Isoform-specific Effects of the β2 Subunit on Voltage-gated Sodium Channel Gating

Name: Work Video:
Duration: 3 min 30 s
Daniel J. Johnson; Eric S. Bennett
{'id': 'https://openalex.org/W2007929236', 'doi': 'https://doi.org/10.1074/jbc.m605060200', 'title': 'Isoform-specific Effects of the β2 Subunit on Voltage-gated Sodium Channel Gating', 'display_name': 'Isoform-specific Effects of the β2 Subunit on Voltage-gated Sodium Channel Gating', 'publication_year': 2006, 'publication_date': '2006-07-18', 'ids': {'openalex': 'https://openalex.org/W2007929236', 'doi': 'https://doi.org/10.1074/jbc.m605060200', 'mag': '2007929236', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16847056'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m605060200', 'pdf_url': 'http://www.jbc.org/article/S0021925819351154/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819351154/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035878753', 'display_name': 'Daniel J. Johnson', 'orcid': 'https://orcid.org/0000-0002-8585-2143'}, 'institutions': [{'id': 'https://openalex.org/I2613432', 'display_name': 'University of South Florida', 'ror': 'https://ror.org/032db5x82', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I2613432']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel Johnson', 'raw_affiliation_strings': ['Department of Molecular Pharmacology & Physiology, University of South Florida College of Medicine, Tampa, Florida 33612, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pharmacology & Physiology, University of South Florida College of Medicine, Tampa, Florida 33612, USA.', 'institution_ids': ['https://openalex.org/I2613432']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5061261292', 'display_name': 'Eric S. Bennett', 'orcid': 'https://orcid.org/0000-0002-1605-7250'}, 'institutions': [{'id': 'https://openalex.org/I2613432', 'display_name': 'University of South Florida', 'ror': 'https://ror.org/032db5x82', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I2613432']}, {'id': 'https://openalex.org/I94062374', 'display_name': 'Florida College', 'ror': 'https://ror.org/010bgev76', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I94062374']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eric S. Bennett', 'raw_affiliation_strings': ['Department of Molecular Pharmacology & Physiology and Programs in Cardiovascular Sciences and Neuroscience, University of South Florida College of Medicine, Tampa, Florida 33612'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pharmacology & Physiology and Programs in Cardiovascular Sciences and Neuroscience, University of South Florida College of Medicine, Tampa, Florida 33612', 'institution_ids': ['https://openalex.org/I2613432', 'https://openalex.org/I94062374']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 2.148, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 72, 'citation_normalized_percentile': {'value': 0.839017, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '281', 'issue': '36', 'first_page': '25875', 'last_page': '25881'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C53345823', 'wikidata': 'https://www.wikidata.org/wiki/Q5531554', 'display_name': 'Gene isoform', 'level': 3, 'score': 0.8617656}, {'id': 'https://openalex.org/C194544171', 'wikidata': 'https://www.wikidata.org/wiki/Q21105679', 'display_name': 'Gating', 'level': 2, 'score': 0.81213856}, {'id': 'https://openalex.org/C50952357', 'wikidata': 'https://www.wikidata.org/wiki/Q424960', 'display_name': 'Sodium channel', 'level': 3, 'score': 0.78686297}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.69132864}, {'id': 'https://openalex.org/C127162648', 'wikidata': 'https://www.wikidata.org/wiki/Q16858953', 'display_name': 'Channel (broadcasting)', 'level': 2, 'score': 0.5035445}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.48746347}, {'id': 'https://openalex.org/C37088560', 'wikidata': 'https://www.wikidata.org/wiki/Q354550', 'display_name': 'Voltage-gated ion channel', 'level': 4, 'score': 0.41422278}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3879659}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.34268755}, {'id': 'https://openalex.org/C537181965', 'wikidata': 'https://www.wikidata.org/wiki/Q658', 'display_name': 'Sodium', 'level': 2, 'score': 0.26128858}, {'id': 'https://openalex.org/C50254741', 'wikidata': 'https://www.wikidata.org/wiki/Q62536', 'display_name': 'Ion channel', 'level': 3, 'score': 0.2411915}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23362744}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.22761014}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.07876074}, {'id': 'https://openalex.org/C76155785', 'wikidata': 'https://www.wikidata.org/wiki/Q418', 'display_name': 'Telecommunications', 'level': 1, 'score': 0.05783826}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.051867604}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.05050841}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015640', 'descriptor_name': 'Ion Channel Gating', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012794', 'descriptor_name': 'Sialic Acids', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015222', 'descriptor_name': 'Sodium Channels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016466', 'descriptor_name': 'CHO Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015640', 'descriptor_name': 'Ion Channel Gating', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008564', 'descriptor_name': 'Membrane Potentials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008564', 'descriptor_name': 'Membrane Potentials', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D062551', 'descriptor_name': 'NAV1.2 Voltage-Gated Sodium Channel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D062554', 'descriptor_name': 'NAV1.5 Voltage-Gated Sodium Channel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018408', 'descriptor_name': 'Patch-Clamp Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012794', 'descriptor_name': 'Sialic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015222', 'descriptor_name': 'Sodium Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015222', 'descriptor_name': 'Sodium Channels', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D062548', 'descriptor_name': 'Voltage-Gated Sodium Channel beta-2 Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m605060200', 'pdf_url': 'http://www.jbc.org/article/S0021925819351154/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16847056', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m605060200', 'pdf_url': 'http://www.jbc.org/article/S0021925819351154/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation', 'score': 0.63}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W1190729038', 'https://openalex.org/W1483635560', 'https://openalex.org/W1555347684', 'https://openalex.org/W1567737562', 'https://openalex.org/W1573864704', 'https://openalex.org/W1886737504', 'https://openalex.org/W1923688770', 'https://openalex.org/W1937176890', 'https://openalex.org/W1964258127', 'https://openalex.org/W1970739996', 'https://openalex.org/W1976241975', 'https://openalex.org/W1978399767', 'https://openalex.org/W1983187084', 'https://openalex.org/W1985146688', 'https://openalex.org/W1989034440', 'https://openalex.org/W1989268481', 'https://openalex.org/W1991798507', 'https://openalex.org/W1996471006', 'https://openalex.org/W1997761743', 'https://openalex.org/W2006271002', 'https://openalex.org/W2012336532', 'https://openalex.org/W2015791130', 'https://openalex.org/W2017908797', 'https://openalex.org/W2019268667', 'https://openalex.org/W2024930504', 'https://openalex.org/W2039398588', 'https://openalex.org/W2044076590', 'https://openalex.org/W2054336104', 'https://openalex.org/W2062833711', 'https://openalex.org/W2078508547', 'https://openalex.org/W2082626069', 'https://openalex.org/W2083115493', 'https://openalex.org/W2085873341', 'https://openalex.org/W2087383295', 'https://openalex.org/W2088094161', 'https://openalex.org/W2089751567', 'https://openalex.org/W2093214695', 'https://openalex.org/W2102982080', 'https://openalex.org/W2105498897', 'https://openalex.org/W2107712284', 'https://openalex.org/W2109914717', 'https://openalex.org/W2127766353', 'https://openalex.org/W2129747642', 'https://openalex.org/W2130972481', 'https://openalex.org/W2141092270', 'https://openalex.org/W2161622051', 