Publication Information

{'id': 'https://openalex.org/W2009080781', 'doi': 'https://doi.org/10.1074/jbc.m607704200', 'title': 'Menadione-induced Reactive Oxygen Species Generation via Redox Cycling Promotes Apoptosis of Murine Pancreatic Acinar Cells', 'display_name': 'Menadione-induced Reactive Oxygen Species Generation via Redox Cycling Promotes Apoptosis of Murine Pancreatic Acinar Cells', 'publication_year': 2006, 'publication_date': '2006-11-07', 'ids': {'openalex': 'https://openalex.org/W2009080781', 'doi': 'https://doi.org/10.1074/jbc.m607704200', 'mag': '2009080781', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17088248'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m607704200', 'pdf_url': 'http://www.jbc.org/article/S0021925820768845/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820768845/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072425437', 'display_name': 'David N. Criddle', 'orcid': 'https://orcid.org/0000-0003-2952-8450'}, 'institutions': [{'id': 'https://openalex.org/I146655781', 'display_name': 'University of Liverpool', 'ror': 'https://ror.org/04xs57h96', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I146655781']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'David N. Criddle', 'raw_affiliation_strings': ['MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom', 'institution_ids': ['https://openalex.org/I146655781']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054133304', 'display_name': 'Stuart Gillies', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I146655781', 'display_name': 'University of Liverpool', 'ror': 'https://ror.org/04xs57h96', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I146655781']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Stuart Gillies', 'raw_affiliation_strings': ['MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom', 'institution_ids': ['https://openalex.org/I146655781']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046966809', 'display_name': 'Heidi K. Baumgartner-Wilson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I146655781', 'display_name': 'University of Liverpool', 'ror': 'https://ror.org/04xs57h96', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I146655781']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Heidi K. Baumgartner-Wilson', 'raw_affiliation_strings': ['MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom', 'institution_ids': ['https://openalex.org/I146655781']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108229836', 'display_name': 'Mohammed Jaffar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1339065421', 'display_name': 'Defence Science and Technology Laboratory', 'ror': 'https://ror.org/04jswqb94', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I1306956679', 'https://openalex.org/I1339065421', 'https://openalex.org/I2802373619']}, {'id': 'https://openalex.org/I28407311', 'display_name': 'University of Manchester', 'ror': 'https://ror.org/027m9bs27', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28407311']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Mohammed Jaffar', 'raw_affiliation_strings': ['Department of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, United Kingdom', 'Morvus Technology Ltd., Porton Down Science Park, Salisbury, Wiltshire SP4 0JQ, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Morvus Technology Ltd., Porton Down Science Park, Salisbury, Wiltshire SP4 0JQ, United Kingdom', 'institution_ids': ['https://openalex.org/I1339065421']}, {'raw_affiliation_string': 'Department of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, United Kingdom', 'institution_ids': ['https://openalex.org/I28407311']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111657284', 'display_name': 'Edwin C. Chinje', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28407311', 'display_name': 'University of Manchester', 'ror': 'https://ror.org/027m9bs27', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28407311']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Edwin C. Chinje', 'raw_affiliation_strings': ['Department of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, United Kingdom', 'institution_ids': ['https://openalex.org/I28407311']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091017304', 'display_name': 'Sarah Passmore', 'orcid': 'https://orcid.org/0000-0003-0510-4047'}, 'institutions': [{'id': 'https://openalex.org/I28407311', 'display_name': 'University of Manchester', 'ror': 'https://ror.org/027m9bs27', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I28407311']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Sarah Passmore', 'raw_affiliation_strings': ['Department of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, United Kingdom', 'institution_ids': ['https://openalex.org/I28407311']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017204235', 'display_name': 'Michael Chvanov', 'orcid': 'https://orcid.org/0000-0003-1747-650X'}, 'institutions': [{'id': 'https://openalex.org/I146655781', 'display_name': 'University of Liverpool', 'ror': 'https://ror.org/04xs57h96', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I146655781']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Michael Chvanov', 'raw_affiliation_strings': ['MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom', 'institution_ids': ['https://openalex.org/I146655781']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070648403', 'display_name': 'Stephanie L. Barrow', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I146655781', 'display_name': 'University of Liverpool', 'ror': 'https://ror.org/04xs57h96', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I146655781']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Stephanie Barrow', 'raw_affiliation_strings': ['MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom', 'institution_ids': ['https://openalex.org/I146655781']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022478197', 'display_name': 'Oleg V. Gerasimenko', 'orcid': 'https://orcid.org/0000-0003-2573-8258'}, 'institutions': [{'id': 'https://openalex.org/I146655781', 'display_name': 'University of Liverpool', 'ror': 'https://ror.org/04xs57h96', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I146655781']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Oleg V. Gerasimenko', 'raw_affiliation_strings': ['MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom', 'institution_ids': ['https://openalex.org/I146655781']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072338475', 'display_name': 'Alexei V. Tepikin', 'orcid': 'https://orcid.org/0000-0002-8172-7513'}, 'institutions': [{'id': 'https://openalex.org/I146655781', 'display_name': 'University of Liverpool', 'ror': 'https://ror.org/04xs57h96', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I146655781']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Alexei V. Tepikin', 'raw_affiliation_strings': ['MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom', 'institution_ids': ['https://openalex.org/I146655781']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087974283', 'display_name': 'Robert Sutton', 'orcid': 'https://orcid.org/0000-0001-6600-562X'}, 'institutions': [{'id': 'https://openalex.org/I146655781', 'display_name': 'University of Liverpool', 'ror': 'https://ror.org/04xs57h96', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I146655781']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Robert Sutton', 'raw_affiliation_strings': ['Division of Surgery and Oncology, University of Liverpool, Liverpool L69 3BX, United Kingdom', 'MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Division of Surgery and Oncology, University of Liverpool, Liverpool L69 3BX, United Kingdom', 'institution_ids': ['https://openalex.org/I146655781']}, {'raw_affiliation_string': 'MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom', 'institution_ids': ['https://openalex.org/I146655781']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5065549009', 'display_name': 'Ole H. Petersen', 'orcid': 'https://orcid.org/0000-0002-6998-0380'}, 'institutions': [{'id': 'https://openalex.org/I146655781', 'display_name': 'University of Liverpool', 'ror': 'https://ror.org/04xs57h96', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I146655781']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ole