Transcription of BRCA1 Is Dependent on the Formation of a Specific Protein-DNA Complex on the Minimal BRCA1 Bi-directional Promoter

Name: Work Video:
Duration: 3 min 30 s
Ting-Chung Suen; Paul E. Goss
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'electrophorectic': [98, 375, 565], 'mobility': [99, 376, 566], 'shift': [100, 377, 567], 'assays.': [101, 378, 4116], 'A': [102, 185, 379, 462, 2640, 2677, 3319, 3505, 3651, 3832, 3860, 4413, 4457, 4492], 'bi-directional': [103, 380, 2674], 'promoter': [104, 381, 1963, 2607, 2650, 2675, 2707, 3178, 4389], 'could': [105, 131, 382, 408, 2567, 2646, 2733, 3021, 3039, 4079, 4088], 'be': [106, 383, 1513, 2521, 2569, 2734, 3022, 3041, 3137, 4080, 4089], 'located': [107, 384, 1118, 3324, 3465, 4460, 4495], 'within': [108, 385, 2667, 2687, 2720, 4405], '229-base': [110, 387, 2641], 'pair': [111, 388, 2642, 3320], '(bp)': [112, 389], 'intergenic': [113, 390, 2644, 2669, 3553, 3600, 4298], 'region': [114, 391, 1964, 2645, 3469, 3547, 3554, 3601, 4299], 'between': [115, 392, 3555, 3602, 4452, 4461], 'BRCA1and': [116, 393, 3081], 'its': [117, 394, 839, 883, 1104, 1468, 1587, 2259, 2656, 4302], 'neighboring': [118, 395, 2657, 3559, 4303], 'NBR2.': [120, 397, 2659], 'Deletion': [121, 398, 2660], 'further': [123, 215, 400, 492], 'delineated': [124, 401], 'minimal': [126, 208, 403, 485, 2664, 2689, 2706], '56-bp': [127, 207, 404, 484, 2665], 'EcoRI-HaeIII': [128, 405], 'fragment,': [129, 406, 2853], 'which': [130, 407, 2671, 3047, 3724, 3785, 3801, 3967, 4263], 'drive': [132, 409, 2709], 'NBR2': [136, 169, 413, 446, 3083, 3561], 'direction': [138, 145, 156, 170, 261, 415, 422, 433, 447, 538, 3064], '2–4-fold': [139, 416], 'higher': [140, 417], 'than': [141, 418, 1652, 3187], 'all': [147, 424, 3128, 3250], 'cell': [148, 162, 201, 235, 249, 425, 439, 478, 512, 526, 890, 1578, 3236, 3267, 3274, 3281, 3288, 3291, 3643, 3669, 4010, 4145], 'lines': [149, 250, 426, 527, 3237, 3292, 3644, 4146], 'tested.': [150, 427], 'Furthermore,': [151, 428], 'activity': [153, 166, 213, 430, 443, 490], 'theBRCA1': [155, 432, 2712], 'was': [157, 171, 189, 214, 229, 434, 448, 466, 491, 506, 2681, 2930, 2943, 3119, 3150, 3168, 3232, 3338, 3351, 3367, 3532, 3615, 3654, 3677, 3694, 3726, 3757, 3783, 3786, 3795, 3802, 3810, 3840, 3849, 3880, 3950, 3957, 4001, 4012, 4042, 4067, 4118, 4140, 4171, 4200, 4254, 4265, 4275, 4391, 4450], 'undetectable': [158, 435], 'muscle': [161, 438], 'line': [163, 440, 891], 'C2C12,': [164, 441, 3284], 'whereas': [165, 442], 'maintained.': [172, 449], 'These': [173, 450], 'results': [174, 451, 931, 4023], 'were': [175, 203, 452, 480, 2538, 2860, 2881, 2898, 2907, 2918, 2987, 2992, 3008, 3059, 3191, 3206, 3243, 3293, 3332, 3386, 3639, 3906, 3937, 3970, 3989, 4024], 'consistent': [176, 453], 'pattern': [180, 457, 2252], 'respective': [183, 460], 'genes.': [184, 461], 'specific': [186, 463, 573, 1836, 2678], 'detected': [190, 231, 467, 508, 2682], 'when': [191, 468, 1342, 3016], 'nuclear': [192, 469, 1201, 4236], 'extracts': [193, 470], 'from': [194, 471, 2862, 2883, 2900, 2920, 3152, 3197, 3252, 3641, 3667, 4142], 'HeLa': [195, 472], 'cells': [196, 473, 2699, 3905, 3962, 3969], 'Caco2,': [198, 475, 3269], 'colon': [200, 477, 3272], 'line,': [202, 479], 'incubated': [204, 481, 3764, 3959, 4255], 'promoter.': [209, 486, 2639, 2690], 'This': [210, 487, 3260, 4107], 'protein': [211, 488, 1508], 'binding': [212, 228, 489, 505, 571, 4208, 4311, 4403, 4420, 4473], 'localized': [216, 493], 'an': [218, 495, 696, 933, 1327, 2151, 2522, 2684, 4238], '18-bp': [219, 496, 2685], 'fragment': [220, 497, 2666, 3012, 3034, 3507, 3653, 4170, 4396], 'might': [222, 499, 2143, 2520, 2546], 'involve': [223, 500], 'tissue-specific': [225, 502], 'factor,': [226, 503], 'because': [227, 504, 1586, 2543], 'C2C12': [234, 511], 'line.': [236, 513, 3289], 'The': [237, 514, 827, 1200, 1338, 1518, 1573, 2250, 2346, 2603, 2691, 2924, 2936, 3145, 3530, 3537, 3591, 3610, 3692, 3808, 3847, 4036, 4168, 4252, 4273], 'correlation': [238, 515], 'detection': [241, 518], 'this': [243, 268, 520, 545, 686, 2694, 2731, 3134, 3246, 3594, 4083, 4406, 4574], 'only': [246, 523, 2002, 2696, 4075, 4085, 4399], 'those': [248, 525, 2544, 3181], 'expressed': [252, 529], 'chloramphenicol': [254, 531, 559, 2961], 'acetyltransferase': [255, 532, 560, 2962], 'suggests': [262, 539, 838, 1532, 2258], 'significant': [264, 541], 'positive': [265, 542], 'role': [266, 543, 840, 1469, 1534], 'gene.': [276, 553], 'base': [554], 'pair(s)': [555], 'polymerase': [556, 1425, 3015, 3147], 'chain': [557], 'reaction': [558], 'kilobase': [561], '(pair)': [562], '1,4-piperazinediethanesulfonic': [563], 'acid': [564, 962], 'assay': [568, 4017], 'cAMP-responsive': [569, 4471], 'element': [570, 2686, 2724, 4472], 'site': [572, 4421, 4475, 4568], 'susceptibility': [581], 'isolated': [583, 3640, 4141, 4172], '(1Miki': [584, 1210, 1849], 'Y.': [585, 725, 966, 1123, 1211, 1481, 1483, 1550, 1683, 1850, 2092, 2236, 2453, 2778, 4434], 'Swensen': [586, 722, 967, 1212, 1680, 1851, 2089, 2775], 'J.': [587, 607, 641, 723, 733, 749, 813, 968, 988, 1022, 1213, 1233, 1267, 1401, 1546, 1554, 1681, 1691, 1707, 