Title: COMPARISON OF CHLOROQUINE, QUINACRINE (ATABRINE), AND QUININE IN THE TREATMENT OF ACUTE ATTACKS OF SPOROZOITE-INDUCED VIV AX MALARIA (CHESSON STRAIN) 1
Abstract: C h I o r o q u i n e, 7-chloro-4-(4-diethylamino-lmethyl-butylamino)-quinoline, a synthetic antimalarial agent developed during the war, has proved superior to atabrine and quinine (1).The following investigations were designed to supple- ment other observations in induced malaria and field observations by a study of the relative effec- tiveness of chloroquine, quinacrine, and quinine in the treatment of acute attacks of standardized sporozoite-induced vivax infections. PROCEDURES AND METHODS GeneralDetails of the general procedure and the plan of in- vestigation are reported elsewhere (2).Thirty-nine healthy Caucasian volunteers at Stateville Penitentiary were infected with South Pacific zAvax malaria (Chesson strain) by the bites of ten infected Anopheles quadrimaculatus mosquitoes or by injection of their infected salivary glands.8The Chesson strain (3) was chosen