H. Petersen', 'raw_affiliation_strings': ['MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool L69 3BX, United Kingdom', 'institution_ids': ['https://openalex.org/I146655781']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5072425437'], 'corresponding_institution_ids': ['https://openalex.org/I146655781'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 13.96, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 348, 'citation_normalized_percentile': {'value': 0.965607, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '281', 'issue': '52', 'first_page': '40485', 'last_page': '40492'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10760', 'display_name': 'Pancreatitis Pathology and Treatment', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10760', 'display_name': 'Pancreatitis Pathology and Treatment', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12554', 'display_name': 'Vitamin C and Antioxidants Research', 'score': 0.9896, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12068', 'display_name': 'Neonatal Health and Biochemistry', 'score': 0.9791, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/menadione', 'display_name': 'Menadione', 'score': 0.8589425}, {'id': 'https://openalex.org/keywords/acinar-cell', 'display_name': 'Acinar cell', 'score': 0.42492694}], 'concepts': [{'id': 'https://openalex.org/C2781095387', 'wikidata': 'https://www.wikidata.org/wiki/Q192471', 'display_name': 'Menadione', 'level': 3, 'score': 0.8589425}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.75885653}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.64594454}, {'id': 'https://openalex.org/C75520062', 'wikidata': 'https://www.wikidata.org/wiki/Q15321392', 'display_name': 'NAD+ kinase', 'level': 3, 'score': 0.63179487}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.54223627}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.49561322}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.44313958}, {'id': 'https://openalex.org/C2991930265', 'wikidata': 'https://www.wikidata.org/wiki/Q5062943', 'display_name': 'Acinar cell', 'level': 3, 'score': 0.42492694}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.22874734}, {'id': 'https://openalex.org/C2778764654', 'wikidata': 'https://www.wikidata.org/wiki/Q9618', 'display_name': 'Pancreas', 'level': 2, 'score': 0.09847236}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D010179', 'descriptor_name': 'Pancreas', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D024483', 'descriptor_name': 'Vitamin K 3', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D024483', 'descriptor_name': 'Vitamin K 3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016660', 'descriptor_name': 'NAD(P)H Dehydrogenase (Quinone)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016660', 'descriptor_name': 'NAD(P)H Dehydrogenase (Quinone)', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D016660', 'descriptor_name': 'NAD(P)H Dehydrogenase (Quinone)', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009249', 'descriptor_name': 'NADP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009249', 'descriptor_name': 'NADP', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009252', 'descriptor_name': 'NADPH Dehydrogenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009252', 'descriptor_name': 'NADPH Dehydrogenase', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009252', 'descriptor_name': 'NADPH Dehydrogenase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010179', 'descriptor_name': 'Pancreas', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010179', 'descriptor_name': 'Pancreas', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D010179', 'descriptor_name': 'Pancreas', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024483', 'descriptor_name': 'Vitamin K 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024483', 'descriptor_name': 'Vitamin K 3', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m607704200', 'pdf_url': 'http://www.jbc.org/article/S0021925820768845/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17088248', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m607704200', 'pdf_url': 'http://www.jbc.org/article/S0021925820768845/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 47, 'referenced_works': ['https://openalex.org/W1508395055', 'https://openalex.org/W1595656597', 'https://openalex.org/W1900078466', 'https://openalex.org/W1978328971', 'https://openalex.org/W1980948951', 'https://openalex.org/W1992346119', 'https://openalex.org/W2000755489', 'https://openalex.org/W2007306449', 'https://openalex.org/W2009809411', 'https://openalex.org/W2011822699', 'https://openalex.org/W2015393586', 'https://openalex.org/W2015423751', 'https://openalex.org/W2016553156', 'https://openalex.org/W2024902129', 'https://openalex.org/W2027262146', 'https://openalex.org/W2028040576', 'https://openalex.org/W2029283043', 'https://openalex.org/W2031652277', 'https://openalex.org/W2038576287', 'https://openalex.org/W2038795056', 'https://openalex.org/W2043155515', 'https://openalex.org/W2043855224', 'https://openalex.org/W2054503211', 'https://openalex.org/W2055388969', 'https://openalex.org/W2063616477', 'https://openalex.org/W2065276651', 'https://openalex.org/W2073310995', 'https://openalex.org/W2074717002', 'https://openalex.org/W2083045297', 'https://openalex.org/W2091938592', 'https://openalex.org/W2105849473', 'https://openalex.org/W2107855685', 'https://openalex.org/W2110328606', 'https://openalex.org/W2118470746', 'https://openalex.org/W2124413979', 'https://openalex.org/W2131467340', 'https://openalex.org/W2136674505', 'https://openalex.org/W2140442678', 'https://openalex.org/W2148724592', 'https://openalex.org/W2150531682', 'https://openalex.org/W2154339406', 'https://openalex.org/W2156241187', 'https://openalex.org/W2159242643', 'https://openalex.org/W2165048131', 'https://openalex.org/W2314469790', 'https://openalex.org/W2337401562', 'https://openalex.org/W60873176'], 'related_works': ['https://openalex.org/W99063305', 'https://openalex.org/W4387741623', 'https://openalex.org/W4367053317', 'https://openalex.org/W3157404951', 'https://openalex.org/W3129821995', 'https://openalex.org/W3091876869', 'https://openalex.org/W3031685627', 'https://openalex.org/W2241760478', 'https://openalex.org/W1604182531', 'https://openalex.org/W1584220612'], 'abstract_inverted_index': {'Oxidative': [0, 221, 500], 'stress': [1, 222, 501, 648, 4054, 4292, 4465, 4571, 4677, 4776], 'may': [2, 205, 223, 426, 649, 2630, 3806, 4076, 4213, 4674, 4839, 4887, 4988, 5052], 'be': [3, 224, 650, 1318, 1600, 2380, 2631, 4077, 4234, 4356, 4366, 4380, 4397], 'an': [4, 213, 225, 434, 651, 915, 966, 1342, 1571, 2480, 2527, 2595, 3040, 3808, 3940, 4038, 4078, 4285, 4566, 4626, 4758, 5062], 'important': [5, 214, 226, 435, 652, 1179, 3809, 4308, 4627, 5063], 'determinant': [6, 227, 653, 4628], 'of': [7, 10, 15, 36, 48, 58, 72, 80, 114, 129, 172, 183, 187, 228, 231, 236, 257, 269, 279, 293, 301, 335, 350, 393, 404, 408, 508, 654, 707, 750, 778, 835, 842, 920, 931, 1062, 1104, 1142, 1255, 1261, 1270, 1289, 1300, 1349, 1361, 1366, 1381, 1395, 1405, 1496, 1505, 1563, 1589, 1612, 1650, 1663, 1670, 1680, 1748, 1764, 1772, 1774, 1819, 1900, 1908, 1979, 2026, 2091, 2102, 2116, 2161, 2169, 2182, 2186, 2195, 2209, 2222, 2245, 2268, 2313, 2360, 2373, 2450, 2475, 2482, 2530, 2539, 2548, 2568, 2572, 2585, 2594, 2597, 2601, 2644, 2652, 2692, 2704, 2731, 2754, 2768, 2772, 2785, 2793, 2801, 2809, 2823, 2835, 2857, 2866, 2869, 2879, 2915, 2931, 2955, 3011, 3032, 3117, 3122, 3133, 3153, 3156, 3167, 3184, 3266, 3290, 3298, 3303, 3336, 3358, 3417, 3423, 3433, 3439, 3441, 3449, 3462, 3481, 3590, 3720, 3850, 3852, 3873, 3879, 3889, 3924, 3930, 3970, 4031, 4041, 4087, 4092, 4226, 4283, 4298, 4317, 4328, 4336, 4353, 4371, 4391, 4410, 4416, 4424, 4441, 4452, 4496, 4500, 4532, 4536, 4601, 4620, 4629, 4643, 4704, 4716, 4745, 4753, 4767, 4780, 4864, 4873, 4882, 4891, 4981, 5003], 'the': [8, 85, 91, 180, 229, 306, 312, 401, 506, 696, 705, 737, 751, 836, 839, 1087, 1252, 1267, 1276, 1286, 1297, 1303, 1403, 1595, 1646, 1667, 1671, 1675, 1681, 1741, 1746, 1749, 1753, 1762, 1779, 1869, 1917, 2100, 2191, 2196, 2214, 2223, 2256, 2269, 2273, 2287, 2334, 2365, 2405, 2451, 2468, 2473, 2494, 2523, 2569, 2591, 2641, 2648, 2653, 2702, 