1771, 1852, 1872, 1906, 1966, 2044, 2090, 2100, 2116, 2200, 2210, 2212, 2298, 2381, 2776, 2786, 2802, 4351, 4438, 4523], 'Shattuck-Eidens': [588, 710, 969, 1214, 1668, 1853, 2077, 2763], 'D.': [589, 629, 667, 711, 795, 797, 970, 1010, 1048, 1083, 1179, 1215, 1255, 1293, 1552, 1669, 1753, 1755, 1785, 1854, 1894, 1932, 2078, 2459, 2764, 3408, 3481, 4328, 4619], 'Futreal': [590, 971, 1216, 1605, 1855], 'P.A.': [591, 707, 776, 778, 972, 1217, 1606, 1665, 1734, 1736, 1856, 2074, 2760], 'Harshman': [592, 714, 973, 1218, 1672, 1857, 2081, 2767], 'K.': [593, 625, 715, 727, 974, 1006, 1171, 1219, 1251, 1475, 1673, 1685, 1858, 1890, 2082, 2094, 2451, 2768, 2780], 'Tavtigan': [594, 716, 975, 1220, 1674, 1859, 2083, 2769], 'S.': [595, 631, 633, 645, 663, 717, 743, 774, 782, 976, 1012, 1014, 1026, 1044, 1150, 1185, 1221, 1257, 1259, 1271, 1289, 1384, 1448, 1675, 1701, 1732, 1740, 1860, 1896, 1898, 1910, 1928, 2084, 2110, 2234, 2439, 2492, 2770, 2796], 'Liu': [596, 708, 977, 1222, 1666, 1861, 2075, 2761, 3492], 'Q.': [597, 709, 978, 1223, 1667, 1862, 2076, 2762], 'Cochran': [598, 712, 979, 1224, 1670, 1863, 2079, 2765], 'C.': [599, 609, 615, 635, 661, 713, 731, 904, 906, 980, 990, 996, 1016, 1042, 1225, 1235, 1241, 1261, 1287, 1671, 1689, 1864, 1874, 1880, 1900, 1926, 2028, 2080, 2098, 2190, 2273, 2766, 2784, 3866], 'Bennett': [600, 718, 981, 1226, 1676, 1865, 2085, 2325, 2771], 'L.M.': [601, 719, 982, 1227, 1677, 1866, 2086, 2326, 2772], 'Ding': [602, 734, 983, 1228, 1692, 1867, 2101, 2787], 'W.': [603, 735, 772, 984, 1229, 1434, 1693, 1730, 1868, 2050, 2102, 2788], 'Bell': [604, 985, 1230, 1869], 'R.': [605, 619, 637, 669, 759, 784, 791, 986, 1000, 1018, 1050, 1177, 1231, 1245, 1263, 1295, 1314, 1428, 1544, 1717, 1742, 1749, 1870, 1884, 1902, 1934, 2126, 2184, 2192, 2373, 2812, 4355], 'Rosenthal': [606, 987, 1232, 1871], 'Hussey': [608, 989, 1234, 1873], 'Tran': [610, 991, 1236, 1875], 'T.': [611, 617, 992, 998, 1237, 1243, 1312, 1556, 1876, 1882, 2395, 2425, 2490], 'McClure': [612, 728, 993, 1238, 1686, 1877, 2095, 2781], 'M.': [613, 657, 729, 780, 945, 994, 1038, 1239, 1283, 1623, 1687, 1738, 1878, 1922, 1968, 2018, 2096, 2194, 2782], 'Frye': [614, 730, 995, 1240, 1688, 1879, 2097, 2783], 'Hattier': [616, 997, 1242, 1881], 'Phelps': [618, 999, 1244, 1883], 'Haugen-Strano': [620, 720, 1001, 1246, 1678, 1885, 2087, 2773], 'A.': [621, 671, 721, 745, 757, 1002, 1052, 1085, 1151, 1247, 1297, 1376, 1385, 1449, 1548, 1602, 1679, 1703, 1715, 1787, 1886, 1936, 2056, 2088, 2112, 2124, 2196, 2198, 2202, 2232, 2275, 2296, 2379, 2401, 2429, 2440, 2774, 2798, 2810], 'Katcher': [622, 1003, 1248, 1887], 'H.': [623, 1004, 1142, 1249, 1378, 1477, 1485, 1888, 2046, 2433, 2455, 2457, 3402, 3475, 3567, 3868, 4322, 4339, 4374, 4550, 4613], 'Yakumo': [624, 1005, 1250, 1889], 'Gholami': [626, 736, 1007, 1252, 1694, 1891, 2103, 2789], 'Z.': [627, 737, 1008, 1253, 1695, 1892, 2104, 2790], 'Shaffer': [628, 1009, 1254, 1893], 'Stone': [630, 1011, 1256, 1895], 'Bayer': [632, 1013, 1258, 1897], 'Wray': [634, 1015, 1260, 1899], 'Bogden': [636, 1017, 1262, 1901], 'Dayananth': [638, 1019, 1264, 1903], 'P.': [639, 643, 653, 655, 739, 1020, 1024, 1034, 1036, 1265, 1269, 1279, 1281, 1629, 1697, 1904, 1908, 1918, 1920, 2106, 2332, 2449, 2496, 2792, 4478, 4521], 'Ward': [640, 1021, 1266, 1905], 'Tonin': [642, 1023, 1268, 1907], 'Narod': [644, 1025, 1270, 1909], 'Bristow': [646, 1027, 1272, 1911], 'P.K.': [647, 1028, 1273, 1912], 'Norris': [648, 1029, 1274, 1913], 'F.H.': [649, 1030, 1275, 1914], 'Helvering': [650, 1031, 1276, 1915], 'L.': [651, 665, 741, 1032, 1046, 1163, 1277, 1291, 1316, 1436, 1699, 1916, 1930, 2042, 2108, 2794, 4349, 4516], 'Morrison': [652, 1033, 1278, 1917], 'Rosteck': [654, 1035, 1280, 1919], 'Lai': [656, 1037, 1282, 1921], 'Barrett': [658, 752, 1039, 1284, 1317, 1710, 1923, 2119, 2805], 'J.C.': [659, 753, 1040, 1285, 1318, 1711, 1924, 2120, 2806], 'Lewis': [660, 1041, 1286, 1925], 'Neuhausen': [662, 1043, 1288, 1927, 1971], 'Cannon-Albright': [664, 1045, 1290, 1929], 'Goldgar': [666, 1047, 1292, 1931], 'Wiseman': [668, 758, 1049, 1294, 1313, 1599, 1716, 1933, 2125, 2333, 2811], 'Kamb': [670, 756, 1051, 1296, 1714, 1935, 2123, 2809], 'Skolnick': [672, 754, 1053, 1298, 1712, 1937, 1969, 2121, 2807], 'M.H.': [673, 755, 1054, 1183, 1299, 1713, 1938, 1970, 2122, 2808], 'Science.': [674, 760, 1055, 1300, 1718, 1939, 2127, 2813], '1994;': [675, 761, 870, 1056, 1301, 1719, 1940, 2128, 2814, 2827, 4357], '266:': [676, 762, 1057, 1302, 1720, 1941, 2129, 2815], '66-71Crossref': [677, 1058, 1303, 1942], 'PubMed': [678, 764, 807, 822, 859, 918, 1059, 1076, 1094, 1155, 1195, 1304, 1368, 1389, 1412, 1453, 1498, 1568, 1722, 1765, 1780, 1796, 1811, 1943, 1979, 2036, 2062, 2131, 2178, 2224, 2245, 2286, 2312, 2341, 2389, 2408, 2444, 2468, 2508, 2598, 2817, 2833, 2975, 3114, 3500, 3580, 3633, 3875, 3899, 4057, 4133, 4163, 4360, 4383, 4445, 4487, 4530, 4559], 'Scopus': [679, 765, 808, 823, 860, 919, 1060, 1077, 1095, 1156, 1196, 1305, 1369, 1390, 1413, 1454, 1499, 1569, 1723, 1766, 1781, 1797, 1812, 1944, 1980, 2037, 2063, 2132, 2179, 2225, 2246, 2287, 2313, 2342, 2390, 2409, 2445, 2469, 2509, 