Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2008491373', 'doi': 'https://doi.org/10.4161/cc.2.5.483', 'title': 'Cell Cycle-Regulated Centers of DNA Double-Strand Break Repair', 'display_name': 'Cell Cycle-Regulated Centers of DNA Double-Strand Break Repair', 'publication_year': 2003, 'publication_date': '2003-09-12', 'ids': {'openalex': 'https://openalex.org/W2008491373', 'doi': 'https://doi.org/10.4161/cc.2.5.483', 'mag': '2008491373', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12963848'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4161/cc.2.5.483', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.4161/cc.2.5.483?needAccess=true', 'source': {'id': 'https://openalex.org/S86011449', 'display_name': 'Cell Cycle', 'issn_l': '1551-4005', 'issn': ['1551-4005', '1538-4101'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.tandfonline.com/doi/pdf/10.4161/cc.2.5.483?needAccess=true', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078694198', 'display_name': 'Michael Lisby', 'orcid': 'https://orcid.org/0000-0002-4830-5247'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael Lisby', 'raw_affiliation_strings': ['Department of Genetics & Development, Columbia University, College of Physicians & Surgeons, New York, New York 10032-2704 USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics & Development, Columbia University, College of Physicians & Surgeons, New York, New York 10032-2704 USA.', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109145468', 'display_name': 'Adriana Antúnez de Mayolo', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Adriana Antúnez de Mayolo', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054962508', 'display_name': 'Uffe Hasbro Mortensen', 'orcid': 'https://orcid.org/0000-0002-7794-7273'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Uffe H. Mortensen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028622476', 'display_name': 'Rodney Rothstein', 'orcid': 'https://orcid.org/0000-0002-4107-9654'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rodney Rothstein', 'raw_affiliation_strings': ['Columbia University'], 'affiliations': [{'raw_affiliation_string': 'Columbia University', 'institution_ids': ['https://openalex.org/I78577930']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.042, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 68, 'citation_normalized_percentile': {'value': 0.751974, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '2', 'issue': '5', 'first_page': '477', 'last_page': '481'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10433', 'display_name': 'Carcinogens and Genotoxicity Assessment', 'score': 0.9895, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9893, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rad52', 'display_name': 'RAD52', 'score': 0.9288036}, {'id': 'https://openalex.org/keywords/ku80', 'display_name': 'Ku80', 'score': 0.5830246}, {'id': 'https://openalex.org/keywords/homology-directed-repair', 'display_name': 'Homology directed repair', 'score': 0.49985886}, {'id': 'https://openalex.org/keywords/replication-protein-a', 'display_name': 'Replication protein A', 'score': 0.4365742}], 'concepts': [{'id': 'https://openalex.org/C2776630724', 'wikidata': 'https://www.wikidata.org/wiki/Q18031020', 'display_name': 'RAD52', 'level': 5, 'score': 0.9288036}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8179159}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.66647303}, {'id': 'https://openalex.org/C102744134', 'wikidata': 'https://www.wikidata.org/wiki/Q22280388', 'display_name': 'Homologous recombination', 'level': 3, 'score': 0.6566531}, {'id': 'https://openalex.org/C2777576037', 'wikidata': 'https://www.wikidata.org/wiki/Q719725', 'display_name': 'Saccharomyces cerevisiae', 'level': 3, 'score': 0.6171411}, {'id': 'https://openalex.org/C193104389', 'wikidata': 'https://www.wikidata.org/wiki/Q18032397', 'display_name': 'Ku80', 'level': 5, 'score': 0.5830246}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.58116496}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5134405}, {'id': 'https://openalex.org/C74054111', 'wikidata': 'https://www.wikidata.org/wiki/Q5891445', 'display_name': 'Homology directed repair', 'level': 5, 'score': 0.49985886}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.49528566}, {'id': 'https://openalex.org/C113271649', 'wikidata': 'https://www.wikidata.org/wiki/Q2565234', 'display_name': 'Replication protein A', 'level': 5, 'score': 0.4365742}, {'id': 'https://openalex.org/C145803527', 'wikidata': 'https://www.wikidata.org/wiki/Q18032396', 'display_name': 'DNA repair protein XRCC4', 'level': 5, 'score': 0.41484168}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.3874334}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3545948}, {'id': 'https://openalex.org/C2779012473', 'wikidata': 'https://www.wikidata.org/wiki/Q3235015', 'display_name': 'RAD51', 'level': 4, 'score': 0.3373615}, {'id': 'https://openalex.org/C60748783', 'wikidata': 'https://www.wikidata.org/wiki/Q2984243', 'display_name': 'DNA mismatch repair', 'level': 4, 'score': 0.30943602}, {'id': 'https://openalex.org/C94966510', 'wikidata': 'https://www.wikidata.org/wiki/Q2252764', 'display_name': 'DNA-binding protein', 'level': 4, 'score': 0.26480263}, {'id': 'https://openalex.org/C2779222958', 'wikidata': 'https://www.wikidata.org/wiki/Q45422', 'display_name': 'Yeast', 