2721, 2728, 2765, 2769, 2791, 2815, 2831, 2836, 2845, 2867, 2928, 2953, 3009, 3115, 3126, 3196, 3235, 3264, 3296, 3334, 3387, 3414, 3465, 3472, 3482, 3856, 3871, 3880, 3887, 3910, 3927, 3931, 4085, 4280, 4294, 4315, 4320, 4323, 4343, 4421, 4457, 4494, 4503, 4510, 4617, 4621, 4705, 4714, 4739, 4742, 4751, 4768, 4778, 4862, 4871, 4889, 4973], 'severity': [9, 230, 656], 'acute': [11, 170, 232, 391, 509, 618, 1012, 1359, 3304, 3415, 3780, 3816, 4644, 4874, 4978], 'pancreatitis.': [12, 233], 'One-electron': [13, 234], 'reduction': [14, 235, 799, 950, 2101, 2187], 'oxidants': [16, 237, 3424], 'generates': [17, 238], 'reactive': [18, 101, 239, 322, 843, 852, 883, 1555, 4090], 'oxygen': [19, 102, 240, 323, 829, 844, 853, 884, 1556, 4093], 'species': [20, 103, 241, 324, 845, 1557], '(ROS)': [21, 242], 'via': [22, 112, 177, 243, 333, 398, 748, 947, 1368, 4534, 4777, 4842, 5008], 'redox': [23, 76, 178, 244, 297, 399, 825, 1370, 2714, 3421, 3896, 5009], 'cycling,': [24, 179, 245, 400, 5010], 'whereas': [25, 139, 159, 246, 360, 380, 3125], 'two-electron': [26, 247, 949, 3976, 4339, 4376, 4439], 'detoxification,': [27, 248], 'e.g.': [28, 249], 'by': [29, 84, 90, 137, 157, 174, 250, 305, 311, 358, 378, 395, 797, 929, 1320, 1570, 1660, 2098, 2332, 2467, 2710, 2790, 2861, 2872, 3180, 3338, 3354, 3420, 3446, 3471, 3522, 3553, 3583, 3723, 3875, 4375, 4445, 4498, 4521, 4709, 4750, 4774, 4993, 5005, 5013], 'NAD(P)H:quinone': [30, 123, 198, 251, 344, 419, 875, 906, 938], 'oxidoreductase,': [31, 199, 252, 420], 'does': [32, 253, 3639, 3961], 'not.': [33, 254], 'The': [34, 78, 255, 299, 816, 1060, 1463, 1561, 1584, 1892, 1922, 2172, 2206, 2240, 2305, 2321, 2343, 2429, 2537, 2736, 2782, 2882, 3848, 4224, 5001], 'actions': [35, 256, 2538, 4673], 'menadione': [37, 175, 258, 396, 739, 1262, 1271, 1301, 1315, 1367, 1830, 1852, 2164, 2400, 2465, 2492, 2540, 2573, 2613, 2717, 2748, 2813, 2875, 2885, 2922, 2942, 2975, 3276, 3442, 3881, 3971, 4227, 4329, 4394, 4425, 4442, 4710, 4746, 5006], 'on': [38, 259, 2108, 2546, 2776, 3013, 3151, 3330, 4043], 'ROS': [39, 67, 81, 173, 210, 260, 288, 302, 394, 431, 926, 959, 1183, 1337, 1350, 2598, 2607, 2778, 2786, 2824, 2870, 2895, 2935, 3418, 3463, 3483, 3514, 3770, 3800, 3874, 3904, 3950, 4360, 4411, 4760, 4837, 4982, 5004, 5057], 'production': [40, 261, 1338, 2779, 2822, 2868, 2936, 3416, 3448, 3515, 3722, 3771, 3951, 5002], 'and': [41, 211, 262, 432, 447, 456, 526, 610, 616, 704, 786, 1007, 1014, 1185, 1215, 1352, 1378, 1392, 1457, 1501, 1558, 1577, 1594, 1619, 1751, 1789, 1802, 1853, 1861, 1883, 1903, 1930, 1962, 1974, 2018, 2141, 2163, 2226, 2238, 2261, 2281, 2316, 2330, 2339, 2385, 2448, 2541, 2552, 2579, 2614, 2746, 2798, 2812, 2841, 2863, 2947, 2952, 2965, 3004, 3161, 3202, 3370, 3398, 3425, 3443, 3479, 3549, 3718, 3799, 3898, 4007, 4011, 4075, 4089, 4143, 4212, 4272, 4303, 4325, 4333, 4413, 4426, 4466, 4540, 4670, 4783, 4817, 4898, 5059], 'cell': [42, 191, 219, 263, 412, 440, 1075, 1107, 1218, 2553, 3197, 3332, 3429, 3729, 3864, 3932, 4222, 4632, 4999, 5068], 'fate': [43, 264, 4633], 'were': [44, 265, 1272, 1400, 1450, 1459, 1525, 1587, 1648, 1814, 1865, 1878, 1924, 1936, 1981, 1993, 2016, 2028, 2174, 2188, 2201, 2228, 2283, 2328, 2350, 2389, 2442, 2449, 2487, 2543, 2905, 3037, 3144, 3468, 3581, 3905, 4418], 'compared': [45, 266, 2940, 3187, 3274, 3363, 3391], 'with': [46, 68, 75, 267, 289, 296, 451, 614, 838, 1508, 1527, 1608, 1809, 1827, 1837, 1848, 1905, 1927, 1945, 1995, 2031, 2067, 2158, 2310, 2526, 2563, 2701, 2707, 2827, 2941, 3039, 3048, 3135, 3188, 3246, 3275, 3364, 3392, 3779, 4434, 4456, 4569, 4757, 4824], 'those': [47, 268], 'a': [49, 69, 270, 290, 445, 452, 824, 833, 948, 953, 1078, 1216, 1257, 1369, 1514, 1609, 1640, 1652, 1817, 1939, 1946, 2001, 2068, 2109, 2114, 2117, 2166, 2180, 2266, 2311, 2519, 2577, 2617, 2690, 2751, 2773, 2818, 2909, 3020, 3026, 3148, 3164, 3181, 3355, 3410, 3475, 3588, 3726, 3895, 3920, 3975, 4145, 4176, 4216, 4338, 4408, 4435, 4828, 4843, 4990], 'non-cycling': [50, 271, 1259], 'analogue': [51, 272, 1260, 1841, 1857, 2886, 3238], '(2,4-dimethoxy-2-methylnaphthalene': [52, 273], '(DMN))': [53, 274], 'using': [54, 275, 1409, 1484, 1513, 1624, 1674, 1778, 1880, 1938, 2113, 2230, 2286, 2352, 2364, 2491, 2647], 'real-time': [55, 276], 'confocal': [56, 277, 1626, 1684, 1943, 2071, 2656], 'microscopy': [57, 278], 'isolated': [59, 280, 1388, 4429], 'perfused': [60, 281], 'murine': [61, 282], 'pancreatic': [62, 130, 189, 283, 351, 410, 521, 745, 1015, 1105, 1326, 1375, 1389, 2635, 2981, 3175, 3349, 3427, 3519, 3523, 3727, 3984, 4220, 4430, 4453, 4609, 4630, 4985], 'acinar': [63, 131, 190, 218, 284, 352, 411, 439, 746, 1074, 1106, 1327, 1376, 1390, 1393, 1672, 2636, 2645, 2982, 3176, 3331, 3350, 3428, 3466, 3520, 3863, 3911, 3985, 4221, 4431, 4610, 4631, 4986, 4995, 5067], 'cells.': [64, 285, 4611], 'Menadione': [65, 126, 286, 347, 2688, 3169], 'generated': [66, 287, 928, 2327, 3908], 'concomitant': [70, 291, 840], 'decrease': [71, 292, 924, 2691, 2958], 'NAD(P)H,': [73, 294], 'consistent': [74, 295, 2706, 3047, 4433], 'cycling.': [77, 298, 2715], 'elevation': [79, 300, 2596, 2784], 'was': [82, 119, 134, 153, 303, 340, 355, 374, 1263, 1283, 1312, 1511, 1568, 1614, 1637, 1657, 1776, 1894, 1956, 1968, 2059, 2096, 2211, 2253, 2308, 2362, 2377, 2397, 2435, 2512, 2558, 2588, 2620, 2699, 2718, 2761, 2787, 2825, 2925, 2937, 2959, 3193, 3270, 3340, 3914, 4506, 4747], 'prevented': [83, 304, 2789], 'antioxidant': [86, 307, 2737, 3473], 'N-acetyl-l-cysteine': [87, 308, 2738], 'but': [88, 106, 309, 327, 3952, 3972], 'not': [89, 310, 1806, 3243, 3249, 3868, 3947, 3962, 4507, 4605], 'NADPH': [92, 313, 3592, 3804, 4012], 'oxidase': [93, 314, 2847, 3593, 3695, 3805, 3866], 'inhibitor': [94, 315, 2481, 2848, 4460], 'diphenyliodonium.': [95, 316], 'DMN': [96, 118, 140, 160, 317, 339, 361, 381, 1282, 1840, 1856, 2049, 2092, 2162, 2210, 2462, 2476, 2515, 2542, 2887, 2932, 3012, 3108, 3154, 3239, 3375, 3885, 3918, 3945, 4042, 4302, 4318, 4427, 4446, 4514], 'produced': [97, 318, 2890, 3379], 'no': [98, 143, 162, 319, 364, 383, 2566, 2855, 2864, 2891, 3110, 3136, 3380, 3906], 'change': [99, 320, 2856, 2892, 3111], 'in': [100, 203, 216, 321, 424, 437, 505, 511, 612, 744, 951, 1010, 1064, 1192, 1265, 1324, 1374, 1417, 1616, 1666, 1868, 1897, 1916, 1932, 2020, 2074, 2147, 2204, 2401, 2489, 2518, 2560, 2606, 2634, 2640, 2764, 2821, 2830, 2893, 2908, 2927, 2980, 3042, 3112, 3114, 3147, 3174, 3195, 3263, 3348, 3464, 3517, 3550, 3725, 3774, 3811, 3814, 3855, 3909, 3926, 3983, 4035, 4055, 4094, 4140, 4187, 4219, 4293, 4342, 4420, 4428, 4437, 4502, 4608, 4634, 4678, 4755, 4822, 4831, 4870, 4983, 5027, 5065], 'per': [104, 164, 325, 385, 2319, 2758, 2897, 3933], 'se': [105, 326, 2759, 2898], 'significantly': [107, 135, 328, 356, 2906, 2938, 2960, 3250], 'potentiated': [108, 136, 329, 357, 2939, 3272, 3954, 4749], 'menadione-induced': [109, 330, 2783, 3268, 3949, 4052], 'effects,': [110, 331], 'probably': [111, 332], 'enhancement': [113, 334], 'one-electron': [115, 336, 798, 1321, 4389, 4401, 5014], 'reduction,': [116, 337], 'since': [117, 338, 4368, 4513, 4637], 'found': [120, 341, 2513], 'to': [121, 342, 794, 964, 1081, 1274, 1291, 1364, 1481, 1553, 1599, 1643, 1796, 2093, 2264, 2379, 2612, 2725, 3007, 3389, 3512, 3883, 3892, 3900, 4233, 4278, 4289, 4358, 4387, 4509, 4529, 4713], 'inhibit': [122, 343, 2094, 2464, 3640, 3948, 4888], 'oxidoreductase': [124, 345, 789, 876, 907, 939], 'detoxification.': [125, 346], 'caused': [127, 348, 2689], 'apoptosis': [128, 349, 743, 1063, 1084, 1108, 1186, 1373, 1775, 1783, 1980, 2433, 3173, 3269, 3915, 4467, 4497, 4531, 4717, 4841, 4867], 'cells': [132, 353, 747, 1328, 1377, 1391, 1399, 1458, 1506, 1524, 1647, 1673, 1765, 1804, 1813, 1825, 1835, 1846, 1923, 1992, 2015, 2027, 2561, 2637, 2837, 2983, 3191, 3467, 3521, 3552, 3912, 3986, 4059, 4083, 4455, 4833, 4865, 4987, 4996], 'that': [133, 169, 354, 390, 646, 736, 1072, 1293, 1314, 1358, 1379, 1645, 2461, 2514, 2587, 2698, 2974, 3192, 3452, 3769, 3862, 3936, 3959, 4081, 4181, 4306, 4312, 4701, 4765, 4835, 4885, 4977], 'DMN,': [138, 158, 359, 379, 855, 886, 2045, 3267, 4754], 'alone': [141, 362, 2943, 3277, 3378, 3394], 'had': [142, 161, 363, 382], 'effect.': [144, 365], 'Furthermore,': [145, 366, 4827], 'bile': [146, 367, 3299, 4524, 4602, 4638], 'acid': [147, 149, 368, 370, 