2599, 2818, 2834, 2976, 3115, 3501, 3581, 3634, 3876, 3900, 4058, 4134, 4164, 4361, 4384, 4446, 4488, 4531, 4560], '(5303)': [680, 1061, 1306, 1945], 'Google': [681, 767, 810, 825, 862, 873, 921, 952, 1062, 1079, 1097, 1139, 1158, 1198, 1307, 1324, 1371, 1392, 1415, 1456, 1501, 1571, 1616, 1637, 1725, 1768, 1783, 1799, 1814, 1946, 1982, 2039, 2065, 2134, 2181, 2227, 2248, 2289, 2315, 2344, 2392, 2411, 2447, 2471, 2511, 2601, 2820, 2836, 2978, 3117, 3415, 3488, 3503, 3583, 3636, 3878, 3902, 4060, 4136, 4166, 4335, 4363, 4386, 4448, 4490, 4533, 4562], 'Scholar),': [682, 3118, 3584, 4061, 4449], 'mutations': [684, 1655, 1993, 2140, 2475, 2537, 2549, 2718, 2744], 'are': [688, 1639, 1842, 2370, 3249, 4101, 4408], 'found': [689, 1658, 2719, 2758, 4451], 'majority': [692], 'families': [694, 837, 1825, 1953], 'increased': [697], 'incidence': [698], 'early': [700, 1951, 2152], 'onset': [701], 'and/or': [703], '(2Futreal': [706, 1664, 2073, 2759], 'Miki': [724, 1682, 2091, 2777], 'Eddington': [726, 1684, 2093, 2779], 'Weaver-Feldhaus': [732, 1690, 2099, 2785], 'Soderkvist': [738, 1696, 2105, 2791], 'Terry': [740, 1698, 2107, 2793], 'Jhanwar': [742, 1700, 2109, 2795], 'Berchuck': [744, 1601, 1702, 2111, 2797], 'Iglehart': [746, 1704, 2113, 2799], 'J.D.': [747, 1400, 1442, 1489, 1604, 1705, 2114, 2800, 4152], 'Marks': [748, 1607, 1706, 2115, 2801], 'Ballinger': [750, 1708, 2117, 2803], 'D.G.': [751, 1709, 2118, 2804], '120-122Crossref': [763, 1721, 2130, 2816], '(1139)': [766, 1724, 2133, 2819], 'Scholar,': [768, 811, 863, 1140, 1159, 1308, 1372, 1726, 1769, 1800, 2040, 2182, 2228, 2290, 2316, 2393, 2821, 3489, 4364], '3Gayther': [769, 1727], 'S.A.': [770, 847, 1728, 2431], 'Warren': [771, 1729], 'Mazoyer': [773, 1731], 'Russell': [775, 1733], 'Harrington': [777, 1735], 'Chiano': [779, 1737], 'Seal': [781, 1739], 'Hamoudi': [783, 1741], 'van': [785, 1743], 'Rensburg': [786, 1744], 'E.J.': [787, 1745], 'Dunnuing': [788, 1746], 'A.M.': [789, 1747, 2168], 'Love': [790, 1748], 'Evans': [792, 850, 1597, 1750], 'G.': [793, 1069, 1596, 1751, 2052], 'Easton': [794, 848, 1752], 'Clayton': [796, 1754], 'Stratton': [798, 1756], 'M.R.': [799, 1165, 1757, 2494], 'Ponder': [800, 852, 1758], 'B.A.J.': [801, 853, 1759], 'Nat.': [802, 854, 913, 1190, 1760, 2031, 2057, 2173, 2307, 2384, 2593], 'Genet.': [803, 855, 914, 1088, 1191, 1761, 1790, 1975, 2032, 2058, 2174, 2308, 2385, 2594, 3576, 4379, 4555], '1995;': [804, 1762, 2033, 2059, 2283, 2309, 2595, 4380, 4484, 4556], '11:': [805, 1763, 2310, 2406, 3897, 4161, 4485], '428-433Crossref': [806, 1764], '(465)': [809, 1767], '4Feunteun': [812, 1770], 'Lenoir': [814, 1772], 'G.M.': [815, 1773], 'Biochim.': [816, 1774], 'Biophys.': [817, 1775], 'Acta.': [818, 1776], '1996;': [819, 915, 949, 1136, 1321, 1365, 1386, 1613, 1777, 1808, 2175, 2216, 2242, 3412, 3485, 3497, 4332], '1242:': [820, 1778], '177-180Crossref': [821, 1779], '(24)': [824, 1782], 'Scholar).': [826, 874, 922, 953, 1098, 1199, 1416, 1457, 1502, 1572, 1815, 1947, 1983, 2135, 2249, 2345, 2472, 2512, 2602, 2837, 2979, 3416, 3504, 3637, 3903, 4137, 4167, 4387, 4491], 'frequent': [828], 'wild': [832], 'typeBRCA1': [833], 'allele': [834], 'these': [836, 1831, 1950, 2367, 2515, 2624], '(5Smith': [846], 'D.F.': [849, 3491], 'D.G.R.': [851], '1992;': [856], '2:': [857], '128-131Crossref': [858], '(391)': [861], '6Neuhausen': [864], 'S.L.': [865, 1972], 'Marshall': [866], 'C.J.': [867], 'Cancer': [868, 1134, 1319, 1806], 'Res.': [869, 1135, 1320, 3110, 4159], '54:': [871], '6069-6072PubMed': [872], 'Tumor': [875], 'function': [877, 1333, 1353, 4390], 'has': [878, 2413, 2756, 3392, 3450, 4313], 'also': [879, 1419, 1584, 2257, 2568, 4108], 'demonstrated': [881, 2158], 'ability': [884, 1459, 2703], 'inhibit': [886], 'MCF7': [892], 'induce': [894], 'tumors': [895], 'nude': [897], 'mice': [898, 2351], '(7Holt': [899], 'J.T.': [900, 2592], 'Thompson': [901], 'M.E.': [902, 2584], 'Szabo': [903], 'Robinson-Benion': [905], 'Arteaga': [907], 'C.L.': [908], 'King': [909], 'M.-C.': [910, 2968, 3626, 3892, 4050, 4126], 'Jensen': [911, 2585], 'R.A.': [912, 1438, 2586, 3495], '12:': [916, 950, 2176, 3413, 3486, 4333], '298-302Crossref': [917, 2388], '(380)': [920], 'Antisense-mediated': [923], 'reduction': [924], 'NIH3T3': [929], 'fibroblasts': [930], 'increase': [934], 'cellular': [936], 'proliferation': [937, 2266], 'transformation': [939], '(8Rao': [940], 'V.N.': [941], 'Shao': [942], 'N.': [943], 'Ahmad': [944], 'Reddy': [946], 'E.S.P.': [947], 'Oncogene.': [948, 2337, 2464, 3411, 3484, 4331], '523-528PubMed': [951], 'encodes': [955], 'product': [958, 3346, 4087], '1863': [960], 'amino': [961], 'residues': [963], '(Ref.': [964], '1Miki': [965], 'Scholar;': [1063], 'reviews,': [1065], 'see': [1066], 'Refs.': [1067], '9Casey': [1068], 'Curr.': [1070, 1086, 1788], 'Opin.': [1071, 1087, 1789], 'Oncol.': [1072], '1997;': [1073, 1152, 1450, 1495, 1560, 1634, 1976, 2386, 2405, 2500, 3577, 4442, 4527], '9:': [1074, 2034, 2060, 2284, 2596], '88-93Crossref': [1075], '(84)': [1078], 'Scholar': [1080], '10Bertwistle': [1082], 'Ashworth': [1084, 1786], '&': [1089, 1611, 1632, 1791, 2240, 2281, 2403], 'Dev.': [1090, 1792, 2241, 2282, 2404, 4482], '1998;': [1091, 1793, 2338, 2441, 2465], '8:': [1092, 1635, 1794], '14-20Crossref': [1093, 1795], '(91)': [1096, 1798], 'Beyond': [1099], 'initial': [1101], 'controversy': [1102], 'subcellular': [1105], 'location,': [1106], 'it': [1107, 3725, 3949, 4264], 'now': [1109, 1955], 'generally': [1110, 4102], 'accepted': [1111], '220-kDa': [1116], 'phosphoprotein,': [1117], 'nucleus': [1121], '(11Chen': [1122], 'Farmer': [1124], 'A.A.': [1125], 'Chen': [1126, 1130, 1174, 1545, 2017], 'C.