'https://openalex.org/W2228644631', 'https://openalex.org/W2796575992', 'https://openalex.org/W4244153167'], 'related_works': ['https://openalex.org/W4225966594', 'https://openalex.org/W4223653241', 'https://openalex.org/W3162484511', 'https://openalex.org/W2375911737', 'https://openalex.org/W2130972481', 'https://openalex.org/W2089774470', 'https://openalex.org/W2077082977', 'https://openalex.org/W2056248932', 'https://openalex.org/W1966343975', 'https://openalex.org/W1556915564'], 'abstract_inverted_index': {'Voltage-gated': [0, 248], 'sodium': [1, 249, 500, 509, 523, 1873, 2469, 2494, 2612, 6154], 'channels': [2, 250, 501, 817, 6344], '(Nav)': [3, 251, 502], 'are': [4, 229, 252, 477, 709, 714, 1042, 1110, 1963, 2122, 2132, 2230, 2631, 3024, 3933, 3973, 4229, 4248, 4282, 4401, 4421, 4885, 5050, 5561, 5625, 5730, 5789, 5847, 6288, 6325], 'complex': [5, 194, 235, 253, 442, 483, 710, 2820, 2910, 3864, 4156, 4346, 4382, 4461, 6149], 'glycoproteins': [6, 254, 712, 2148, 6037], 'comprised': [7, 255], 'of': [8, 84, 115, 209, 220, 256, 332, 363, 457, 468, 498, 716, 793, 1050, 1054, 1139, 1274, 1458, 1579, 1737, 1741, 1754, 1855, 1865, 1945, 1978, 2042, 2152, 2223, 2239, 2301, 2465, 2477, 2487, 2490, 2627, 2646, 2651, 2670, 2679, 2690, 2719, 2747, 2827, 2845, 2868, 2881, 2907, 2946, 2959, 3785, 3802, 3925, 3939, 3946, 3982, 4065, 4078, 4098, 4179, 4195, 4210, 4214, 4217, 4223, 4264, 4278, 4300, 4314, 4322, 4328, 4352, 4372, 4418, 4426, 4443, 4455, 4473, 4492, 4518, 4568, 4588, 4608, 4670, 4674, 4746, 4761, 4804, 4810, 4867, 4872, 4895, 4908, 4955, 4957, 4964, 4982, 5011, 5045, 5064, 5095, 5136, 5174, 5193, 5218, 5312, 5342, 5351, 5375, 5381, 5397, 5410, 5520, 5546, 5557, 5571, 5578, 5589, 5604, 5619, 5700, 5723, 5793, 5799, 5807, 5861, 6012, 6038, 6114, 6118, 6139, 6234, 6249, 6252, 6279, 6317, 6334, 6342, 6353], 'an': [9, 82, 257, 330, 1452, 1517, 1942, 2143, 3826, 4342, 4581, 4584, 5436, 5444, 5470, 6147, 6256, 6263], 'α': [10, 29, 156, 258, 277, 404, 719, 777, 810, 1038, 1462, 1588, 2024, 2209, 2228, 2243, 2422, 2457, 2468, 2493, 2673, 2950, 3038, 3856, 3907, 3957, 4072, 4080, 4354, 4446, 4499, 4968, 5178, 5345, 5362, 5433, 5498, 6175, 6286], 'subunit': [11, 259, 720, 778, 811, 1130, 1463, 1491, 1589, 2025, 2210, 2229, 2304, 2309, 2319, 3857, 4355, 4363, 4447, 4485, 5346, 5363, 5426, 5638, 5646, 5684, 6176, 6237, 6311, 6318], 'and': [12, 30, 57, 159, 170, 175, 222, 226, 232, 239, 260, 278, 305, 407, 418, 423, 470, 474, 480, 487, 536, 544, 555, 571, 584, 1039, 1504, 1516, 1635, 1743, 1952, 2028, 2033, 2135, 2199, 2236, 2247, 2281, 2291, 2356, 2373, 2375, 2423, 2458, 2480, 2498, 2513, 2534, 2695, 2707, 2744, 2752, 2787, 2811, 2856, 2956, 2973, 3029, 3112, 3141, 3170, 3199, 3251, 3282, 3311, 3370, 3401, 3430, 3475, 3527, 3560, 3640, 3669, 3698, 3727, 3759, 3850, 3859, 3888, 3897, 3948, 3971, 4002, 4032, 4075, 4093, 4102, 4131, 4189, 4225, 4231, 4234, 4254, 4266, 4297, 4305, 4406, 4429, 4479, 4527, 4570, 4583, 4610, 4763, 4806, 4862, 4914, 4952, 5059, 5167, 5204, 5211, 5278, 5281, 5315, 5328, 5332, 5404, 5412, 5443, 5463, 5522, 5530, 5539, 5541, 5548, 5564, 5621, 5669, 5711, 5713, 5733, 5761, 5987, 6062, 6126, 6156, 6161, 6241, 6276, 6291, 6331, 6338], 'often': [13, 261, 823, 1111, 3959], 'one': [14, 262, 828, 3964, 4338, 5399, 5405, 5682, 5800, 5998], 'to': [15, 27, 130, 263, 275, 378, 548, 577, 814, 969, 1048, 1058, 1128, 1135, 1408, 1494, 1523, 1748, 1958, 1972, 2056, 2297, 2313, 2360, 2364, 2642, 2662, 2765, 2824, 2852, 2858, 2982, 3779, 3809, 3832, 3854, 3860, 4147, 4150, 4312, 4350, 4482, 4829, 4853, 4875, 4887, 5052, 5082, 5128, 5214, 5357, 5595, 5659, 5763, 5844, 5854, 6000, 6027, 6035, 6053, 6122, 6171], 'several': [16, 264, 1946, 4519, 5859], 'β': [17, 265, 1040, 2303, 4331, 4427, 4451, 5559, 5637, 5645, 5683, 5702, 5725, 6280], 'subunits.': [18, 266, 2951, 3908, 4218, 5179, 5506], 'We': [19, 267, 1969, 3837, 4900, 6348], 'have': [20, 137, 268, 385, 780, 1451, 1495, 2251], 'shown': [21, 269, 1134, 2630, 2714, 3881, 4402, 4434, 5100, 5208, 5535], 'that': [22, 133, 270, 381, 713, 721, 832, 1402, 1448, 1510, 1520, 2051, 2131, 2192, 2219, 2242, 2314, 2348, 2773, 2841, 2864, 2923, 2977, 3824, 3868, 3886, 3900, 3915, 4022, 4120, 4166, 4275, 4347, 4351, 4420, 4441, 4463, 4508, 4558, 4666, 4753, 4799, 4819, 4902, 5123, 5157, 5168, 5209, 5336, 5389, 5400, 5406, 5423, 5454, 5553, 5616, 6029, 6272, 6300], 'sialic': [23, 40, 65, 94, 118, 181, 205, 271, 288, 313, 342, 366, 429, 453, 512, 526, 1114, 1990, 2153, 2692, 2834, 2854, 2936, 3044, 3095, 3124, 3153, 3182, 3234, 3265, 3294, 3353, 3384, 3413, 3458, 3510, 3543, 3623, 3652, 3681, 3710, 3742, 3811, 3917, 4211, 4268, 4920, 5012, 5057, 5086, 5125, 5377, 5402, 6119], 'acid': [24, 272, 2127, 3096, 3125, 3154, 3183, 3235, 3266, 3295, 3354, 3385, 3414, 3459, 3511, 3544, 3624, 3653, 3682, 3711, 3743], 'residues': [25, 273], 'linked': [26, 274, 5853], 'Nav': [28, 44, 146, 244, 276, 292, 394, 492, 542, 708, 1129, 1140, 1286, 1386, 1461, 1947, 1967, 2023, 2195, 2672, 2949, 3906, 3951, 4445, 4520, 4967, 5344, 5352, 5419, 5432, 5497, 5514, 5739, 6106, 6174, 6285, 6301, 6310], 'β1': [31, 158, 174, 221, 279, 406, 422, 469, 1989, 2224, 2318, 2424, 3040, 3067, 3090, 3321, 3346, 3485, 3505, 3604, 3617, 3947, 4023, 4066, 4085, 4101, 4123, 4201, 4224, 4243, 4265, 4304, 4362, 4396, 4509, 4893, 4903, 4919, 5411, 5455, 5521, 5547, 5579, 5620, 5668, 6236], 'subunits': [32, 280, 967, 1041, 3958, 4088, 4332, 4428, 4452, 4474, 4961, 5499, 5560, 5703, 5726, 6128, 6281, 6287], 'alter': [33, 281, 568], 'channel': [34, 282, 834, 971, 1037, 1056, 1288, 1752, 3117, 3146, 3175, 3204, 3256, 3287, 3316, 3375, 3406, 3435, 3480, 3532, 3565, 3645, 3674, 3703, 3732, 3764, 3852, 3863, 3956, 4174, 4181, 4292, 4345, 4381, 5652, 6048, 6180, 6336], 'gating.': [35, 88, 100, 122, 142, 187, 283, 336, 348, 370, 390, 435, 1968, 2737, 2805, 3943, 5140, 5197, 5450, 6268], 'To': [36, 284, 2016, 4059, 5180], 'determine': [37, 285, 1959, 1973, 2676, 3797, 4060], 'whether': [38, 286, 1960, 1974, 2677, 3798, 4061, 5084], 'β2-linked': [39, 287], 'acids': [41, 66, 119, 289, 314, 367, 1115, 1991, 2154, 2835, 2855, 3918, 4212, 4269, 4921, 5058, 5087, 5126, 5403, 6120], 'similarly': [42, 290, 2312, 2762, 4192, 4349], 'impact': [43, 114, 139, 291, 362, 387, 2984, 5512, 5977, 6179], 'gating,': [45, 75, 110, 293, 323, 358, 2885, 4368, 5121, 6243], 'we': [46, 294, 1956, 2019, 2217, 2996, 4556, 4797, 4817, 4889, 5080, 5452], 'co-expressed': [47, 295, 2699, 2790, 3838, 4302, 5285, 5672], 'β2': [48, 64, 85, 91, 116, 134, 144, 160, 176, 210, 223, 296, 312, 333, 339, 364, 382, 392, 408, 424, 458, 471, 1490, 1580, 1627, 1728, 1856, 1886, 1940, 1961, 2043, 2193, 2240, 2308, 2459, 2481, 2664, 2684, 2691, 2701, 2720, 2774, 2786, 2798, 2846, 2853, 2869, 2882, 2890, 2935, 2939, 2960, 2979, 3016, 3042, 3209, 3229, 3323, 3348, 3570, 3593, 3606, 3619, 3780, 3786, 3803, 3816, 3891, 3926, 3930, 3940, 3949, 3972, 4087, 4103, 4125, 4167, 4203, 4226, 4245, 4267, 4306, 4373, 4398, 4488, 4589, 4681, 4692, 4754, 4800, 4820, 4846, 4868, 4972, 5002, 5096, 5106, 5129, 5137, 5158, 5175, 5194, 5198, 5212, 5287, 5313, 5337, 5355, 5376, 5384, 5390, 5413, 5425, 5523, 5549, 5572, 5609, 5622, 5670, 6127, 6253], 'with': [49, 164, 297, 412, 786, 825, 1046, 1113, 1586, 1984, 2149, 2211, 2233, 2700, 2721, 2830, 2886, 3015, 3840, 3905, 3961, 4070, 4100, 4161, 4303, 4501, 4605, 4689, 5176, 5286, 5364, 5503, 5550, 5673, 5752, 5755, 5981, 6058, 6314], 'Nav1.5': [50, 73, 87, 109, 121, 165, 186, 225, 298, 321, 335, 357, 369, 413, 434, 473, 1757, 2029, 2682, 2696, 2722, 2788, 2804, 2828, 2848, 2871, 3012, 3788, 3805, 3841, 3876, 4033, 4099, 4115, 4173, 4185, 4205, 4228, 4241, 4983, 5006, 5120, 5139, 5196, 5210, 5271, 5323, 5368, 5441, 5462, 5525, 5674, 5694, 5728, 6242, 6260], 'or': [51, 166, 299, 414, 1276, 1284, 1756, 2040, 2831, 2918, 2969, 2992, 3842, 4082, 4124, 4842, 5706, 5809, 6018], 'Nav1.2': [52, 99, 126, 141, 167, 197, 212, 227, 300, 347, 374, 389, 415, 445, 460, 475, 1742, 2027, 2680, 2694, 2884, 2929, 2991, 3795, 3843, 3893, 3942, 4031, 4301, 4315, 4334, 4367, 4394, 4569, 4595, 4828, 4849, 4873, 4896, 4909, 5148, 5165, 5382, 5449, 5464, 5551, 5590, 5624, 6240, 6267], 'in': [53, 58, 72, 98, 168, 185, 301, 306, 320, 346, 416, 433, 532, 789, 1290, 1394, 1405, 1455, 1630, 1636, 1733, 1858, 1861, 1872, 1876, 1950, 1965, 2037, 2044, 2053, 2124, 2147, 2622, 2702, 2715, 2723, 2735, 2791, 2898, 2916, 2919, 2928, 3007, 