Title: EFFECTS OF SWITCHING FROM CARVEDILOL TO BISOPROLOL IN PATIENTS WITH CHRONIC HEART FAILURE
Abstract: Asrac Caegor: 13. Hear ailure: Therareseaio Numer: 1214-102Auhors: Tatsunori Taniguchi, Yasuhiro Ichibori, Machiko Matsui Kanzaki, Hitoshi Minamiguchi, Isamu Mizote, Tomohito Ohtani, Yoshihiro Asano, Yasushi Sakata, Issei Komuro, Osaka University Graduate School of Medicine, Osaka, JapanBackground: Treame ih careilol has ee esalishe as a rimar hera i aies ih hear failure. Hoeer, aerse smoms or sigs ofe iscourages coiuaio or icreases i osage of his meicaio. We seculae ha sichig o isorolol oul hel aoi aerse smoms a sigs relae o careilol amiisraio.Methods: Daa ere reroseciel collece from 23 aies ih hear failure (age 57±18 ears, NHA 2.±0.7, lef ericular ejecio fracio (LVE) 33±15%) ho coul o icrease heir osage of careilol (5.0±3.43 mg) ecause of aerse smoms (iiess, scoe) or sigs (hoesio: ssolic loo ressure (SB) <90 mmHg). Six mohs afer sichig o isorolol, e chece smoms, ial sigs, laoraor aa a cliical saus (NHA class). urhermore, lef ericular (LV) imesio a coracio ere ealuae i 17 of 23 aies usig echocariograh.Results: All of 13 smomaic aies (100%) a 5 of 10 asmomaic aies (50%) ere reliee of aerse smoms or sigs. The ose of isorolol as icrease from 1.84±1.08 o 3.13±1.74 mg (<0.01). A -moh follo-u examiaios, LV fucio measure LVE as sigiical imroe, accomaie imroeme of exercise olerace.Conclusions: Sichig from careilol o isorolol ma hel ih coiuaio of ʼ-locer reame as ell as osage icrease i aies ih aerse smoms or sigs, alloig hem o reach he arge ose.arameers Baselie mohs alueSB, mmHg 94.1±44.1 109.4±55.1 <0.05HR, m 77.1±38.2 74.±37.2 NSNHA class 2.±1.2 2.4±1.1 <0.05H, mg/l 11.±5.9 12.0±.2 NSCre, mg/l 1.08±0. 1.25±0.78 <0.01BN, g/ml 340.8±417.2 374.9±529.5 NSLVD, mm 59.8±31.5 58.0±31.5 NSLVDs, mm 51.4±27.9 4.2±25.7 <0.01LVE, % 30.3±18.1 39.4±21.8 <0.001