-F.': [1127, 1802, 3400, 3473, 3563, 4320, 4341, 4366, 4542, 4611], 'Jones': [1128, 4344], 'D.C.': [1129], 'P.-L.': [1131], 'Lee': [1132, 2237], 'W.-H.': [1133, 2238], '56:': [1137, 1322], '3168-3172PubMed': [1138], '12Ruffner': [1141], 'Verma': [1143, 1362], 'I.M.': [1144, 1363], 'Proc.': [1145, 1379, 1443, 2434], 'Natl.': [1146, 1380, 1444, 2435], 'Acad.': [1147, 1381, 1445, 2436], 'Sci.': [1148, 1382, 1446, 2437], 'U.': [1149, 1383, 1447, 2438], '94:': [1153, 1451], '7138-7143Crossref': [1154], '(179)': [1157], '13Wilson': [1160], 'C.A.': [1161, 2279], 'Ramos': [1162], 'Villasenor': [1164], 'Anders': [1166], 'K.H.': [1167], 'Press': [1168], 'M.F.': [1169], 'Clarke': [1170], 'Karlan': [1172], 'B.': [1173, 1627, 2823, 3404, 3477, 3590, 4324, 4343, 4372, 4518, 4548, 4615], 'J.-J.': [1175], 'Scully': [1176], 'Livingston': [1178, 1439, 1557], 'Zuch': [1180], 'R.H.': [1181], 'Kanter': [1182], 'Cohen': [1184], 'Calzone': [1186], 'F.J.': [1187], 'Alamon': [1188], 'D.J.': [1189], '1999;': [1192, 1404], '21:': [1193], '236-240Crossref': [1194], '(370)': [1197], 'localization': [1202], 'existence': [1205, 2692], 'Ring-finger': [1208], 'domain': [1209, 1329], '14Bienstock': [1309], 'R.J.': [1310], 'Darden': [1311], 'Pedersen': [1315], '2539-2545PubMed': [1323], 'Scholar)': [1325, 1393, 1617, 1638, 2066, 3879, 4534, 4563], 'acidic': [1328, 1340], 'support': [1330], 'proposed': [1332], 'factor.': [1337], 'C-terminal': [1339], 'domain,': [1341, 1349], 'fused': [1343], 'yeast': [1346, 3672], 'Gal4': [1347], 'DNA-binding': [1348], 'able': [1351], 'activator': [1357], 'bothin': [1358], 'vivo': [1359], '(15Chapman': [1360], 'M.S.': [1361, 2277], 'Nature.': [1364, 1494, 4356], '382:': [1366], '678-679Crossref': [1367], '(436)': [1370], '16Monteiro': [1373], 'A.N.A.': [1374, 2427], 'August': [1375, 2428], 'Hanafusa': [1377, 2432], '93:': [1387], '13595-13599Crossref': [1388], '(428)': [1391], 'vitro': [1396], '(17Haile': [1397], 'D.T.': [1398], 'Parvin': [1399, 1441], 'Biol.': [1402, 1807, 2971, 3629, 3871, 3895, 4053, 4129, 4441, 4483, 4526], 'Chem.': [1403], '274:': [1405], '2113-2117Abstract': [1406], 'Full': [1407, 1409, 1563, 1565, 2219, 2221, 2503, 2505, 2830], 'Text': [1408, 1410, 1564, 1566, 2220, 2222, 2504, 2506, 2831], 'PDF': [1411, 1567, 2223, 2507, 2832], '(73)': [1414], 'component': [1421], 'RNA': [1424], 'holoenzyme': [1426], '(18Scully': [1427], 'Anderson': [1429], 'S.F.': [1430], 'Chao': [1431], 'D.M.': [1432, 1440, 1558, 4353], 'Wei': [1433], 'Ye': [1435], 'Young': [1437], '5605-5610Crossref': [1452], '(422)': [1455], 'stimulate': [1461], 'p21': [1462], 'provides': [1464], 'direct': [1465], 'evidence': [1466], 'factor': [1473, 2728, 4310, 4402], '(19Somasundaram': [1474], 'Zhang': [1476, 1484, 2456], 'Zeng': [1478, 2235], 'Y.-X.': [1479], 'Houvras': [1480], 'Peng': [1482, 2452], 'Wu': [1486], 'G.S.': [1487], 'Licht': [1488], 'Weber': [1490, 2023, 2303, 2460], 'B.L.': [1491, 2024, 2166, 2304, 3571], 'El-Deiry': [1492, 2462], 'W.S.': [1493, 2463], '389:': [1496], '187-190Crossref': [1497], '(471)': [1500], 'interacts': [1504], 'Rad51,': [1506], 'known': [1511, 1956, 3837, 4506], 'involved': [1514], 'DNA': [1516, 1642, 2984, 3006, 3183, 3322, 3345, 3366, 3839, 3936, 4169], 'repair.': [1517], 'co-localization': [1519], 'proteins': [1522], 'on': [1523, 2619, 3001, 3340, 3827, 4091, 4191], 'asynapsed': [1524], 'elements': [1525], 'human': [1527, 2637, 3264, 3271, 3278, 3341, 3381], 'synaptonemal': [1528], 'complexes': [1529], 'during': [1530, 2578], 'meiosis': [1531], 'control': [1539, 1582], 'genome': [1541], 'integrity': [1542], '(20Scully': [1543], 'Plug': [1547], 'Xiao': [1549], 'Weaver': [1551], 'Feunteun': [1553], 'Ashley': [1555], 'Cell.': [1559, 2215, 2826, 2970, 3628, 3870, 3894, 4052, 4128], '88:': [1561], '265-275Abstract': [1562], '(1326)': [1570], 'cycle': [1579, 3999], 'check': [1580], 'point': [1581], 'apparent': [1585], '(21Vaughn': [1589], 'J.P.': [1590], 'Davis': [1591, 2335], 'P.L.': [1592], 'Jarboe': [1593], 'M.D.': [1594], 'Huper': [1595], 'A.C.': [1598], 'R.W.': [1600, 2334], 'Igelehart': [1603], 'J.R.': [1608], 'Cell': [1609, 1630, 2913, 4440, 4481, 4525], 'Growth': [1610, 1631], 'Differ.': [1612, 1633], '7:': [1614, 1809, 3873], '711-715PubMed': [1615], 'phosphorylation': [1619], '(22Thomas': [1620], 'J.E.': [1621], 'Smith': [1622], 'Tonkinson': [1624], 'J.L.': [1625, 2188, 2377], 'Rubinfeld': [1626], 'Polakis': [1628], '801-809PubMed': [1636], 'induced': [1640], 'before': [1641, 3920, 3948], 'synthesis.': [1643], 'Since': [1644], 'cloning': [1646, 2933, 2955], 'more': [1651], 'hundred': [1654], 'throughout': [1659, 