3021, 3026, 3030, 3102, 3131, 3160, 3189, 3241, 3272, 3301, 3360, 3391, 3420, 3465, 3517, 3550, 3630, 3659, 3688, 3717, 3749, 3771, 3819, 3844, 3882, 3936, 3979, 4030, 4091, 4094, 4104, 4114, 4207, 4251, 4256, 4286, 4307, 4341, 4403, 4408, 4435, 4453, 4465, 4594, 4602, 4684, 4749, 4831, 4897, 4910, 4978, 5008, 5034, 5075, 5101, 5107, 5201, 5275, 5325, 5372, 5440, 5465, 5469, 5536, 5542, 5707, 5804, 6046, 6108, 6130, 6246, 6259, 6266, 6345], 'Pro5': [54, 169, 302, 417, 2108, 2706, 2727, 2917, 3110, 3139, 3168, 3197, 3249, 3280, 3309, 3368, 3399, 3428, 3473, 3525, 3558, 3638, 3667, 3696, 3725, 3757, 3848, 4092, 4105, 4308], '(complete': [55, 303], 'sialylation)': [56, 62, 304, 310], 'Lec2': [59, 171, 307, 419, 2119, 2376, 2710, 2795, 2920, 3115, 3144, 3173, 3202, 3254, 3285, 3314, 3373, 3404, 3433, 3478, 3530, 3563, 3643, 3672, 3701, 3730, 3762, 4095], '(essentially': [60, 308], 'no': [61, 106, 138, 309, 354, 386, 2776, 2800, 2983, 3873, 4169, 4283, 4364, 4987, 5117, 5162], 'cells.': [63, 172, 311, 420, 4096], 'caused': [67, 92, 315, 340, 1729, 2730, 2891, 4107, 4821, 4973, 5796], 'a': [68, 93, 178, 316, 341, 426, 717, 723, 790, 1119, 1395, 1496, 1500, 1505, 1730, 2140, 2226, 2350, 2361, 2485, 2731, 2865, 2892, 3000, 3099, 3128, 3157, 3186, 3238, 3269, 3298, 3357, 3388, 3417, 3462, 3514, 3547, 3627, 3656, 3685, 3714, 3746, 3772, 3813, 3833, 4108, 4460, 4591, 4965, 4974, 5028, 5104, 5189, 5319, 6172], 'significant': [69, 317, 1870, 2777, 3001, 3100, 3129, 3158, 3187, 3239, 3270, 3299, 3358, 3389, 3418, 3463, 3515, 3548, 3628, 3657, 3686, 3715, 3747, 4284, 4988, 5190], 'hyperpolarizing': [70, 183, 318, 431, 1859, 2733, 4028, 4110, 4976, 5438, 5576], 'shift': [71, 97, 184, 319, 345, 432, 1732, 2734, 2895, 2927, 4111, 4593, 4757, 4830, 4977, 5033, 5071, 5439, 6258, 6265], 'voltage-dependent': [74, 322, 2736, 4824], 'thus': [76, 324, 2136], 'describing': [77, 325, 5188], 'for': [78, 326, 1583, 1988, 2142, 2317, 2602, 2816, 2878, 2965, 2990, 3037, 3783, 3921, 4153, 4240, 4393, 4672, 4827, 4892, 5039, 5068, 5091, 5133, 5152, 5321, 5417, 5461, 5636, 5742, 6044, 6296], 'the': [79, 113, 154, 192, 204, 217, 234, 327, 361, 402, 440, 452, 465, 482, 809, 964, 1051, 1055, 1271, 1277, 1291, 1524, 1587, 1631, 1734, 1751, 1862, 1975, 2038, 2125, 2202, 2208, 2220, 2234, 2287, 2299, 2366, 2605, 2610, 2628, 2647, 2652, 2688, 2703, 2724, 2745, 2766, 2769, 2792, 2817, 2861, 2879, 2908, 2924, 2944, 2962, 2978, 2986, 3106, 3135, 3164, 3193, 3245, 3276, 3305, 3364, 3395, 3424, 3469, 3521, 3554, 3634, 3663, 3692, 3721, 3753, 3799, 3845, 3855, 3861, 3869, 3913, 3922, 3937, 3976, 3983, 4062, 4071, 4154, 4162, 4208, 4215, 4220, 4260, 4291, 4320, 4325, 4329, 4353, 4361, 4370, 4378, 4412, 4424, 4471, 4477, 4480, 4498, 4516, 4523, 4566, 4606, 4667, 4685, 4758, 4802, 4808, 4832, 4837, 4865, 4870, 4905, 4911, 4950, 4979, 5009, 5015, 5046, 5061, 5065, 5076, 5134, 5143, 5177, 5185, 5202, 5215, 5326, 5340, 5361, 5373, 5424, 5466, 5511, 5517, 5528, 5554, 5558, 5568, 5575, 5585, 5596, 5617, 5632, 5701, 5720, 5991, 6013, 6030, 6036, 6039, 6115, 6123, 6131, 6137, 6235, 6247, 6273, 6297, 6308, 6329, 6339, 6350], 'first': [80, 328, 2862, 5186, 6298], 'time': [81, 329, 2863, 3978, 6299], 'effect': [83, 107, 331, 355, 2778, 2802, 2867, 2880, 3002, 3874, 4171, 4371, 4600, 4855, 4989, 4997, 5016, 5094, 5118, 5135, 5146, 5163, 5192, 5447], 'on': [86, 108, 120, 140, 211, 224, 334, 356, 368, 388, 459, 472, 2225, 2241, 2668, 2687, 2779, 2803, 2847, 2870, 2883, 2934, 2943, 2961, 2985, 3003, 3787, 3794, 3804, 3875, 3927, 3941, 3950, 4172, 4227, 4270, 4333, 4423, 4470, 4497, 4515, 4565, 4869, 4918, 4962, 4990, 5017, 5097, 5119, 5138, 5147, 5164, 5195, 5430, 5448, 5513, 5524, 5623, 5640, 5727, 5984, 6282], 'In': [89, 337, 1726, 2215, 2994, 4319, 4794, 4970, 5269, 5842], 'contrast,': [90, 338, 4971], 'acid-independent': [95, 206, 343, 454], 'depolarizing': [96, 207, 344, 455, 1731, 2894, 2926, 4592, 5145, 5446, 5569], 'A': [101, 349], 'deglycosylated': [102, 350, 2367, 3814, 3870], 'mutant,': [103, 351, 2368], 'β2-ΔN,': [104, 352, 5115], 'had': [105, 353, 2775, 2799, 2940, 3872, 4168, 4986, 5116, 5161], 'indicating': [111, 359, 2922, 2976, 4165, 5122, 5156], 'further': [112, 360, 2614], 'N-linked': [117, 135, 365, 383, 1449, 3775, 3810, 3916, 3931, 5085, 5124, 5159, 5805], 'Conversely,': [123, 371], 'β2-ΔN': [124, 372, 3839, 3871, 3887, 3901, 5141], 'modulated': [125, 373, 4204, 4848, 5370, 6305], 'gating': [127, 147, 213, 228, 375, 395, 461, 476, 565, 1141, 1289, 2196, 2813, 2825, 2843, 2866, 2902, 2930, 2945, 2988, 3035, 3103, 3132, 3161, 3190, 3242, 3273, 3302, 3361, 3392, 3421, 3466, 3518, 3551, 3631, 3660, 3689, 3718, 3750, 3806, 3853, 3877, 3894, 3923, 4034, 4116, 4206, 4221, 4238, 4287, 4299, 4313, 4335, 4390, 4415, 4517, 4567, 4596, 4825, 4850, 4871, 4906, 4963, 4984, 5007, 5149, 5166, 5324, 5341, 5353, 5442, 5459, 5555, 5587, 5653, 5695, 5729, 6181, 6261], 'virtually': [128, 376], 'identically': [129, 377, 3896, 4852], 'β2,': [131, 379, 1979, 4079, 4559, 5155], 'confirming': [132, 380], 'sugars': [136, 384, 3932, 5160], 'Thus,': [143, 216, 391, 464, 1939, 2938, 4219, 4377, 4864, 5310, 5584, 5716], 'modulates': [145, 393, 833, 2194, 5339], 'through': [148, 237, 396, 485, 725, 2197, 2305], 'multiple': [149, 397, 4450, 4466, 5978], 'mechanisms': [150, 398, 4574, 5396], 'possibly': [151, 399], 'determined': [152, 400, 2206, 5359], 'by': [153, 242, 401, 490, 962, 2207, 2683, 4122, 4449, 4476, 5056, 5072, 5354, 5360, 5383, 5698, 5745, 5797, 6151, 6306], 'associated': [155, 403, 824, 5502], 'subunit.': [157, 405, 2244, 3966, 4969], 'were': [161, 214, 409, 462, 1133, 1982, 2284, 2378, 2425, 2460, 2482, 2505, 2516, 2654, 2697, 2760, 2789, 2821, 2876, 2953, 3807, 4067, 4089, 4144, 4310, 5088, 5113, 5130, 5611, 5671], 'expressed': [162, 410, 819, 1393, 1629, 1949, 2020, 2915, 3014, 3974, 4090, 4475, 4748, 5200, 5274, 6129], 'together': [163, 411, 6143], 'Together': [173, 421, 4946], 'produced': [177, 425, 2608], 'significantly': [179, 427, 4117], 'larger': [180, 428], 'acid-dependent': [182, 430], 'Under': [188, 436], 'fully': [189, 437, 2704, 2725, 3107, 3136, 3165, 3194, 3246, 3277, 3306, 3365, 3396, 3425, 3470, 3522, 3555, 3635, 3664, 3693, 3722, 3754, 3846, 3919, 4135, 4857, 5089, 5131, 5581, 5597, 5676], 'sialylating': [190, 438, 2705, 2726, 3847, 4136, 5582], 'conditions,': [191, 439, 4137], 'Nav1.2·β1·β2': [193, 441, 4380, 5599], 'behaved': [195, 443, 4191], 'like': [196, 444], 'alone.': [198, 446, 3017, 4356], 'When': [199, 447, 2785, 4357, 4840, 5690], 'sialylation': [200, 448, 4358, 4430, 4841, 5316, 5691], 'was': [201, 449, 1746, 2295, 2310, 2358, 2599, 2872, 2911, 2931, 3013, 3817, 3830, 4359, 4374, 4682, 4844, 4915, 4998, 5021, 5592, 5634, 5685, 5692, 5696], 'reduced,': [202, 450, 4360, 5693], 'only': [203, 451, 2421, 2954, 5371, 5607, 5681, 6245], 'effects': [208, 219, 456, 467, 1977, 2222, 2238, 2844, 2942, 2958, 3801, 3924, 3938, 4064, 4077, 4222, 4263, 4327, 4419, 4514, 4564, 4866, 4884, 5429, 5519, 5532, 5556, 5610, 5618, 5639, 5722, 5983, 6278], 'apparent.': [215, 463], 'varied': [218, 466, 4456, 5428, 6274], 'apparently': [230, 478, 2231, 4068, 4232, 5562, 5629, 5731, 6289], 'synergistic': [231, 479], 'highlight': [233, 481], 'manner,': [236, 484], 'subunit-': [238, 486], 'sugar-dependent': [240, 488], 'mechanisms,': [241, 489], 'which': [243, 491, 726, 963, 1117, 2121, 2212, 3820, 4483, 5108, 5365, 6050, 6152], 'activity': [245, 493, 835, 6302], 'is': [246, 494, 538, 546, 812, 822, 973, 1403, 1492, 1581, 1628, 1941, 2205, 2685, 4459, 4486, 4601, 5184, 5199, 5272, 5335, 5369, 5385, 5510, 5852, 6025, 6111], 'modulated.': [247, 495], 'The': [496, 960, 1489, 1576, 1853, 2107, 2279, 2307, 2503, 3879, 3944, 4236, 4388, 4432, 5037, 5613, 6168, 6269, 6293, 6320], 'importance': [497], 'voltage-gated': [499, 508, 522, 6153], '3The': [503], 'abbreviations': [504, 518], 'used': [505, 519], 'are:': [506, 520], 'Nav,': [507, 521], 'channel(s);': [510, 524], 'SA,': [511, 525], 'acid(s);': [513, 527], 'CDGS,': [514, 528, 5794, 5845], 'carbohydrate-deficient': [515, 529, 2156], 'glycoprotein': [516, 530, 2157], 'syndrome.3The': [517], 'syndrome.': [531], 'action': [533, 4956, 6163], 'potential': [534, 1513, 2351, 5110], 'initiation': [535], 'propagation': [537], 'well': [539, 1868], 'established.': [540], 'Orchestrated': [541], 'activation': [543, 1738, 2741, 2968, 4762], 'inactivation': [545, 1740, 1866, 2749, 