Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2008977447', 'doi': 'https://doi.org/10.1016/j.orthres.2004.08.011', 'title': 'Molecular mechanism of nitric oxide‐induced osteoblast apoptosis', 'display_name': 'Molecular mechanism of nitric oxide‐induced osteoblast apoptosis', 'publication_year': 2005, 'publication_date': '2005-03-01', 'ids': {'openalex': 'https://openalex.org/W2008977447', 'doi': 'https://doi.org/10.1016/j.orthres.2004.08.011', 'mag': '2008977447', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15734263'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.orthres.2004.08.011', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.orthres.2004.08.011', 'source': {'id': 'https://openalex.org/S12558119', 'display_name': 'Journal of Orthopaedic Research®', 'issn_l': '0736-0266', 'issn': ['0736-0266', '1554-527X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.orthres.2004.08.011', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089973746', 'display_name': 'Ruei‐Ming Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I47519274', 'display_name': 'Taipei Medical University', 'ror': 'https://ror.org/05031qk94', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I47519274']}, {'id': 'https://openalex.org/I4210142271', 'display_name': 'Wan Fang Hospital', 'ror': 'https://ror.org/058y0nn10', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210142271']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Ruei-Ming Chen', 'raw_affiliation_strings': ['Department of Anesthesiology, Wan-Fang Hospital, College of Medicine, Taipei Medical University, No. 111, Hsing-Lung Rd., Sec. 3, Taipei 116, Taiwan. [email protected]'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology, Wan-Fang Hospital, College of Medicine, Taipei Medical University, No. 111, Hsing-Lung Rd., Sec. 3, Taipei 116, Taiwan. [email protected]', 'institution_ids': ['https://openalex.org/I47519274', 'https://openalex.org/I4210142271']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047493622', 'display_name': 'Ta-Liang Chen', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ta-Liang Chen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076432899', 'display_name': 'Wen‐Ta Chiu', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Wen-Ta Chiu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012429408', 'display_name': 'Chia-Chen Chang', 'orcid': 'https://orcid.org/0000-0001-5466-4724'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Chia-Chen Chang', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3750, 'currency': 'USD', 'value_usd': 3750, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.67, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 72, 'citation_normalized_percentile': {'value': 0.911298, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '23', 'issue': '2', 'first_page': '462', 'last_page': '468'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10155', 'display_name': 'Role of Nitric Oxide in Health and Disease', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10155', 'display_name': 'Role of Nitric Oxide in Health and Disease', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11597', 'display_name': 'Role of Neutrophil Extracellular Traps in Immunity', 'score': 0.9846, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10290', 'display_name': 'Pathophysiology and Management of Preeclampsia', 'score': 0.9793, 'subfield': {'id': 'https://openalex.org/subfields/2729', 'display_name': 'Obstetrics and Gynecology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.6043412}, {'id': 'https://openalex.org/keywords/neutrophil-extracellular-traps', 'display_name': 'Neutrophil Extracellular Traps', 'score': 0.467608}, {'id': 'https://openalex.org/keywords/sodium-nitroprusside', 'display_name': 'Sodium nitroprusside', 'score': 0.44654468}], 'concepts': [{'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.6757899}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.65507966}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.6043412}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.58812165}, {'id': 'https://openalex.org/C2778260815', 'wikidata': 'https://www.wikidata.org/wiki/Q917177', 'display_name': 'Osteoblast', 'level': 3, 'score': 0.5544151}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.532059}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.51592577}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4642746}, {'id': 'https://openalex.org/C2777318727', 'wikidata': 'https://www.wikidata.org/wiki/Q409464', 'display_name': 'Lactate dehydrogenase', 'level': 3, 'score': 0.4554597}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.4482607}, {'id': 'https://openalex.org/C2779610285', 'wikidata': 'https://www.wikidata.org/wiki/Q27108300', 'display_name': 'Sodium nitroprusside', 'level': 3, 'score': 0.44654468}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3800316}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.36248046}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.19056937}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.084730834}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D010006', 'descriptor_name': 'Osteoblasts', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009599', 'descriptor_name': 'Nitroprusside', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009599', 'descriptor_name': 'Nitroprusside', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010006', 'descriptor_name': 'Osteoblasts', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D010006', 'descriptor_name': 'Osteoblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.orthres.2004.08.011', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.orthres.2004.08.011', 'source': {'id': 