2255], 'entire': [1661], 'coding': [1662], 'sequence': [1663, 3361, 3448, 3531, 3538, 4407, 4494, 4600], 'Scholar,10Bertwistle': [1784], '23Xu': [1801], 'Solomon': [1803, 2047, 3409, 3482, 3572, 4329, 4346, 4375, 4551, 4620], 'E.': [1804, 2048, 2054, 2206, 3410, 3483, 3573, 4330, 4347, 4376, 4552, 4621], 'Semin.': [1805], '33-40Crossref': [1810], '(49)': [1813], 'However,': [1816, 4592], 'remain': [1818], 'unknown': [1827], 'mutations.': [1828, 2626], 'Some': [1829], 'patient': [1832], 'samples': [1833, 2545], 'exhibit': [1834], 'allelic': [1837], 'transcripts': [1840], 'thought': [1843], 'regulatory': [1847, 2565, 2613, 2625, 2743], 'mutation': [1848, 2753], 'One': [1948], 'reported': [1952, 2000], 'harbor': [1958], 'deletion': [1960], '(24Swensen': [1965], 'Hoffman': [1967], 'Hum.': [1973, 3574, 4377, 4553], 'Mol.': [1974, 2969, 3575, 3627, 3869, 3893, 4051, 4127, 4378, 4554], '6:': [1977, 3578], '1513-1517Crossref': [1978], '(108)': [1981], 'contrast': [1985], 'familial': [1987, 2486], 'somatic': [1992], 'very': [2004, 2481], 'few': [2005], '(25Merajver': [2011], 'S.D.': [2012], 'Pham': [2013], 'T.M.': [2014], 'Caduff': [2015], 'R.F.': [2016], 'Poy': [2019], 'E.L.': [2020], 'Cooney': [2021], 'K.A.': [2022, 2324, 4345], 'Collins': [2025, 2327], 'F.S.': [2026], 'Johnston': [2027], 'Frank': [2029], 'T.S.': [2030], '439-443Crossref': [2035], '(376)': [2038], '26Hosking': [2041], 'Trowsdale': [2043, 4350], 'Nicolai': [2045, 3401, 3474, 3566, 4321, 4338, 4373, 4549, 4612], 'Foulkes': [2049], 'Stamp': [2051], 'Signer': [2053], 'Jeffery': [2055], '343-344Crossref': [2061], '(143)': [2064], 'none': [2068], 'It': [2136, 2528, 2714], 'hypothesized': [2138], 'affect': [2144], 'process': [2146], 'growth': [2148], 'stage': [2153], 'development,': [2155], 'mouse': [2160, 3286], 'knock-out': [2161, 2350], 'experiments': [2162], '(27Gowen': [2163], 'L.C.': [2164], 'Johnson': [2165], 'Latour': [2167], 'Sulik': [2169], 'K.K.': [2170], 'Koller': [2171], 'B.H.': [2172], '191-194Crossref': [2177], '(396)': [2180], '28Hakem': [2183], 'de': [2185, 2374], 'La': [2186, 2375, 2940], 'Pompa': [2187, 2376], 'Sirard': [2189], 'Mo': [2191], 'Woo': [2193], 'Hakem': [2195], 'Wakeham': [2197], 'Potter': [2199, 2380], 'Reitmair': [2201], 'Billia': [2203], 'F.': [2204], 'Firpo': [2205], 'Hui': [2207], 'C.C.': [2208], 'Roberts': [2209], 'Rossant': [2211], 'Mak': [2213, 2382], 'T.W.': [2214, 2383], '85:': [2217], '1009-1023Abstract': [2218], '(577)': [2226], '29Liu': [2229], 'C.-Y.': [2230], 'Lesken-Nikitin': [2231], 'Li': [2233], 'Genes': [2239, 2280, 2402], '10:': [2243, 2973, 3631, 4055, 4131], '1835-1843Crossref': [2244], '(274)': [2247], 'development': [2256], 'importance': [2260], 'tissues': [2262, 3240], 'undergo': [2264], 'rapid': [2265], 'terminal': [2268], 'differentiation': [2269], '(30Lane': [2270], 'T.F.': [2271], 'Deng': [2272], 'Elson': [2274], 'Lyu': [2276], 'Kozak': [2278], '2712-2722Crossref': [2285], '(197)': [2288], '31Marquis': [2291], 'S.T.': [2292], 'Rajan': [2293], 'J.V.': [2294], 'Wynshaw-Boris': [2295], 'Xu': [2297, 3399, 3472, 4319, 4340, 4538, 4610], 'Yin': [2299], 'G.-Y.': [2300], 'Abel': [2301], 'K.J.': [2302], 'Chodosh': [2305], 'L.A.': [2306], '17-26Crossref': [2311], '(331)': [2314], '32Blackshear': [2317], 'P.E.': [2318], 'Goldsworthy': [2319], 'S.M.': [2320], 'Foley': [2321], 'J.F.': [2322], 'McAllister': [2323], 'N.K.': [2328], 'Bunch': [2329], 'D.O.': [2330], 'Brown': [2331, 3564, 4367, 4431, 4543], 'B.J.': [2336], '16:': [2339, 2387, 2466], '61-68Crossref': [2340], '(78)': [2343], 'generation': [2347], 'double': [2349], 'disruptions': [2353], 'p53': [2356, 2474, 2519, 2548], 'raises': [2359], 'possibility': [2361], 'developmental': [2364], 'pathways': [2365], 'two': [2368], 'genes': [2369, 2423, 2556], '(33Hakem': [2372], 'Elia': [2378], '(227)': [2391], '34Ludwig': [2394], 'Chapman': [2396], 'D.L.': [2397, 2590], 'Papaioannou': [2398], 'V.E.': [2399], 'Efstratiadis': [2400], '1226-1241Crossref': [2407], '(462)': [2410], 'Scholar).BRCA1': [2412], 'shown': [2415, 3519, 3586], 'physically': [2417], 'associate': [2418], 'withp53': [2419], 'co-activate': [2421], 'p53-responsive': [2422], '(35Ouchi': [2424], 'Monteiro': [2426], 'Aaronson': [2430], '95:': [2442], '2302-2306Crossref': [2443], '(333)': [2446], 'Scholar,36Zhang': [2448], 'Somasundaram': [2450], 'Tian': [2454], 'Bi': [2458], 'B.I.': [2461], '1713-1721Crossref': [2467], '(426)': [2470], 'Interestingly,': [2473], 'seem': [2476], 'occur': [2478], 'high': [2482], 'frequency': [2483], 'BRCA1-associated': [2485, 2526], '(37Crook': [2489], 'Crossland': [2491], 'Crompton': [2493], 'Osin': [2495], 'Gusterson': [2497], 'B.A.': [2498], 'Lancet.': [2499], '350:': [2501], '638-639Abstract': [2502], '(159)': [2510], 'Taken': [2513], 'together,': [2514], 'suggest': [2517], 'important': [2523, 2612], 'checkpoint': [2524], 'tumorigenesis.': [2527], 'most': [2533], 'cancers,BRCA1': [2536], 'being': [2540], 'searched': [2541], 'other': [2551, 2560, 2841], 'oncogenes': [2552], 'identified.': [2557], 'On': [2558, 4622], 'hand,': [2561], 'disruption': [2563], 'sequences': [2566, 2614, 3513, 4602], 'cause': [2571], 