2756, 2782, 2970, 4140, 4671, 4764, 4805, 4993, 5020], 'vital': [547, 6340], 'normal': [549, 564, 2112], 'neuronal': [550, 1953, 6162], 'signaling,': [551], 'skeletal': [552, 6159], 'muscle': [553, 5770], 'contraction,': [554], 'regular': [556], 'heart': [557, 5327], 'rhythms.': [558], 'Even': [559], 'small': [560, 1501], 'syncopations': [561], 'from': [562, 783, 1281, 1882, 2754, 4018, 4678, 4812, 5748, 5768, 5997, 6006, 6322], 'this': [563, 2017, 3022, 4880, 4898, 5040, 5092, 5183, 6323], 'rhythm': [566], 'may': [567, 5026, 5317, 6041], 'cellular': [569, 4881, 6346], 'excitability': [570], 'whole': [572, 2525, 2639], 'animal': [573], 'physiology': [574], 'significantly,': [575], 'leading': [576], 'such': [578, 5857], 'disorders': [579, 5849], 'as': [580, 1867, 1869, 2139, 2380, 2428, 2536, 2914, 5150, 5858], 'long': [581], 'QT': [582], 'syndrome': [583, 2158], 'epilepsy': [585], '(1Abriel': [586], 'H.': [587, 848, 941, 1706, 1813, 5228, 5816, 5868, 5955], 'Cabo': [588], 'C.': [589, 599, 1702, 1809, 1888, 1902, 2173, 4613, 4627, 4694, 4708, 5224], 'Wehrens': [590], 'X.H.': [591], 'Rivolta': [592, 1703, 1810, 5225], 'I.': [593, 650, 683, 933, 990, 1704, 1771, 1811, 2163, 4778, 5226, 5961], 'Motoike': [594], 'H.K.': [595], 'Memmi': [596], 'M.': [597, 654, 1256, 1372, 1680, 1840, 5925, 5943], 'Napolitano': [598], 'Priori': [600], 'S.G.': [601, 1260, 1376], 'Kass': [602, 665, 1713, 1820, 5235], 'R.S.': [603, 666, 1714, 1821, 5236], 'Circ.': [604], 'Res.': [605, 1843, 5301], '2001;': [606, 800, 998, 1028, 1263, 1379, 1718, 1779, 1825, 3994, 4786, 5240], '88:': [607], '740-745Crossref': [608], 'PubMed': [609, 627, 644, 673, 703, 739, 755, 771, 803, 859, 886, 923, 957, 1001, 1020, 1031, 1071, 1089, 1105, 1158, 1170, 1194, 1209, 1231, 1248, 1266, 1310, 1325, 1347, 1364, 1382, 1427, 1439, 1484, 1552, 1571, 1606, 1624, 1661, 1674, 1694, 1721, 1782, 1801, 1828, 1848, 1934, 2011, 2076, 2089, 2102, 2184, 2274, 2340, 2390, 2414, 2450, 2555, 2567, 2591, 3997, 4011, 4054, 4550, 4659, 4740, 4789, 4941, 5243, 5264, 5305, 5492, 5782, 5823, 5837, 5875, 5889, 5901, 5933, 5969, 6084, 6099, 6189, 6213, 6228], 'Scopus': [610, 628, 645, 674, 704, 740, 756, 772, 804, 860, 887, 924, 1002, 1021, 1032, 1072, 1159, 1171, 1195, 1210, 1232, 1249, 1311, 1326, 1348, 1365, 1428, 1440, 1485, 1553, 1572, 1662, 1675, 1695, 1722, 1783, 1802, 1829, 1849, 1935, 2012, 2077, 2090, 2103, 2185, 2275, 2341, 2391, 2415, 2451, 2556, 2568, 2592, 3998, 4012, 4055, 4551, 4660, 4741, 4790, 4942, 5244, 5265, 5306, 5493, 5783, 5824, 5838, 5876, 5890, 5902, 5934, 5970, 6085, 6100, 6190, 6214, 6229], '(107)': [611], 'Google': [612, 630, 647, 676, 706, 742, 758, 774, 806, 862, 889, 926, 958, 1004, 1023, 1034, 1074, 1090, 1106, 1161, 1173, 1197, 1212, 1234, 1251, 1267, 1313, 1328, 1350, 1367, 1383, 1430, 1442, 1487, 1555, 1574, 1607, 1625, 1664, 1677, 1697, 1724, 1785, 1804, 1831, 1851, 1937, 2014, 2079, 2092, 2105, 2187, 2277, 2343, 2393, 2417, 2453, 2558, 2570, 2594, 4000, 4014, 4057, 4553, 4662, 4743, 4792, 4944, 5246, 5267, 5308, 5495, 5785, 5826, 5840, 5878, 5892, 5904, 5936, 5972, 6087, 6102, 6192, 6216, 6231], 'Scholar,': [613, 631, 648, 677, 743, 759, 863, 890, 927, 1005, 1024, 1075, 1091, 1162, 1174, 1198, 1213, 1235, 1252, 1314, 1329, 1351, 1368, 1431, 1556, 1608, 1665, 1678, 1698, 1786, 1805, 1832, 2080, 2093, 2394, 2559, 2571, 5247, 5827, 5879, 5893, 5905, 5937, 6088, 6193, 6217], '2Bennett': [614], 'P.B.': [615], 'Yazawa': [616], 'K.': [617, 850, 892, 902, 910, 984, 1765, 1834, 1909, 4634, 4715, 4772], 'Makita': [618], 'N.': [619, 2062], 'George': [620], 'Jr.,': [621], 'A.L.': [622, 639, 796, 852, 3990], 'Nature.': [623], '1995;': [624, 697, 880, 1546, 1655], '376:': [625], '683-685Crossref': [626], '(767)': [629], '3Spampanato': [632], 'J.': [633, 681, 750, 846, 906, 943, 952, 1080, 1096, 1152, 1165, 1183, 1203, 1241, 1242, 1261, 1304, 1319, 1357, 1358, 1377, 1421, 1434, 1473, 1558, 1560, 1597, 1615, 2000, 2263, 2329, 2385, 2403, 2439, 2549, 2562, 2580, 4043, 4539, 4930, 5481, 5775, 5777, 5814, 5829, 5830, 5866, 5881, 5882, 5927, 6073, 6093, 6184, 6202, 6222], 'Escayg': [634], 'A.': [635, 658, 919, 1682, 1684, 1896, 1930, 4621, 4655, 4702, 4736, 5917], 'Meisler': [636], 'M.H.': [637], 'Goldin': [638, 851], 'Neuroscience.': [640, 1016, 1670, 1797], '2003;': [641, 954, 4008, 5779, 5834, 5886], '116:': [642], '37-48Crossref': [643], '(85)': [646, 1196, 1486, 2013, 2276, 2342, 2416, 2452, 2593, 4056, 4552, 4943, 5494, 6086, 6215], '4Splawski': [649], 'Timothy': [651], 'K.W.': [652], 'Tateyama': [653], 'Clancy': [655], 'C.E.': [656], 'Malhotra': [657, 1707, 1814, 1897, 4622, 4703, 5229], 'Beggs': [659], 'A.H.': [660], 'Cappuccio': [661], 'F.P.': [662], 'Sagnella': [663], 'G.A.': [664], 'Keating': [667, 694], 'M.T.': [668, 695], 'Science.': [669, 855], '2002;': [670, 1017, 1167, 1436, 1798, 1931, 2387, 2564, 4656, 4737, 6186], '297:': [671], '1333-1336Crossref': [672], '(462)': [675], '5Wang': [678], 'Q.': [679], 'Shen': [680], 'Splawski': [682], 'Atkinson': [684], 'D.': [685, 937, 982, 1176, 1466, 1763, 1900, 1993, 2256, 2322, 2396, 2432, 2573, 4036, 4532, 4625, 4706, 4770, 4923, 5474, 5911, 6066, 6195], 'Li': [686], 'Z.': [687], 'Robinson': [688], 'J.L.': [689], 'Moss': [690], 'A.J.': [691, 1011, 1792, 1836], 'Towbin': [692], 'J.A.': [693, 1062], 'Cell.': [696, 879, 1545, 1654, 2069, 2084, 2097], '80:': [698], '805-811Abstract': [699], 'Full': [700, 766, 768, 883, 1086, 1102, 1189, 1191, 1228, 1344, 1479, 1481, 1549, 1603, 1621, 1658, 2006, 2008, 2073, 2269, 2271, 2335, 2337, 2409, 2411, 2445, 2447, 2586, 2588, 4049, 4051, 4545, 4547, 4936, 4938, 5487, 5489, 6079, 6081, 6208, 6210], 'Text': [701, 767, 769, 884, 1087, 1103, 1190, 1192, 1229, 1345, 1480, 1482, 1550, 1604, 1622, 1659, 2007, 2009, 2074, 2270, 2272, 2336, 2338, 2410, 2412, 2446, 2448, 2587, 2589, 4050, 4052, 4546, 4548, 4937, 4939, 5488, 5490, 6080, 6082, 6209, 6211], 'PDF': [702, 770, 885, 1088, 1104, 1193, 1230, 1346, 1483, 1551, 1605, 1623, 1660, 2010, 2075, 2273, 2339, 2413, 2449, 2590, 4053, 4549, 4940, 5491, 6083, 6212], '(1417)': [705], 'Scholar).': [707, 775, 807, 959, 1035, 1107, 1268, 1384, 1443, 1488, 1575, 1626, 1725, 1852, 1938, 2015, 2106, 2188, 2278, 2344, 2418, 2454, 2595, 4015, 4058, 4554, 4744, 4793, 4945, 5268, 5309, 5496, 5786, 5841, 5973, 6232], 'transmembrane': [711], 'composed': [715], 'large': [718, 1506], 'forms': [722, 5792, 5860], 'pore': [724], 'ions': [727], 'can': [728, 2137, 2849, 4575, 6165, 6177, 6303], 'pass': [729], '(6Fozzard': [730], 'H.A.': [731, 1239, 1355, 5945], 'Hanck': [732], 'D.A.': [733, 1610], 'Physiol.': [734, 751, 799, 1154, 1166, 1205, 1306, 1321, 1423, 1435, 2386, 2551, 2563, 3993, 6095, 6185, 6224], 'Rev.': [735, 798, 3992], '1996;': [736], '76:': [737], '887-926Crossref': [738], '(233)': [741], '7Marban': [744], 'E.': [745, 1143, 1215, 1295, 1331, 1412, 2540], 'Yamagishi': [746], 'T.': [747, 876, 949, 994, 1542, 1651, 1775, 1919, 2165, 4644, 4725, 4782, 5257, 5773], 'Tomaselli': [748], 'G.F.': [749], '1998;': [752, 1691], '508:': [753], '647-657Crossref': [754], '(253)': [757], '8Catterall': [760], 'W.A.': [761, 854, 878, 947, 992, 1095, 1544, 1566, 1596, 1614, 1653, 1773, 1921, 4646, 4727, 4780, 5259], 'Neuron.': [762, 1224, 1340], '2000;': [763, 920, 5302, 5898], '26:': [764, 5835, 5887], '13-25Abstract': [765], '(1667)': [773], 'Ten': [776], 'isoforms': [779, 1464, 1948, 4448, 4530], 'been': [781, 2252], 'cloned': [782], 'excitable': [784], 'tissues,': [785], 'orthologues': [787], 'present': [788, 5686, 5754], 'wide': [791], 'range': [792], 'species': [794], '(9Goldin': [795], 'Annu.': [797, 3991], '63:': [801, 3995], '871-894Crossref': [802, 3996], '(580)': [805, 3999], 'Although': [808, 2596, 5014, 5990], 'sufficient': [813], 'form': [815], 'functional': [816, 1885, 4467, 5191, 6309], 'when': [818, 1392, 3011, 5667, 5680], 'alone,': [820, 4186], 'it': [821, 2213, 5025, 5366, 6024], 'at': [826, 1122, 1388, 2518, 2633, 3975, 4384, 5392], 'least': [827, 2634, 5393], 'auxiliary': [829, 966, 3965, 4960, 5505], 'subunit,': [830], 'β1–β4,': [831], '(10Isom': [836], 'L.L.': [837, 865, 1026, 1531, 1640, 1716, 1823, 1923, 4648, 4729, 5238], 'De': [838, 868, 1534, 1643], 'Jongh': [839, 869, 1535, 1644], 'K.S.': [840, 870, 1536, 1645], 'Patton': [841], 'D.E.': [842, 5941], 'Reber': [843, 873, 1539, 1648], 'B.F.': [844, 874, 1540, 1649], 'Offord': [845], 'Charbonneau': [847], 'Walsh': [849], 