Title: Effect of Long-Term Isolation of the Rat on <i>in vitro </i>Biosynthesis of Gonadal Steroids from Dehydroepiandrosterone
Abstract:In vitro biosynthesis of gonadal steroids from dehydroepiandrosterone was studied in isolated and in socially reared male and female rats. Acetone-dried powder of gonadal tissue incubated with dehydro...In vitro biosynthesis of gonadal steroids from dehydroepiandrosterone was studied in isolated and in socially reared male and female rats. Acetone-dried powder of gonadal tissue incubated with dehydroepiandrosterone-4–14C yielded androstenedione, androst-5-ene-3β, 17β-diol, 11β-hydroxyandrostenedione and testosterone. In the male, conversion to androstenedione was significantly increased after isolation and conversion to androst-5-ene-3β, 17β-diol was significantly lowered. In the female, conversion to androstenedione and androstenediol was significantly lowered by isolation. Testosterone and 11β-hydroxyandrostenedione were not affected by isolation. Gonadal tissue of isolated and of socially reared male and female rats metabolizes dehydroepiandrosterone in a different way. These findings support the view that the conditions of housing affect the production of sex steroids.Read More
Publication Year: 1975
Publication Date: 1975-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 4
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