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'John': [233, 667], 'authorRoger': [259, 693], 'E.': [260, 264, 290, 295, 694, 698, 724, 729], 'McLendon': [261, 265, 695, 699], 'Roger': [263, 697], 'Pathology,': [269, 703], 'Herndon': [291, 296, 725, 730], 'II': [292, 297, 726, 731], 'Cancer': [301, 331, 735, 765, 1184, 1189], 'Center': [302, 332, 736, 766], 'Biostatistics,': [303, 333, 737, 767], 'authorApril': [323, 757], 'Coan': [324, 327, 758, 761], 'MS,': [325, 759], 'April': [326, 760], 'MS': [328, 762], 'authorStevie': [353, 787], 'Threatt': [354, 357, 788, 791], 'BS,': [355, 789], 'Stevie': [356, 790], 'BS': [358, 792], 'authorAllan': [381, 815], 'Friedman': [383, 387, 413, 417, 817, 821, 847, 851], 'Allan': [385, 819], 'authorHenry': [411, 845], 'S.': [412, 416, 846, 850], 'Henry': [415, 849], 'author': [458, 892], 'First': [893], 'published:': [894], '16': [895, 2332, 2349, 3658], 'May': [896], '2011': [897, 1187], 'https://doi.org/10.1002/cncr.26188Citations:': [898], '68': [899], 'AboutSectionsPDF': [900], 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2174, 2220, 2240, 2269, 2373, 2457, 2461, 2508, 2511, 2517, 2528, 2534, 2543, 2557, 2586, 3028, 3065, 3138, 3152, 3159, 3166, 3175, 3280, 3410, 3469, 3611, 3784, 3791, 3942, 4162, 4219], 'Wiley': [937], 'Online': [938], 'Library': [939], 'UseShareable': [944], 'LinkUse': [945], 'link': [947], 'a': [951, 986, 1244, 1401, 1442, 1617, 1626, 1780, 1975, 2167, 2280, 2295, 2320, 2341, 2617, 2739, 2767, 2792, 3081, 3156, 3284, 3535, 3796, 3832, 3988, 4003, 4010, 4030, 4034, 4041, 4085, 4133, 4159, 4275, 4286], 'article': [956], 'with': [957, 1169, 1204, 1226, 1242, 1303, 1362, 1370, 1434, 1454, 1534, 1538, 1590, 1759, 1869, 1932, 1957, 2273, 2290, 2319, 2386, 2483, 2635, 2653, 2724, 2738, 2791, 3019, 3062, 3113, 3525, 3547, 3551, 3565, 3592, 3892, 3927, 3998, 4078, 4084, 4091, 4111, 4224, 4293], 'your': [958], 'friends': [959], 'colleagues.': [961], 'Learn': [962], 'more.Copy': [963], 'URL': [964], 'Abstract': [965], 'BACKGROUND:': [966], 'efficacy': [968, 2329, 2367], 'among': [974, 1175, 1257, 1415, 1536, 2228, 2249, 2285, 2382, 3518, 3921], '(GBM)': [977], 'patients': [978, 996, 1019, 1029, 1095, 1152, 1178, 1260, 1372, 1394, 1607, 1687, 1789, 1837, 2231, 2252, 2288, 2303, 2333, 2350, 2385, 2588, 2647, 2664, 2685, 2698, 2717, 2745, 2968, 2974, 3023, 3048, 3091, 3101, 3130, 3207, 3216, 3230, 3236, 3239, 3251, 3398, 3453, 3470, 3478, 3501, 3519, 3540, 3558, 3579, 3595, 3789, 3813, 3837, 3860, 3891, 3925, 3993, 4022, 4058, 4097, 4110, 4292], 'prior': [980, 1102, 1544, 1586, 1591, 1701, 1717, 1726, 1762, 1897, 2236, 2257, 2644, 2661, 2670, 2681, 2778, 2859, 2872, 2897, 2913, 2926, 4017], 'in': [985, 1147, 1281, 1282, 1310, 1327, 1466, 1478, 1558, 1909, 1947, 2106, 2602, 2722, 2962, 3191, 3205, 3214, 3228, 3234, 3439, 3451, 3458, 3513, 3537, 3549, 3610, 3763, 3790, 3814, 4020, 4088, 4132, 4192, 4214, 4227, 4291], 'phase': [987, 1793, 3820, 3827, 4070], '2,': [988, 3173], 'open-label,': [989], 'single-arm': [990], 'trial': [991], 'was': [992, 1075, 1118, 1130, 1167, 1487, 1516, 1604, 1774, 1806, 1826, 2001, 2114, 2144, 2217, 2244, 2304, 2339, 2369, 2451, 2505, 2525, 2554, 2788, 3399, 3407, 3448, 3464, 3510, 3533, 3555, 3908, 3914, 3945, 3953, 4240, 4246], 'evaluated.': [993], 'METHODS:': [994], 'Eligible': [995, 1606, 1788], 'received': [997, 1796, 2761, 3521, 3528, 3995, 4024], 'carboplatin': [998, 1445, 1530, 1727, 3246, 4079, 4180, 4183, 4206, 4300], '(area': [999], 'under': [1000, 1811], 'plasma': [1002, 1813], 'curve': [1003, 1814], '[AUC]': [1004], '4': [1005, 1141, 1577, 1601, 1668, 1817, 1929, 2049, 2135, 2406, 2448, 2776, 3005, 3181, 3188, 3202, 3295, 3318, 3350, 3459], 'mg/ml-min)': [1006], 'day': [1008, 1819, 3422], '1,': [1009, 2953], 'whereas': [1010, 2418, 2673, 2696, 2726, 2965, 3174, 3198, 3249, 3461], '(10': [1012], 'mg/kg)': [1013], 