518, 867, 898, 1997, 2035, 2082, 2387, 3360, 4525], '(taurolithocholic': [148, 369], '3-sulfate)-induced': [150, 371], 'caspase': [151, 372, 1143, 2005, 3346, 3381, 4518], 'activation': [152, 373, 3335, 3347, 4519, 4535], 'also': [154, 375, 3294, 4515], 'greatly': [155, 376, 3271, 3385, 4516, 4748], 'increased': [156, 377, 1009, 2907, 3146, 3386], 'effect': [163, 182, 384, 403, 2733, 3851, 4567], 'se.': [165, 386], 'These': [166, 387], 'results': [167, 388], 'suggest': [168, 389, 3861, 4884, 4976], 'generation': [171, 392, 841, 1184, 1351, 1360, 2547, 3432, 3872, 4412, 4838, 4980, 5058], 'occurs': [176, 397, 3436, 5007], 'net': [181, 402], 'which': [184, 200, 405, 421, 952, 1266, 1345, 2271, 2760, 3036, 3508, 4008, 4354, 4438, 4994, 5024], 'is': [185, 406, 444, 830, 956, 962, 1008, 1077, 3444, 3772, 3867, 4049, 4138, 4185, 4231, 4275, 4443, 4711, 4763, 4772, 4868, 4876], 'induction': [186, 407, 1103], 'apoptotic': [188, 409, 1801, 3426], 'death.': [192, 413, 3430, 5000], 'Two-electron': [193, 414, 5017], 'detoxifying': [194, 415, 969, 3977, 4287, 4340, 4622, 5018], 'enzymes': [195, 416, 911, 2712, 4378, 5020], 'such': [196, 417, 936, 3579, 3643, 3979, 4284, 4337, 5021], 'as': [197, 418, 914, 925, 937, 1416, 1639, 1693, 1731, 1983, 2276, 2407, 2479, 2493, 2496, 2638, 3025, 3051, 3178, 3210, 3352, 3454, 3587, 3644, 3980, 4013, 4625, 5022], 'are': [201, 422, 700, 792, 927, 1729, 4640, 4821, 5025], 'elevated': [202, 423, 4186, 4367, 5026], 'pancreatitis,': [204, 425, 525], 'provide': [206, 427, 2265, 5053], 'protection': [207, 428, 5054], 'against': [208, 429, 1086, 1111, 4051, 4084, 5055], 'excessive': [209, 430, 5056], 'exert': [212, 433], 'role': [215, 436, 1061, 3810, 4218, 5064], 'determining': [217, 438, 5066], 'fate.': [220, 441, 2554, 5069], 'Acute': [442], 'pancreatitis': [443, 510, 619, 1013, 1065, 1113, 1147, 3305, 3781, 3817, 4188, 4645, 4875, 5028], 'severe': [446, 617], 'debilitating': [448], 'inflammatory': [449], 'disease': [450, 655, 1082, 1088, 4900], 'steadily': [453], 'increasing': [454], 'incidence': [455], 'significant': [457, 2580, 3182, 3356, 3901, 4217], 'mortality': [458], '(1Sutton': [459], 'R.': [460, 483, 718, 1432, 1709, 2291, 2671, 3067, 3311, 4547, 4549, 4573, 4651], 'Criddle': [461], 'D.': [462, 4016, 4022, 4543, 4551, 4583], 'Raraty': [463, 1423], 'M.G.': [464, 596, 1424, 4683], 'Tepikin': [465, 714, 762, 1427, 1704, 2666, 2990, 3062, 3094, 3219, 4724], 'A.': [466, 569, 579, 715, 761, 1155, 1195, 1439, 2989, 3095, 3218, 3535, 3750, 4469, 4579, 4723, 4800, 4935], 'Neoptolemos': [467, 1425, 1706, 2668, 3064], 'J.P.': [468, 1233, 1426, 1707, 2669, 3065], 'Petersen': [469, 712, 764, 1429, 1710, 2672, 2992, 3068, 3092, 3221, 4726], 'O.H.': [470, 481, 713, 765, 1430, 1711, 2673, 2993, 3069, 3093, 3222, 4727], 'Pancreatology.': [471, 4962], '2003;': [472, 1237, 2422, 3541], '3:': [473], '497-505Crossref': [474], 'PubMed': [475, 495, 544, 563, 588, 638, 675, 691, 727, 811, 982, 1002, 1035, 1055, 1098, 1135, 1173, 1210, 1245, 1443, 1721, 2128, 2300, 2506, 2683, 3079, 3325, 3503, 3544, 3572, 3615, 3631, 3659, 3685, 3713, 3761, 3794, 3843, 4002, 4070, 4107, 4133, 4170, 4207, 4269, 4488, 4561, 4593, 4665, 4794, 4812, 4856, 4923, 4953, 4966, 5047], 'Scopus': [476, 496, 545, 564, 589, 639, 676, 692, 728, 812, 983, 1003, 1036, 1056, 1136, 1174, 1211, 1246, 1444, 1722, 2129, 2301, 2425, 2507, 2684, 3080, 3102, 3326, 3504, 3545, 3573, 3616, 3632, 3660, 3686, 3714, 3762, 3795, 3844, 4003, 4071, 4108, 4171, 4208, 4489, 4562, 4594, 4666, 4795, 4813, 4857, 4924, 4954, 4967, 5048], '(88)': [477], 'Google': [478, 498, 547, 566, 591, 608, 641, 678, 694, 730, 774, 814, 985, 1005, 1038, 1058, 1099, 1138, 1176, 1213, 1248, 1446, 1724, 2131, 2303, 2427, 2509, 2686, 3002, 3082, 3104, 3231, 3328, 3506, 3547, 3575, 3618, 3634, 3662, 3688, 3716, 3764, 3797, 3846, 4005, 4028, 4073, 4110, 4134, 4173, 4210, 4270, 4491, 4564, 4596, 4668, 4695, 4736, 4797, 4815, 4859, 4926, 4956, 4969, 5050], 'Scholar,': [479, 548, 567, 592, 679, 986, 1039, 3083, 3619, 3663, 4111, 4798, 4927, 4957], '2Petersen': [480], 'Sutton': [482, 1431, 1708, 2670, 3066], 'Trends': [484], 'Pharmacol.': [485, 998, 2124, 2502], 'Sci.': [486, 723, 770, 1436, 2998, 3227, 4732], '2006;': [487, 1032, 1165, 1713, 2297, 2675, 3071, 3564, 3758, 4204, 4853, 4945, 5044], '27:': [488], '113-120Abstract': [489], 'Full': [490, 492, 1168, 1170, 1240, 1242, 1716, 1718, 2678, 2680, 3074, 3076, 3322, 3498, 3500, 3567, 3569, 3610, 3612, 3680, 3682, 3838, 3840, 4130, 4165, 4167, 4266, 4556, 4558, 4588, 4590, 4662, 4948, 4950], 'Text': [491, 493, 1169, 1171, 1241, 1243, 1717, 1719, 2679, 2681, 3075, 3077, 3323, 3499, 3501, 3568, 3570, 3611, 3613, 3681, 3683, 3839, 3841, 4131, 4166, 4168, 4267, 4557, 4559, 4589, 4591, 4663, 4949, 4951], 'PDF': [494, 1172, 1244, 1720, 2682, 3078, 3324, 3502, 3571, 3614, 3684, 3842, 4132, 4169, 4268, 4560, 4592, 4664, 4952], '(127)': [497], 'Scholar).': [499, 642, 731, 775, 815, 1059, 1100, 1177, 1249, 1447, 1725, 2132, 2304, 2428, 2510, 2687, 3105, 3232, 3576, 3689, 3765, 3847, 4029, 4135, 4174, 4492, 4696, 4737, 4860, 4970], 'has': [502, 1069, 1187, 3509, 4179, 4526, 4603], 'been': [503, 1070, 1188, 2077, 3510, 4527, 4606], 'implicated': [504], 'development': [507, 4715, 4872], 'diverse': [512], 'animal': [513], 'experimental': [514, 1343, 1769, 3815], 'models,': [515], 'including': [516, 781], 'fatty': [517], 'infusion,': [519], 'ischemia,': [520], 'duct': [522, 3524], 'obstruction,': [523], 'gallstone': [524], 'alcohol': [527], 'ingestion': [528], '(3Nordback': [529], 'I.H.': [530], 'Clemens': [531], 'J.A.': [532, 1231], 'Chacko': [533], 'V.P.': [534], 'Olson': [535], 'J.L.': [536, 538, 600, 685, 1123, 3673, 4687, 4911], 'Cameron': [537, 599, 684, 4686], 'Ann.': [539, 686], 'Surg.': [540, 687], '1991;': [541], '213:': [542], '341-349Crossref': [543], '(31)': [546], '4Altomare': [549], 'E.': [550, 1045, 3821, 3992], 'Grattagliano': [551], 'I.': [552, 804, 1159, 3601, 4939], 'Vendemiale': [553], 'G.': [554, 558, 1225, 1701, 2663, 3059, 3091, 3313, 4119, 4255, 4653], 'Palmieri': [555], 'V.': [556, 3823, 4577], 'Palasciano': [557], 'Gut.': [559, 634, 671, 3790], '1996;': [560], '38:': [561], '742-746Crossref': [562], '(79)': [565], '5Urunuela': [568], 'Sevillano': [570], 'S.': [571, 992, 1022, 1024, 1438, 1703, 2665, 3061, 3085, 3487, 3527, 3734, 3746, 3831, 4123, 4152, 4194, 4196, 4259, 4575, 4581, 5034, 5036], 'de': [572, 3528], 'la': [573, 3529], 'Mano': [574, 3530], 'A.M.': [575, 3531], 'Manso': [576, 3532], 'M.A.': [577, 1117, 3533, 3623, 3651, 4905], 'Orfao': [578, 3534], 'De': [580, 3536], 'D.I.': [581, 3537], 'Biochim.': [582, 805, 3538], 'Biophys.': [583, 806, 1129, 3539, 3625, 3653, 4917], 'Acta.': [584, 807, 3540], '2002;': [585, 771, 2999, 3099, 3228, 3835, 4553, 4733], '1588:': [586], '159-164Crossref': [587], '(56)': [590, 3546], '6Sanfey': [593], 'H.': [594, 681, 3702, 4113, 4249, 4681], 'Sarr': [595, 4682], 'Bulkley': [597, 682, 4684], 'G.B.': [598, 683, 4685], 'Acta': [601, 4688], 'Physiol.': [602, 3097, 4689], 'Scand.': [603, 4690], 'Suppl.': [604, 4691], '1986;': [605, 4692], '548:': [606, 4693], '109-118PubMed': [607, 4694], 'Scholar),': [609, 695, 1139, 3329, 3507, 3635, 3798, 4271, 4565, 4597, 4669, 4816, 5051], 'measured': [611, 1957, 1969, 2632], 'patients': [613, 3778], 'mild': [615], '(7Tsai': [620, 657], 'K.': [621, 658, 1223, 2419, 3752, 3754], 'Wang': [622, 659, 3488, 4062], 'S.S.': [623, 660], 'Chen': [624, 661, 3666], 'T.S.': [625, 662], 'Kong': [626, 663], 'C.W.': [627, 664], 'Chang': [628, 665], 'F.Y.': [629, 666], 'Lee': [630, 667, 1120, 4908], 'S.D.': [631, 668], 'Lu': [632, 669], 'F.J.': [633, 670], '1998;': [635, 672, 1132, 3628, 3656, 4920], '42:': [636, 673], '850-855Crossref': [637, 674], '(145)': [640, 677], 'While': [643], 'evidence': [644, 1191, 3767, 4883], 'suggests': [645, 3768, 4834], 'oxidative': [647, 4053, 4291, 4464, 4570, 4775], '8Sanfey': [680], '1984;': [688], '200:': [689], '405-413Crossref': [690], '(305)': [693], 'precise': [697], 'underlying': [698], 'mechanisms': [699], 'still': [701], 'poorly': [702], 'understood': [703], 'extent': [706], 'involvement': [708], 'unclear': [709], '(9Chvanov': [710], 'M.': [711, 1090, 1115, 1201, 3309, 3489, 3597, 3740, 3744, 4158, 4471, 4649, 4804, 4903], 'Philos.': [716], 'Trans.': [717], 'Soc.': [719], 'Lond.': [720], 