Title: Chronotropic actions of bPTH-(1–34) in the right atrium of the rat
Abstract:Bovine parathyroid hormone and its N-terminal (1–34) peptide fragment (bPTH-(1–34)) are known to possess direct hypotensive activity in the rat. The purpose of the present study was to determine if bP...Bovine parathyroid hormone and its N-terminal (1–34) peptide fragment (bPTH-(1–34)) are known to possess direct hypotensive activity in the rat. The purpose of the present study was to determine if bPTH-(1–34) possessed a direct chronotropic action as well. In vivo studies revealed that bPTH-(1–34) did produce a chronotropic effect in the rat comprising both a direct component as well as a reflex tachycardia related to its hypotensive actions. In vitro studies of isolated right atria indicated that while bPTH-(1–34) had no positive inotropic effect, it did produce significant chronotropic effects which were direct and dose-dependent. The potency of bPTH-(1–34) was found to be similar to that of isoproterenol, however, it was only one-third as effective as isoproterenol in maximally increasing atrial rate. A slight but significant increase in atrial cyclic AMP was generated prior to the chronotropic actions of bPTH-(1–34).Read More
Publication Year: 1983
Publication Date: 1983-10-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 26
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