'irinotecan': [1015, 1407, 1447, 1532, 3016, 3907, 4081, 4185, 4200, 4202], '(340': [1016], 'mg/m2': [1017, 1027, 1835, 1854], 'CYP3A': [1021, 1841, 2938], 'enzyme-inducing': [1022, 1842, 2939], 'anti-epileptics': [1023, 1843], '[EIAEDs]': [1024], '125': [1026, 1853], 'not': [1030, 1857, 2006, 2261, 2452, 2494, 3465, 3752, 3878, 3915, 4176], 'EIAEDs)': [1032], 'were': [1033, 1045, 1143, 1158, 1255, 1470, 1565, 1594, 1608, 1624, 1684, 1692, 1710, 2035, 2070, 2076, 2102, 2334, 2415, 2424, 2438, 2467, 2486, 2571, 2606, 2626, 2632, 3069, 3078, 3131, 3146, 3171, 3183, 3224, 3258, 3480, 3487, 3503, 3581, 3597, 4209], 'administered': [1034, 1413, 1807, 1827, 3079, 3164], 'days': [1036, 1829], '1': [1037, 1101, 1633, 1820, 1830, 2063, 2322, 2477, 2513, 2669, 2674, 2733, 2839, 2869, 2874, 2881, 2910, 2916, 2920, 2955, 2980, 2993, 3109, 3242, 3309, 3331, 3336, 3340, 3346, 3352, 3376, 3383, 3415, 3426, 3462], '14': [1039, 1803, 1832, 2636, 3356], 'every': [1041, 1057, 1802, 1899], '28-day': [1042, 1823], 'cycle.': [1043, 1059, 1824], 'Patients': [1044, 1564, 1589, 1709, 2093, 2605, 2631, 3621, 3637], 'evaluated': [1046, 3808, 3965], 'each': [1048, 1822, 2158, 2337, 2445], 'first': [1051, 1891, 2276, 2293], 'cycles': [1053, 1894, 2985, 3006, 3075, 3085, 3163], 'then': [1055, 1896, 2760], 'other': [1058, 1311, 1365, 1467, 1900, 2147, 2967], 'Treatment': [1060, 1786, 3631], 'continued': [1061, 1862], 'until': [1062, 1863, 2057, 2146, 2561], 'progressive': [1063, 1374, 1492, 1719, 1864, 2946, 3098, 3456], 'disease,': [1064, 1865, 3118], 'unacceptable': [1065, 1866, 2393, 2430, 2465], 'toxicity,': [1066, 1867, 2044, 2394, 2410, 3123], 'noncompliance,': [1067, 3124], 'or': [1068, 1111, 1140, 1363, 1581, 1673, 1705, 1721, 1728, 1750, 1767, 1783, 1873, 1938, 1959, 1992, 1995, 2010, 2021, 2040, 2064, 2121, 2133, 2139, 2195, 2345, 2352, 2404, 2407, 2413, 2422, 2522, 2541, 2563, 2765, 3180, 3187, 3201, 3262, 3516, 3675, 3845, 3937, 4157, 4182, 4205], 'voluntary': [1069, 3126, 3429], 'withdrawal.': [1070, 3430], 'primary': [1072, 1199, 1514, 2215], 'end': [1073, 1084], 'point': [1074], 'progression-free': [1076, 1523, 3587, 3739], 'survival': [1077, 1091, 1207, 1322, 1358, 1524, 3775, 3864, 3913, 4290], 'at': [1078, 1099, 1525, 1610, 1631, 1676, 1798, 1808, 1833, 1852, 1927, 2275, 2292, 2527, 2542, 2620, 2629, 2694, 2886, 2896, 3147, 3275, 3483, 3530, 3843], '6': [1079, 1267, 1526, 3033, 3192, 3589], 'months': [1080, 1120, 1212, 1380, 1527, 2356, 2777, 2790, 3401, 3590, 3947, 3978, 4008, 4015, 4039], '(PFS-6),': [1081], 'secondary': [1083], 'points': [1085], 'included': [1086, 1638, 1969, 4247], 'safety': [1087, 1174, 1554], 'median': [1089, 1116, 1205, 3082, 3394, 3900, 3943, 3969, 4004, 4011, 4035, 4042], 'overall': [1090, 1113, 1206, 3745, 3774], '(OS).': [1092], 'RESULTS:': [1093], 'All': [1094, 1686, 2646, 3129], 'had': [1096, 1236, 1307, 1616, 2233, 2254, 2260, 2616, 2648, 2666, 4033], 'least': [1100, 1611, 1632, 1667, 1677, 1928, 2621, 3148], 'regimen': [1104, 1443, 1465, 1557, 3154, 4128, 4164, 4239, 4288], '56%': [1106], 'enrolled': [1107, 2590, 2676, 2687, 2700, 2747, 4109], 'either': [1109, 1459, 1697, 2762, 3514, 3842, 3935, 4179], 'second': [1110], 'third': [1112], 'progression.': [1114, 2552, 2645], 'OS': [1117, 2553, 2570, 3517, 3538, 3944, 3970, 4012, 4043], '5.8': [1119, 3660], '(95%': [1121, 1132, 3402, 3641, 3645, 3650, 3948, 3955], 'confidence': [1122, 2578, 3742], 'interval': [1123], '[CI],': [1124], '4.0-7.0': [1125], 'months)': [1126], 'PFS-6': [1128, 2221, 2281, 2313, 3435, 3952, 3972], 'rate': [1129, 2222, 2282, 2324, 3436], '16%': [1131], 'CI,': [1133, 3403, 3741, 3949, 3956], '5.0%-32.5%).': [1134], 'most': [1136, 1196, 1371, 3176], 'common': [1137, 1197, 3177], 'grade': [1138, 1576, 1600, 1713, 1722, 2038, 2045, 2048, 2062, 2119, 2134, 2149, 2154, 2206, 2210, 2397, 2405, 3120, 3141, 3172, 3178, 