'Catterall': [853, 877, 946, 991, 1094, 1543, 1565, 1595, 1613, 1652, 1772, 1920, 4645, 4726, 4779, 5258], '1992;': [856], '256:': [857], '839-842Crossref': [858], '(598)': [861], '11Isom': [864], 'Ragsdale': [866, 1014, 1532, 1641, 1795], 'D.S.': [867, 1015, 1219, 1335, 1533, 1642, 1796], 'Westenbroek': [871, 930, 1537, 1646, 1893, 4618, 4699, 5250], 'R.E.': [872, 931, 1538, 1647, 1894, 4619, 4700, 5251], 'Scheuer': [875, 948, 993, 1541, 1650, 1774, 1918, 4643, 4724, 4781, 5256], '83:': [881, 1547, 1656], '433-442Abstract': [882, 1548, 1657], '(395)': [888, 1554, 1663], '12Morgan': [891], 'Stevens': [893], 'E.B.': [894], 'Shah': [895], 'B.': [896], 'Cox': [897], 'P.J.': [898, 908, 1180, 1200, 1316, 1470, 1905, 1997, 2260, 2326, 2400, 2436, 2577, 4040, 4536, 4630, 4711, 4927, 5478, 6070, 6090, 6199, 6219], 'Dixon': [899], 'A.K.': [900], 'Lee': [901, 5292], 'Pinnock': [903], 'R.D.': [904, 5959], 'Hughes': [905], 'Richardson': [907], 'Mizuguchi': [909], 'Jackson': [911], 'A.P.': [912], 'Proc.': [913, 1924, 4649, 4730], 'Natl.': [914, 1925, 4650, 4731], 'Acad.': [915, 1926, 4651, 4732], 'Sci.': [916, 1927, 4652, 4733], 'U.': [917, 1928, 4653, 4734], 'S.': [918, 1929, 4654, 4735], '97:': [921], '2308-2313Crossref': [922], '(255)': [925], '13Yu': [928], 'F.H.': [929], 'Silos-Santiago': [932, 989, 1770, 4777], 'McCormick': [934, 5252], 'K.A.': [935, 1907, 4632, 4713, 5253], 'Lawson': [936, 981, 1762, 4769], 'Ge': [938, 985, 1766, 4773], 'P.': [939, 986, 1688, 1767, 1911, 2064, 2082, 2095, 4636, 4717, 4774], 'Ferriera': [940], 'Lilly': [942], 'DiStefano': [944, 987, 1768, 4775], 'P.S.': [945, 988, 1769, 4776], 'Curtis': [950, 979, 1760, 4767, 5254], 'R.': [951, 980, 1686, 1708, 1761, 1815, 2177, 2179, 4768, 5230, 5255, 5921, 5939], 'Neurosci.': [953, 997, 1262, 1378, 1689, 1778, 4785], '23:': [955], '7577-7585Crossref': [956], 'mechanism(s)': [961], 'different': [965, 1460, 2022, 2888, 2948, 4444, 4573, 4959, 5395, 6284], 'act': [968, 2138], 'modulate': [970, 3892, 5005], 'function': [972, 6107], 'still': [974, 3903, 4847], 'under': [975, 4134, 4193, 4276, 4856, 5580, 5602, 5675], 'investigation': [976], '(14Qu': [977, 1758, 4765], 'Y.': [978, 1237, 1353, 1759, 1892, 4617, 4698, 4766], 'Gilbride': [983, 1764, 4771], 'Mol.': [995, 1776, 2083, 2096, 4783], 'Cell': [996, 1777, 2371, 2511, 4784], '18:': [999, 1780, 4787], '570-580Crossref': [1000, 1781, 4788], '(114)': [1003, 1784, 4791], '15Meadows': [1006, 1787], 'L.S.': [1007, 1788], 'Chen': [1008, 1701, 1789, 1808, 1891, 4609, 4616, 4697, 5223], 'Y.H.': [1009, 1790], 'Powell': [1010, 1791, 1835], 'Clare': [1012, 1793], 'J.J.': [1013, 1794, 2171], '114:': [1018, 1799], '745-753Crossref': [1019, 1800], '(78)': [1022, 1803], '16Isom': [1025], 'Neuroscientist.': [1027], '7:': [1029], '42-54Crossref': [1030], '(281)': [1033], 'Sodium': [1036], 'typically': [1043], 'extensively': [1044], 'glycosylated,': [1045], 'up': [1047], '30%': [1049], 'total': [1052, 2486], 'mass': [1053], 'estimated': [1057], 'be': [1059, 1136, 2850, 4876, 5027, 5284, 5358, 5501, 6042, 6136, 6166, 6304], 'carbohydrate': [1060], '(17Miller': [1061], 'Agnew': [1063], 'W.S.': [1064], 'Levinson': [1065, 1150, 1220, 1302, 1336, 1419, 2547], 'S.R.': [1066, 1151, 1221, 1303, 1337, 1420, 2548], 'Biochemistry.': [1067], '1983;': [1068], '22:': [1069], '462-470Crossref': [1070], '(159)': [1073], '18Roberts': [1076], 'R.H.': [1077], 'Barchi': [1078], 'R.L.': [1079, 1915, 4640, 4721], 'Biol.': [1081, 1097, 1184, 1244, 1360, 1474, 1598, 1616, 2001, 2085, 2098, 2264, 2330, 2404, 2440, 2581, 4044, 4540, 4931, 5482, 6074, 6203], 'Chem.': [1082, 1098, 1185, 1475, 1599, 1617, 2002, 2265, 2331, 2405, 2441, 2582, 4045, 4541, 4932, 5483, 6075, 6204], '1987;': [1083, 1099, 1618], '262:': [1084, 1100, 1619], '2298-2303Abstract': [1085], '19Schmidt': [1092], 'J.W.': [1093], '13713-13723Abstract': [1101], 'Glycosylation': [1108], 'structures': [1109, 1132], 'capped': [1112], '(SA),': [1116], 'carry': [1118], 'negative': [1120, 4686, 5054, 5077], 'charge': [1121], 'physiological': [1123], 'pH.': [1124], 'SA': [1125, 1275, 1450, 1962, 4247, 4400, 6032, 6169], 'attached': [1126, 2833, 5127, 6034, 6121, 6170], 'directly': [1127], 'N-glycosylation': [1131, 1514, 2352, 3827, 4843, 5111], 'important': [1137, 1453, 1943, 5331], 'modulators': [1138], '(20Bennett': [1142, 1294, 1411, 2539], 'Urcan': [1144, 1296, 1413, 2541], 'M.S.': [1145, 1297, 1414, 2542], 'Tinkle': [1146, 1298, 1415, 2543], 'S.S.': [1147, 1299, 1416, 2544], 'Koszowski': [1148, 1300, 1417, 2545], 'A.G.': [1149, 1301, 1418, 2546], 'Gen.': [1153, 1204, 1305, 1320, 1422, 2550, 6094, 6223], '1997;': [1155, 1307, 1424, 1568, 2552], '109:': [1156, 1308, 1425, 2553, 5262], '327-343Crossref': [1157, 1309, 1426, 2554], '(139)': [1160, 1312, 1429, 2557], '21Bennett': [1163, 1432, 2560], 'E.S.': [1164, 1182, 1202, 1318, 1433, 1472, 1999, 2262, 2328, 2384, 2402, 2438, 2561, 2579, 4042, 4538, 4929, 5480, 6072, 6092, 6183, 6201, 6221], '538:': [1168, 1437, 2388, 2565, 6187], '675-690Crossref': [1169, 1438, 2389, 2566, 6188], '(67)': [1172, 1441, 2392, 2569, 6191], '22Johnson': [1175, 2395, 2572, 6194], 'Montpetit': [1177, 1467, 1994, 2257, 2323, 2397, 2433, 2574, 4037, 4533, 4924, 5475, 6067, 6196], 'M.L.': [1178, 1468, 1995, 2258, 2324, 2398, 2434, 2575, 4038, 4534, 4925, 5476, 6068, 6197], 'Stocker': [1179, 1469, 1996, 2259, 2325, 2399, 2435, 2576, 4039, 4535, 4926, 5477, 6069, 6198], 'Bennett': [1181, 1201, 1317, 1471, 1998, 2261, 2327, 2401, 2437, 2578, 4041, 4537, 4928, 5479, 6071, 6091, 6200, 6220], '2004;': [1186, 1476, 1845, 2003, 2266, 2332, 2406, 2442, 2583, 4046, 4542, 4933, 5261, 5484, 5820, 5872, 5966, 6076, 6205], '279:': [1187, 1477, 2004, 2267, 2333, 2407, 2443, 2584, 4047, 4543, 4934, 5485, 6077, 6206], '44303-44310Abstract': [1188, 1478, 2005, 2268, 2334, 2408, 2444, 2585, 4048, 4544, 4935, 5486, 6078, 6207], '23Stocker': [1199, 1315, 6089, 6218], '2006;': [1206, 1322, 6096, 6225], '127:': [1207, 1323, 6097, 6226], '253-265Crossref': [1208, 1324, 6098, 6227], '(52)': [1211, 1327, 6101, 6230], '24Recio-Pinto': [1214, 1330], 'Thornhill': [1216, 1332], 'W.B.': [1217, 1333, 5907], 'Duch': [1218, 1334], 'Urban': [1222, 1338], 'B.W.': [1223, 1339], '1990;': [1225, 1341], '5:': [1226, 1342, 2087], '675-684Abstract': [1227, 1343], '(93)': [1233, 1349], '25Zhang': [1236, 1352], 'Hartmann': [1238, 1354], 'Satin': [1240, 1356], 'Membr.': [1243, 1359], '1999;': [1245, 1361, 1671], '171:': [1246, 1362], '195-207Crossref': [1247, 1363], '(74)': [1250, 1366], '26Tyrrell': [1253, 1369], 'L.': [1254, 1370], 'Renganathan': [1255, 1371], 'Dib-Hajj': [1257, 1373], 'S.D.': [1258, 1374], 'Waxman': [1259, 1375], '21:': [1264, 1380], '9629-9637Crossref': [1265, 1381], 'For': [1269, 3967, 6055], 'example,': [1270, 3968, 6056], 'enzymatic': [1272], 'removal': [1273], 'entire': [1278], 'glycosylation': [1279, 5812, 5856, 5994, 6337], 'structure,': [1280], 'purified,': [1282], 'transfected,': [1283], 'endogenous': [1285], 'shifted': [1287, 2761, 4145, 4683, 4904, 5051, 5456, 5658], 'depolarized': [1292, 1390, 4386, 4833], 'direction': [1293, 4687, 4834, 4913, 5468], 'Additionally,': [1385], 'gated': [1387, 4383], 'more': [1389, 3962, 4385, 5053], 'potentials': [1391, 4148, 5055, 5663], 'mutant': [1396, 3815, 5105], 'Chinese': [1397, 2046, 2113], 'hamster': [1398, 2047, 2114], 'ovary': [1399, 2048, 2115], 'cell': [1400, 1526, 2049, 2109, 2116, 2526, 2640, 2711, 2728, 2796, 4478], 'line': [1401, 2110, 2729], 'deficient': [1404, 2123, 2150], 'its': [1406, 4854], 'ability': [1407, 2055], 'sialylate': [1409, 2057], 'proteins': [1410, 2058, 2130], 'Our': [1444, 2189], 'recent': [1445, 5205], 'work': [1446, 4017, 4505, 5206], 'demonstrated': [1447, 4021, 4507, 4665, 4752], 'role': [1454, 6341], 'β1-dependent': [1456], 'modulation': [1457, 2678, 4442, 4894, 5350, 5380], 'three': [1459, 1512], '(22Johnson': [1465, 1992, 2255, 2321, 2431, 4035, 4531, 4922, 5473, 6065], 'predicted': [1493], 'single': [1497], 'transmembrane-spanning': [1498], 'domain,': [1499, 1503], 'intracellular': [1502, 2648], 'extracellular': [1507], 'N-terminal': [1508], 'end': [1509], 'contains': [1511], 'sites': [1515, 5112], 'immunoglobulin-like': [1518], 'fold': [1519], 'shows': [1521], 'similarity': [1522], 'neural': [1525], 'adhesion': [1527], 'molecule,': [1528], 'contactin': [1529], '(11Isom': [1530, 1639], '27Eubanks': [1557], 'Srinivasan': [1559], 'Dinulos': [1561], 