'decrease': [2574], 'progression': [2582], '(38Thompson': [2583], 'Obermiller': [2587], 'P.S.': [2588], 'Page': [2589], 'Holt': [2591], '444-450Crossref': [2597], '(544)': [2600], 'analysis': [2604, 4295], 'identification': [2610], 'will': [2615, 3136], 'therefore': [2616], 'provide': [2617], 'information': [2618], 'where': [2620, 2751], 'search': [2622], 'We': [2627], 'report': [2628, 2732, 3595], 'here': [2629], 'isolation': [2631, 3429], '(bp)1': [2643], 'serve': [2647], 'delimited': [2662], 'region,': [2670], 'retained': [2672], 'activity.': [2676], 'BRCA1-expressing': [2698], 'correlated': [2700], 'direction.': [2713], 'conceivable': [2716], 'either': [2721], 'cis-acting': [2723], 'thetrans-acting': [2726], 'described': [2729, 3394, 3887, 4045, 4121], 'target': [2736], 'mutagenesis': [2738], 'cancers': [2741], 'even': [2746], 'no': [2752, 3017], '39Vogelstein': [2822], 'Kinzler': [2824], 'K.W.': [2825], '79:': [2828], '1-3Abstract': [2829], '(58)': [2835], 'Restriction': [2838], 'enzymes': [2839, 2843, 3020], 'DNA-modifying': [2842], 'such': [2844], 'T4': [2846, 2848, 2850, 3014, 3661], 'kinase,': [2847], 'polymerase,': [2849], 'ligase,': [2851], 'Klenow': [2852, 3011, 4196], 'calf': [2854, 3307], 'intestinal': [2855], 'phosphatase,': [2856], 'S1': [2858, 2891, 3611, 3706, 3735, 3755], 'nuclease': [2859, 2892, 3612, 3756], 'purchased': [2861, 2899, 3151], 'Life': [2863, 2921], 'Technologies': [2864], 'Inc.,': [2865], 'New': [2866], 'England': [2867], 'Biolabs': [2868], '(Mississauga,': [2869], 'Ontario,': [2870], 'Canada),': [2871], 'Roche': [2872], 'Molecular': [2873], 'Biochemicals,': [2874], 'Amersham': [2876, 2884, 3153], 'Pharmacia': [2877, 2885, 3154, 3166, 4072], 'Biotech.': [2878, 2886, 3155], 'All': [2879, 3054, 3290], 'isotopes': [2880], 'products': [2882, 2908, 4099], 'Chemicals': [2887], 'used': [2888, 2931, 2944, 3023, 3120, 3132, 3233, 3244, 3616, 3881, 4002, 4013, 4025], 'protection,': [2893], 'CAT,': [2894], 'β-galactosidase': [2896, 4016], 'assays': [2897, 4041], 'Sigma.': [2901], 'Thin': [2902], 'layer': [2903], 'chromatography': [2904], '(TLC)': [2905], 'plates': [2906], 'Kodak': [2910, 3854, 4287], '(Rochester,': [2911], 'NY).': [2912], 'culture': [2914, 3915], 'media': [2915], 'reagents': [2917], 'obtained': [2919, 3042, 3196], 'Technologies,': [2922, 3301, 3649], 'Inc.': [2923], 'plasmid': [2925, 2937, 2952, 3038, 3093, 3358, 3838, 4176], 'pCR2.1': [2926], '(Invitrogen,': [2927], 'Carlsbad,': [2928], 'CA)': [2929, 2942], 'PCR-amplified': [2934], 'products.': [2935], 'pBluescript(IIKS)': [2938, 2990, 3225], '(Stratagene,': [2939], 'Jolla,': [2941], 'general': [2946], 'subcloning': [2947], 'purposes.': [2948], 'pMT.IC3': [2949, 3037], 'containing': [2953, 3508, 3752], 'multiple': [2954], 'sites': [2956, 3000, 3607, 3622, 4312, 4404], 'placed': [2957], 'upstream': [2958, 3512, 3546], '(CAT)': [2963], '(40Suen': [2965, 3623, 4047, 4123], 'T.-C.': [2966, 3624, 3890, 4048, 4124], 'Hung': [2967, 3625, 3891, 4049, 4125], '1990;': [2972, 3630, 4054, 4130], '6306-6315Crossref': [2974, 3632, 4056, 4132], '(41)': [2977, 3635, 4059, 4135], 'Most': [2980, 3174], 'restriction': [2985, 2999, 3019, 3420, 4181, 4193], 'fragments': [2986, 3007, 3440], 'into': [2989, 2995, 3356, 3912], 'then': [2993, 3803], 'shuffled': [2994], 'matching': [2997], 'unique': [2998], 'polylinker': [3003], 'pMT.IC3.': [3005], 'blunt-ended': [3009], 'appropriate': [3018, 4180, 4239], 'directional': [3025], 'cloning.': [3026], 'reversed': [3029], 'orientation': [3030], 'subcloned': [3033, 3355, 3439], 'easily': [3040], 'cutting': [3044], 'HindIII,': [3046], 'flank': [3048], 'polylinker,': [3050], 'followed': [3051, 3787], 'religation.': [3053], 'CAT': [3057, 3074, 3934, 4034, 4040, 4115], 'constructs': [3058], 'named': [3060, 4573], 'according': [3061, 3170], 'transcription.': [3066], 'Therefore': [3067], 'pBR': [3069], 'pNB': [3071], 'series': [3072], 'plasmids': [3075, 3131, 3160], 'indicate': [3076], 'promoters': [3077], 'transcribing': [3078], 'toward': [3079], 'directions,': [3085], 'respectively.': [3086], 'pCMVβ': [3087, 3928], '(CLONTECH,': [3088], 'Palo': [3089], 'Alto,': [3090], 'CA),': [3091], 'contains': [3095], 'lacZ': [3097], 'driven': [3099], 'cytomegalovirus': [3102], 'enhancer': [3103], '(41MacGregor': [3104], 'G.R.': [3105], 'Caskey': [3106], 'C.T.': [3107], 'Nucleic': [3108, 4157], 'Acids': [3109, 4158], '1989;': [3111], '17:': [3112], '2365Crossref': [3113], '(440)': [3116], 'monitoring': [3122], 'transfection': [3123, 3883], 'efficiency.': [3124], 'Detailed': [3125], 'maps': [3126], 'study': [3135, 3247], 'distributed': [3138], 'along': [3139], 'materials': [3142], 'upon': [3143, 4593], 'request.': [3144], 'T7': [3146], 'sequencing': [3148, 3157, 3220, 3833], 'kit': [3149], 'Dideoxy': [3156], 'double-stranded': [3159], '[α-35S]dATP': [3162], '[α-35S]dCTP': [3164], '(Amersham': [3165, 4071], 'Biotech)': [3167], 'performed': [3169, 3339, 4043, 4119], 'manufacturer.': [3173], 'subclones,': [3179], 'particularly': [3180], 'inserts': [3184], 'less': [3186], '300-bp': [3188], 'size,': [3190], 'confirmed': [3192, 3441], 'sequencing.': [3194], 