3199, 3210, 3221], '3': [1139, 2039, 2046, 2098, 2150, 2641, 2880, 3084, 3179, 3186, 3200, 3206, 3211, 3222, 3229, 3294, 3320, 3360, 3372, 3441, 3821, 4154], 'events': [1142, 2151, 3144, 3170, 3182, 3223], 'hematologic': [1144, 3002, 3122], 'occurred': [1146, 3190, 3204, 3213], '29%': [1148], 'cycles.': [1150], 'Nine': [1151, 3238], '(38%)': [1153], 'required': [1154, 1566, 1916, 1944, 2019, 2086, 2095, 2160, 3241, 3253, 4150], 'dose': [1155, 1629, 2100, 2849, 3243, 3255], 'modification.': [1156], 'There': [1157, 1691, 3257, 3509], 'no': [1159, 1693, 3114, 3259, 3511], 'treatment-related': [1160], 'deaths.': [1161], 'CONCLUSIONS:': [1162], 'Carboplatin,': [1163], 'associated': [1168, 1302, 1433, 1453, 2482, 4083], 'modest': [1170, 1369, 1409, 4086], 'activity': [1171, 1294, 1411], 'adequate': [1173], 'GBM': [1177, 1259, 1262, 1285, 1393, 1540, 2230, 2251, 2287, 2302, 2712, 3620, 3735, 3788, 3812, 3836, 3894, 3924, 4096], 'who': [1179, 1541, 2094, 2232, 2253, 2589, 2982, 2995, 3034, 3417, 3479, 3502, 3520, 3527, 3541, 3559, 3567, 3580, 3596, 3895, 3994, 4023, 4098], 'progressed': [1180, 1542, 1584, 2234, 2255, 2351, 2649, 2667, 2690, 2718, 2728, 2735, 2756, 3036, 3542, 3560, 3568, 3896, 4100], 'previously.': [1183], '2011;.': [1185], '©': [1186], 'American': [1188], 'Society.': [1190], 'Outcome': [1191, 3392, 3405, 3609], '(GBM),': [1194], 'malignant': [1198, 1417, 1578, 1602], 'brain': [1200], 'tumor,': [1201, 1974], 'remains': [1202, 2989], 'poor': [1203, 2389], '(OS)': [1208], 'only': [1210, 3909], '14.6': [1211], 'current': [1214, 1480], 'standard': [1215, 2651], 'that': [1217, 1441, 1583, 1985, 2085, 3145, 3992, 4050, 4074, 4140, 4199, 4254, 4280], 'includes': [1218, 3414], 'maximum': [1219], 'safe': [1220], 'resection': [1221, 1672], 'followed': [1222], 'involved-field': [1224], 'radiation': [1225, 1765, 2654], 'temozolomide': [1227, 2274, 2291, 2656, 2764, 3936], 'adjuvant': [1229, 2707, 3522], 'temozolomide.1': [1230], 'Salvage': [1231], 'therapies': [1232], 'recurrence': [1234, 3844], 'limited': [1237, 3225], 'activity.2-4': [1238], 'Initial': [1239], 'clinical': [1240, 1300, 1996], 'trials': [1241], 'bevacizumab,': [1243, 3899, 4204], 'humanized': [1245], 'monoclonal': [1246, 1769], 'antibody': [1247, 1770], '(MAb)': [1248], 'against': [1249], 'vascular': [1250], 'endothelial': [1251], 'growth': [1252, 1280], 'factor': [1253], '(VEGF),': [1254], 'conducted': [1256], 'because': [1261, 4263], 'tumors': [1263], 'are': [1264, 1432, 2600, 3035, 3041, 3437, 3777, 3838], 'highly': [1265], 'angiogenic5,': [1266], 'secrete': [1269], 'high': [1270, 3833], 'levels': [1271], 'VEGF.7-9': [1273], 'In': [1274, 1420, 1547, 3802], 'addition,': [1275, 1421, 1548, 3803], 'VEGF': [1276], 'targeting': [1277], 'MAbs': [1278], 'inhibit': [1279], 'vivo': [1283], 'orthotopic': [1284], 'xenograft': [1286], 'models10,': [1287], '11': [1288, 2875], 'can': [1290, 4266], 'enhance': [1291], 'antitumor': [1293, 1410, 1456], 'cytotoxic': [1296], 'therapy.12-14': [1297], 'Furthermore,': [1298, 3863, 4274], 'significant': [1299, 1979], 'benefit': [1301, 1359, 1457, 4149, 4213, 4222], 'plus': [1305, 3571, 3603, 3906, 3929, 4203, 4207], 'chemotherapy': [1306, 1506, 2068, 2099, 2657, 3572, 3933, 4001, 4027, 4272], 'been': [1308, 2262, 3879, 3887, 4167, 4256], 'noted': [1309], 'aggressive': [1312], 'solid': [1313], 'tumors.15-20': [1314], 'Encouraging': [1315], 'rates': [1316, 2314, 2391, 2419, 3853], 'radiographic': [1318, 1354, 3446, 3474, 3855], 'response': [1319, 1882, 1914, 1942, 3447, 3856], 'improved': [1321, 2022, 3556, 4190], 'reported': [1323, 3916, 3991, 4229, 4257, 4279], 'initial': [1325, 2785, 3847], 'studies': [1326, 3822, 3885], 'GBM21,': [1329], '22': [1330, 2863], 'triggered': [1331], 'follow-up': [1332, 2500, 2532, 3395], 'studies,': [1333], 'which': [1334], 'ultimately': [1335, 3861], 'led': [1336], 'accelerated': [1338], 