'B': [721, 4332], 'Biol.': [722, 977, 1030, 1163, 1235, 3493, 3562, 3605, 3675, 3709, 4102, 4125, 4202, 4261, 4943, 5042], '2005;': [724, 3677, 3710, 4585], '360:': [725], '2273-2284Crossref': [726], '(62)': [729], 'We': [732, 2970], 'have': [733, 2076, 2971, 3692, 4347, 4699], 'previously': [734, 1695, 2120, 2409, 2498, 2972, 3053, 3212, 4604], 'shown': [735, 2973, 3511, 4528], 'oxidant': [738, 3891, 4511, 4676], '(2-methyl-1,4-naphthoquinone)': [740], 'induces': [741, 2976], 'Ca2+-dependent': [742, 4702], 'opening': [749, 4703, 4766], 'mitochondrial': [752, 787, 918, 1353, 2550, 2693, 2833, 2902, 3141, 3447, 3645, 3928], 'permeability': [753, 4706, 4769], 'transition': [754, 4707, 4770], 'pore': [755, 4708, 4771], '(10Gerasimenko': [756, 2984, 3213, 4718], 'J.V.': [757, 2985, 3214, 4719], 'Gerasimenko': [758, 2986, 3215, 4720], 'O.V.': [759, 2987, 3216, 4721], 'Palejwala': [760, 2988, 3217, 4722], 'A.V.': [763, 1428, 1705, 2667, 2991, 3063, 3220, 4725], 'Watson': [766, 2994, 3223, 4728], 'A.J.': [767, 2995, 3224, 3827, 4729], 'J.': [768, 994, 1047, 1091, 1162, 1227, 1234, 1699, 2294, 2661, 2996, 3057, 3096, 3225, 3492, 3558, 3561, 3604, 3674, 3706, 3736, 3748, 3994, 4124, 4156, 4260, 4730, 4942], 'Cell': [769, 1029, 1092, 1386, 2997, 3226, 3708, 4201, 4731, 5041], '115:': [772, 3000, 3229, 4734], '485-497PubMed': [773, 3001, 3230, 4735], 'A': [776, 1603, 2024, 2371, 2797, 2840, 2946, 3201, 3369, 3397], 'variety': [777], 'reductive': [779, 934, 1298, 1322, 2711, 3458, 3942, 3967, 4183, 4377, 4385, 4402, 5015, 5019], 'enzymes,': [780, 935], 'microsomal': [782, 4244], 'NADPH-cytochrome': [783, 4245], 'P450': [784, 3555, 4246], 'reductase': [785, 4247], 'NADH-ubiquinone': [788], '(complex': [790], 'I),': [791], 'known': [793], 'metabolize': [795, 945], 'quinones': [796, 946], 'reactions': [800, 2173, 2200], '(11Iyanagi': [801], 'T.': [802, 2411, 2413, 2415, 3087, 3732, 3756, 3787], 'Yamazaki': [803], '1970;': [808], '216:': [809], '282-294Crossref': [810], '(308)': [813], 'resultant': [817], 'unstable': [818], 'semiquinones': [819], 'can': [820], 'readily': [821], 'enter': [822, 3893], 'into': [823, 1285, 1816, 3894, 4866], 'cycle': [826, 3897], 'when': [827], 'molecular': [828, 2457], 'present,': [831], 'causing': [832, 1335], 'reformation': [834], 'quinone,': [837], '(ROS).': [846], '3The': [847, 878], 'abbreviations': [848, 879], 'used': [849, 880, 1460, 1615, 1931], 'are:': [850, 881], 'ROS,': [851, 882, 1362, 1497, 2549, 2705], 'species;': [854, 885], '2,4-dimethoxy-2-methylnaphthalene;': [856, 887], 'CM-H2DCFDA,': [857, 888, 2384, 2564], '5-chloromethyl-2,7-dichlorodihydrofluorescein': [858, 889, 1529], 'diacetate': [859, 890, 1530], 'acetyl': [860, 891, 1531], 'ester;': [861, 892], 'FITC,': [862, 893], 'fluorescein': [863, 894], 'isothiocyanate;': [864, 895], 'TLC-S,': [865, 896], 'taurolitholcholic': [866, 897, 2034], '3-sulfate;': [868, 899], 'NAC,': [869, 900], 'N-acetyl-l-cysteine;': [870, 901], 'DPI,': [871, 902, 3584], 'diphenyliodonium': [872, 903, 2849], 'chloride;': [873, 904], 'NQO1,': [874, 905, 3981, 5023], '1.': [877, 908], 'Since': [909, 2455, 3944], 'these': [910, 921, 4372], 'use': [912], 'NAD(P)H': [913, 1354, 2628, 2694, 2846, 2903, 2957, 3450, 3694, 3865, 3925, 4363, 4417], 'electron': [916, 3455, 3966, 4373], 'donor,': [917], 'levels': [919, 2629, 2723, 2896, 2904, 3143, 3366, 4364], 'co-substrates': [922, 3451], 'should': [923], 'metabolism': [930, 1365, 1656, 2466, 4327, 4390, 4440], 'oxidants.': [932], 'Other': [933], '1': [940, 1474, 1890, 2170], '(EC': [941], '1.6.99.2,': [942], 'NQO1;': [943], 'DT-diaphorase),': [944], 'stable': [954], 'hydroquinone': [955], 'formed': [957], 'without': [958], 'generation.': [960], 'NQO1': [961, 1290, 1382, 2087, 2095, 2144, 2247, 2469, 2486, 2517, 3291, 4034, 4048, 4230, 4304, 4459, 4501, 4624], 'thought': [963, 4232, 4764], 'constitute': [965, 4989], 'endogenous': [967, 3941, 4079, 4286, 4979], 'cellular': [968, 4892], 'mechanism': [970, 3166, 4080, 4288], '(12Dinkova-Kostova': [971, 4096], 'A.T.': [972, 4097], 'Talalay': [973, 4098], 'P.': [974, 1153, 4099, 4117, 4253, 4933], 'Free': [975, 4100], 'Radic.': [976, 4101], 'Med.': [978, 1094, 2295, 4103], '2000;': [979, 4104], '29:': [980, 4105], '231-240Crossref': [981, 4106], '(222)': [984, 4109], '13Robertson': [987], 'N.': [988, 1221, 3783, 3785], 'Stratford': [989], 'I.J.': [990], 'Houlbrook': [991], 'Carmichael': [993], 'Adams': [995], 'G.E.': [996], 'Biochem.': [997, 1128, 2123, 2501, 3624, 3652, 3707, 4916], '1992;': [999], '44:': [1000], '409-412Crossref': [1001], '(80)': [1004], 'Scholar)': [1006, 1214, 3003, 3548, 3717, 4006, 4074, 4211], 'both': [1011, 1849, 2810, 4352, 4463], 'adenocarcinoma': [1016], '(14Lyn-Cook': [1017, 4189, 5029], 'B.D.': [1018, 1049, 3996, 4190, 5030], 'Yan-Sanders': [1019, 4191, 5031], 'Y.': [1020, 2417, 3621, 3649, 3742, 3789, 4192, 5032], 'Moore': [1021, 4193, 5033], 'Taylor': [1023, 4195, 5035], 'Word': [1025, 4197, 5037], 'B.': [1026, 1119, 1229, 4198, 4907, 5038], 'Hammons': [1027, 4199, 5039], 'G.J.': [1028, 1041, 1043, 3988, 3990, 4200, 5040], 'Toxicol.': [1031, 4203, 5043], '22:': [1033, 4205, 5045], '73-80Crossref': [1034, 4206, 5046], '(41)': [1037, 4209, 5049], '15Hammons': [1040], 'Warren': [1042, 3989], 'Blann': [1044, 3991], 'Nichols': [1046, 3993], 'Lyn-Cook': [1048, 3995], 'Cancer': [1050, 3997, 4023, 4159, 4483], 'Lett.': [1051, 3998, 4808], '1995;': [1052, 3999], '96:': [1053, 4000], '9-14Crossref': [1054, 4001], '(4)': [1057, 4004], 'remains': [1066], 'controversial.': [1067], 'It': [1068, 2511, 4762], 'suggested': [1071, 1189, 2460], 'while': [1073, 1140], 'necrosis': [1076], 'key': [1079], 'contributor': [1080], 'severity,': [1083], 'protects': [1085, 4082], '(16Bhatia': [1089], 'Mol.': [1093], '2004;': [1095, 1440, 3495, 3607, 4162, 4485, 4809, 4963], '8:': [1096], '402-409Crossref': [1097], 'Thus,': [1101], 'prior': [1102], 'protected': [1109, 1273], 'mice': [1110, 1408], 'cerulein-induced': [1112], '(17Bhatia': [1114, 4902], 'Wallig': [1116, 4904], 'Hofbauer': [1118, 4906], 'H.S.': [1121, 4909], 'Frossard': [1122, 4910], 'Steer': [1124, 4912], 'M.L.': [1125, 1205, 3829, 4913], 'Saluja': [1126, 4914], 'A.K.': [1127, 4545, 4915], 'Res.': [1130, 3626, 3654, 4024, 4484, 4918], 'Commun.': [1131, 3627, 3655, 4919], '246:': [1133, 4921], '476-483Crossref': [1134, 4922], '(119)': [1137, 4925], 'inhibition': [1141, 1380, 2216, 2865, 3289, 3719, 4499], 'activity': [1144, 3696], 'elicited': [1145, 2871, 3109, 3919], 'necrotizing': [1146], '(18Mareninova': [1148], 'O.A.': [1149, 4929], 'Sung': [1150, 4930], 'K.F.': [1151, 4931], 'Hong': [1152, 4932], 'Lugea': [1154, 4934], 'Pandol': [1156, 3598, 3832, 4936, 4960], 'S.J.': [1157, 3599, 3833, 4937, 4961], 'Gukovsky': [1158, 3600, 4938], 'Gukovskaya': [1160, 3602, 4940], 'A.S.': [1161, 3603, 3819, 4941, 4959], 'Chem.': [1164, 1236, 2296, 3494, 3563, 3606, 3676, 4126, 4262, 4944], '281:': [1166, 3565, 4946], '3370-3381Abstract': [1167, 4947], '(248)': [1175, 4955], 'An': [1178], 'potential': [1180, 1299, 4146, 4281, 4299, 4386, 4618], 'link': [1181, 3412], 'between': [1182, 3413, 4301], 'from': [1190, 1402, 1491, 1581, 1733, 1875, 2079, 2190, 2213, 2255, 2391, 2399, 2437, 2444, 2814, 3252, 3777, 3802], 'T-cells': [1193], '(19Dumont': [1194], 'Hehner': [1196], 'S.P.': [1197], 'Hofmann': [1198], 'T.G.': [1199], 'Ueffing': [1200], 'Droge': [1202], 'W.': [1203], 'Schmitz': [1204], 'Oncogene.': [1206, 3757], '1999;': [1207, 2125, 2503, 4067], '18:': [1208], '747-757Crossref': [1209], '(296)': [1212], 'leukemia': [1217], 'line': [1219, 1576, 3730], '(20Li': [1220], 'Ragheb': [1222], 'Lawler': [1224], 'Sturgis': [1226], 'Rajwa': [1228], 'Melendez': [1230], 'Robinson': [1232], '278:': [1238], '8516-8525Abstract': [1239], '(989)': [1247], 'To': [1250, 3286], 'investigate': [1251, 3008, 3287], '“redox”': [1253], 'effects': [1254, 2474, 3010, 3297], 'menadione,': [1256, 4512], 'potentially': [1258], 'designed': [1264], '1,4-dione': [1268], 'groups': [1269, 4786], 'give': [1275], 'corresponding': [1277], '2,4-dimethoxy-2-methylnaphthalene': [1278], '(DMN;': [1279], 'Fig.': [1280], '1A).': [1281], 'modeled': [1284], 'three-dimensional': [1287, 2220, 2456], 'structure': [1288, 2244], 'ensure': [1292, 1644], 'it': [1294, 1311, 3384, 3937, 3956, 3960], 'could': [1295], 'counteract': [1296], 