Title: Using Secondary α Deuterium Kinetic Isotope Effects To Determine the Symmetry of S<sub>N</sub>2 Transition States
Abstract:The secondary α deuterium and heavy atom kinetic isotope effects found for two different SN2 reactions suggest that the magnitude of secondary α deuterium kinetic isotope effects can be determined by ...The secondary α deuterium and heavy atom kinetic isotope effects found for two different SN2 reactions suggest that the magnitude of secondary α deuterium kinetic isotope effects can be determined by the length of only the shorter (stronger) reacting bond in an unsymmetrical SN2 transition state rather than by the usual nucleophile−leaving group distance. Although this means the interpretation of these isotope effects is more complex than has been recognized, the results suggest that they can be used to determine whether an SN2 transition state is symmetrical or unsymmetrical.Read More
Publication Year: 1997
Publication Date: 1997-04-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 29
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