Publication Information

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[491], '(particularly': [492], 'JNK)': [493], 'pathways.6\r\n\r\nAlthough': [494], 'mechanism': [496, 706], 'used': [497], 'inhibit': [501], 'parallels': [505], 'IL-1R': [508], 'pathway,': [509], 'striking': [512], 'differences.': [513], 'interacts': [518], 'accessory': [520], 'proteins': [521, 535], 'Tax1bp1': [524, 550, 565], 'Itch': [526, 552, 567], 'efficiently': [528], 'hydrolyze': [529], 'K63-linked': [530], 'substrates.': [531], 'Deletion': [532], 'results': [536], 'phenotype': [539], 'similar': [540], 'lack': [543], 'A20,': [545], 'though': [546], 'less': [547], 'severe.2': [548], 'Unexpectedly,': [549], 'were': [553], 'dispensable': [554], 'A20s': [556], 'activity': [557], 'siRNA-mediated': [562], 'did': [568], 'affect': [570], 'expression.7': [573], 'finding': [575], 'raised': [576], 'possibility': [578], 'either': [581], 'functions': [582], 'solo': [583], 'uses': [585], 'alternate': [586], 'adaptor': [587], 'molecules.': [588], 'Accordingly,': [589], 'found': [591, 651], 'associates': [594, 654, 687], 'AnapC5': [596, 632], '(APC5),': [597], 'subunit': [599], 'multi-protein': [602], 'E3': [603], 'ubiquitin': [604], 'ligase': [605], 'complex': [606], 'known': [607], 'Anaphase': [610], 'Promoting': [611], 'Complex': [612], '(APC).': [613], 'APC': [614], 'subunits': [615], 'have': [616, 805], 'been': [618, 793], 'previously': [619, 671], 'suggesting': [627], 'novel': [629], 'outside': [633], 'regulating': [635, 748], 'cycle': [638], '(Fig.\xa01).\r\n\r\nIn': [639], 'analyzing': [640], 'how': [641, 837], 'recruited': [644], 'complex,': [649], 'directly': [655, 819], 'IL-17RA': [658, 668], 'subunit.6': [659], 'C-terminal': [665], 'domain': [666], 'shown': [672], 'downmodulate': [674], 'signaling.8': [676], 'To': [677, 798], 'our': [678], 'knowledge,': [679], 'demonstration': [684], 'inducing': [690], 'interaction': [693], 'receptors': [695], 'may': [696], 'occur': [698], 'systems,': [701], 'potentially': [702], 'serving': [703], 'recruit': [708], 'after': [711], 'event': [714], 'triggered.\r\n\r\nThese': [716], 'discoveries': [717], 'about': [718], 'function': [720], 'context': [723], 'suggest': [726], 'which': [732], 'It': [737], 'will': [738, 829], 'be': [739, 775, 786, 830], 'key': [740], 'define': [742], 'contribution': [744], 'vivo.': [751], 'As': [752], 'noted,': [753], 'SNPs': [754], 'associated': [761], 'activity.': [770], 'Therefore,': [771], 'would': [773], 'surprising': [776], 'if': [777], 'patients': [778], 'polymorphisms': [781], 'likely': [784], 'responsive': [787], 'anti-IL-17': [789], 'therapy,': [790], 'demonstrated': [794], 'inhibitors.': [797], 'date,': [799], 'therapeutic': [800], 'strategies': [801], 'block': [803], 'mainly': [806], 'focused': [807], 'biologic': [809], 'drugs': [810], 'target': [812], '(anti-IL-6': [815], 'anti-IL-12/23)': [817], 'neutralize': [820], 'cytokine': [822], '(anti-IL-17,': [823], 'anti-IL-17RA).': [824], 'Development': [825], 'small-molecule': [827], 'inhibitors': [828], 'aided': [831], 'better': [834], 'understanding': [835], 'pathways': [839], 'regulated': [841], 'nature.': [843]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2009145571', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2025-01-07T23:29:12.569534', 'created_date': '2016-06-24'}