Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2009443436', 'doi': 'https://doi.org/10.1210/endo-114-4-1358', 'title': 'Decreased<i>β</i>- Adrenergic Receptors in Rat Heart in Streptozotocin-Induced Diabetes: Role of Thyroid Hormones<sup>*</sup>', 'display_name': 'Decreased<i>β</i>- Adrenergic Receptors in Rat Heart in Streptozotocin-Induced Diabetes: Role of Thyroid Hormones<sup>*</sup>', 'publication_year': 1984, 'publication_date': '1984-04-01', 'ids': {'openalex': 'https://openalex.org/W2009443436', 'doi': 'https://doi.org/10.1210/endo-114-4-1358', 'mag': '2009443436', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6323144'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/endo-114-4-1358', 'pdf_url': 'https://academic.oup.com/endo/article-pdf/114/4/1358/10687333/endo1358.pdf', 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/endo/article-pdf/114/4/1358/10687333/endo1358.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111463973', 'display_name': 'P. R. Sundaresan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'PAVUR R. SUNDARESAN', 'raw_affiliation_strings': ['Department of Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642', 'institution_ids': ['https://openalex.org/I5388228']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110327022', 'display_name': 'Virendra K. Sharma', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'VIRENDRA K. SHARMA', 'raw_affiliation_strings': ['Department of Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642', 'institution_ids': ['https://openalex.org/I5388228']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062535246', 'display_name': 'Scott I. Gingold', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'SCOTT I. GINGOLD', 'raw_affiliation_strings': ['Department of Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642', 'institution_ids': ['https://openalex.org/I5388228']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103287059', 'display_name': 'Shailesh P. Banerjee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'SHAILESH P. BANERJEE', 'raw_affiliation_strings': ['Department of Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642', 'institution_ids': ['https://openalex.org/I5388228']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3400, 'currency': 'USD', 'value_usd': 3400, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.941, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 94, 'citation_normalized_percentile': {'value': 0.941051, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '114', 'issue': '4', 'first_page': '1358', 'last_page': '1363'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11146', 'display_name': 'Hormonal and reproductive studies', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dihydroalprenolol', 'display_name': 'Dihydroalprenolol', 'score': 0.84866774}], 'concepts': [{'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.9107648}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.9069703}, {'id': 'https://openalex.org/C2779280383', 'wikidata': 'https://www.wikidata.org/wiki/Q257331', 'display_name': 'Streptozotocin', 'level': 3, 'score': 0.88608325}, {'id': 'https://openalex.org/C2778438532', 'wikidata': 'https://www.wikidata.org/wiki/Q5276415', 'display_name': 'Dihydroalprenolol', 'level': 5, 'score': 0.84866774}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.6600429}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.658985}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.61506325}, {'id': 'https://openalex.org/C2779306644', 'wikidata': 'https://www.wikidata.org/wiki/Q2002370', 'display_name': 'Insulin', 'level': 2, 'score': 0.5898075}, {'id': 'https://openalex.org/C40465926', 'wikidata': 'https://www.wikidata.org/wiki/Q410568', 'display_name': 'Adrenergic receptor', 'level': 3, 'score': 0.5026972}, {'id': 'https://openalex.org/C158453852', 'wikidata': 'https://www.wikidata.org/wiki/Q4684738', 'display_name': 'Adrenergic', 'level': 3, 'score': 0.5010052}, {'id': 'https://openalex.org/C526584372', 'wikidata': 'https://www.wikidata.org/wiki/Q16399', 'display_name': 'Thyroid', 'level': 2, 'score': 0.4699716}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.46073386}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.15234011}, {'id': 'https://openalex.org/C58732023', 'wikidata': 'https://www.wikidata.org/wiki/Q770260', 'display_name': 'Partial agonist', 'level': 4, 'score': 0.04866737}], 'mesh': [{'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D011943', 'descriptor_name': 'Receptors, Adrenergic, beta', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D013974', 'descriptor_name': 'Thyroxine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000262', 'descriptor_name': 'Adenylyl Cyclases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000262', 'descriptor_name': 'Adenylyl Cyclases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000242', 'descriptor_name': 'Cyclic AMP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000242', 'descriptor_name': 'Cyclic