'Oligonucleotides,': [3195], 'Hospital': [3199], 'Sick': [3201], 'Children': [3202], 'Biotechnology': [3203], 'Center,': [3204], 'Toronto,': [3205], 'follows:': [3208], 'PCR': [3209, 3337], 'primer,': [3210, 3221], '+': [3212, 3217], '89': [3213], '(5′-GCAGAGGGTGAAGGCCTCCTG-3′)': [3214], '2': [3218], '(5′-GCTCGCTGAGACTTCCTGGAC-3′);': [3219], 'pMTIC3': [3222], '(5′-TAGGCGTATCACGAGGCCC-3′)': [3223], '(the': [3226], 'reverse': [3227], 'primer': [3228, 3231], 'universal': [3230], '(Stratagene)).': [3234], 'Several': [3235], 'representing': [3238], 'different': [3239, 3642, 4144], 'origin': [3242], 'available': [3251], 'American': [3253], 'Type': [3254], 'Culture': [3255], 'Collection': [3256], '(ATCC,': [3257], 'Manassas,': [3258], 'VA).': [3259], 'includes': [3261], 'HeLa,': [3262], 'cervical': [3265], 'carcinoma': [3266, 3273, 3280], 'line;': [3268, 3275, 3282], 'MCF7,': [3276], 'mammary': [3279], 'myoblast': [3287], 'cultured': [3294], "Dulbecco's": [3296], 'modified': [3297, 3885], "Eagle's-F12": [3298], 'medium': [3299], '(Life': [3300, 3648], 'Inc.)': [3302], 'supplemented': [3303], '10%': [3305], 'fetal': [3306], 'serum': [3308], 'kept': [3310], 'humidified,': [3313], '37': [3314, 3766, 3985], '°C,': [3315], '5%': [3316, 4227], 'CO2': [3317], 'incubator.': [3318, 3987], 'primers': [3323], 'exon': [3326, 3364, 3424, 3542], '1': [3327, 3365, 3425, 3510, 3528, 3543, 3589, 3720, 3817, 3925, 4219, 4224, 4411, 4536, 4590], 'cDNA': [3331], 'synthesized': [3333], '(Fig.1': [3334], 'B),': [3335], 'lymphocyte': [3342], 'DNA.': [3343, 3383], 'Amplified': [3344], 'expected': [3349], 'size': [3350, 3845], 'gel': [3352, 3848, 4274, 4281], 'purified': [3353], 'pCR2.1.': [3359], 'After': [3360], 'confirmation,': [3362], 'labeled': [3368, 3657, 4185], 'probe': [3371, 3683], 'screen': [3373], 'phage': [3375], 'artificial': [3376], 'chromosome': [3377], '(PAC)': [3378], 'library': [3379], 'genomic': [3382, 3447, 3525], 'Three': [3384], 'clones': [3385], 'obtained,': [3387], 'one': [3388, 4076, 4086], 'which,': [3390], 'P103014,': [3391], 'others': [3396], '(42Brown': [3397, 3470, 4317, 4608], 'M.A.': [3398, 3471, 3565, 4318, 4337, 4368, 4544, 4609], 'Griffiths': [3403, 3476, 3570, 4323, 4342, 4371, 4547, 4614], 'Chambers': [3405, 3478, 3568, 4325, 4369, 4545, 4616], 'J.A.': [3406, 3479, 3569, 4326, 4370, 4546, 4617], 'Black': [3407, 3480, 4327, 4352, 4618], '2507-2513PubMed': [3414, 3487, 4334], 'Repeated': [3417], 'rounds': [3418], 'mapping,': [3421], 'subcloning,': [3422], 'probing': [3426], 'allowed': [3427], '3.8-kb': [3432], 'PstI': [3433], 'fragment.': [3434, 4197], 'Sequencing': [3435], 'various': [3438, 3668], 'their': [3442, 4578], 'identity': [3443], 'deposited': [3452], 'GenBankTM': [3455], '(accession': [3456], 'no.': [3457], 'U37574)': [3458], 'duplicated': [3463], 'pseudogene': [3464], 'same': [3468, 4606], '43Barker': [3490], 'X.': [3493], 'Almeida': [3494], 'Genomics.': [3496], '38:': [3498], '215-222Crossref': [3499], '(27)': [3502], '2.7-kbPstI-XbaI': [3506], 'intron': [3509], 'schematically': [3520], 'respect': [3522, 4306], 'organization': [3526], '(Fig.': [3527, 4410, 4535], 'A).': [3529], 'numbered': [3533], 'U37574.': [3536], 'untranslated': [3541], 'BRCA1,': [3549], 'including': [3550], 'complete': [3552], '(44Xu': [3562], '1057-1062Crossref': [3579], '(75)': [3582], 'Fig.': [3588, 4589], 'focus': [3592], 'restricted': [3597], 'theEcoRI': [3603], 'SstI': [3606], '(shown': [3608], 'inbold).': [3609], 'protection': [3613], 'method': [3614, 3864, 4000, 4038, 4150], 'determine': [3618], 'initiation': [3621], 'RNAs': [3638, 3666], 'Triazol': [3646], 'Reagent': [3647], 'Inc.).': [3650], '728-bpStuI-StuI': [3652], 'dephosphorylated': [3655], '[γ-32P]ATP': [3659], 'kinase.': [3662], '20': [3663, 3749], 'μg': [3664, 3926, 3931, 4230, 4234], 'lines,': [3670], 'tRNA': [3673], '(as': [3674], 'control),': [3676], 'co-precipitated': [3678, 3938], '50,000': [3680], 'cpm': [3681, 4249], 'ethanol': [3685, 3794], 'addition': [3688], 'lithium': [3690], 'acetate.': [3691], 'precipitate': [3693, 3798], 'washed': [3695, 3971, 3990], '70%': [3697], 'ethanol,': [3698], 'dried,': [3699], 'resuspended': [3701, 3811], '50': [3703, 3741, 3771, 4216], 'μl': [3704, 3733, 3772], 'hybridization': [3707], 'buffer': [3708, 3737, 3775, 3941, 4209], '(80%': [3709], 'deionized': [3710], 'formamide,': [3711], '40': [3712], 'mm': [3713, 3718, 3721, 3739, 3742, 3747, 3781, 3818, 4212, 4217, 4222], 'PIPES,': [3714], 'pH': [3715, 4214], '6.8,': [3716], '400': [3717], 'NaCl,': [3719, 3740], 'EDTA),': [3722], 'after': [3723, 3966, 3993, 4262], 'submerged': [3727], '60': [3729], '°C': [3730, 3767, 3986], 'overnight.': [3731], '300': [3732], 'digestion': [3736], '(280': [3738], 'sodium': [3743], 'acetate,': [3744, 3779], 'pH4.6,': [3745], '4.5': [3746], 'ZnSO4,': [3748], 'μg/ml': [3750], 'ssDNA)': [3751], '200': [3753], 'units/ml': [3754], 'added': [3758, 3796, 3951, 4201], 'hybridized': [3761], 'mix': [3762], '30': [3769], 'min.': [3770], 'stop': [3774], '(4': [3776], 'm': [3777], 'ammonium': [3778], '0.1': [3780, 4221], 'EDTA)': [3782], 'added,': [3784], 'phenol/chloroform': [3789], 