'https://openalex.org/S12558119', 'display_name': 'Journal of Orthopaedic Research®', 'issn_l': '0736-0266', 'issn': ['0736-0266', '1554-527X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15734263', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.orthres.2004.08.011', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.orthres.2004.08.011', 'source': {'id': 'https://openalex.org/S12558119', 'display_name': 'Journal of Orthopaedic Research®', 'issn_l': '0736-0266', 'issn': ['0736-0266', '1554-527X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1540254174', 'https://openalex.org/W1547749433', 'https://openalex.org/W1571251056', 'https://openalex.org/W1662237934', 'https://openalex.org/W1903145737', 'https://openalex.org/W1906196386', 'https://openalex.org/W1929009802', 'https://openalex.org/W1966746490', 'https://openalex.org/W196897566', 'https://openalex.org/W1974213596', 'https://openalex.org/W1975096632', 'https://openalex.org/W1991961175', 'https://openalex.org/W2008258524', 'https://openalex.org/W2008693250', 'https://openalex.org/W2010416621', 'https://openalex.org/W2017293256', 'https://openalex.org/W2047571097', 'https://openalex.org/W2049110705', 'https://openalex.org/W2051390158', 'https://openalex.org/W2059654459', 'https://openalex.org/W2067489969', 'https://openalex.org/W2077336138', 'https://openalex.org/W2078496036', 'https://openalex.org/W2083086713', 'https://openalex.org/W2085936016', 'https://openalex.org/W2090661829', 'https://openalex.org/W2098381715', 'https://openalex.org/W2101043399', 'https://openalex.org/W2114388515', 'https://openalex.org/W2115632410', 'https://openalex.org/W2123076322', 'https://openalex.org/W2131512996', 'https://openalex.org/W2144316315', 'https://openalex.org/W2156241187', 'https://openalex.org/W2164332161', 'https://openalex.org/W2169980516', 'https://openalex.org/W2184145343', 'https://openalex.org/W2400837910', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W2383006763', 'https://openalex.org/W2364053234', 'https://openalex.org/W2243000210', 'https://openalex.org/W2078651850', 'https://openalex.org/W2065238429', 'https://openalex.org/W2057784986', 'https://openalex.org/W2052966837', 'https://openalex.org/W2040714484', 'https://openalex.org/W1914380123', 'https://openalex.org/W106950581'], 'abstract_inverted_index': {'Abstract': [0], 'Nitric': [1, 29], 'oxide': [2, 30], '(NO)': [3], 'can': [4, 219], 'regulate': [5], 'osteoblast': [6, 15, 32, 57, 221], 'activities.': [7], 'Our': [8], 'previous': [9], 'study': [10, 47, 212], 'showed': [11], 'that': [12, 170, 214], 'NO': [13, 90, 215], 'induced': [14], 'apoptosis': [16, 33, 58], '[Chen': [17], 'RM,': [18], 'Liu': [19], 'HC,': [20], 'Lin': [21], 'YL,': [22], 'Jean': [23], 'WC,': [24], 'Chen': [25], 'JS,': [26], 'Wang': [27], 'JH.': [28], 'induces': [31], 'through': [34], 'the': [35, 53, 60, 69, 79, 99, 155, 190, 226, 230], 'de': [36], 'novo': [37], 'synthesis': [38], 'of': [39, 55, 62, 83, 95, 112, 143, 162, 196, 210, 232], 'Bax': [40], 'protein.': [41, 241], 'J': [42], 'Orthop': [43], 'Res': [44], '2002;20:295–302].': [45], 'This': [46], 'was': [48, 125], 'further': [49], 'aimed': [50], 'to': [51, 85, 118, 177], 'evaluate': [52], 'mechanism': [54, 227], 'NO‐induced': [56], 'from': [59, 217], 'viewpoints': [61], 'mitochondrial': [63, 122, 156, 203, 233], 'functions,': [64, 234], 'intracellular': [65, 163, 235], 'oxidative': [66], 'stress,': [67], 'and': [68, 102, 108, 180, 198, 206, 223, 225, 239], 'anti‐apoptotic': [70], 'Bcl‐2': [71, 173, 240], 'protein': [72, 174], 'using': [73], 'neonatal': [74], 'rat': [75], 'calvarial': [76], 'osteoblasts': [77, 84, 115], 'as': [78], 'experimental': [80], 'model.': [81], 'Exposure': [82, 176], 'sodium': [86], 'nitroprusside': [87], '(SNP),': [88], 'an': [89], 'donor,': [91], 'significantly': [92, 126], 'increased': [93, 160, 183], 'amounts': [94], 'lactate': [96], 'dehydrogenase': [97, 136], 'in': [98, 106, 114, 138, 192], 'culture': [100], 'medium,': [101], 'decreased': [103, 132], 'cell': [104, 201], 'viability': [105], 'concentration‐': [107], 'time‐dependent': [109, 140], 'manners.': [110], 'Administration': [111], 'SNP': [113, 129, 131, 158, 171, 218], 'time‐dependently': [116, 159], 'led': [117], 'DNA': [119], 'fragmentation.': [120], 'The': [121], 'membrane': [123, 204], 'potential': [124], 'reduced': [127, 172], 'following': [128], 'administration.': [130], 'complex': [133], 'I': [134], 'NADH': [135], 'activity': [137], 'a': [139], 'manner.': [141], 'Levels': [142], 'cellular': [144], 'adenosine': [145], 'triphosphate': [146], '(ATP)': [147], 'were': [148], 'suppressed': [149, 200], 'by': [150, 248], 'SNP.': [151], 'In': [152, 187], 'parallel': [153, 188], 'with': [154, 189], 'dysfunction,': [157], 'levels': [161], 'reactive': [164, 236], 'oxygen': [165, 237], 'species.': [166], 'Immunoblotting': [167], 'analysis': [168], 'revealed': [169], 'levels.': [175], 'lipopolysaccharide': [178], '(LPS)': [179], 'IFN‐γ': [181, 199], 'significant': [182], 'endogenous': [184, 193], 'nitrite': [185], 'production.': [186], 'increase': [191], 'NO,': [194], 'administration': [195], 'LPS': [197], 'viability,': [202], 'potential,': [205], 'ATP': [207], 'synthesis.': [208], 'Results': [209], 'this': [211], 'show': [213], 'released': [216], 'induce': [220], 'insults': [222], 'apoptosis,': [224], 'may': [228], 'involve': [229], 'modulation': [231], 'species,': [238], '©': [242], '2004': [243], 'Orthopaedic': [244], 'Research': [245], 'Society.': [246], 'Published': [247], 'Elsevier': [249], 'Ltd.': [250], 'All': [251], 'rights': [252], 'reserved.': [253]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2008977447', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-08-15T12:21:53.709721', 'created_date': '2016-06-24'}