'approval': [1339], 'US': [1342], 'Food': [1343], 'Drug': [1345, 3053], 'Administration': [1346, 3054], '(FDA)': [1347], 'single-agent': [1349, 2763, 3898], 'based': [1351, 1695, 1902, 2432, 3408, 4217, 4241], 'durable': [1353], 'responses.23-25': [1355], 'However,': [1356, 3553, 4195], 'without': [1364, 2538, 4029, 4186], 'systemic': [1366], 'agents': [1367, 1423, 3687, 3700, 3710, 4156], 'is': [1368, 3008, 3781, 3805, 3868, 4082, 4139, 4197], 'developing': [1373], 'disease': [1375, 1720, 1776, 1967, 1999, 2017, 2520, 2539, 2551, 3450, 3457], 'within': [1376, 1657, 2354], '8': [1377, 2817], '10': [1379, 1799, 2624, 2824, 2846, 3358, 3477], 'dying': [1382], 'from': [1383, 2556, 2830], 'refractory': [1384], 'tumor': [1385, 1493, 1501, 1923, 1956, 1983, 4252, 4268], 'soon': [1386], 'thereafter.22-24,': [1387], '26-30': [1388], 'Thus,': [1389, 3831], 'effective': [1390, 3872], 'bevacizumab-based': [1398, 1587], 'represents': [1400], 'major': [1402], 'unmet': [1403], 'need.': [1404], 'Carboplatin': [1405, 1805], 'exhibit': [1408], 'when': [1412], 'separately': [1414], 'glioma': [1418, 1579, 1593, 1603], 'patients.31-38': [1419], 'both': [1422], 'impair': [1424], 'DNA': [1425], 'replication': [1426], 'via': [1427], 'potentially': [1428, 1499], 'complementary': [1429], 'mechanisms': [1430], 'primarily': [1435], 'nonoverlapping': [1436], 'toxicities.': [1437], 'We': [1438], 'therefore': [1439, 2372], 'hypothesized': [1440], 'combining': [1444], 'may': [1448, 4053, 4165, 4188], 'be': [1449, 2363, 4130], 'adequately': [1450], 'tolerated': [1451], 'greater': [1455, 2122, 2423], 'than': [1458, 2097, 2614], 'agent': [1460, 2741], 'alone.': [1461, 2112], 'Studies': [1462], 'evaluating': [1463], 'cancer': [1468], 'populations': [1469], 'basis': [1472], 'dosing': [1475], 'schedule': [1476], 'utilized': [1477], 'study.': [1481, 3167, 4194], 'rationale': [1483, 4235], 'continuing': [1485], 'avoid': [1489, 4249], 'rebound,': [1490], 'fulminant': [1491, 4250], 'discontinuation39': [1496, 4261], 'normalize': [1500, 4267], 'vasculature': [1502, 4269], 'allow': [1504, 2307], 'enhanced': [1505], 'delivery.40': [1507], 'MATERIALS': [1508], 'AND': [1509], 'METHODS': [1510], 'Protocol': [1511], 'Objectives': [1512], 'Our': [1513, 2214, 4069], 'objective': [1515], 'evaluate': [1518, 1552, 2219, 4177], 'activity,': [1520], 'defined': [1521, 2002, 2395, 2506], '(PFS-6)': [1528], 'combined': [1533], 'adults': [1537], 'therapy.': [1546, 1588, 2238, 2972, 3046, 4103], 'we': [1549, 2265, 4174], 'sought': [1550], 'patient': [1560, 2535, 2675, 2734, 2956, 2981, 2994, 3416, 3463], 'population.': [1561], 'Patient': [1562, 2582, 2801], 'Eligibility': [1563], 'histologic': [1569, 1597], 'confirmation': [1570], 'World': [1572], 'Health': [1573], 'Organization': [1574], '(WHO)': [1575], '(GBM': [1580], 'gliosarcoma)': [1582], 'low-grade': [1592], 'eligible': [1595], 'if': [1596, 2533, 2548, 2566, 4158], 'transformation': [1598], 'confirmed.': [1605], 'also': [1609, 2018, 2077], '18': [1612], 'years': [1613], 'age;': [1615], 'Karnofsky': [1618, 2934], 'performance': [1619, 2935, 4121], 'status': [1620, 1963], '(KPS)': [1621], '≥70;': [1622], 'stable': [1627, 2016, 2020, 3020, 3449], 'corticosteroid': [1628, 1933], 'week.': [1634], 'Additional': [1635], 'enrollment': [1636, 1683, 2861, 2887], 'criteria': [1637, 3472], 'hematocrit': [1639], '>29%;': [1640], 'absolute': [1641, 2162], 'neutrophil': [1642, 2163], 'count': [1643, 1647, 2164, 2169], '>1000': [1644], 'cells/μl;': [1645, 1649], 'platelet': [1646, 2168], '>100,000': [1648], 'serum': [1651], 'creatinine,': [1652], 'aspartate': [1653, 2186], 'aminotransferase,': [1654], 'bilirubin': [1656, 2181], '1.5': [1658], 'times': [1659, 2173], 'institutional': [1661], 'upper': [1662, 2175], 'limit': [1663, 2176], 'normal.': [1665], 'At': [1666, 2239], 'weeks': [1669, 1679, 1930, 2088], 'between': [1670, 