'at': [1302, 1452, 1539, 1550, 1745, 1756, 1871, 1885, 1919, 1953, 1958, 1970, 2007, 2054, 2105, 2165, 2176, 2622, 3019], 'active': [1304], 'site': [1305], '(Fig.': [1306, 1339, 2471, 2535, 2599, 2696, 2734, 2780, 2795, 2838, 2876, 2899, 2912, 2944, 2962, 3034, 3045, 3119, 3199, 3254, 3278, 3367, 3395, 4046, 4330, 4447], '1B).': [1307], 'In': [1308, 1630, 1989, 2843, 3106, 3139, 3233, 3577, 4449, 4738, 4971], 'doing': [1309], 'so,': [1310], 'envisaged': [1313], 'would': [1316, 2463, 3293, 3859, 3957, 4313, 4346, 4355, 4365, 4379, 4395], 'then': [1317, 1895, 1925, 2029, 2544], 'commandeered': [1319], 'pathways': [1323], 'live': [1325, 4984], 'rather': [1329, 3953], 'than': [1330, 4236, 4240], '2-electron': [1331], '(detoxification)': [1332], 'pathways,': [1333], 'thereby': [1334, 4382, 4894], 'greater': [1336, 2828, 4239, 4384], '1C).': [1340, 4448], 'Using': [1341], 'approach,': [1344], 'allowed': [1346], 'simultaneous': [1347], 'measurement': [1348, 1632], 'levels,': [1355], 'we': [1356, 4698], 'show': [1357, 1807, 3409], 'due': [1363], 'cycle,': [1371], 'promotes': [1372], 'enhances': [1383], 'this': [1384, 2732, 3637, 3890, 4044, 4182, 4599, 4825, 4886], 'process.': [1385, 3943], 'Preparation—Freshly': [1387], 'clusters': [1394], 'two': [1396, 2402, 4348], 'or': [1397, 1542, 1565, 2046], 'three': [1398, 4307], 'prepared': [1401], 'pancreases': [1404], 'adult': [1406], 'CD1': [1407], 'collagenase': [1410], '(Worthington': [1411], 'Biochemical': [1412], 'Corp.,': [1413], 'Lakewood,': [1414], 'NJ)': [1415], 'our': [1418, 4818], 'previous': [1419], 'work': [1420], '(21Criddle': [1421], 'D.N.': [1422, 1697, 2659, 3055], 'Proc.': [1433], 'Natl.': [1434], 'Acad.': [1435], 'U.': [1437], '101:': [1441], '10738-10743Crossref': [1442], '(168)': [1445], 'All': [1448, 1726, 2199, 2439], 'experiments': [1449, 1618, 1633, 4345], 'performed': [1451, 1512, 1777, 1937, 2175, 2363], 'room': [1453, 1551, 1872, 1920, 2008, 2055, 2177], 'temperature': [1454, 2009, 2056, 2178], '(23-25': [1455], '°C),': [1456], 'within4hof': [1461], 'isolation.': [1462], 'extracellular': [1464], 'solution': [1465], 'contained': [1466, 2136], '(mm):': [1467], '140': [1468], 'NaCl,': [1469], '4.7': [1470], 'KCl,': [1471], '1.13': [1472], 'MgCl2,': [1473], 'CaCl2,': [1475], '10': [1476, 1478, 1537, 2314, 2740, 2852, 2878, 2880], 'd-glucose,': [1477], 'HEPES': [1479], '(adjusted': [1480], 'pH': [1482, 2152], '7.35': [1483], 'NaOH)': [1485], '(all': [1486], 'chemicals': [1487, 2441], 'highest': [1488, 2452], 'grade': [1489, 2453], 'available': [1490], 'Sigma,': [1492], 'Gillingham,': [1493], 'UK).': [1494], 'Measurements': [1495], 'Cytosolic': [1498], 'Calcium': [1499], '([Ca2+]c),': [1500], 'Mitochondrial': [1502, 1655, 2627], 'NADH—Confocal': [1503], 'imaging': [1504], 'loaded': [1507, 1526, 1994, 2562], 'fluorescent': [1509, 2002], 'dyes': [1510], 'Zeiss': [1515, 1519, 1625, 1682, 2654], 'LSM510': [1516, 1627, 1683, 2655], 'system': [1517, 1686, 2657], '(Carl': [1518], 'Jena': [1520], 'GmbH).': [1521], 'Freshly': [1522], 'dispersed': [1523], 'either': [1528], 'ester': [1532], '(CM-H2DCFDA;': [1533], '2.5': [1534], 'μm)': [1535, 1546, 1793, 2478, 2575, 2889, 2924, 3171, 3241, 3344, 3377], 'for': [1536, 1547, 1767, 1831, 1842, 1858, 1889, 1913, 2010, 2051, 2347, 3015, 3457, 3870, 3964, 4148, 4228, 4243], 'min': [1538, 1549, 2053, 2624, 2744], '37': [1540], '°C,': [1541], 'Fluo': [1543, 1566], '4-AM': [1544], '(3': [1545], '30': [1548, 1828, 1832, 1838, 1843, 1850, 1854, 1859, 2011, 2043, 2047, 2052, 2183, 2873], 'temperature,': [1552], 'measure': [1554], '[Ca2+]c,': [1559], 'respectively.': [1560], 'fluorescence': [1562, 1727, 1735, 1743, 1754, 2058, 2075, 2557, 2586, 2757, 2860, 3362], 'CM-H2DCFDA': [1564], '4': [1567], 'excited': [1569], 'argon': [1572], '488': [1573, 1959, 1971, 2062], 'nm': [1574, 1635, 1960, 1964, 1972, 1976, 2107], 'laser': [1575], 'emitted': [1578], 'light': [1579], 'collected': [1580], '505-550': [1582], 'nm.': [1583], 'images': [1585], 'obtained': [1586, 2212, 3776], 'composed': [1588], '256': [1590, 1592], '×': [1591, 1605, 1887], 'pixels': [1593], 'optical': [1596], 'section': [1597], 'selected': [1598], '5-6': [1601], 'μm.': [1602], 'C-Apochromat': [1604], '63': [1606], 'objective': [1607], 'numerical': [1610], 'aperture': [1611, 1951], '1.2': [1613], 'all': [1617, 1862], 'image': [1620, 1628], 'analysis': [1621, 2357, 2359], 'carried': [1622, 1866, 2202, 5011], 'out': [1623, 1867, 2203, 2720, 5012], 'software.': [1629], '[Ca2+]c': [1631, 3014, 3033, 3113, 3134], '50': [1634], 'acetylcholine': [1636], 'applied': [1638, 2742, 2926, 3018], 'positive': [1641], 'control': [1642, 1822, 3190, 3365], 'capable': [1649], 'generating': [1651], 'Ca2+': [1653, 2978], 'response.': [1654], 'assessed': [1658], 'contemporaneously': [1659], 'monitoring': [1661], 'changes': [1662, 1732], 'NADH': [1664, 2155, 2722, 3043, 3142, 3646, 4010], 'autofluorescence': [1665, 2639, 2695, 3044], 'perigranular': [1668, 2642, 2832], 'region': [1669, 2643, 2767, 2834, 3929], 'fast': [1676, 2649], 'switching': [1677, 2650], 'multichannel': [1678], 'mode': [1679, 2651], 'microscope': [1685, 1944], '(excitation': [1687, 2061], '363': [1688], 'nm,': [1689, 2063], 'emission': [1690, 2064], '390-450': [1691], 'nm)': [1692, 2066, 3024], 'reported': [1694, 2497, 3052, 4607], '(22Criddle': [1696, 2658, 3054], 'Murphy': [1698, 2660, 3056], 'Fistetto': [1700, 2662, 3058], 'Barrow': [1702, 2664, 3060], 'Gastroenterology.': [1712, 2674, 3070, 3318, 3834, 4552, 4584, 4658], '130:': [1714, 2676, 3072], '781-793Abstract': [1715, 2677, 3073], '(193)': [1723, 2685, 3081], 'measurements': [1728, 1935], 'expressed': [1730, 1982, 3982], 'basal': [1734, 2080, 2755, 2777, 2858], '(F/F0': [1736], 'ratio),': [1737], 'where': [1738], 'F0': [1739], 'represents': [1740, 1761], 'initial': [1742, 2192], 'recorded': [1744, 1755, 2060], 'start': [1747], 'experiment': [1750], 'F': [1752], 'specific': [1757], 'time': [1758], 'points': [1759], '(“n”': [1760], 'number': [1763, 1818], 'studied': [1766], 'each': [1768, 1876, 2134, 2348], 'protocol).': [1770], 'Detection': [1771], 'Apoptosis—Detection': [1773], 'annexin': [1780, 1909, 1984, 2430, 3185, 3247], 'V': [1781, 1910, 2431], 'FITC': [1782, 1911, 2432], 'kit': [1784, 2434], '(CloneTech,': [1785], 'Palo': [1786], 'Alto,': [1787], 'CA)': [1788], 'propidium': [1790, 1810], 'iodide': [1791, 1967], '(10': [1792], 'exclusion': [1794], 'employed': [1795, 3586], 'eliminate': [1797], 'necrotic': [1798], 'cells;': [1799, 3158], 'early': [1800], 'non-apoptotic': [1803], 'do': [1805], 'staining': [1808, 3186, 3248], 'iodide.': [1811], 'Isolated': [1812], 'divided': [1815], 'samples:': [1820], '1)': [1821], 'cells,': [1823, 2770, 2803, 2917, 3177, 3351, 4432], '2)': [1824], 'incubated': [1826, 1836, 1847, 1904], 'μm': [1829, 1839, 1851, 1855, 2033, 2040, 2044, 2048, 2534, 2874], 'min,': [1833, 1844, 1860, 1915], '3)': [1834], '4)': [1845], 'incubation': [1863], 'procedures': [1864], 'dark': [1870], 'temperature.': [1873, 1921], 'Cells': [1874], 'sample': [1877], 'washed': [1879, 1926, 2017, 2719], 'standard': [1881], 'buffer': [1882, 1929, 2022, 2149], 'centrifuged': [1884], '1000': [1886], 'g': [1888], 'min.': [1891, 2012], 'pellet': [1893], 're-suspended': [1896, 2019], '150': [1898], 'μl': [1899, 1907], 'binding': [1901, 1928, 2337], 'buffer,': [1902], '1.25': [1906], 'conjugate': [1912], '15': [1914], 'dark,': [1918], 'analysis.': [1933], 'Fluorescence': [1934], 'Leica': [1940, 2069], 'TCS': [1941], 'SP2': [1942, 2070], '63×': [1947], 'water': [1948], 'immersion': [1949], 'objective,': [1950], 'set': [1952], '1.2.': [1954], 'Annexin': [1955], 'excitation': [1961, 1973], '504-553': [1963], 'emission.': [1965, 1977], 'Propidium': [1966], '630-693': [1975], 'Levels': [1978], 'FI': [1985], 'intensity': [1986, 2084, 2829], '(arbitrary': [1987], 'units).': [1988], 'separate': [1990], 'experiments,': [1991], 'R110-aspartic': [1996, 2081, 2386, 3359], 'amide': [1998, 2083, 2388, 3361], '(20': [1999], 'μm),': [2000, 2157, 2853, 2934], 'indicator-linked': [2003], 'general': [2004, 4095], 'substrate,': [2006, 2495], 'After': [2013, 2807], 'loading,': [2014], 'calcium-free': [2021], 'solution.': [2023], 'portion': [2025], 'treated': [2030], '300': [2032, 2039], '3-sulfate': [2036], '(TLC-S)': [2037], 'alone,': [2038, 