'extraction.': [3790], 'Two': [3791], 'volumes': [3792], 'DNA,': [3800], 'dried': [3804, 3850, 4276], 'SpeedVac.': [3807], 'sample': [3809], 'loading': [3813], 'dye': [3814], '(48%': [3815], 'urea,': [3816], 'EDTA,': [3819, 4223], '0.1m': [3820], 'NaOH,': [3821], '0.01%': [3822], 'bromophenol': [3823], 'blue)': [3824], 'run': [3826, 3841], '7.5%': [3829], 'denaturing': [3830], 'gel.': [3831, 4272], 'ladder': [3834], 'alongside': [3842], 'marker.': [3846], 'exposed': [3852, 4284], 'XAR-5': [3855], 'film': [3856, 4290], '−80': [3858, 4292], '°C.': [3859, 4293], 'calcium': [3861], 'phosphate': [3862], 'precipitation': [3863], '(45Chen': [3865], 'Okayama': [3867], '1987;': [3872], '2745-2752Crossref': [3874], '(4821)': [3877], 'previously': [3888, 4046, 4122], '(46Suen': [3889], '1991;': [3896], '354-362Crossref': [3898], '(56)': [3901], 'Briefly,': [3904], 'split': [3907], 'predetermined': [3910], 'ratio': [3911], '100-mm': [3913], 'tissue': [3914], 'dishes': [3916], '(Falcon)': [3917], 'day': [3919], 'transfection.': [3921], 'Unless': [3922], 'otherwise': [3923], 'indicated,': [3924], '10': [3930, 4211, 4233], 'room': [3943, 4257], 'temperature': [3944, 4258], '25': [3946, 4260], 'min,': [3947, 4261], 'directly': [3952], 'cells.': [3955, 4006], 'Precipitate': [3956], 'left': [3958], '16–20': [3964], 'h,': [3965, 3995], 'three': [3972, 4097], 'times': [3973], 'phosphate-buffered': [3975], 'saline,': [3976], 're-fed': [3977], 'fresh': [3979], 'medium,': [3980], 'returned': [3982], 'Cells': [3988], 'harvested': [3992], '20–24': [3994], 'freeze/thaw': [3998], 'lyse': [4004], 'One-fifth': [4007], 'lysate': [4011, 4031], 'usingO-nitrophenyl-β-d-galactopyranoside': [4018], 'substrate,': [4020, 4084], 'adjust': [4027], 'amount': [4029, 4240], 'assay.': [4035], 'TLC': [4037, 4093], 'except': [4062], 'standard': [4065], '[14C]chloramphenicol': [4066], 'replaced': [4068], '1-deoxy[dichloro-acetyl-1-14C]chloramphenicol': [4070], 'Biotech).': [4073], 'Because': [4074, 4388], 'acetyl': [4077], 'group': [4078], 'transferred': [4081], 'seen': [4090], 'opposed': [4095], 'observed': [4103], 'literature.': [4106], 'improves': [4109], 'quantitative': [4111], 'aspect': [4112], 'EMSA': [4117], 'Nuclear': [4138], 'extract': [4139], 'Dignam': [4149], '(47Dignam': [4151], 'Leibovitz': [4153], 'R.M.': [4154], 'Roeder': [4155], 'R.G.': [4156], '1983;': [4160], '1475-1489Crossref': [4162], '(9160)': [4165], 'digesting': [4174], 'subclone': [4177], 'enzymes,': [4182], 'gel-purified,': [4183], '[α-32P]dATP': [4187], '[α-32P]dCTP': [4189], '(depending': [4190], 'site)': [4194], 'Reaction': [4198], 'mixture': [4199, 4253], 'order': [4204], 'H2O,': [4206], '10×': [4207], '(1×,': [4210], 'Tris,': [4213], '7.5,': [4215], 'KCl,': [4218], 'mmdithiothreitol,': [4220], 'mmMgCl2,': [4225], 'glycerol),': [4228], '3': [4229], 'poly(dI·dC)·poly(dI·dC),': [4232], 'extract,': [4237], 'unlabeled': [4242], 'competitor': [4243], 'if': [4244], 'desired,': [4245], 'finally,': [4247], '20,000': [4248], 'probe.': [4251], 'loaded': [4266], 'onto': [4267], '6%': [4269], 'native': [4270], 'polyacrylamide': [4271], 'under': [4277], 'vacuum': [4278], 'dryer': [4282], 'BioMAX': [4288], 'MR': [4289], 'Sequence': [4294], 'betweenBRCA1': [4300], 'consensus': [4308, 4470], 'discussed': [4315], 'extensively': [4316], 'Scholar,48Brown': [4336], 'Hosking': [4348], 'McFarlane': [4354], '372:': [4358], '733Crossref': [4359], '(31)': [4362], '49Xu': [4365], '4:': [4381, 4557], '2259-2264Crossref': [4382, 4558], '(94)': [4385, 4561], 'confined': [4392], '56-bpEcoRI-HaeIII': [4395], '(see': [4397], 'below),': [4398], 'potential': [4400], 'highlighted': [4409], 'B).': [4412, 4537, 4591], 'CT': [4414], '(or': [4415], 'AG)-rich': [4416], 'sequence,': [4417, 4459], 'Ets': [4424], 'family': [4425, 4511], 'factors': [4428, 4514], '(50Sharrocks': [4429], 'A.D.': [4430], 'A.L.': [4432], 'Ling': [4433], 'Yates': [4435], 'P.R.': [4436], 'Int.': [4437, 4522], 'Biochem.': [4439, 4524], '29:': [4443, 4528], '1371-1387Crossref': [4444], '(283)': [4447], 'nucleotides': [4453], '1380': [4454], '1406.': [4456], '“TTACGTCA”': [4458], '1405': [4462], '1412,': [4464], 'almost': [4466], 'identical': [4467, 4501], '(CREB)': [4474], '(TGACGTCA)': [4476], '(51Sassone-Corsi': [4477], 'Annu.': [4479], 'Rev.': [4480], '355-377Crossref': [4486], '(337)': [4489], '“GGGTGG”': [4493], '1427': [4497], '1432': [4499], 'GT': [4504], 'box,': [4505], 'bind': [4508], 'Sp1': [4510], '(52Lania': [4515], 'Majello': [4517], 'De': [4519], 'Luca': [4520], '1313-1323Crossref': [4529], '(263)': [4532], 'co-workers': [4540], '(49Xu': [4541], 'mapped': [4564], 'start': [4567], 'position': [4570], '1579,': [4571], 'nucleotide': [4575, 4587], '+1': [4576], 'paper': [4579], '(marked': [4580], 'closed': [4583], 'circle': [4584], 'above': [4585], 'careful': [4594], 'inspection': [4595], 'comparison': [4597], 'our': [4599], 'published': [4603], 'authors': [4607]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2009397884', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-16T12:21:57.240545', 'created_date': '2016-06-24'}
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