1680, 2312, 2510, 2594], 'surgical': [1671, 2129], 'chemotherapy,': [1674, 2725], '12': [1678, 2344, 2697, 2984], 'radiotherapy': [1681], 'required.': [1685], 'provided': [1688], 'informed': [1689], 'consent.': [1690, 1876], 'limits': [1694], 'number': [1699, 3161, 3798], 'episodes': [1702, 2642, 3263], 'therapeutic': [1706, 1757, 4148, 4171, 4212], 'regimens': [1707, 4226], 'received.': [1708], 'excluded': [1711], '≥3': [1714, 1723, 2207], 'toxicity': [1715, 1724, 2431, 2458, 2466, 3003], 'bevacizumab;': [1718, 3748, 4062], 'irinotecan;': [1729, 3750], 'uncontrolled': [1730], 'hypertension;': [1731], 'acute': [1732], 'hemorrhage': [1733, 2403], 'baseline': [1735], 'magnetic': [1736], 'resonance': [1737], 'imaging': [1738], '(MRI);': [1739], 'urine': [1740, 2196], 'protein:creatinine': [1741], 'ratio': [1742, 2199], '>1;': [1743], 'homozygosity': [1744], '*28UGT1A1': [1747], 'allele;': [1748], 'pregnancy': [1749], 'nursing;': [1751], 'active': [1752, 3117], 'infection': [1753], 'requiring': [1754, 2128], 'intravenous': [1755], 'antibiotics;': [1756], 'anticoagulation': [1758], 'warfarin;': [1760], 'stereotactic': [1763, 3759, 3996, 4051], 'radiosurgery,': [1764], 'implants,': [1766], 'radiolabeled': [1768], 'unless': [1772, 2460], 'there': [1773, 3534], 'unequivocal': [1775], '(such': [1778], 'as': [1779, 2003, 2377, 2396, 2507, 2658, 2660, 3155, 3283, 3823, 3825], 'new': [1781, 1976], 'lesion': [1782], 'biopsy-proven': [1784], 'recurrence).': [1785], 'Design': [1787, 3633], 'open-label': [1792], 'mg/kg': [1800], 'intravenously': [1801], 'days.': [1804], 'an': [1809, 2161, 2387, 3492], 'area': [1810], '(AUC)': [1815], 'Irinotecan': [1825], '340': [1834], 'receiving': [1838, 3010, 3043, 3840], 'cytochrome': [1839], 'P450': [1840], '(EIAEDs;': [1844], 'phenytoin,': [1845], 'phenobarbital,': [1846], 'carbamazepine,': [1847], 'oxcarbazepine,': [1848], 'primidone)': [1850], 'those': [1856, 3526, 3566], 'EIAEDs.': [1859], 'Study': [1860, 1879, 3052, 3057, 3281, 3613, 3632], 'noncompliance': [1868], 'protocol': [1871], 'guidelines,': [1872], 'withdrawal': [1874], 'Response': [1877, 1907], 'Evaluation': [1878], 'investigators': [1880], 'determined': [1881], 'neurologic': [1884, 1936, 1962], 'examination': [1885], 'contrast-enhanced': [1887], 'MRI': [1888], 'treatment': [1893, 2547, 3063, 3785, 3873], 'cycle': [1901, 2159, 2512, 2963, 3013, 3425], 'recently': [1905], 'published': [1906], 'Assessment': [1908], 'Neuro-Oncology': [1910], 'criteria.41': [1911], 'A': [1912, 1940, 3071], 'complete': [1913], '(CR)': [1915], 'disappearance': [1917], 'all': [1919, 2744, 2966, 3397, 3859, 4153], 'enhancing': [1920, 1955, 1973, 1977], 'nonenhancing': [1922, 1982], 'consecutive': [1925], 'MRIs': [1926], 'apart,': [1931], 'discontinuation': [1934], 'stability': [1937, 1958], 'improvement.': [1939], 'partial': [1941], '(PR)': [1943], '≥50%': [1945], 'reduction': [1946, 3244], 'size': [1948, 2297], '(product': [1949], 'largest': [1951], 'perpendicular': [1952], 'diameters)': [1953], 'improvement': [1960, 4087], 'corticosteroids.': [1965], 'Progressive': [1966], '(PD)': [1968], '≥25%': [1970], 'increase': [1971], 'lesion,': [1978], 'worsening': [1980], 'including': [1984, 2576, 2979, 3027, 3080, 3499, 4116], 'detected': [1986], 'fluid-attenuated': [1988], 'inversion': [1989], 'recovery': [1990], '(FLAIR)': [1991], 'T2': [1993], 'sequences,': [1994], 'decline.': [1997], 'Stable': [1998], '(SD)': [2000], 'any': [2004, 2082, 2204], 'assessment': [2005], 'meeting': [2007], 'CR,': [2008], 'PR,': [2009], 'PD': [2011, 2873, 2915], 'criteria.': [2012, 2092], 'Partial': [2013], 'responses': [2014], 'signal': [2023], 'abnormality': [2024], 'FLAIR': [2026], 'sequences.': [2027], 'Dose': [2028], 'Modification': [2029], 'Retreatment': [2031], 'Criteria': [2032], 'Chemotherapy': [2033, 2074, 2902], 'doses': [2034, 2069, 2075], 'held': [2036, 