Title: Complex Inhibition of [<sup>3</sup>H]Imipramine Binding by Serotonin and Nontricyclic Serotonin Uptake Blockers
Abstract: Abstract: Tricyclic antidepressant drugs inhibit [ 3 H]imipramine binding to the rat brain cortex in a competitive manner, giving linear Hofstee plots and Hill coefficients of approximately 1.0. Serotonin, the only neurotransmitter to inhibit [ 3 H]imipramine binding, does so in a complex manner, exhibiting a Hill coefficient of 0.40‐0.50. Nontricyclic inhibitors of serotonin uptake such as fluoxetine, paroxetine, norzimelidine, and citalopram inhibit [ 3 H]imiprarnine binding in the same complex manner as serotonin. These results are interpreted as suggesting that [ 3 H]imipramine binds to a site associated with the serotonin uptake system but different from either the substrate recognition site for serotonin or the site of action of the nontricyclic inhibitors of neuronal uptake of serotonin.
Publication Year: 1983
Publication Date: 1983-03-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 145
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