Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2008092800', 'doi': 'https://doi.org/10.1016/j.ijcard.2012.07.021', 'title': 'Myocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients', 'display_name': 'Myocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients', 'publication_year': 2012, 'publication_date': '2012-08-09', 'ids': {'openalex': 'https://openalex.org/W2008092800', 'doi': 'https://doi.org/10.1016/j.ijcard.2012.07.021', 'mag': '2008092800', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22882958'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ijcard.2012.07.021', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S13342628', 'display_name': 'International Journal of Cardiology', 'issn_l': '0167-5273', 'issn': ['0167-5273', '1874-1754'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://repositorio.unican.es/xmlui/bitstream/10902/1127/1/Hurle.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5076991806', 'display_name': 'Ana V. Villar', 'orcid': 'https://orcid.org/0000-0003-4588-9598'}, 'institutions': [{'id': 'https://openalex.org/I4210113075', 'display_name': 'Instituto de Investigación Marqués de Valdecilla', 'ror': 'https://ror.org/025gxrt12', 'country_code': 'ES', 'type': 'other', 'lineage': ['https://openalex.org/I4210113075']}, {'id': 'https://openalex.org/I13134134', 'display_name': 'Universidad de Cantabria', 'ror': 'https://ror.org/046ffzj20', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I13134134']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Ana V. Villar', 'raw_affiliation_strings': ['Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain', 'Universidad de Cantabria, Santander, Spain'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain', 'institution_ids': ['https://openalex.org/I4210113075']}, {'raw_affiliation_string': 'Universidad de Cantabria, Santander, Spain', 'institution_ids': ['https://openalex.org/I13134134']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064406939', 'display_name': 'Raquel García', 'orcid': 'https://orcid.org/0000-0002-1621-5474'}, 'institutions': [{'id': 'https://openalex.org/I4210113075', 'display_name': 'Instituto de Investigación Marqués de Valdecilla', 'ror': 'https://ror.org/025gxrt12', 'country_code': 'ES', 'type': 'other', 'lineage': ['https://openalex.org/I4210113075']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Raquel García', 'raw_affiliation_strings': ['Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain', 'institution_ids': ['https://openalex.org/I4210113075']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010015056', 'display_name': 'David Merino', 'orcid': 'https://orcid.org/0000-0002-0119-9459'}, 'institutions': [{'id': 'https://openalex.org/I4210113075', 'display_name': 'Instituto de Investigación Marqués de Valdecilla', 'ror': 'https://ror.org/025gxrt12', 'country_code': 'ES', 'type': 'other', 'lineage': ['https://openalex.org/I4210113075']}, {'id': 'https://openalex.org/I13134134', 'display_name': 'Universidad de Cantabria', 'ror': 'https://ror.org/046ffzj20', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I13134134']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'David Merino', 'raw_affiliation_strings': ['Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain', 'Universidad de Cantabria, Santander, Spain'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain', 'institution_ids': ['https://openalex.org/I4210113075']}, {'raw_affiliation_string': 'Universidad de Cantabria, Santander, Spain', 'institution_ids': ['https://openalex.org/I13134134']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083888737', 'display_name': 'Miguel Llano', 'orcid': 'https://orcid.org/0009-0003-1955-6594'}, 'institutions': [{'id': 'https://openalex.org/I4210113075', 'display_name': 'Instituto de Investigación Marqués de Valdecilla', 'ror': 'https://ror.org/025gxrt12', 'country_code': 'ES', 'type': 'other', 'lineage': ['https://openalex.org/I4210113075']}, {'id': 'https://openalex.org/I4210099858', 'display_name': 'Marqués de Valdecilla University Hospital', 'ror': 'https://ror.org/01w4yqf75', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099858']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Miguel Llano', 'raw_affiliation_strings': ['Hospital Universitario Marqués de Valdecilla, Santander, Spain', 'Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain', 'institution_ids': ['https://openalex.org/I4210113075']}, {'raw_affiliation_string': 'Hospital Universitario Marqués