'M.B.': [1562], 'Disteche': [1563], 'C.M.': [1564], 'Neuroreport.': [1567], '8:': [1569], '2775-2779Crossref': [1570], '(20)': [1573], 'external': [1577], 'portion': [1578], 'responsible': [1582, 5090, 5132, 6043], 'efficient': [1584], 'association': [1585, 5173], 'via': [1590], 'disulfide': [1591], 'bonds': [1592], '(28Messner': [1593], 'D.J.': [1594, 1612], '1985;': [1600, 2086], '260:': [1601], '10597-10604Abstract': [1602], '29Wollner': [1609], 'Messner': [1611], '14709-14715Abstract': [1620], 'central': [1632], 'nervous': [1633, 2031], 'system': [1634, 2032], 'cardiac': [1637, 1951, 2034, 4528, 6105], 'tissue': [1638], '30Blackburn-Munro': [1666], 'G.': [1667, 2175], 'Fleetwood-Walker': [1668], 'S.M.': [1669], '90:': [1672], '153-164Crossref': [1673], '(47)': [1676], '31Gastaldi': [1679], 'Robaglia-Schlupp': [1681], 'Massacrier': [1683], 'Planells': [1685], 'Cau': [1687], 'Lett.': [1690], '249:': [1692], '53-56Crossref': [1693], '(34)': [1696], '32Malhotra': [1699, 1806], 'J.D.': [1700, 1807, 1898, 4623, 4704, 5222], 'Abriel': [1705, 1812, 5227], 'Mattei': [1709, 1816, 5231], 'L.N.': [1710, 1817, 5232], 'Brosius': [1711, 1818, 5233], 'F.C.': [1712, 1819, 5234], 'Isom': [1715, 1822, 1922, 4647, 4728, 5237], 'Circulation.': [1717, 1824, 5239, 5260], '103:': [1719, 1826, 5241], '1303-1310Crossref': [1720, 1827, 5242], '(185)': [1723, 1830, 5245], 'general,': [1727], 'voltage': [1735, 1863, 2770, 4668, 4759, 4838, 4980, 5067], 'dependence': [1736, 1864, 4669, 4760, 4981], 'and/or': [1739, 2681, 6021], 'Nav1.8': [1744], 'but': [1745, 3790, 4985, 6244, 6262], 'reported': [1747], 'not': [1749, 2932, 2998, 3934, 5004, 5022, 5171], 'affect': [1750], 'properties': [1753], 'Nav1.3': [1755], '33Vijayaragavan': [1833], 'Kinghorn': [1837], 'I.J.': [1838], 'Chahine': [1839], 'Biochem.': [1841], 'Biophys.': [1842], 'Commun.': [1844], '319:': [1846], '531-540Crossref': [1847], '(45)': [1850], 'loss': [1854], 'resulted': [1857], 'shifts': [1860, 4029, 6239], 'decreases': [1871], 'current': [1874, 2607], 'density': [1875], 'acutely': [1877], 'dissociated': [1878], 'hippocampal': [1879, 4675], 'neurons': [1880, 4676], 'isolated': [1881, 4677], 'mice': [1883, 4679, 4690], 'lacking': [1884, 4680], '(34Chen': [1887, 4612, 4693], 'Bharucha': [1889, 4614, 4695], 'V.': [1890, 2167, 4615, 4696, 5895], 'Brown': [1895, 4620, 4701], 'Jones': [1899, 4624, 4705], 'Avery': [1901, 4626, 4707], 'Gillespie': [1903, 4628, 4709], 'III,': [1904, 4629, 4710], 'Kazen-Gillespie': [1906, 4631, 4712], 'Kazarinova-Noyes': [1908, 4633, 4714], 'Shrager': [1910, 4635, 4716], 'Saunders': [1912, 4637, 4718], 'T.L.': [1913, 4638, 4719], 'Macdonald': [1914, 4639, 4720], 'Ransom': [1916, 4641, 4722], 'B.R.': [1917, 4642, 4723], '99:': [1932, 4657, 4738], '17072-17077Crossref': [1933, 4658, 4739], '(151)': [1936, 4661, 4742], 'modulator': [1944], 'tissues.': [1954], 'Here,': [1955], 'wished': [1957, 1971], 'involved': [1964, 3935, 5803], 'modulating': [1966, 5322], 'also': [1970, 5273], 'SA-dependent': [1976, 2198, 2221, 2235, 3800, 4027, 4063, 4074, 4230, 4513, 4582, 5032, 5437, 5471, 5518, 5529, 5648, 5721, 6257, 6275], 'if': [1980], 'any,': [1981], 'additive': [1983, 2232, 4069, 4233, 4262, 5563, 5732], 'those': [1985, 4151, 4888], 'recently': [1986], 'observed': [1987, 4152, 5151, 6014], 'end,': [2018], 'two': [2021, 2045, 2671, 2947, 4330, 4958, 5343, 5394, 5431, 6283], 'isoforms,': [2026, 2035, 4521], '(central': [2030], 'respectively)': [2036], 'presence': [2039, 2689, 4321, 5374, 6248, 6333], 'absence': [2041, 4209, 5010], 'lines': [2050], 'differ': [2052], 'their': [2054], '(35Deutscher': [2059], 'S.L.': [2060], 'Nuwayhid': [2061], 'Stanley': [2063], 'Briles': [2065], 'E.I.': [2066], 'Hirschberg': [2067], 'C.B.': [2068], '1984;': [2070], '39:': [2071], '295-299Abstract': [2072], '(195)': [2078], '36Stanley': [2081], '923-929Crossref': [2088], '(46)': [2091], '37Stanley': [2094], '1989;': [2099, 5930], '9:': [2100], '377-383Crossref': [2101], '(168)': [2104], 'allows': [2111], 'sialylation,': [2117, 4280, 4324, 5606], 'whereas': [2118, 3929, 4369, 5379], 'cells,': [2120, 2921], 'CMP-sialic': [2126], 'transporter,': [2128], 'produce': [2129], 'essentially': [2133, 2708, 2793, 4336, 4511, 4835, 5573], 'nonsialylated': [2134, 2818, 3113, 3142, 3171, 3200, 3252, 3283, 3312, 3371, 3402, 3431, 3476, 3528, 3561, 3641, 3670, 3699, 3728, 3760, 4379], 'model': [2141], 'inherited': [2144], 'disorder': [2145], 'resulting': [2146, 2621, 4340], 'levels': [2151, 6033, 6117, 6316], 'attached,': [2155], '(CDGS),': [2159], 'type': [2160, 3890, 5154], 'IIf': [2161], '(38Martinez-Duncker': [2162], 'Dupre': [2164], 'Piller': [2166, 2168], 'F.': [2169, 5915], 'Candelier': [2170], 'Trichet': [2172], 'Tchernia': [2174], 'Oriol': [2176], 'Mollicone': [2178], 'Blood.': [2180], '2005;': [2181], '105:': [2182], '2671-2676Crossref': [2183], '(122)': [2186], 'data': [2190, 2532, 2629, 2839, 3880, 3911, 4164, 4433, 5614, 5718, 6060, 6145, 6270], 'indicate': [2191, 5615, 6271, 6295], 'SA-independent': [2200, 2237, 4076, 4585, 4878, 5445, 5608, 6264, 6277], 'mechanisms;': [2201], 'exact': [2203, 5992], 'mechanism': [2204, 6150], 'associates.': [2214, 5367], 'addition,': [2216, 2995, 4795, 5270], 'show': [2218, 3885, 4557, 4798], 'specific': [2227, 4951, 4966, 6173], 'Clones—Nav1.2,': [2245], 'Nav1.5,': [2246, 3928, 5641], 'green': [2248], 'fluorescent': [2249], 'protein': [2250, 5811, 6008], 'described': [2253, 2315, 2382, 2430, 2538, 4891, 6063], 'previously': [2254, 2316, 2381, 2429, 2537, 4890, 6064], 'hβ1': [2280], 'hβ2': [2282, 2472, 2500], 'cDNAs': [2283], 'subcloned': [2285], 'into': [2286], 'bicistronic': [2288], 'vectors,': [2289], 'pIRES-DsRed2': [2290], 'pIRES2-EGFP,': [2292], 'respectively.': [2293], 'This': [2294, 4599, 4996, 5387], 'done': [2296], 'verify': [2298], 'expression': [2300, 5314, 5699], 'each': [2302, 2346, 3821, 4484, 5644, 5795], 'fluorescence.': [2306], 'mutated': [2311, 3831, 5993], 'mutagenesis': [2320], 'Specifically,': [2345, 2738], 'asparagine': [2347, 3822], 'initiates': [2349, 3825], 'site': [2353], '(Asn42,': [2354], 'Asn66,': [2355], 'Asn74)': [2357], 'changed': [2359], 'glutamine': [2362, 3834], 'residue': [2363, 3823, 3835], 'create': [2365], 'β2-ΔN.': [2369], 'Mammalian': [2370], 'Culture': [2372], 'Transfection—Pro5': [2374], 'cells': [2377, 3849, 3981, 4106, 4309, 4751], 'grown': [2379], '(21Bennett': [2383, 6182], 'Transfections': [2419, 2455], 'involving': [2420, 2456], 'carried': [2426], 'out': [2427], 'performed': [2461, 2483, 2506], 'using': [2462, 2484, 2523, 2609, 2656], '2.2': [2463], 'μg': [2464, 2489], 'DNA': [2466, 2491], '(91%': [2467], 'channel,': [2470, 2495], '9%': [2471], 'vector': [2473, 2501], 'cDNAs).': [2474, 2502], 'Triple': [2475], 'transfections': [2476], 'α,': [2478, 6124], 'β1,': [2479, 3970, 4561, 6125], '2.5': [2488], '(80%': [2492], '12%': [2496], 'hβ1,': [2497], '8%': [2499], 'experiments': [2504], '72': [2507], 'h': [2508], 'post-transfection.': [2509], 'Whole': [2510], 'Recording': [2512], 'Data': [2514], 'Analysis—INa': [2515], 'recorded': [2517, 2632], 'room': [2519], 'temperature': [2520], '(∼22': [2521], '°C)': [2522], 'established': [2524], 'patch': [2527], 'clamp': [2528], 'techniques,': [2529], 'pulse': [2530], 'protocols,': [2531], 'analyses,': [2533], 'solutions': [2535, 2613, 2653], 'series': [2597, 2618], 'resistance': [2598, 2619], 'compensated': [2600], '95–98%': [2601], 'all': [2603, 2759, 2808, 2842, 2899, 4180, 4822, 5044, 5109, 5457, 5975, 6002], 'data,': [2604], 'smaller': [2606], 'low': [2611], 'minimized': [2615], 'any': [2616, 3008], 'remaining': [2617], 'error,': [2620], '<1': [2623], 'mV': [2624, 5074], 'error.': [2625], 'All': [2626, 2650], '5': [2635, 5538], 'min': [2636], 'after': [2637], 'attaining': [2638], 'configuration': [2641], 'ensure': [2643], 'complete': [2644], 'dialysis': [2645], 'solution.': [2649], 'filtered': [2655], 'Gelman': [2657], '0.2-μm': [2658], 'filters': [2659], 'immediately': [2660], 'prior': [2661], 'use.': [2663], 'Has': [2665, 4489], 'Opposing': [2666], 'Effects': [2667, 3784, 3945], 'Gating': [2669, 2906, 3018, 3789, 3952, 4178], 'Subunit': [2674, 4500], 'Isoforms—To': [2675], 'dependent': [2686, 2933, 4422, 4917], 'acids,': [2693, 3812, 5378], 'individually': [2698], 'nonsialylating': [2709, 2794], 'lines.': [2712], 'As': [2713, 5099, 5534], 'Fig.': [2716, 3027, 3883, 4252, 4404, 5102], '1,': [2717, 5544], 