'level': 2, 'score': 0.2625535}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16256016}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.101050675}], 'mesh': [{'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D004260', 'descriptor_name': 'DNA Repair', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D011995', 'descriptor_name': 'Recombination, Genetic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004260', 'descriptor_name': 'DNA Repair', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004260', 'descriptor_name': 'DNA Repair', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051721', 'descriptor_name': 'Rad52 DNA Repair and Recombination Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011995', 'descriptor_name': 'Recombination, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016196', 'descriptor_name': 'S Phase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016196', 'descriptor_name': 'S Phase', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4161/cc.2.5.483', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.4161/cc.2.5.483?needAccess=true', 'source': {'id': 'https://openalex.org/S86011449', 'display_name': 'Cell Cycle', 'issn_l': '1551-4005', 'issn': ['1551-4005', '1538-4101'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12963848', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4161/cc.2.5.483', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.4161/cc.2.5.483?needAccess=true', 'source': {'id': 'https://openalex.org/S86011449', 'display_name': 'Cell Cycle', 'issn_l': '1551-4005', 'issn': ['1551-4005', '1538-4101'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'display_name': 'Life on land', 'score': 0.45}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1264092735', 'https://openalex.org/W1509538618', 'https://openalex.org/W1526043578', 'https://openalex.org/W1548308567', 'https://openalex.org/W1970456889', 'https://openalex.org/W1991617089', 'https://openalex.org/W1992398829', 'https://openalex.org/W2000285763', 'https://openalex.org/W2006611386', 'https://openalex.org/W2008651684', 'https://openalex.org/W2015061812', 'https://openalex.org/W2028637581', 'https://openalex.org/W2032162025', 'https://openalex.org/W2035994249', 'https://openalex.org/W2043786547', 'https://openalex.org/W2046104827', 'https://openalex.org/W2054889035', 'https://openalex.org/W2058761693', 'https://openalex.org/W2060710645', 'https://openalex.org/W2061262165', 'https://openalex.org/W2063669071', 'https://openalex.org/W2070721957', 'https://openalex.org/W2077835601', 'https://openalex.org/W2084825928', 'https://openalex.org/W2086871899', 'https://openalex.org/W2102865022', 'https://openalex.org/W2107130407', 'https://openalex.org/W2107913200', 'https://openalex.org/W2112348939', 'https://openalex.org/W2113227424', 'https://openalex.org/W2118211036', 'https://openalex.org/W2123794134', 'https://openalex.org/W2131646714', 'https://openalex.org/W2140732239', 'https://openalex.org/W2144550200', 'https://openalex.org/W2161996750', 'https://openalex.org/W2428256829', 'https://openalex.org/W2467886257'], 'related_works': ['https://openalex.org/W3162159158', 'https://openalex.org/W2974992562', 'https://openalex.org/W2959790085', 'https://openalex.org/W2904099259', 'https://openalex.org/W2050345170', 'https://openalex.org/W2043786547', 'https://openalex.org/W2022266714', 'https://openalex.org/W2012090280', 'https://openalex.org/W2007919127', 'https://openalex.org/W1995284691'], 'abstract_inverted_index': {'AbstractIn': [0], 'eukaryotes,': [1], 'homologous': [2], 'recombination': [3], 'is': [4], 'an': [5], 'important': [6], 'pathway': [7], 'for': [8, 136], 'the': [9, 24, 74, 83, 91, 103, 115, 119], 'repair': [10, 61], 'of': [11, 59, 76, 82, 94, 105, 114, 122], 'DNA': [12, 38, 60, 64, 138], 'double-strand': [13, 65, 96], 'breaks.': [14], 'We': [15, 50], 'have': [16, 51], 'studied': [17], 'this': [18], 'process': [19], 'in': [20, 23, 102, 108], 'living': [21], 'cells': [22], 'yeast': [25], 'Saccharomyces': [26], 'cerevisiae': [27], 'using': [28], 'Rad52': [29, 40, 55, 77, 84], 'as': [30], 'a': [31, 71, 95, 109, 123], 'cell': [32], 'biological': [33], 'marker.': [34], 'In': [35, 86], 'response': [36], 'to': [37, 130], 'damage,': [39], 'redistributes': [41], 'itself': [42], 'and': [43, 80, 132], 'forms': [44], 'foci': [45, 56], 'specifically': [46], 'during': [47], 'S': [48, 116], 'phase.': [49], 'shown': [52], 'previously': [53], 'that': [54, 90, 127], 'are': [57, 98], 'centers': [58], 'where': [62], 'multiple': [63], 'breaks': [66], 'colocalize.': [67], 'Here': [68], 'we': [69, 88], 'report': [70], 'correlation': [72], 'between': [73], 'timing': [75], 'focus': [78], 'formation': [79], 'modification': [81], 'protein.': [85], 'addition,': [87], 'show': [89], 'two': [92, 120], 'ends': [93, 121, 135], 'break': [97, 124], 'held': [99], 'tightly': [100], 'together': [101], 'majority': [104], 'cells.': [106], 'Interestingly,': [107], 'small': [110], 'but': [111], 'significant': [112], 'fraction': [113], 'phase': [117], 'cells,': [118], 'separate': [125], 'suggesting': [126], 'mechanisms': [128], 'exist': [129], 'reassociate': [131], 'align': [133], 'these': [134], 'proper': [137], 'repair.': [139]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2008491373', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 8}], 'updated_date': '2024-12-08T18:28:42.858790', 'created_date': '2016-06-24'}