2145], '4,': [2041], 'related,': [2042], 'nonhematologic': [2043, 2409, 3219], 'thrombocytopenia,': [2047], 'neutropenia,': [2050], 'fever': [2052], 'neutropenia': [2054, 3189], '(any': [2055], 'grade)': [2056], 'event': [2059, 2084, 2208], 'resolved': [2060, 2152], 'pretreatment': [2065], 'baseline.': [2066], 'Thereafter,': [2067], 'reduced': [2071, 2078], '25%.': [2073], '25%': [2080, 2318], 'related': [2083, 2148, 2205, 3150], '>2': [2087], 'satisfy': [2090], 'retreatment': [2091], 'reductions': [2101], 'allowed': [2103], 'remain': [2105, 2975, 3025], 'receive': [2110, 2959], 'Bevacizumab': [2113, 2143, 3624, 3780, 4245], 'discontinued': [2115, 2970, 2996, 3093, 3102, 3418], 'uncontrollable': [2117], 'hypertension,': [2118], 'hemorrhage,': [2123], 'arterial': [2124], 'thrombosis,': [2125, 2137], 'wound': [2126], 'dehiscence': [2127], 'intervention,': [2130], 'intestinal': [2131], 'perforation': [2132], 'venous': [2136], 'proteinuria,': [2138], 'congestive': [2140], 'heart': [2141], 'failure.': [2142], '≤1.': [2155, 2211], 'Initiation': [2156], '(ANC)': [2165], '≥1000/mm3;': [2166], '≥100,000/mm3;': [2170], 'creatinine': [2171, 2198], '≤1.5': [2172], 'normal': [2178], '(×': [2179], 'ULN),': [2180], '≤2': [2182], '×': [2183, 2189], 'ULN': [2184], 'aminotransferase': [2187], '≤2.5': [2188], 'ULN;': [2190], 'proteinuria': [2191], '<3+': [2192], 'urinalysis': [2194], 'protein:': [2197], '≤1.0;': [2200], 'resolution': [2202], 'Statistical': [2212], 'Considerations': [2213], 'goal': [2216, 2298], 'time': [2241, 2509, 2529, 3769], 'designed,': [2245], 'benchmarks': [2246], 'outcome': [2248, 4055, 4089, 4191], 'established;': [2263], 'therefore,': [2264], 'chose': [2266], 'use': [2268], 'historical': [2270, 4092], 'benchmark': [2271], 'established': [2272], 'recurrence.': [2277], 'Hence,': [2278], 'given': [2279], '21%': [2284], 'treated': [2289, 3582, 3598, 3926], 'recurrence,42': [2294], 'sample': [2296], '24': [2300, 2842, 2917], 'chosen': [2305], '88%': [2308], 'power': [2309], 'differentiate': [2311], '5%': [2316], 'type': [2321, 2476, 2479], 'error': [2323], '0.03.': [2326], 'An': [2327], 'interim': [2328, 2366], 'analysis': [2330, 3406], 'accrued': [2335, 2502], 'arm': [2338], 'planned': [2340], 'priori.': [2342], 'If': [2343], 'these': [2348, 3918, 4064, 4225], 'died': [2353], 'initiation,': [2359, 3485], 'further': [2360, 4124], 'accrual': [2361, 2376], 'would': [2362], 'suspended.': [2364], 'threshold': [2368], 'met,': [2370], 'completed': [2375, 2983], 'specified.': [2378], 'For': [2379], 'heavily': [2383], 'pretreated': [2384, 2634], 'extremely': [2388], 'prognosis,': [2390], '≥2': [2398, 3142, 3272], 'central': [2399], 'nervous': [2400], 'system': [2401], '(CNS)': [2402], '5': [2408, 3363, 3486], '15%': [2412], 'less': [2414], 'considered': [2416, 2425, 4131], 'desirable,': [2417], '40%': [2421], 'undesirable.': [2426], 'Stopping': [2427], 'rules': [2428], 'upon': [2433, 4258], 'boundaries': [2434], 'proposed': [2435], 'Pocock': [2437], 'used': [2439, 2693], 'monitor': [2441], 'group': [2446], 'patients.43': [2449], 'Accrual': [2450], 'suspended': [2453], 'formally': [2455], 'assess': [2456], 'profile': [2459], 'following': [2462], 'thresholds': [2463], 'satisfied:': [2468], '≥3/4;': [2469], '≥4/8;': [2470], '≥5/12;': [2471], '≥6/16;': [2472], '≥7/20;': [2473], '≥7/24.': [2474], 'errors': [2481], 'monitoring': [2485], '0.05': [2487], '0.07,': [2489], 'respectively.': [2490, 3128], 'These': [2491, 4047], 'guidelines': [2492], 'did': [2493, 4175], 'adjust': [2495], 'differential': [2497], 'length': [2498], 'patients.': [2503, 2713], 'PFS': [2504, 2524, 2568, 3515, 3554, 3901, 4005, 4036], 'start': [2514, 2544, 2558], 'date': [2515, 2518], 'death.': [2523], 'censored': [2526], 'last': [2531, 2564], 'remained': [2536, 3586], 'alive': [2537], 'progression,': [2540], 'nonstudy': [2546, 3015], 'initiated': [2549], 