de Valdecilla, Santander, Spain', 'institution_ids': ['https://openalex.org/I4210099858']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089757170', 'display_name': 'Manuel Cobo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210113075', 'display_name': 'Instituto de Investigación Marqués de Valdecilla', 'ror': 'https://ror.org/025gxrt12', 'country_code': 'ES', 'type': 'other', 'lineage': ['https://openalex.org/I4210113075']}, {'id': 'https://openalex.org/I4210099858', 'display_name': 'Marqués de Valdecilla University Hospital', 'ror': 'https://ror.org/01w4yqf75', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099858']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Manuel Cobo', 'raw_affiliation_strings': ['Hospital Universitario Marqués de Valdecilla, Santander, Spain', 'Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain', 'institution_ids': ['https://openalex.org/I4210113075']}, {'raw_affiliation_string': 'Hospital Universitario Marqués de Valdecilla, Santander, Spain', 'institution_ids': ['https://openalex.org/I4210099858']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046409223', 'display_name': 'Cecilia Montalvo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210113075', 'display_name': 'Instituto de Investigación Marqués de Valdecilla', 'ror': 'https://ror.org/025gxrt12', 'country_code': 'ES', 'type': 'other', 'lineage': ['https://openalex.org/I4210113075']}, {'id': 'https://openalex.org/I13134134', 'display_name': 'Universidad de Cantabria', 'ror': 'https://ror.org/046ffzj20', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I13134134']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Cecilia Montalvo', 'raw_affiliation_strings': ['Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain', 'Universidad de Cantabria, Santander, Spain'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain', 'institution_ids': ['https://openalex.org/I4210113075']}, {'raw_affiliation_string': 'Universidad de Cantabria, Santander, Spain', 'institution_ids': ['https://openalex.org/I13134134']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005896903', 'display_name': 'Rafael Martín‐Durán', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210099858', 'display_name': 'Marqués de Valdecilla University Hospital', 'ror': 'https://ror.org/01w4yqf75', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099858']}, {'id': 'https://openalex.org/I4210113075', 'display_name': 'Instituto de Investigación Marqués de Valdecilla', 'ror': 'https://ror.org/025gxrt12', 'country_code': 'ES', 'type': 'other', 'lineage': ['https://openalex.org/I4210113075']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Rafael Martín-Durán', 'raw_affiliation_strings': ['Hospital Universitario Marqués de Valdecilla, Santander, Spain', 'Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain'], 'affiliations': [{'raw_affiliation_string': 'Hospital Universitario Marqués de Valdecilla, Santander, Spain', 'institution_ids': ['https://openalex.org/I4210099858']}, {'raw_affiliation_string': 'Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain', 'institution_ids': ['https://openalex.org/I4210113075']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003823337', 'display_name': 'María A. Hurlé', 'orcid': 'https://orcid.org/0000-0002-7710-1358'}, 'institutions': [{'id': 'https://openalex.org/I4210113075', 'display_name': 'Instituto de Investigación Marqués de Valdecilla', 'ror': 'https://ror.org/025gxrt12', 'country_code': 'ES', 'type': 'other', 'lineage': ['https://openalex.org/I4210113075']}, {'id': 'https://openalex.org/I13134134', 'display_name': 'Universidad de Cantabria', 'ror': 'https://ror.org/046ffzj20', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I13134134']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'María A. Hurlé', 'raw_affiliation_strings': ['Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain', 'Universidad de Cantabria, Santander, Spain'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain', 'institution_ids': ['https://openalex.org/I4210113075']}, {'raw_affiliation_string': 'Universidad de Cantabria, Santander, Spain', 'institution_ids': ['https://openalex.org/I13134134']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062793793', 'display_name': 'J. Francisco Nistal', 'orcid': 'https://orcid.org/0000-0002-4152-7621'}, 'institutions': [{'id': 'https://openalex.org/I4210099858', 'display_name': 'Marqués de Valdecilla University Hospital', 'ror': 