AMP', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004082', 'descriptor_name': 'Dihydroalprenolol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004082', 'descriptor_name': 'Dihydroalprenolol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011919', 'descriptor_name': 'Rats, Inbred Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011943', 'descriptor_name': 'Receptors, Adrenergic, beta', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011943', 'descriptor_name': 'Receptors, Adrenergic, beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013965', 'descriptor_name': 'Thyroidectomy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013974', 'descriptor_name': 'Thyroxine', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D013974', 'descriptor_name': 'Thyroxine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014284', 'descriptor_name': 'Triiodothyronine', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D014284', 'descriptor_name': 'Triiodothyronine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/endo-114-4-1358', 'pdf_url': 'https://academic.oup.com/endo/article-pdf/114/4/1358/10687333/endo1358.pdf', 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6323144', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/endo-114-4-1358', 'pdf_url': 'https://academic.oup.com/endo/article-pdf/114/4/1358/10687333/endo1358.pdf', 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.84}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 25, 'referenced_works': ['https://openalex.org/W1491635941', 'https://openalex.org/W1544622500', 'https://openalex.org/W1578458937', 'https://openalex.org/W1578828922', 'https://openalex.org/W1584222430', 'https://openalex.org/W1775749144', 'https://openalex.org/W1970179449', 'https://openalex.org/W1970780506', 'https://openalex.org/W1974874590', 'https://openalex.org/W1975624480', 'https://openalex.org/W1983649348', 'https://openalex.org/W1996466550', 'https://openalex.org/W2014748341', 'https://openalex.org/W2019659346', 'https://openalex.org/W2033117349', 'https://openalex.org/W2036739972', 'https://openalex.org/W2041700875', 'https://openalex.org/W2043516771', 'https://openalex.org/W2054375586', 'https://openalex.org/W2072661348', 'https://openalex.org/W2091828650', 'https://openalex.org/W2128472423', 'https://openalex.org/W2131852577', 'https://openalex.org/W2415495407', 'https://openalex.org/W282545198'], 'related_works': ['https://openalex.org/W67240778', 'https://openalex.org/W2105448249', 'https://openalex.org/W2095417671', 'https://openalex.org/W2067871988', 'https://openalex.org/W2061360488', 'https://openalex.org/W2042327713', 'https://openalex.org/W2015333399', 'https://openalex.org/W1979666929', 'https://openalex.org/W1979037112', 'https://openalex.org/W1978597946'], 'abstract_inverted_index': {'The': [0, 41, 147], 'effect': [1, 126], 'of': [2, 23, 36, 45, 64, 75, 101, 152], 'streptozotocin-induced': [3], 'diabetes': [4, 122, 158], 'on': [5, 127], 'the': [6, 21, 33, 62, 81, 97, 107, 115, 150], 'β-adrenergic': [7, 25, 66, 129, 140, 154], 'receptor-coupled': [8], 'adenylate': [9], 'cyclase': [10], 'was': [11, 51], 'studied': [12], 'in': [13, 32, 47, 96, 118, 132, 143, 149, 157], 'rat': [14, 49], 'heart': [15], 'particulate': [16], 'fractions.': [17], 'Streptozotocin': [18], 'treatment': [19], 'decreased': [20, 52, 95], 'number': [22, 63, 131, 142, 151], 'myocardial': [24, 65, 153], 'receptors': [26, 38, 67, 155], 'by': [27, 53], '34%': [28], 'with': [29], 'no': [30, 124], 'change': [31], 'apparent': [34], 'affinity': [35], 'these': [37], 'for': [39], '[3H]dihydroalprenolol.': [40], 'maximal': [42], 'isoproterenol-activated': [43], 'accumulation': [44], 'cAMP': [46], 'steptozotocin-treated': [48], 'hearts': [50], 'only': [54], '10%.': [55], 'Insulin': [56, 135], 'administration': [57], 'to': [58, 68, 77, 103], 'streptozotocin-treated': [59, 104], 'rats': [60, 79, 105], 'increased': [61, 106], 'near': [69], 'or': [70, 113], 'above': [71, 114], 'control': [72, 119], 'levels.': [73], 'Administration': [74, 100], 'l-T4': [76], 'streptozotocintreated': [78], 'had': [80, 123], 'same': [82], 'effect.': [83], 'Total': [84], 'T4,': [85], 'free': [86], 'T4)': [87], 'and': [88], 'total': [89], 'T3': [90], 'levels': [91, 111, 116], 'were': [92], 'all': [93], 'significantly': [94], 'diabetic': [98, 145], 'animals.': [99, 120], 'insulin': [102], 'serum': [108], 'thyroid': [109, 164], 'hormone': [110], 'toward': [112], 'found': [117], 'Streptozotocin-induced': [121], 'significant': [125], 'cardiac': [128, 139], 'receptor': [130, 141], 'thyroidectomized': [133, 144], 'rats.': [134, 146], 'did': [136], 'not': [137], 'elevate': [138], 'decrease': [148], 'occurring': [156], 'mellitus': [159], 'is': [160], 'probably': [161], 'mediated': [162], 'through': [163], 'hormones.': [165], '(Endocrinology114:': [166], '1358,': [167], '1984)': [168]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2009443436', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-08T19:48:51.953613', 'created_date': '2016-06-24'}