2050], 'TLC-S': [2041, 3339, 3342, 3390, 3393], '+': [2042], 'before': [2057, 2745], '>505': [2065], 'microscope.': [2072], 'Changes': [2073], 'normalized': [2078], 'values': [2085], '(F/F0).': [2086], 'Inhibition': [2088, 4335], 'Assay—The': [2089], 'ability': [2090], 'determined': [2097], 'measuring': [2099], 'cytochrome': [2103, 2137, 3554], 'c': [2104, 2138], '550': [2106], 'Beckman': [2110], 'DU650': [2111], 'spectrophotometer': [2112], 'modification': [2115, 3878], 'method': [2118], 'described': [2119, 2408, 3211], '(23Phillips': [2121, 2499], 'R.M.': [2122, 2500], '58:': [2126, 2504], '303-310Crossref': [2127, 2505], '(24)': [2130, 2508], 'Briefly,': [2133], 'assay': [2135], '(70': [2139], 'μmol)': [2140], 'recombinant': [2142, 2484, 4033], 'human': [2143, 2246, 2485, 4032], '(1': [2145], 'μg)': [2146], 'Tris-HCl': [2148], '(50': [2150, 3023], 'mm,': [2151], '7.5)': [2153], 'containing': [2154], '(100': [2156], 'varying': [2159], 'concentrations': [2160], 'final': [2167], 'volume': [2168], 'ml.': [2171], 'over': [2179, 2522], 'period': [2181], 's': [2184], '(rates': [2185], 'calculated': [2189], 'linear': [2193], 'part': [2194], 'reaction': [2197], 'curve).': [2198], 'triplicate.': [2205], 'IC50': [2207, 2528], 'value': [2208, 2372, 2529], 'enzyme': [2215, 2470, 3292, 3968, 3978, 4045, 4137, 4184, 4341, 4623], 'curve.': [2217], 'Computational': [2218], 'Chemistry—The': [2219], 'structures': [2221], 'ligands': [2224, 2279], '(menadione': [2225, 2280], 'DMN)': [2227, 2282], 'constructed': [2229], 'ChemSketch': [2231], 'freeware': [2232], '(Advanced': [2233], 'Chemistry': [2234], 'Development': [2235], 'version': [2236], '8.0)': [2237], 'energy-minimized.': [2239], 'x-ray': [2241], 'crystallographic': [2242], 'crystal': [2243], '(Protein': [2248], 'Data': [2249, 2259], 'Bank': [2250], 'file': [2251], '1H69)': [2252], 'downloaded': [2254], 'RCSB': [2257], 'Protein': [2258], 'Base': [2260], 'edited': [2262], 'accordingly': [2263], 'monomer': [2267], 'protein': [2270], 'included': [2272], 'bound': [2274], 'FADH2': [2275], 'cofactor.': [2277], 'Both': [2278, 4407], 'flexibly': [2284], 'docked': [2285], 'MolDock': [2288], 'algorithm': [2289], '(24Thomsen': [2290], 'Christensen': [2292], 'M.H.': [2293], '49:': [2298], '3315-3321Crossref': [2299], '(1644)': [2302], 'docking': [2306], 'procedure': [2307], 'randomized': [2309], 'minimum': [2312], 'runs': [2315], '5000': [2317], 'iterations': [2318], 'ligand.': [2320], 'best': [2322], 'five': [2323], 'poses': [2324], '(ligand': [2325], 'orientation)': [2326], 'recalculated': [2329], 're-ranked': [2331], 'analyzing': [2333], 'energy': [2335], 'scores,': [2336], 'affinities,': [2338], 'ligand-residue': [2340], '(H-bond)': [2341], 'interactions.': [2342], 'top': [2344], 'ranked': [2345], 'pose': [2346], 'ligand': [2349], 'visualized': [2351], 'ViewerLite': [2353], '(Accelryls).': [2354], 'Statistical': [2355], 'Analysis—Statistical': [2356], '(one-way': [2358], 'variance)': [2361], 'statistical': [2366], 'software': [2367], 'package': [2368], 'Origin': [2369], '7.': [2370], 'p': [2374, 2804, 2918, 2949, 2967, 3207, 3259, 3283, 3403], '<': [2375, 2582, 2805, 2919, 2950, 2968, 3208, 3284, 3404], '0.05': [2376], 'considered': [2378], 'significant.': [2381], 'Chemicals—Fluo': [2382], '4-AM,': [2383], 'purchased': [2390, 2436, 2443], 'Molecular': [2392, 4296], 'Probes': [2393], '(Eugene,': [2394], 'OR).': [2395], '1,4-Dimethoxy-2-methylnaphthalene': [2396], 'synthesized': [2398], 'steps': [2403], '(via': [2404], '1,4-dihydroxy-2-methylnaphthalene)': [2406], '(25Ito': [2410], 'Ikemoto': [2412], 'Yamano': [2414], 'Mizuno': [2416], 'Tomimatsu': [2418], 'Tetrahedron': [2420], 'Asymmetry.': [2421], '14:': [2423], '3525-3531Crossref': [2424], '(18)': [2426], 'CloneTech.': [2438], 'other': [2440, 3641, 4784], 'Sigma': [2445], '(Gillingham,': [2446], 'UK)': [2447], 'available.': [2454], 'modeling': [2458, 4297], 'studies': [2459, 3691], '1B),': [2472], '(0.5-250': [2477], 'purified': [2483], 'evaluated': [2488], 'vitro': [2490, 4036], 'inhibited': [2516, 4444], 'concentration-dependent': [2520], 'manner': [2521, 2911, 3150], 'micromolar': [2524], 'range,': [2525], '46.7': [2531], '±': [2532], '9.1': [2533], '2).': [2536, 4047], 'investigated': [2545], 'metabolism,': [2551], 'Stable': [2555], 'baseline': [2556, 2894], 'observed': [2559, 3854, 4419], 'indicating': [2565, 2727, 3935], 'auto-oxidation': [2567], 'dye.': [2570], 'Application': [2571], '(30': [2574, 2888, 2923, 2933, 3170, 3240, 3376], 'induced': [2576, 2750, 2854, 3028, 3172, 3345, 3419, 3516, 4462, 4520], 'clear': [2578], '(p': [2581], '0.05)': [2583], 'rise': [2584, 2703], 'generalized': [2589], 'throughout': [2590], 'cell,': [2592, 2646], 'indicative': [2593, 2771], '3A;8': [2600], '8': [2602, 2914, 2916], 'cells).': [2603, 2881], 'This': [2604, 3431, 4136, 4523], 'increase': [2605, 2820, 3041, 3183, 3357, 3923], 'started': [2608], 'immediately': [2609], 'after': [2610, 2625], 'exposure': [2611], 'continued': [2615, 2929], 'until': [2616], 'maximum': [2618], 'level': [2619], 'attained': [2621], '∼5': [2623], 'application.': [2626], 'concomitantly': [2633], '3C)': [2697], 'associated': [2700, 2956, 3038, 4568], 'substrate': [2708], 'usage': [2709, 4370, 4415], 'during': [2713, 2747], 'When': [2716, 2921], 'began': [2724], 'recover,': [2726], 'reversible': [2729], 'nature': [2730], '3C).': [2735], '(NAC;': [2739], 'mm),': [2741], '3': [2743, 4541], 'application,': [2749], 'slight': [2752], 'decline': [2753], 'H2DCFDA': [2756, 2859], 'more': [2762, 4235, 4405], 'evident': [2763], 'basolateral': [2766], 'scavenging': [2774], 'action': [2775, 4040, 4600, 4744], '4A).': [2781], 'completely': [2788], 'presence': [2792, 2930, 3265, 4316, 4423, 4752], 'NAC': [2794, 2811], '4,': [2796, 2839], 'B;': [2799, 2948], '16': [2800, 2802], '0.05).': [2806, 2920, 2969, 3261], 'withdrawal': [2808], 'perfusion': [2816], 'medium,': [2817], '“rebound”': [2819], 'observed,': [2826], 'B).': [2842], 'contrast,': [2844, 3107, 3140, 3234, 3578], 'chloride': [2850], '(DPI;': [2851], 'itself': [2862], '4C;': [2877], 'non-redox': [2883, 3236], 'cycling': [2884, 3237, 3422], '5A);': [2900], 'however,': [2901, 3383, 4879], 'sustained': [2910, 3149], '5C;': [2913], '5,': [2945, 2963], '0.05),': [2951], 'rate': [2954], 'accelerated': [2961, 4414], 'C': [2964], 'D;': [2966], 'oscillatory': [2977, 3030], 'signals': [2979], 'therefore': [3005, 4615, 5060], 'decided': [3006], 'comparison.': [3016], 'Acetylcholine,': [3017], 'quasi-physiological': [3021], 'concentration': [3022], 'control,': [3027], 'typical': [3029], 'elevations': [3031], '6A),': [3035], '6B),': [3046], 'stimulus-metabolism': [3049], 'coupling': [3050], '26Voronina': [3084], 'Sukhomlin': [3086], 'Johnson': [3088], 'P.R.': [3089], 'Erdemli': [3090], '(Lond.).': [3098], '539:': [3100], '41-52Crossref': [3101], '(92)': [3103], 'majority': [3116], 'cases': [3118], '6A;': [3120], '20': [3121], '31': [3123, 3157], 'cells),': [3124], 'remainder': [3127], 'exhibited': [3128], 'only': [3129], 'occasional,': [3130], 'transient': [3131], 'increases': [3132, 3461, 3580], 'discernible': [3137], 'pattern.': [3138], 'always': [3145], 'application': [3152, 3440], '(31': [3155], 'Figs.': [3159], '6B': [3160], '5C),': [3162], 'suggesting': [3163], 'Ca2+-independent': [3165, 3922], 'action.': [3168], 'indicated': [3179, 3353], 'non-treated': [3189], 'predominantly': [3194], 'membrane': [3198, 3591], '7,': [3200], 'B,': [3203, 3371, 3399], 'n': [3204, 3256, 3280, 3372, 3400], '=': [3205, 3257, 3281, 3373, 3401], '84;': [3206], '0.01),': [3209], 'did': [3242, 3946], 'induce': [3244, 4530], 'apoptosis,': [3245], 'different': [3251], 'controls': [3253], '7B,': [3255, 3279], '81;': [3258], '>': [3260], 'However,': [3262], '(>2-fold)': [3273], '83;': [3282], '0.01).': [3285, 3405], 'whether': [3288], 'modify': [3295], 'acids,': [3300], 'recognized': [3301, 4641], 'precipitants': [3302, 4642], '(27Niederau': [3306, 4646], 'C.': [3307, 4647, 4802], 'Niederau': [3308, 4648], 'Luthen': [3310, 4650], 'Strohmeyer': [3312, 4652], 'Ferrell': [3314, 4654], 'L.D.': [3315, 4655], 'Grendell': [3316, 4656], 'J.H.': [3317, 3698, 4657], '1990;': [3319, 4025, 4659], '99:': [3320, 4660], '1120-1127Abstract': [3321, 4661], '(188)': [3327, 4667], 'fate,': [3333], 'caspases': [3337, 4537], 