'https://ror.org/01w4yqf75', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099858']}, {'id': 'https://openalex.org/I13134134', 'display_name': 'Universidad de Cantabria', 'ror': 'https://ror.org/046ffzj20', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I13134134']}, {'id': 'https://openalex.org/I4210113075', 'display_name': 'Instituto de Investigación Marqués de Valdecilla', 'ror': 'https://ror.org/025gxrt12', 'country_code': 'ES', 'type': 'other', 'lineage': ['https://openalex.org/I4210113075']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'J. Francisco Nistal', 'raw_affiliation_strings': ['Hospital Universitario Marqués de Valdecilla, Santander, Spain', 'Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain', 'Universidad de Cantabria, Santander, Spain'], 'affiliations': [{'raw_affiliation_string': 'Hospital Universitario Marqués de Valdecilla, Santander, Spain', 'institution_ids': ['https://openalex.org/I4210099858']}, {'raw_affiliation_string': 'Universidad de Cantabria, Santander, Spain', 'institution_ids': ['https://openalex.org/I13134134']}, {'raw_affiliation_string': 'Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain', 'institution_ids': ['https://openalex.org/I4210113075']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5003823337', 'https://openalex.org/A5062793793'], 'corresponding_institution_ids': ['https://openalex.org/I4210113075', 'https://openalex.org/I13134134', 'https://openalex.org/I4210099858', 'https://openalex.org/I13134134', 'https://openalex.org/I4210113075'], 'apc_list': {'value': 3340, 'currency': 'USD', 'value_usd': 3340, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 5.773, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 140, 'citation_normalized_percentile': {'value': 0.999895, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '167', 'issue': '6', 'first_page': '2875', 'last_page': '2881'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA Regulation in Cancer and Development', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA Regulation in Cancer and Development', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11765', 'display_name': 'Biogenesis and Functions of Circular RNAs', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11962', 'display_name': 'Molecular Mechanisms of Cardiac Remodeling and Repair', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pressure-overload', 'display_name': 'Pressure overload', 'score': 0.8777013}, {'id': 'https://openalex.org/keywords/myocardial-fibrosis', 'display_name': 'Myocardial fibrosis', 'score': 0.78968406}, {'id': 'https://openalex.org/keywords/cardiac-remodeling', 'display_name': 'Cardiac Remodeling', 'score': 0.508707}, {'id': 'https://openalex.org/keywords/ventricular-pressure', 'display_name': 'Ventricular pressure', 'score': 0.47885108}, {'id': 'https://openalex.org/keywords/ventricular-remodeling', 'display_name': 'Ventricular remodeling', 'score': 0.4397685}, {'id': 'https://openalex.org/keywords/cardiac-fibrosis', 'display_name': 'Cardiac fibrosis', 'score': 0.42140302}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8859407}, {'id': 'https://openalex.org/C2778271984', 'wikidata': 'https://www.wikidata.org/wiki/Q17126794', 'display_name': 'Pressure overload', 'level': 4, 'score': 0.8777013}, {'id': 'https://openalex.org/C3018763269', 'wikidata': 'https://www.wikidata.org/wiki/Q5038318', 'display_name': 'Myocardial fibrosis', 'level': 3, 'score': 0.78968406}, {'id': 'https://openalex.org/C2780559512', 'wikidata': 'https://www.wikidata.org/wiki/Q605709', 'display_name': 'Fibrosis', 'level': 2, 'score': 0.6982559}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.67639595}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.6645194}, {'id': 'https://openalex.org/C2781197716', 'wikidata': 'https://www.wikidata.org/wiki/Q864574', 'display_name': 'Biomarker', 'level': 2, 'score': 0.61583173}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.6003657}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.47956413}, {'id': 'https://openalex.org/C26635844', 'wikidata': 'https://www.wikidata.org/wiki/Q2002035', 'display_name': 'Ventricular pressure', 'level': 3, 'score': 0.47885108}, {'id': 'https://openalex.org/C2778198053', 'wikidata': 'https://www.wikidata.org/wiki/Q181754', 'display_name': 'Heart failure', 'level': 2, 'score': 0.461687}, {'id': 'https://openalex.org/C2780007028', 'wikidata': 'https://www.wikidata.org/wiki/Q2343082', 'display_name': 'Stenosis', 'level': 2, 'score': 0.4462833}, {'id': 