Title: Atypical fibroxanthoma of the skin: A reappraisal of 19 cases in which the original diagnosis was spindle-cell squamous carcinoma
Abstract: CancerVolume 29, Issue 2 p. 413-422 ArticleFree Access Atypical fibroxanthoma of the skin: A reappraisal of 19 cases in which the original diagnosis was spindle-cell squamous carcinoma Dr. Albert W. Hudson MD, Dr. Albert W. Hudson MD Mayo Graduate School of Medicine (University of Minnesota), RochesterSearch for more papers by this authorDr. R. K. Winkelmann MD, PhD, Dr. R. K. Winkelmann MD, PhD Mayo Clinic and Mayo Foundation: Department of DermatologySearch for more papers by this author Dr. Albert W. Hudson MD, Dr. Albert W. Hudson MD Mayo Graduate School of Medicine (University of Minnesota), RochesterSearch for more papers by this authorDr. R. K. Winkelmann MD, PhD, Dr. R. K. Winkelmann MD, PhD Mayo Clinic and Mayo Foundation: Department of DermatologySearch for more papers by this author First published: February 1972 https://doi.org/10.1002/1097-0142(197202)29:2<413::AID-CNCR2820290224>3.0.CO;2-0Citations: 67AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract A retrospective study was made of 21 cutaneous tumors microscopically diagnosed as spindle-cell squamous carcinomas. The tumors occurred as noduloulcerative, vascular masses predominantly in roentgen- and solar-radiationdamaged skin of the head, neck, and hands of men and women. These lesions were biologically benign, as established by the indications of follow-up study. Histologically, a highly cellular proliferation of fibroblasts, histiocytes, and bizarre giant cells occupied the dermis. The overlying epidermis frequently was ulcerated, but lacked evidence of dysplasia or carcinoma in situ. The clinicopathologic features were consistent with those of atypical fibroxanthoma. References 1 Bourne, R. C.: Paradoxical fibrosarcoma of skin (pseudosarcoma): a review of 13 cases. Med. J. Aust. 1: 504–510, 1963 2 Gordon, H. W.: Pseudosarcomatous reticulohistiocytotna: a report of four cases. Arch. Dermatol. (Chicago) 90: 319–325, 1964. 3 Kempson, R. L., and McGavran, M. H.: Atypical fibroxanthomas of the skin. Cancer. 17: 1463–1471, 1964. 4 Levan, N. E., Hirsch, P., and Kwong, M. Q.: Pseudosarcomatous dermatofibroma. Arch. Dermatol. (Chicago) 88: 908–912, 1963. 5 Lever, W. F.: Histopathology of the Skin, 4th ed. Philadelphia, J. B. Lippincott Company, 1967; p. 509, 631. 6 Lichtiger, B., Mackay, B., and Tessmer, C. F.: Spindle–cell variant of squamous carcinoma: a light and electron microscopic study of 13 cases. Cancer 26: 1311–1320, 1970. 7 Lund, H. Z.: Tumors of the skin. In Atlas of Tumor Pathology, fasc. 2. Washington, D. C., Armed Forces Institute of Pathology, 1957; pp. 272–273. 8 Martin, H. E., and Stewart, F. W.: Spindle–cell epidermoid carcinoma. Am. J. Cancer 24: 273–298, 1935. 9 Montgomery, H.: Dermatopathology, vol. 2. New York, Hoeber Medical Division, Harper & Row, Publishers, Inc., 1967; pp. 961–962. 10 Pettit, V. D., Chamness, J. T., and Ackerman, L. V.: Fibromatosis and firbosarcoma following irradiation therapy. Cancer 7: 149–158, 1954. 11 Rachmaninoff, N., McDonald, J. R., and Cook, J. C.: Sarcoma–like tumors of the skin following irradiation. Am. J. Clin. Pathol. 36: 427–437, 1961. 12 Sams, W. M., Jr., Smith, J. G., Jr., and Finlayson, G. R.: The histochemistry of the basal cell cpithelioma. J. Invest Dermatol. 41: 457–462, 1963. 13 Sims, C. F., and Kirsch, N.: Spindle–cell epidermoid epithelioma simulating sarcoma in chronic radiodermatitis. Arch. Dermatol. (Chicago) 57: 63–68, 1948. 14 Smith, J. L.: Pseudoxanthomatous carcinoma versus atypical fibroxanthoma. Dermal Pathology Course, University of Minnesota, Minneapolis, Minn., October 1969. Unpublished. 15 Stewart, F. W.: Cited by Pettit, V. D., Chamness, J. T., and Ackerman, L. V.10 16 Strauss, M. J.: Spindle–cell epidermoid carcinoma: report of five cases in patients who had never been exposed to roentgen rays. Arch. Dermatol. (Chicago) 61: 633–645, 1950. 17 Underwood, L. J., Montgomery, H., and Broders, A. C.: Squamous–cell epithelioma that simulates sarcoma. Arch Dermatol. (Chicago) 64: 149–158, 1951. Citing Literature Volume29, Issue2February 1972Pages 413-422 ReferencesRelatedInformation