'co-expression': [2718, 5545], 'generalized': [2732, 4109, 4975], 'steady': [2739, 2780, 2809, 2966, 4138, 4991, 5018, 5655], 'state': [2740, 2781, 2810, 2967, 4139, 4296, 4992, 5019, 5656], '(Fig.': [2742, 2750, 2757, 2783, 2836, 2904, 3865, 4127, 4142, 4176, 4317, 4597, 4994], '1A)': [2743], 'kinetics': [2746], 'fast': [2748, 2755, 4813], '1C)': [2751], 'recovery': [2753, 4811], '1D)': [2758], '(∼8': [2763], 'mV)': [2764, 2897, 4113, 5666], 'left': [2767, 4375], 'along': [2768, 4836], 'axis.': [2771, 4839], 'Note': [2772, 3867, 4259, 4411], '1B).': [2784, 4177], 'line,': [2797], 'measurable': [2801, 4170], 'That': [2806, 4198, 4494, 4815, 5348, 5566, 5650], 'is,': [2807, 4199, 4816, 5349, 5567, 5651], 'kinetic': [2812, 4298], 'characteristics': [2814, 2826, 2903], 'measured': [2815, 2901, 3020, 3034, 4237, 4823, 5049, 5586], 'Nav1.5·β2': [2819], 'nearly': [2822, 2912, 3895, 4851, 5593], 'identical': [2823, 2913, 5594], 'alone': [2829, 3858, 4126, 4316, 5591, 5705, 6254], 'without': [2832], '1).': [2837, 4995, 5715], 'These': [2838, 4883], 'suggest': [2840, 3899, 5719, 6016, 6146], 'assigned': [2851], 'represent,': [2857], 'our': [2859, 4019, 5181, 6059], 'knowledge,': [2860], 'observed.': [2873, 5612], 'Similar': [2874], 'questions': [2875], 'asked': [2877], 'very': [2887], 'results.': [2889], 'uniform': [2893, 4512], '(∼7': [2896], 'four': [2900], '2).': [2905, 4598], 'Nav1.2·β2': [2909, 4747], 'β2-induced': [2925], 'acids.': [2937, 5013], 'opposing': [2941, 4326, 4563, 4578], 'There': [2952], 'modest': [2955], 'inconsistent': [2957], 'slope': [2963], 'factors': [2964], 'relationships': [2971], '(Ka': [2972], 'Ki,': [2974], 'respectively),': [2975], 'has': [2980, 4506, 4510, 4562, 5207, 5391, 5427], 'little': [2981], 'effective': [2987], 'valence': [2989], 'Nav1.5.': [2993, 4571, 5098], 'did': [2997, 5170], 'observe': [2999], 'peak': [3004], 'conductance': [3005], 'values': [3006, 4289, 4392], 'condition': [3009], 'except': [3010], 'parameters': [3019, 3036, 4239, 4826, 4907, 5048, 5460], 'study': [3023, 6324], 'detailed': [3025], '6': [3028, 4253, 4405, 4439, 5540, 5712], 'Table': [3031, 4257, 4409, 5543, 5714], '1.TABLE': [3032], '1The': [3033], '±': [3039, 3041, 3043, 3050, 3052, 3054, 3056, 3059, 3061, 3063, 3065, 3070, 3075, 3080, 3085, 3093, 3122, 3151, 3180, 3212, 3217, 3219, 3224, 3232, 3261, 3263, 3292, 3326, 3331, 3336, 3341, 3351, 3380, 3382, 3411, 3441, 3443, 3445, 3447, 3450, 3452, 3454, 3456, 3488, 3493, 3498, 3500, 3508, 3537, 3539, 3541, 3573, 3578, 3583, 3588, 3596, 3598, 3600, 3602, 3609, 3611, 3613, 3615, 3621, 3650, 3679, 3708, 4084, 4086, 4242, 4244, 4246, 4395, 4397, 4399], 'acidChannel': [3045], 'constructnVaViτhτrec': [3046], '(-120': [3047], 'mV)mVmVmsMsNav1.5+': [3048], 'SA13-29.0': [3049], '2.2-78.7': [3051], '2.52.8': [3053], '0.44.0': [3055], '0.1-': [3057, 3448], 'SA10-29.5': [3058], '1.6-79.5': [3060], '1.52.4': [3062], '0.24.1': [3064], '0.1+': [3066, 3603, 3616], '+': [3068, 3210, 3322, 3324, 3347, 3486, 3571, 3605, 3607, 3618], 'SA11-37.4': [3069], '1.6aSignificant': [3071, 3213], '(p': [3072, 3077, 3082, 3087, 3119, 3148, 3177, 3206, 3214, 3221, 3226, 3258, 3289, 3318, 3328, 3333, 3338, 3343, 3377, 3408, 3437, 3482, 3490, 3495, 3502, 3534, 3567, 3575, 3580, 3585, 3590, 3647, 3676, 3705, 3734, 3738, 3766], '<': [3073, 3078, 3083, 3088, 3215, 3222, 3227, 3329, 3334, 3339, 3344, 3491, 3496, 3503, 3576, 3581, 3586, 3591, 3739], '0.05).-86.1': [3074], '3.2aSignificant': [3076], '0.05).2.0': [3079], '0.1aSignificant': [3081, 3337, 3501, 3589], '0.05).5.6': [3084], '0.3aSignificant': [3086, 3225], '0.05).+': [3089, 3208, 3228, 3320, 3345, 3484, 3504, 3569, 3592], '-': [3091, 3230, 3349, 3506, 3594], 'SA9-28.6': [3092], '0.9bIndicates': [3094], 'dependence.': [3097, 3126, 3155, 3184, 3236, 3267, 3296, 3355, 3386, 3415, 3460, 3512, 3545, 3625, 3654, 3683, 3712, 3744], 'Represents': [3098, 3127, 3156, 3185, 3237, 3268, 3297, 3356, 3387, 3416, 3461, 3513, 3546, 3626, 3655, 3684, 3713, 3745], 'difference': [3101, 3130, 3159, 3188, 3240, 3271, 3300, 3359, 3390, 3419, 3464, 3516, 3549, 3629, 3658, 3687, 3716, 3748], 'parameter': [3104, 3133, 3162, 3191, 3243, 3274, 3303, 3362, 3393, 3422, 3467, 3519, 3552, 3632, 3661, 3690, 3719, 3751, 4288, 4391], 'between': [3105, 3134, 3163, 3192, 3244, 3275, 3304, 3363, 3394, 3423, 3468, 3520, 3553, 3633, 3662, 3691, 3720, 3752], 'sialylated': [3108, 3137, 3166, 3195, 3247, 3278, 3307, 3366, 3397, 3426, 3471, 3523, 3556, 3636, 3665, 3694, 3723, 3755, 4858, 5598, 5677], '(in': [3109, 3114, 3138, 3143, 3167, 3172, 3196, 3201, 3248, 3253, 3279, 3284, 3308, 3313, 3367, 3372, 3398, 3403, 3427, 3432, 3472, 3477, 3524, 3529, 3557, 3562, 3637, 3642, 3666, 3671, 3695, 3700, 3724, 3729, 3756, 3761, 4879], 'cells)': [3111, 3116, 3140, 3145, 3169, 3174, 3198, 3203, 3250, 3255, 3281, 3286, 3310, 3315, 3369, 3374, 3400, 3405, 3429, 3434, 3474, 3479, 3526, 3531, 3559, 3564, 3639, 3644, 3668, 3673, 3697, 3702, 3726, 3731, 3758, 3763], 'complex.': [3118, 3147, 3176, 3205, 3257, 3288, 3317, 3376, 3407, 3436, 3481, 3533, 3566, 3646, 3675, 3704, 3733, 3765, 5600], '≤': [3120, 3149, 3178, 3207, 3259, 3290, 3319, 3378, 3409, 3438, 3483, 3535, 3568, 3648, 3677, 3706, 3735, 3767], '0.05).-78.8': [3121], '1.6bIndicates': [3123], '0.05).2.9': [3150], '0.2bIndicates': [3152, 3264, 3412], '0.05).4.1': [3179], '0.1bIndicates': [3181, 3293, 3457, 3542, 3709], 'SA8-36.5': [3211], '0.05).-82.7': [3216], '3.42.0': [3218], '0.2aSignificant': [3220], '0.05).6.0': [3223], 'SA9-28.7': [3231], '1.1bIndicates': [3233], '0.05).-78.6': [3260], '2.83.3': [3262], '0.05).4.7': [3291], 'SA9-42.1': [3325], '2.1aSignificant': [3327], '0.05).-86.4': [3330], '3.4aSignificant': [3332], '0.05).1.5': [3335, 3587], '0.05).6.7': [3340], '0.4aSignificant': [3342], 'SA10-27.4': [3350], '0.7bIndicates': [3352], '0.05).-80.9': [3379], '1.43.1': [3381], '0.3bIndicates': [3383], '0.05).4.2': [3410], '0.05).Nav1.2+': [3439], 'SA9-14.6': [3440], '1.6-60.5': [3442], '3.13.3': [3444], '0.72.5': [3446], 'SA10-11.7': [3449], '1.8-62.7': [3451], '3.13.1': [3453], '0.52.2': [3455], 'SA12-20.8': [3487], '0.7aSignificant': [3489], '0.05).-68.1': [3492], '2.7aSignificant': [3494], '0.05).2.3': [3497], '0.33.1': [3499], 'SA9-11.9': [3507], '1.0bIndicates': [3509], '0.05).-62.2': [3536], '2.83.2': [3538], '0.62.2': [3540], 'SA9-7.9': [3572], '1.4aSignificant': [3574], '0.05).-50.7': [3577], '2.9aSignificant': [3579], '0.05).7.7': [3582], '1.2aSignificant': [3584], 'SA12-6.3': [3595], '1.1-51.8': [3597], '1.96.3': [3599], '0.91.8': [3601], 'SA12-11.0': [3608], '1.4-61.7': [3610], '1.42.8': [3612], '0.12.3': [3614], 'SA12-6.4': [3620], '1.3bIndicates': [3622, 3680], '0.05).-56.4': [3649], '1.9bIndicates': [3651], '0.05).6.3': [3678], '0.05).1.9': [3707], '0.05).a': [3736], 'Significant': [3737], '0.05).b': [3740], 'Indicates': [3741], '0.05).': [3768], 'Open': [3769], 'table': [3770], 'new': [3773], 'tab': [3774], 'Sialic': [3776], 'Acids': [3777], 'Attached': [3778], 'Fully': [3781], 'Account': [3782, 5741], 'Have': [3791], 'No': [3792], 'Impact': [3793], 'Gating—To': [3796], 'limited': [3808], 'constructed': [3818], 'consensus': [3828], 'sequence': [3829], '(β2-ΔN).': [3836], 'compared': [3851, 4688], 'α·β2': [3862], '3).': [3866, 4863], '(3A).': [3878], '3B': [3884], 'wild': [3889, 5153], 'thereby': [3898, 6157], 'likely': [3902, 5734], 'interacts': [3904], 'Together,': [3909], 'these': [3910, 4271, 4577, 4947, 5717, 6144], 'support': [3912], 'conclusion': [3914], 'account': [3920], 'Are': [3953, 4495, 5516, 5527], 'Apparently': [3954], 'Additive—Sodium': [3955], 'associate': [3960], 'than': [3963, 4119, 5679], 'Nav1.2,': [3969], 'same': [3977, 5144, 5633], 'granule': [3980], 'cerebellum': [3984], '(for': [3985], 'reviews': [3986], 'see': [3987], 'Refs.': [3988], '9Goldin': [3989], 'Scholar': [4001], '39Schaller': [4003], 'K.L.': [4004], 'Caldwell': [4005], 'J.H.': [4006], 'Cerebellum.': [4007], '2:': [4009], '2-9Crossref': [4010], '(98)': [4013], 'Previous': [4016], 'laboratory': [4020], 'induced': [4024, 4121, 4590], 'similar,': [4025], 'uniform,': [4026], 'subunit-specific,': [4073], '(Nav1.2': [4081], 'Nav1.5)': [4083], 'Co-expression': [4097, 4587, 5409, 6233, 6251], '(∼15': [4112], 'greater': [4118, 5661], '4,': [4128, 4437], 'A,': [4129], 'C,': [4130], 'D).': [4132], 'However,': [4133, 5601], 'curves': [4141], '4B)': [4143], 'negatively': [4146], 'similar': [4149, 