Title: Dramatic Improvement of the Enantiomeric Excess in the Asymmetric Conjugate Addition Reaction Using New Experimental Conditions
Abstract: The asymmetric conjugate addition of dialkylzincs is usually performed with Cu(OTf)2 in toluene. We show that by using a copper carboxylate in Et2O, THF, or EtOAc, we strongly improve the enantioselectivity with a given ligand. Ee values up to 99.1% could be reached with new ligands based on the induced atropisomerism of a simple biphenol unit. In addition, we show that the Lewis acid effect of Cu(OTf)2 is not a significant.
Publication Year: 2002
Publication Date: 2002-04-18
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 277
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