 'Oxygen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010100', 'descriptor_name': 'Oxygen', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010504', 'descriptor_name': 'Periodic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010504', 'descriptor_name': 'Periodic Acid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013056', 'descriptor_name': 'Spectrophotometry, Ultraviolet', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013056', 'descriptor_name': 'Spectrophotometry, Ultraviolet', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m109.080457', 'pdf_url': 'http://www.jbc.org/article/S0021925820873050/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2838329', 'pdf_url': 'https://europepmc.org/articles/pmc2838329?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838329', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20100839', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m109.080457', 'pdf_url': 'http://www.jbc.org/article/S0021925820873050/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 61, 'referenced_works': ['https://openalex.org/W1510114475', 'https://openalex.org/W1512221515', 'https://openalex.org/W1528942864', 'https://openalex.org/W1530956732', 'https://openalex.org/W1549637062', 'https://openalex.org/W1754901624', 'https://openalex.org/W1788023629', 'https://openalex.org/W1968622705', 'https://openalex.org/W1969098449', 'https://openalex.org/W1970672385', 'https://openalex.org/W1971122340', 'https://openalex.org/W1980748217', 'https://openalex.org/W1982348345', 'https://openalex.org/W1982418801', 'https://openalex.org/W1984770267', 'https://openalex.org/W1986976679', 'https://openalex.org/W1991588694', 'https://openalex.org/W2003869743', 'https://openalex.org/W2009832280', 'https://openalex.org/W2009935099', 'https://openalex.org/W2010279439', 'https://openalex.org/W2013051417', 'https://openalex.org/W2021187444', 'https://openalex.org/W2024304683', 'https://openalex.org/W2033126675', 'https://openalex.org/W2038520392', 'https://openalex.org/W2043450052', 'https://openalex.org/W2044465955', 'https://openalex.org/W2045581790', 'https://openalex.org/W2053461569', 'https://openalex.org/W2058114341', 'https://openalex.org/W2065248209', 'https://openalex.org/W2066397665', 'https://openalex.org/W2071478187', 'https://openalex.org/W2074015787', 'https://openalex.org/W2075188898', 'https://openalex.org/W2076853819', 'https://openalex.org/W2085752444', 'https://openalex.org/W2094360785', 'https://openalex.org/W2096165653', 'https://openalex.org/W2099511949', 'https://openalex.org/W2110695873', 'https://openalex.org/W2112602860', 'https://openalex.org/W2114926334', 'https://openalex.org/W2116768591', 'https://openalex.org/W2125814580', 'https://openalex.org/W2133022777', 'https://openalex.org/W2136573162', 'https://openalex.org/W2139190669', 'https://openalex.org/W2144321662', 'https://openalex.org/W2147112318', 'https://openalex.org/W2150874458', 'https://openalex.org/W2170560729', 'https://openalex.org/W2175128997', 'https://openalex.org/W2182445821', 'https://openalex.org/W2241539696', 'https://openalex.org/W2293438303', 'https://openalex.org/W2335950222', 'https://openalex.org/W2401181276', 'https://openalex.org/W2431749342', 'https://openalex.org/W4211027922'], 'related_works': ['https://openalex.org/W4293102437', 'https://openalex.org/W2923238538', 'https://openalex.org/W2327149835', 'https://openalex.org/W2072176055', 'https://openalex.org/W2070869769', 'https://openalex.org/W2067888302', 'https://openalex.org/W2067031238', 'https://openalex.org/W2026593038', 'https://openalex.org/W1991127274', 'https://openalex.org/W1985110858'], 'abstract_inverted_index': {'Chicken': [0], 'avidin': [1, 62, 73, 84, 88, 127, 151, 199, 204, 219], 'and': [2, 19, 38, 70, 115, 130, 139, 157], 'bacterial': [3], 'streptavidin': [4], 'are': [5, 22, 102], 'widely': [6], 'employed': [7, 222], 'in': [8, 30, 140, 167, 192, 210, 229], 'vitro': [9, 136], 'for': [10, 232], 'their': [11, 17, 28], 'capacity': [12, 209], 'to': [13, 93, 154, 223], 'bind': [14, 155], 'biotin,': [15], 'but': [16], 'pharmacokinetics': [18], 'immunological': [20], 'properties': [21, 40, 91], 'not': [23], 'always': [24], 'optimal,': [25], 'thereby': [26], 'limiting': [27], 'use': [29], 'medical': [31], 'treatments.': [32], 'Here': [33], 'we': [34], 'investigate': [35], 'the': [36, 67, 122, 126, 152, 183, 187, 193, 233], 'biochemical': [37], 'biological': [39], 'of': [41, 52, 58, 61, 72, 80, 95, 171, 178, 186, 235], 'a': [42, 168, 225], 'new': [43], 'modified': [44, 198], 'avidin,': [45, 97], 'obtained': [46], 'by': [47, 66, 78], 'ligand-assisted': [48, 123], 'sodium': [49], 'periodate': [50], 'oxidation': [51, 68, 105, 124], 'avidin.': [53, 180], 'This': [54], 'method': [55], 'allows': [56], 'protection': [57], 'biotin-binding': [59], 'sites': [60], 'from': [63, 75, 83, 104], 'inactivation': [64], 'caused': [65], 'step': [69], 'delay': [71], 'clearance': [74], 'injected': [76, 189], 'tissue': [77, 142, 169], 'generation': [79], 'aldehyde': [81, 147], 'groups': [82, 148, 161], 'carbohydrate': [85], 'moieties.': [86], 'Oxidized': [87], 'shows': [89], 'spectroscopic': [90], 'similar': [92], 'that': [94, 99, 121, 146, 201, 217], 'native': [96, 179], 'indicating': [98], 'tryptophan': [100], 'residues': [101], 'spared': [103], 'damage.': [106], 'In': [107, 135, 181], 'strict': [108], 'agreement': [109], 'with': [110, 175, 197], 'these': [111], 'results,': [112], 'circular': [113], 'dichroism': [114], 'isothermal': [116], 'titration': [117], 'calorimetry': [118], 'analyses': [119], 'confirm': [120], 'preserves': [125], 'protein': [128, 159], 'structure': [129], 'its': [131, 206], 'biotin': [132, 207], 'binding': [133, 138, 208], 'capacity.': [134], 'cell': [137], 'vivo': [141], 'residence': [143], 'experiments': [144], 'demonstrate': [145], 'provide': [149], 'oxidized': [150, 203, 218], 'property': [153], 'cellular': [156], 'interstitial': [158], 'amino': [160], 'through': [162], "Schiff's": [163], 'base': [164], 'formation,': [165], 'resulting': [166], 'half-life': [170], '2': [172, 176], 'weeks,': [173], 'compared': [174], 'h': [177], 'addition,': [182], 'efficient': [184], 'uptake': [185], 'intravenously': [188], '(111)In-BiotinDOTA': [190], '(ST2210)': [191], 'site': [194], 'previously': [195], 'treated': [196], 'underlines': [200], 'tissue-bound': [202], 'retains': [205], 'vivo.': [211], 'The': [212], 'results': [213], 'presented': [214], 'here': [215], 'indicate': [216], 'could': [220], 'be': [221], 'create': [224], 'stable': [226], 'artificial': [227], 'receptor': [228], 'diseased': [230], 'tissues': [231], 'targeting': [234], 'biotinylated': [236], 'therapeutics.': [237]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2009540913', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-14T04:21:33.936984', 'created_date': '2016-06-24'}