4311], 'Nav1.5·β1': [4155], '(by': [4157], '∼9': [4158], 'mV),': [4159], 'consistent': [4160, 4413, 6057], 'previous': [4163], 'availability': [4175], 'complexes': [4182, 4293], 'studied': [4183], '(i.e.': [4184], 'Nav1.5·β1,': [4187], 'Nav1.5·β2,': [4188], 'Nav1.5·β1·β2)': [4190], 'conditions': [4194, 4277, 4454, 4859, 5603, 5678], 'reduced': [4196, 4279, 5605, 6007, 6019, 6116], 'sialylation.': [4197, 6009], 'neither': [4200], 'nor': [4202], 'regardless': [4213], 'combination': [4216, 4425, 4472, 5708], 'independent.': [4235, 5565, 5735], 'represented': [4249], 'graphically': [4250], 'listed': [4255, 4407], '1.': [4258, 4410], 'apparent': [4261, 4343], 'values.': [4272], 'Further,': [4273], 'note': [4274], 'there': [4281, 5788, 5846], 'differences': [4285], 'among': [4290], 'studied.': [4294], 'Steady': [4295], '5).': [4318], 'full': [4323], 'balanced': [4337], 'another,': [4339, 6001], 'trimeric': [4344], 'gates': [4348], 'longer': [4365], 'impacted': [4366], 'intact.': [4376], 'potentials.': [4387], 'calculated': [4389], '(among': [4414], 'parameters)': [4416], 'spectrum': [4417], 'conditions.': [4431, 5583], 'Figs.': [4436, 5537], '5,': [4438], 'demonstrate': [4440, 4949], 'post-translational': [4457], 'modification': [4458], 'process': [4462], 'results': [4464, 6294], 'phenotypes': [4468, 6015], 'depending': [4469], 'degree': [4481], 'glycosylated/sialylated.': [4487], 'Multiple': [4490, 5415], 'Mechanisms': [4491, 5416], 'Action': [4493], 'Dependent': [4496], 'Which': [4502], 'It': [4503], 'Associates—Previous': [4504], 'including': [4522], 'adult': [4524, 5279], 'brain': [4525, 5280], '(Nav1.2)': [4526], '(Nav1.5)': [4529], 'Here': [4555], 'unlike': [4560], 'Two': [4572], 'explain': [4576], 'isoform-specific': [4579], 'effects,': [4580], 'mechanism.': [4586], 'general': [4603], 'agreement': [4604], 'observations': [4607], 'co-workers': [4611], 'Scholar),': [4663, 6103], 'who': [4664], 'INa': [4673], 'expressing': [4691], 'Studies': [4745], 'HEK': [4750], 'could': [4755, 5003, 5282], 'positively': [4756], 'here': [4796, 5422, 6061], 'slows': [4801], 'rate': [4803, 4809], 'increases': [4807], 'inactivation.': [4814], 'find': [4818], 'prevented,': [4845], '(Figs.': [4860, 5709], '2': [4861], 'appear': [4874], 'entirely': [4877, 4916, 4999], 'system).': [4882], 'opposite': [4886], 'system.': [4899], 'showed': [4901, 5453], 'hyperpolarized': [4912, 5467, 5662], 'studies': [4948, 6134], 'alternative': [4953], 'modes': [4954], 'SA-dependent,': [5000], 'because': [5001, 6113], 'statistically': [5023], 'significant,': [5024], 'real,': [5029], 'albeit': [5030], 'small,': [5031], 'half-inactivation': [5035, 5066], 'voltage.': [5036], 'reasons': [5038], 'possibility': [5041], 'include:': [5042], '1)': [5043], 'other': [5047, 5848], '2)': [5060], 'mean': [5062], 'value': [5063], 'Nav1.5+β2': [5069], 'does': [5070, 5407], '∼4': [5073], 'direction.': [5078], 'Next,': [5079], 'sought': [5081], 'question': [5083], 'novel': [5093, 5333], '3,': [5103], 'removed,': [5114], 'imposed': [5142], 'deglycosylation': [5169], 'prevent': [5172], 'knowledge': [5182], 'report': [5187, 5421], 'heart,': [5203], 'colocalize': [5213], 'intercalated': [5216], 'disks': [5217], 'ventricular': [5219], 'myocytes': [5220], '(32Malhotra': [5221], '40Maier': [5248], 'S.K.': [5249], '1421-1427Crossref': [5263], '(194)': [5266], 'both': [5276, 5504, 5724], 'fetal': [5277], 'potentially': [5283, 6326], '(41Donahue': [5288], 'L.M.': [5289], 'Coates': [5290], 'P.W.': [5291], 'V.H.': [5293], 'Ippensen': [5294], 'D.C.': [5295], 'Arze': [5296], 'S.E.': [5297, 5299], 'Poduslo': [5298], 'Brain': [5300], '887:': [5303], '335-343Crossref': [5304], '(39)': [5307], 'control': [5311], 'provide': [5318], 'means': [5320], 'brain.': [5329], 'Another': [5330], 'finding': [5334], 'differentially': [5338, 6178], 'isoforms.': [5347], 'appears': [5356], 'SA-independent.': [5386], 'suggests': [5388], 'action:': [5398], 'involves': [5401], 'not.': [5408], 'Provides': [5414], 'Modulating': [5418], 'Function—We': [5420], 'subunits,': [5434], 'causing': [5435], 'Previously,': [5451], 'tested': [5458], 'manner': [5472], 'might': [5500, 6051], 'If': [5507], 'so,': [5508], 'what': [5509], 'gating?': [5515], 'independent?': [5526], '-independent': [5531], 'additive?': [5533], 'indicated': [5552], 'influence': [5570, 5577], 'negated': [5574], 'behavior': [5588], 'independent': [5626, 6290], 'and,': [5627], 'indeed,': [5628], 'additive.': [5630, 6292], 'Interestingly,': [5631], 'true': [5635], 'even': [5642, 5660], 'though': [5643], 'conferred': [5647], 'effects.': [5649], '(except': [5654], 'inactivation)': [5657], '(shifted': [5664, 5687], '∼15': [5665], '∼8–9': [5688], 'mV).': [5689], 'unaffected': [5697], 'either': [5704], '4': [5710], 'Could': [5736], 'Less': [5737], 'Sialylated': [5738], 'Partially': [5740], 'Symptoms': [5743], 'Exhibited': [5744], 'Those': [5746], 'Suffering': [5747], 'Carbohydrate-deficient': [5749], 'Glycoprotein': [5750], 'Syndrome?—Patients': [5751], 'CDGS': [5753, 5976, 5999, 6003, 6109], 'severe': [5756], 'developmental': [5757], 'delay,': [5758], 'neurological': [5759], 'abnormalities,': [5760], 'failure': [5762], 'thrive.': [5764], 'Surviving': [5765], 'adults': [5766], 'suffer': [5767, 6005], 'progressive': [5769], 'atrophy': [5771], '(42Marquardt': [5772], 'Denecke': [5774], 'Eur.': [5776], 'Pediatr.': [5778, 5819, 5871], '162:': [5780], '359-379Crossref': [5781], '(239)': [5784], 'Currently,': [5787], '20': [5790], 'documented': [5791], 'dysfunction': [5798], 'gene': [5801], 'product': [5802], '(16': [5806], '20)': [5808], 'O-linked': [5810], '(43Jaeken': [5813, 5865], 'Carchon': [5815, 5867], 'Curr.': [5817, 5869], 'Opin.': [5818, 5870], '16:': [5821, 5873], '434-439Crossref': [5822, 5874], '(83)': [5825, 5877], '44Jaeken': [5828, 5880], 'Inherit.': [5831, 5883], 'Metab.': [5832, 5884], 'Dis.': [5833, 5885], '99-118Crossref': [5836, 5888], '(128)': [5839, 5891], 'addition': [5843], 'whose': [5850], 'pathology': [5851], 'aberrant': [5855], 'congenital': [5862], 'muscular': [5863], 'dystrophy': [5864], '45Dubowitz': [5894], 'Ann.': [5896], 'Neurol.': [5897], '47:': [5899], '143-144Crossref': [5900], '(16)': [5903], '46Dobyns': [5906], 'Pagon': [5908], 'R.A.': [5909], 'Armstrong': [5910], 'Curry': [5912], 'C.J.': [5913], 'Greenberg': [5914], 'Grix': [5916], 'Holmes': [5918], 'L.B.': [5919], 'Laxova': [5920], 'Michels': [5922], 'V.V.': [5923], 'Robinow': [5924], 'Am.': [5926], 'Med.': [5928, 5965], 'Genet.': [5929], '32:': [5931], '195-210Crossref': [5932], '(373)': [5935], '47Barresi': [5938], 'Michele': [5940], 'Kanagawa': [5942], 'Harper': [5944], 'Dovico': [5946], 'S.A.': [5947, 5951], 'Satz': [5948], 'J.S.': [5949], 'Moore': [5950], 'Zhang': [5952], 'W.': [5953], 'Schachter': [5954], 'Dumanski': [5956], 'J.P.': [5957], 'Cohn': [5958], 'Nishino': [5960], 'Campbell': [5962], 'K.P.': [5963], 'Nat.': [5964], '10:': [5967], '696-703Crossref': [5968], '(230)': [5971], 'Nearly': [5974], 'organ': [5979], 'systems,': [5980], 'prominent': [5982], 'neuronal,': [5985], 'muscular,': [5986], 'cardiovascular': [5988, 6022], 'systems.': [5989], 'structure': [5995], 'varies': [5996], 'victims': [6004], 'Because': [6010], 'many': [6011], 'sluggish': [6017], 'neuromuscular': [6020], 'activity,': [6023, 6049], 'intriguing': [6026], 'consider': [6028], 'lowered': [6031], 'patient': [6040], 'changes': [6045], 'ion': [6047, 6335, 6343], 'contribute': [6052], 'symptoms.': [6054], 'perhaps': [6104], 'patients': [6110], 'compromised': [6112], 'heart.': [6132], 'Such': [6133], 'will': [6135], 'focus': [6138], 'future': [6140], 'investigations.': [6141], 'Summary—Taken': [6142], 'increasingly': [6148], 'channels,': [6155], 'cardiac,': [6158], 'muscle,': [6160], 'potentials,': [6164], 'regulated.': [6167], 'uniformly': [6238], 'SA.': [6250], 'causes': [6255], 'altering': [6307], 'composition': [6312], 'coupled': [6313], 'varying': [6315], 'glycosylation/sialylation.': [6319], 'implications': [6321], 'far-reaching': [6327], 'given': [6328], 'diversity': [6330], 'ubiquitous': [6332], 'function.': [6347], 'acknowledge': [6349], 'technical': [6351], 'expertise': [6352], 'Jean': [6354], 'Harper.': [6355]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2007929236', 'counts_by_year': [{'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-13T20:36:22.724005', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
