Publication Information

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'development': [405], '(Bladt': [406], '1995).': [409], 'A': [410], 'attempts': [413], 'made': [416], 'identify': [418], 'role': [420], 'proto-oncogene': [424, 557], 'neoplasia': [427], '(Di': [428, 446], 'Renzo': [429, 447], '1994).': [432], 'Altered': [433], 'expression': [436, 1094], 'has': [437], 'observed': [439], '1991;': [450], 'Tsarfaty': [451], '1994),': [454], 'it': [456], 'might': [457], 'activated': [459], 'Interestingly,': [465], 'missense': [466, 514], 'mutations,': [467], 'predicted': [468], 'cause': [470], 'constitutive': [471, 500], 'activation': [472, 502], 'absence': [478], 'its': [480, 610, 1027], 'ligand,': [481], 'patients': [490], 'hereditary': [492], 'sporadic': [494, 567, 582, 1021], 'carcinomas,': [497], 'suggesting': [498, 1088], 'contributes': [503], '(Schmidt': [507, 738], 'were': [513, 684, 789, 847, 859, 958], 'changes,': [515], 'located': [516, 720, 1039, 1113], 'exons': [518], '17,': [519], '18': [520], '19': [522], 'gene,': [530], 'homologous': [533], 'proto-oncogenes,': [541], 'are': [543, 599, 625], 'targets': [545], 'naturally': [547], 'occurring': [548], '(Mulligan': [550], 'inherited': [561], 'syndrome,': [563], 'MEN2,': [564], 'thyroid': [568], 'medullary': [569], '(Santoro': [571], '1995),': [574], 'while': [575], 'familial': [580], 'gastro-intestinal': [583], 'stromal': [584], '(Hirota': [586, 613], '1998;': [589], 'Nishida': [590], 'As': [594], 'consequence,': [596], 'mutants': [598], 'constitutively': [600], 'phosphorylated': [601], 'addition': [605], 'stem': [607], 'factor,': [609], 'To': [617], 'determine': [618], 'if': [619, 1013], 'tumorigenesis,': [629], 'sample': [646], '7q31.': [653], 'In': [654, 1066], 'study,': [656], 'examined': [658], 'evidence': [664], '(Table': [676, 855], 'I).': [677], 'Six': [678], 'samples': [679, 749], 'bore': [680], '5': [683, 909], 'basis': [693], 'microsatellite': [695], 'sequenced': [702, 971], 'cDNA': [704, 816], 'dye': [707], 'terminator': [708], 'technique': [709, 977], '(Applied': [710, 785, 943, 984], 'Biosystems,': [711], 'Foster': [712], 'City,': [713], 'CA)': [714, 969], 'HPRC': [737, 1000], 'Total': [742, 759], 'RNA': [743, 760, 781], 'was': [744, 763], 'extracted': [745], 'acid-phenol': [752], 'guanidinium': [753], 'method': [754], '(Chomczynski': [755], 'Sacchi,': [757], '1987).': [758], '(1': [761], 'mg)': [762], 'reverse-transcribed': [764], 'random': [766], 'hexamers': [767], 'MuLV': [769], 'reverse': [770], 'transcriptase': [771], '(RT)': [772], 'according': [773], 'protocol': [776], 'supplied': [777], 'GeneAmp': [780], 'PCR': [782, 845, 857, 901, 956, 963], 'Core': [783], 'kit': [784, 965], 'Biosystems).': [786, 944, 985], 'Primer': [787, 805], 'pairs': [788, 851, 947], 'chosen': [790], 'assistance': [793, 1151], 'computer': [796], 'programme': [797], 'Oligo': [798], '4.0': [799], '(National': [800], 'Biosciences,': [801], 'Plymouth': [802], 'Meeting,': [803], 'MN).': [804], 'designations': [806], 'consist': [807], 'nucleotide': [810], 'position': [811], 'published': [814], 'sequence': [817], '(Park': [818], '1987)': [821], '5′': [825], 'position,': [826], 'followed': [827], 'letter': [830], '"U"': [831], 'upper': [833], '(i.e.,': [834], 'sense': [835], 'strand)': [836], '"L"': [838], 'lower': [840], '(anti-sense': [841], 'strand).': [842], 'Two': [843], 'different': [844], 'procedures': [846], 'performed': [848], 'primer': [850, 946], '3565U/3889L': [852], '3788U/4044L': [854], 'II).': [856], 'amplifications': [858], 'carried': [860], 'out': [861, 1106], 'final': [864, 930], 'volume': [865], '50μl': [867], 'containing': [868], '1μl': [869], 'RT': [872], 'reaction': [873], 'mix,': [874], '20': [875], 'pmol': [876], 'each': [878, 882], 'primer,': [879], '200': [880], 'mM': [881, 885, 888, 893], 'dNTP,': [883], '1.5': [884], 'MgCl2,': [886], '10': [887, 934], 'Tris-HCl': [889], '(pH': [890], '8.3),': [891], '50': [892], 'KCl': [894], '1': [896], 'unit': [897], 'Taq': [898], 'polymerase.': [900], 'consisted': [902], 'initial': [904], 'denaturation': [905], '94°C': [907], 'min': [910, 935], '35': [912], 'cycles': [913], '30': [915, 919], 'sec': [916, 920, 925], '94°C,': [918], '60°C': [922], '45': [924], '60°C,': [927], 'extension': [931], 'step': [932], '74°C,': [937], '9600': [940], 'thermocycler': [942], 'yielded': [948], 'RT-PCR': [950], 'fragment': [951], 'fitting': [952], 'expected': [954], 'size.': [955], 'products': [957], 'purified': [959], 'QIAquick': [962], 'purification': [964], '(Qiagen,': [966], 'Santa': [967], 'Clarita,': [968], 'Dye': [974], 'Terminator': [975], 'Cycle': [976], '373A': [980], 'sequencing': [982], 'system': [983], 'detected': [987], 'no': [988], 'as': [997, 1024], 'region.': [1009], 'This': [1010], 'suggested': [1011], 'that,': [1012], 'indeed': [1018], 'supported': [1025], '30%': [1030], '40%': [1032], 'tumours,': [1034], 'would': [1037], 'outside': [1040], 'consequence': [1052], 'epigenetic': [1054], 'mechanisms': [1055], '(e.g.,': [1056], 'modification': [1057], 'CpG': 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