'before': [2550], 'calculated': [2555], 'death': [2562], 'contact': [2565], 'censored.': [2567], 'summarized': [2572, 2601, 3438], 'using': [2573, 3934], 'Kaplan-Meier': [2574, 3766], 'estimator': [2575], '95%': [2577], 'intervals': [2579], '(CIs).': [2580], 'RESULTS': [2581], 'Characteristics': [2583, 2584, 2802], '25': [2587, 3655], 'September': [2595], '2009': [2596], 'July': [2598], '2010': [2599], 'Table': [2603, 2799, 3135, 3267, 3440, 3605], '1.': [2604, 2800, 3444], 'relatively': [2607, 3959, 4112], 'young': [2608], '(median': [2609], 'age,': [2610], '52': [2611, 2809], 'years),': [2612], 'half': [2615], 'KPS': [2618, 2819, 2932], '90,': [2622], '(40%)': [2625], 'corticosteroids': [2628], 'enrollment.': [2630, 2781], 'moderately': [2633], '(56%)': [2637], 'having': [2638, 2689], 'well': [2659, 3824], 'bevacizumab.': [2662, 2949], 'Most': [2663, 3168], '(96%)': [2665], 'regimen,': [2672], 'regimens.': [2683], 'Thirteen': [2684], '(52%)': [2686], 'recurrence,': [2695, 3531], '(48%)': [2699], 'progressing': [2702, 2749], 'incorporated': [2705], 'into': [2706], 'newly': [2710, 3810], 'diagnosed': [2711, 3811], 'Sixty': [2714], 'percent': [2715], 'previously': [2719, 4228], 'combination': [2723, 3550, 4151, 4298], '36%': [2727], 'monotherapy': [2731, 3545, 3563, 3585], 'targeted': [2740], '(sorafenib).': [2742], 'Nearly': [2743], '(92%)': [2746], 'while': [2748], 'therapy;': [2752], 'however,': [2753, 4063], '(8%)': [2755, 3196, 3252], 'XL-184,': [2766], 'dual': [2768], 'VEGFR-2/met': [2769], 'tyrosine': [2770], 'kinase': [2771], 'inhibitor,': [2772], 'Median': [2782, 2808, 2833, 2928, 3431, 3638, 3647], 'duration': [2783], '9': [2789, 2900, 2929], 'range': [2793], '34': [2797], 'months.': [2798, 3911, 4046], 'Characteristic': [2803], 'No.': [2804, 2871, 2912, 2922, 3635], '(%)': [2805], 'Age,': [2806], 'y': [2807], 'Range': [2810, 2835, 2852, 2930], '19-76': [2811], 'Sex': [2812], 'Male': [2813], '17': [2814], '(68)': [2815], 'Female': [2816], '(32)': [2818], '90-100': [2820], '13': [2821, 2878, 2908, 3368], '(52)': [2822, 2879], '80': [2823, 3074], '(40)': [2825, 2847], '70': [2826], '(8)': [2828, 2867, 2890], 'Time': [2829], 'diagnosis': [2831], '(wk)': [2832], '58.1': [2834], '29.9-260.9': [2836], 'EIAED': [2837], 'Yes': [2838, 2845, 2891], '(4)': [2840, 2870, 2882, 2911, 2921], 'No': [2841, 2855, 2888], '(96)': [2843, 2918], 'Corticosteroids': [2844], 'Average': [2848], '(mg/day)': [2850, 2853], '2.8': [2851], '0-16': [2854], '15': [2856, 2903], '(60)': [2857, 2904], 'Surgery': [2858], 'None': [2862, 2899, 3467], '(88)': [2864], 'Biopsy': [2865], 'STR': [2868], '(44)': [2876], 'Progression': [2883, 3627], 'BV': [2885, 2894, 2914, 2927], '(92)': [2893], 'partner': [2895], '(36)': [2901], 'Etoposide': [2905], 'Temozolomide': [2907], 'Sorafenib': [2909], 'mo': [2924, 3640, 3649], '2-34': [2931], 'indicates': [2933, 3736], 'status;': [2936], 'EIAED,': [2937], 'anti-epileptic': [2940], 'drugs;': [2941], 'STR,': [2942], 'subtotal': [2943], 'resection;': [2944], 'PD,': [2945], 'disease;': [2947], 'BV,': [2948, 3747], 'As': [2950], 'January': [2952], '2011,': [2954], 'continues': [2957], '6,': [2964], 'Two': [2973, 3883], 'free': [2976], 'off': [2990], 'due': [2999, 3096, 3105, 3427], 'currently': [3009, 3042, 3806, 3839], 'her': [3011], 'fifth': [3012], 'disease.': [3021, 3099], 'Eight': [3022], '(32%)': [3024], 'alive,': [3026], 'described': [3030], 'above': [3031], 'additional': [3044, 3826], 'salvage': [3045], 'Seventeen': [3047], '(68%)': [3049], 'died.': [3051], 'Safety': [3056], 'drug': [3058], 'administration': [3059], 'compliance': [3061], 'intent-to-treat': [3066, 3411], 'population': [3068, 3412], 'excellent.': [3070], 'total': [3072, 3160], '(range,': [3086], '1-12)': [3087], 'per': [3088, 3497], 'patient.': [3089], 'Twenty-one': [3090], '(84%)': [3092], 'Single': [3100], 'completion': [3107], 