Title: Carbon 11–Labeled Pittsburgh Compound B Positron Emission Tomographic Amyloid Imaging in Patients With APP Locus Duplication
Abstract: <h3>Objective</h3> To investigate amyloid accumulation by carbon 11–labeled Pittsburgh Compound B (<sup>11</sup>C-PiB) in hereditary cerebral amyloid angiopathy and<i>APP</i>locus duplication. <h3>Design, Setting, and Patients</h3> Positron emission tomography with<sup>11</sup>C-PiB and magnetic resonance imaging were performed for 2 patients, 49-year-old and 60-year-old siblings with<i>APP</i>locus duplication, with hereditary Alzheimer disease and cerebral amyloid angiopathy. <h3>Main Outcome Measure</h3> Change in<sup>11</sup>C-PiB uptake. <h3>Results</h3> Uptake of<sup>11</sup>C-PiB was increased especially in the striatum (caudate nucleus to 225% and 280% of the control mean and putamen to 166% and 185% of the control mean) and in the posterior cingulate (to 168% and 198% of the control mean), and it was marginally increased in other cortical brain areas. The pattern of increased<sup>11</sup>C-PiB uptake was different from that seen in sporadic Alzheimer disease. <h3>Conclusions</h3> Amyloid imaging with<sup>11</sup>C-PiB positron emission tomography is a useful tool for detecting in vivo amyloid accumulation in patients with hereditary cerebral amyloid angiopathy. However, the pattern of<sup>11</sup>C-PiB accumulation differs between patients with typical AD and patients with<i>APP</i>locus duplication.
Publication Year: 2008
Publication Date: 2008-04-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 67
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