'assessed.': [3341], '(300': [3343], '8,': [3368, 3396, 4538], '57).': [3374], 'activation;': [3382], 'response': [3388], '56;': [3402], 'Our': [3406, 4612], 'present': [3407, 3857, 4344, 4504, 4740, 4819, 4974], 'findings': [3408], 'major': [3411, 4349], 'free': [3434, 3476], 'radicals': [3435], 'within': [3437, 4319], 'minutes': [3438], 'fuelled': [3445], 'serve': [3453], 'donors': [3456, 4374], 'enzymes.': [3459, 5016], 'Menadione-induced': [3460], 'clearly': [3469, 4276], 'abolished': [3470], 'N-acetylcysteine,': [3474], 'radical': [3477], 'scavenger': [3478, 3484], 'precursor': [3480], 'glutathione': [3485, 4782], '(28Qanungo': [3486], 'Nieminen': [3490], 'A.L.': [3491], '279:': [3496, 3608], '50455-50464Abstract': [3497], '(93)': [3505], 'block': [3513, 3939], 'rat': [3518], 'obstruction': [3525], '(29Sevillano': [3526], '1639:': [3542], '177-184Crossref': [3543], 'HepG2': [3551, 4832], '2E1': [3556], '(30Bai': [3557], 'Cederbaum': [3559], 'A.I.': [3560], '5128-5136Abstract': [3566], '(71)': [3574], 'unaffected': [3582], 'widely': [3585], 'blocker': [3589], '(31Vaquero': [3594], 'E.C.': [3595], 'Edderkaoui': [3596], '34643-34654Abstract': [3609], '(307)': [3617], '32Li': [3620], 'Trush': [3622, 3650], '253:': [3629, 3657], '295-299Crossref': [3630, 3658], '(399)': [3633, 3661], 'although': [3636, 4598], 'compound': [3638], 'flavoenzymes': [3642], 'dehydrogenase': [3647], '(32Li': [3648], '33Chen': [3664], 'Y.R.': [3665], 'C.L.': [3667], 'Zhang': [3668], 'L.': [3669, 4473], 'Green-Church': [3670], 'K.B.': [3671], 'Zweier': [3672], '280:': [3678], '37339-37348Abstract': [3679], '(116)': [3687], 'Recent': [3690], 'demonstrated': [3693, 4180, 4700], '(34Yu': [3697], 'Lim': [3699, 4850], 'J.W.': [3700], 'Kim': [3701, 3703], 'K.H.': [3704], 'Int.': [3705], '37:': [3711], '1458-1469Crossref': [3712], '(65)': [3715], 'superoxide': [3721], 'DPI': [3724, 3853], 'cancer': [3728, 4149, 4454], '(35Mochizuki': [3731], 'Furuta': [3733], 'Mitsushita': [3735], 'Shang': [3737], 'W.H.': [3738], 'Ito': [3739], 'Yokoo': [3741], 'Yamaura': [3743], 'Ishizone': [3745], 'Nakayama': [3747], 'Konagai': [3749], 'Hirose': [3751], 'Kiyosawa': [3753], 'Kamata': [3755], '25:': [3759], '3699-3707Crossref': [3760], '(199)': [3763], 'Current': [3766], 'enhanced': [3773, 4759], 'neutrophils': [3775], '(36Tsuji': [3782], 'Watanabe': [3784], 'Okamoto': [3786], 'Niitsu': [3788], '1994;': [3791], '35:': [3792], '1659-1664Crossref': [3793], '(33)': [3796, 4814], 'derived': [3801], 'neutrophil': [3803], 'play': [3807, 4215, 5061], 'implementing': [3812], 'damage': [3813, 4897], '(37Gukovskaya': [3818], 'Vaquero': [3820], 'Zaninovic': [3822], 'Gorelick': [3824], 'F.S.': [3825], 'Lusis': [3826], 'Brennan': [3828], 'Holland': [3830], '122:': [3836, 4554], '974-984Abstract': [3837], '(205)': [3845], 'lack': [3849], 'study': [3858, 4178, 4505, 4830], 'strongly': [3860], 'responsible': [3869], 'menadione.': [3876, 4392], 'Chemical': [3877], 'molecule': [3882], 'form': [3884], 'blocked': [3886], 'capacity': [3888], 'led': [3899], 'physiological': [3902], 'consequences;': [3903], 'longer': [3907], 'nor': [3913], 'induced.': [3916], 'Interestingly,': [3917, 4175, 4493], 'reversible,': [3921], 'se,': [3934], 'might': [3938], 'it,': [3955], 'appear': [3958], 'compete': [3963], 'one': [3965], 'target(s)': [3969], 'instead': [3973], 'inhibits': [3974], '(15Hammons': [3987], 'utilizes': [4009], 'co-factors': [4014], '(38Siegel': [4015], 'Gibson': [4017], 'N.W.': [4018], 'Preusch': [4019], 'P.C.': [4020], 'Ross': [4021], '50:': [4026], '7293-7300PubMed': [4027], 'Analysis': [4030], 'confirmed': [4037], 'inhibitory': [4039], 'protective': [4050], 'P19': [4056], 'embryonal': [4057], 'carcinoma': [4058], '(39Chiou': [4060], 'T.J.': [4061], 'Y.T.': [4063], 'Tzeng': [4064], 'W.F.': [4065], 'Toxicology.': [4066, 4852], '139:': [4068], '103-110Crossref': [4069], '(20)': [4072], 'toxicity': [4086], 'electrophiles': [4088], 'forms': [4091], '40Thor': [4112], 'Smith': [4114, 4250], 'M.T.': [4115, 4251], 'Hartzell': [4116, 4252], 'Bellomo': [4118, 4254], 'Jewell': [4120, 4256], 'S.A.': [4121, 4257], 'Orrenius': [4122, 4258], '1982;': [4127, 4263], '257:': [4128, 4264], '12419-12425Abstract': [4129, 4265], 'overexpressed': [4139], 'many': [4141], 'tumors': [4142], 'constitutes': [4144], 'target': [4147], 'chemotherapy': [4150], '(41Danson': [4151], 'Ward': [4153], 'T.H.': [4154], 'Butler': [4155], 'Ranson': [4157], 'Treat.': [4160], 'Rev.': [4161], '30:': [4163], '437-449Abstract': [4164], '(167)': [4172], 'recent': [4177, 4829], 'thus': [4214], 'protection.': [4223], 'affinity': [4225, 4242], 'hepatic': [4229], 'ten': [4237], 'times': [4238], 'its': [4241], '(40Thor': [4248], 'further': [4273], 'investigation': [4274], 'required': [4277], 'clarify': [4279], 'importance': [4282], 'counter': [4290], 'pancreas.': [4295], 'interactions': [4300], 'predicts': [4305], 'hydrogen-bonding': [4309], 'sites': [4310], 'exist': [4311], 'stabilize': [4314], 'enzyme,': [4321], 'inhibiting': [4322], 'entry': [4324, 4863], 'subsequent': [4326], '1,': [4331], 'C).': [4334], 'predicted': [4350], 'consequences,': [4351], 'expected': [4357], 'potentiate': [4359], 'production.': [4361, 4761], 'First,': [4362], 'enzymatic': [4369], 'diminished,': [4381], 'providing': [4383], 'drive': [4388], 'Second,': [4393], 'now': [4396], 'preferentially': [4398], 'shunted': [4399], 'through': [4400], 'system(s)': [4403], 'releasing': [4404], 'ROS.': [4406], 'potentiation': [4409, 4495], 'combined': [4422], 'model': [4436], 'accordance,': [4450], 'treatment': [4451], 'nonspecific': [4458], 'dicoumarol': [4461], '(42Lewis': [4468], 'Ough': [4470], 'Li': [4472], 'Hinkhouse': [4474], 'M.M.': [4475], 'Ritchie': [4476], 'J.M.': [4477], 'Spitz': [4478], 'D.R.': [4479], 'Cullen': [4480], 'J.J.': [4481], 'Clin.': [4482], '10:': [4486], '4550-4558Crossref': [4487], '(58)': [4490, 4796], 'confined': [4508], 'augmented': [4517], 'TLC-S.': [4522], 'hepatocytes': [4533], '9,': [4539], '(43Graf': [4542], 'Kurz': [4544], 'Fischer': [4546], 'Reinehr': [4548], 'Haussinger': [4550, 4582], '1411-1427Abstract': [4555], '(95)': [4563], '(44Reinehr': [4572], 'Becker': [4574], 'Keitel': [4576], 'Eberle': [4578], 'Grether-Beck': [4580], '129:': [4586], '2009-2031Abstract': [4587], '(134)': [4595], 'current': [4613], 'data': [4614, 4820, 4975], 'underscore': [4616], 'relevance': [4619], 'pathological': [4635], 'situations,': [4636], 'acids': [4639], 'whose': [4671], 'detrimental': [4672], 'involve': [4675], 'vivo': [4679], '(6Sanfey': [4680], 'Previously': [4697], 'linked': [4712], 'study,': [4741], 'pro-apoptotic': [4743], 'association': [4756], 'favored': [4773], 'oxidation': [4779], 'intracellular': [4781], 'sulfydryl': [4785], '(45Chernyak': [4787], 'B.V.': [4788], 'Biosci.': [4789], 'Rep.': [4790], '1997;': [4791], '17:': [4792], '293-302Crossref': [4793], '46Colell': [4799], 'Garcia-Ruiz': [4801], 'Mari': [4803], 'Fernandez-Checa': [4805], 'J.C.': [4806], 'FEBS': [4807], '560:': [4810], '63-68Crossref': [4811], 'accord': [4823], 'notion.': [4826], 'cadmium-induced': [4836], 'trigger': [4840], 'caspase-dependent': [4844], 'pathway': [4845, 4992], '(47Oh': [4846], 'S.H.': [4847], 'Choi': [4848], 'J.E.': [4849], 'S.C.': [4851], '220:': [4854], '1-12Crossref': [4855], '(61)': [4858], 'Whether': [4861], 'beneficial': [4869], 'currently': [4877], 'unresolved,': [4878], 'several': [4880], 'lines': [4881], 'formation': [4890], 'necrosis,': [4893], 'limiting': [4895], 'organ': [4896], 'improving': [4899], 'outcome': [4901], '18Mareninova': [4928], '48Gukovskaya': [4958], '4:': [4964], '567-586Crossref': [4965], '(135)': [4968], 'conclusion,': [4972], 'natural': [4991], 'promote': [4997], 'programmed': [4998]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2009080781', 'counts_by_year': [{'year': 2024, 'cited_by_count': 29}, {'year': 2023, 'cited_by_count': 17}, {'year': 2022, 'cited_by_count': 23}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 21}, {'year': 2019, 'cited_by_count': 29}, {'year': 2018, 'cited_by_count': 19}, {'year': 2017, 'cited_by_count': 20}, {'year': 2016, 'cited_by_count': 16}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 30}, {'year': 2013, 'cited_by_count': 18}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2024-12-14T04:24:22.561208', 'created_date': '2016-06-24'}