'year': [3110], 'evidence': [3115], '3-4': [3121], 'withdrawal,': [3127], 'assessable': [3132], 'toxicity.': [3134], 'summarizes': [3137], 'frequency': [3139], 'adverse': [3143, 3169], 'possibly': [3149], 'percentage': [3157, 3834], 'during': [3165], 'hematologic.': [3184], 'Grade': [3185, 3271, 3292], '(24%)': [3193], 'patients,': [3197, 3966], 'thrombocytopenia': [3203], '(13%),': [3208], 'anemia': [3212], '(8%).': [3217, 3237], 'Among': [3218, 3476, 3889], 'events,': [3220], 'fatigue': [3227], '(13%)': [3231, 3359], 'hypertension': [3233], '(36%)': [3240], 'reductions.': [3256], 'study-related': [3260], 'deaths': [3261], 'intracranial': [3265], 'hemorrhage.': [3266], '2.': [3268], 'Frequency': [3269], 'Adverse': [3273], 'Events': [3274], 'Least': [3276], 'Possibly': [3277], 'Related': [3278], 'Regimen': [3282, 3634], 'Percentage': [3285], 'Total': [3287], 'Cycles': [3288], 'Administered': [3289], '(N=80)': [3290], 'Event': [3291], 'Anemia': [3296], '7': [3297, 3370], '(9%)': [3298, 3371], '(3%)': [3300, 3304, 3314, 3325, 3327, 3382, 3389], '—': [3301, 3305, 3306, 3308, 3311, 3315, 3316, 3322, 3328, 3330, 3333, 3335, 3338, 3342, 3343, 3345, 3348, 3354, 3365, 3366, 3375, 3378, 3385, 3390, 3391], 'Anorexia': [3302], 'Dehydration': [3307], '(1%)': [3310, 3332, 3337, 3341, 3347, 3353, 3377, 3384], 'Diarrhea': [3312], 'Fatigue': [3317], '(5%)': [3319, 3351], '(4%)': [3321, 3361, 3373], 'Hypertension': [3323], 'Hyponatremia': [3329], 'Hypophosphatemia': [3334], 'Infection': [3339], 'Mucositis': [3344], 'Nausea/emesis': [3349], 'Neutropenia': [3355], '(18%)': [3357], 'Proteinuria': [3362], '(6%)': [3364], 'Thrombocytopenia': [3367], '(16%)': [3369], 'Thrombosis': [3374], 'Transaminase': [3379], 'elevation': [3380], 'Weight': [3386], 'loss': [3387], '7.99': [3400], '6.25-11.02).': [3404], 'OS,': [3432, 3648, 3744], 'PFS,': [3433, 3639, 3738, 3858], 'Figure': [3443, 3761], 'Best': [3445], '20': [3452], '(80%)': [3454], '(16%),': [3460], 'evaluable.': [3466], 'met': [3471], 'response.': [3475], 'dexamethasone': [3482], 'able': [3488, 3504], 'taper': [3490], 'average': [3493], '4.6': [3495], 'mg': [3496], 'day,': [3498], 'completely': [3506], 'discontinue': [3507], 'dexamethasone.': [3508], 'difference': [3512, 3536], 'compared': [3524, 3546, 3564, 3591, 4090], 'nor': [3532], 'chemotherapy.': [3552, 3604], '(P': [3573], '=': [3574], '.0356).': [3575], 'Specifically,': [3576, 4173], '44.4%': [3577], '0%': [3593, 3980], '3.': [3606], 'Summary': [3607], 'Current': [3612, 3662], 'Relative': [3614], 'Previously': [3616], 'Reported': [3617], 'Series': [3618], 'Treated': [3622], 'With': [3623], 'Therapy': [3625], 'After': [3626], 'Prior': [3629], 'Bevacizumab-Based': [3630], 'CI)': [3642], 'PFS-6,': [3643], '%': [3644], 'Cl)': [3646, 3651], 'Citation': [3652], 'Prospective': [3653, 3664, 3672], 'BV+carboplatin+CPT-11': [3654], '2.3': [3656], '(1.8-3.6)': [3657], '(5.0-32.5)': [3659], '(4.0-7.0)': [3661], 'BV+CPT-11': [3665], '19': [3666, 3701, 3890], '1.1': [3667, 3910], '(NR)': [3668, 3694, 3696, 3713, 3721, 3724, 3730, 3733], 'NR': [3669, 3670, 3714, 3715, 3722, 3731], 'Kreisl24': [3671], 'BV+daily': [3673], 'TMZ': [3674], 'VP-16': [3676], '1.8': [3678, 3712], '(1.0-2.1)': [3679], '4.4': [3680], '(3.1-18.2)': [3681], '4.1': [3682, 3946, 3977], '(2.8-5.8)': [3683], 'Reardon46': [3684], 'Retrospective': [3685, 3698, 3708, 3717, 3726], 'BV+miscellaneous': [3686, 3699, 3709], '54': [3688], '(35': [3689], 'GBM)': [3690], '1.3': [3691], '(1.2-1.5)': [3692], '2.9': [3695], 'Quant27': [3697], '(1.2-3.3)': [3703], '0': [3704], '5.2': [3705], '(3.3-8.4)': [3706], 'Iwamoto48': [3707], 'Norden26': [3716], 'BV+SRS+chemotherapy': [3718], '2.6': [3720, 4007], '7.2': [3723, 4014], 'Torcuator47': [3725, 3734], 'BV+chemotherapy': [3727], '1.7': [3729, 4038], '3.3': [3732, 4045], 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