'https://openalex.org/C2779537366', 'wikidata': 'https://www.wikidata.org/wiki/Q7920323', 'display_name': 'Ventricular remodeling', 'level': 3, 'score': 0.4397685}, {'id': 'https://openalex.org/C207886595', 'wikidata': 'https://www.wikidata.org/wiki/Q1456138', 'display_name': 'Pathological', 'level': 2, 'score': 0.4371549}, {'id': 'https://openalex.org/C2777420927', 'wikidata': 'https://www.wikidata.org/wiki/Q5038318', 'display_name': 'Cardiac fibrosis', 'level': 3, 'score': 0.42140302}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.36484322}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C3018791406', 'wikidata': 'https://www.wikidata.org/wiki/Q945225', 'display_name': 'Cardiac hypertrophy', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001024', 'descriptor_name': 'Aortic Valve Stenosis', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': True}, {'descriptor_ui': 'D001024', 'descriptor_name': 'Aortic Valve Stenosis', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D006352', 'descriptor_name': 'Heart Ventricles', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006352', 'descriptor_name': 'Heart Ventricles', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001024', 'descriptor_name': 'Aortic Valve Stenosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001024', 'descriptor_name': 'Aortic Valve Stenosis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015331', 'descriptor_name': 'Cohort Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005355', 'descriptor_name': 'Fibrosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005355', 'descriptor_name': 'Fibrosis', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D005355', 'descriptor_name': 'Fibrosis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005355', 'descriptor_name': 'Fibrosis', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D006352', 'descriptor_name': 'Heart Ventricles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ijcard.2012.07.021', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S13342628', 'display_name': 'International Journal of Cardiology', 'issn_l': '0167-5273', 'issn': ['0167-5273', '1874-1754'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/10902/1127', 'pdf_url': 'https://repositorio.unican.es/xmlui/bitstream/10902/1127/1/Hurle.pdf', 'source': {'id': 'https://openalex.org/S4306400398', 'display_name': 'UCrea (University of Cantabria)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I13134134', 'host_organization_name': 'Universidad de Cantabria', 'host_organization_lineage': ['https://openalex.org/I13134134'], 'host_organization_lineage_names': ['Universidad de Cantabria'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22882958', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/10902/1127', 'pdf_url': 'https://repositorio.unican.es/xmlui/bitstream/10902/1127/1/Hurle.pdf', 'source': {'id': 'https://openalex.org/S4306400398', 'display_name': 'UCrea (University of Cantabria)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I13134134', 'host_organization_name': 'Universidad de Cantabria', 'host_organization_lineage': ['https://openalex.org/I13134134'], 'host_organization_lineage_names': ['Universidad de Cantabria'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.8, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W1531768958', 'https://openalex.org/W155024021', 'https://openalex.org/W1967033333', 'https://openalex.org/W1979960493', 'https://openalex.org/W1981421887', 'https://openalex.org/W1989846600', 'https://openalex.org/W1989892200', 'https://openalex.org/W1994115987', 'https://openalex.org/W2007701028', 'https://openalex.org/W2010587976', 'https://openalex.org/W2010890329', 'https://openalex.org/W2012957301', 'https://openalex.org/W2015547750', 'https://openalex.org/W2018352906', 'https://openalex.org/W2039820053', 'https://openalex.org/W2047362768', 'https://openalex.org/W2051403674', 'https://openalex.org/W2061558045', 'https://openalex.org/W2066665398', 'https://openalex.org/W2067512788', 'https://openalex.org/W2074156641', 'https://openalex.org/W2081146306', 'https://openalex.org/W2085786241', 'https://openalex.org/W2090786835', 'https://openalex.org/W2092322021', 'https://openalex.org/W2094077020', 'https://openalex.org/W2096144819', 'https://openalex.org/W2097492628', 'https://openalex.org/W2097837136', 'https://openalex.org/W2097869179', 'https://openalex.org/W2102823685', 'https://openalex.org/W2105161080', 'https://openalex.org/W2107033535', 'https://openalex.org/W2107359871', 'https://openalex.org/W2107387191', 'https://openalex.org/W2108935861', 'https://openalex.org/W2114741516', 'https://openalex.org/W2115898766', 'https://openalex.org/W2117486652', 'https://openalex.org/W2121236121', 'https://openalex.org/W2122473579', 'https://openalex.org/W2126250632', 'https://openalex.org/W2132093971', 'https://openalex.org/W2141570739', 'https://openalex.org/W2149966907', 'https://openalex.org/W2150037286', 'https://openalex.org/W2151383898', 'https://openalex.org/W2152667145', 'https://openalex.org/W2159864284', 'https://openalex.org/W2163655902', 'https://openalex.org/W2168915540', 'https://openalex.org/W2170459650', 'https://openalex.org/W4251765607', 'https://openalex.org/W76973823'], 'related_works': ['https://openalex.org/W4286007524', 'https://openalex.org/W3013125152', 'https://openalex.org/W2886313418', 'https://openalex.org/W2783430812', 'https://openalex.org/W2779089668', 'https://openalex.org/W2375599833', 'https://openalex.org/W2074067577', 'https://openalex.org/W2037749195', 'https://openalex.org/W2008092800', 'https://openalex.org/W1971126299'], 'abstract_inverted_index': {'Background': [0], 'Various': [1], 'human': [2], 'cardiovascular': [3], 'pathophysiological': [4], 'conditions': [5], 'associate': [6], 'aberrant': [7], 'expression': [8, 177], 'of': [9, 42, 51, 68, 96, 120, 133, 184, 191, 204, 213, 218, 236], 'microRNAs': [10], '(miRNAs)': [11], 'and': [12, 44, 64, 86, 99, 101, 113, 130, 146, 162, 200, 202, 232], 'circulating': [13, 237], 'miRNAs': [14], 'are': [15], 'emerging': [16], 'as': [17, 70, 215, 239], 'promising': [18], 'biomarkers.': [19], 'In': [20, 78, 117], 'mice,': [21], 'myocardial': [22, 43, 75, 93, 125, 129, 175, 181, 243], 'miR-21': [23, 46, 69, 104, 121, 134, 155, 182, 189, 197, 214, 238], 'overexpression': [24, 156], 'is': [25], 'related': [26], 'to': [27, 38, 159, 226], 'cardiac': [28], 'fibrosis': [29], 'elicited': [30], 'by': [31, 56, 180], 'pressure': [32, 57, 227], 'overload.': [33], 'This': [34], 'study': [35], 'was': [36, 122, 157, 178], 'designed': [37], 'determine': [39], 'the': [40, 48, 52, 65, 92, 139, 144, 150, 172, 196, 211, 219, 234], 'role': [41, 212], 'plasmatic': [45], 'in': [47, 59, 109, 114, 124, 138, 164, 174, 224, 229], 'maladaptive': [49], 'remodeling': [50], 'extracellular': [53], 'matrix': [54], 'induced': [55], 'overload': [58, 228], 'aortic': [60], 'stenosis': [61], '(AS)': [62], 'patients': [63, 85, 141, 231], 'clinical': [66], 'value': [67, 235], 'a': [71, 216, 240], 'biomarker': [72, 241], 'for': [73, 242], 'pathological': [74], 'fibrosis.': [76, 244], 'Methods': [77], 'left': [79], 'ventricular': [80], 'biopsies': [81], 'from': [82], '75': [83], 'AS': [84, 115, 140, 230], '32': [87], 'surgical': [88], 'controls,': [89], 'we': [90], 'quantified': [91], 'transcript': [94], 'levels': [95, 106, 132], 'miR-21,': [97], 'miR-21-targets': [98], 'ECM-': [100], 'TGF-β-signaling-related': [102], 'elements.': [103], 'plasma': [105, 131, 188], 'were': [107, 135], 'determined': [108], '25': [110], 'healthy': [111], 'volunteers': [112], 'patients.': [116], 'situ': [118], 'hybridization': [119], 'performed': [123], 'sections.': [126], 'Results': [127], 'The': [128], 'significantly': [136], 'higher': [137], 'compared': [142], 'with': [143, 149, 195], 'controls': [145], 'correlated': [147], 'directly': [148], 'echocardiographic': [151], 'mean': [152], 'transvalvular': [153], 'gradients.': [154], 'confined': [158], 'interstitial': [160], 'cells': [161], 'absent': [163], 'cardiomyocytes.': [165], 'Using': [166], 'bootstrap': [167], 'validated': [168], 'multiple': [169], 'linear': [170], 'regression,': [171], 'variance': [173], 'collagen': [176, 185, 192], 'predicted': [179], '(70%': [183], 'variance)': [186], 'or': [187], '(52%': [190], 'variance),': [193], 'together': [194], 'targets': [198], 'RECK': [199], 'PDCD4,': [201], 'effectors': [203], 'TGF-ß': [205], 'signaling.': [206], 'Conclusions': [207], 'Our': [208], 'results': [209], 'support': [210], 'regulator': [217], 'fibrotic': [220], 'process': [221], 'that': [222], 'occurs': [223], 'response': [225], 'underscore': [233]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2008092800', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 17}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 22}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 19}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 6}], 'updated_date': '2024-09-19T06:57:59.912788', 'created_date': '2016-06-24'}