Title: Galα(1,3)Gal, the Major Xenoantigen(s) Recognised in Pigs by Human Natural Antibodies
Abstract: Immunological ReviewsVolume 141, Issue 1 p. 169-190 Galα(1,3)Gal, the Major Xenoantigen(s) Recognised in Pigs by Human Natural Antibodies MauroS. Sandrin, MauroS. Sandrin Molecular Immunogenetics Laboratory, Austin Research Institute, Kronheimer Building, Austin Hospital, Heidelberg, Victoria, 3084 Australia.Search for more papers by this authorIan F. C. Mckenzie, Ian F. C. Mckenzie Molecular Immunogenetics Laboratory, Austin Research Institute, Kronheimer Building, Austin Hospital, Heidelberg, Victoria, 3084 Australia.Search for more papers by this author MauroS. Sandrin, MauroS. Sandrin Molecular Immunogenetics Laboratory, Austin Research Institute, Kronheimer Building, Austin Hospital, Heidelberg, Victoria, 3084 Australia.Search for more papers by this authorIan F. C. Mckenzie, Ian F. C. Mckenzie Molecular Immunogenetics Laboratory, Austin Research Institute, Kronheimer Building, Austin Hospital, Heidelberg, Victoria, 3084 Australia.Search for more papers by this author First published: October 1994 https://doi.org/10.1111/j.1600-065X.1994.tb00877.xCitations: 256AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES Ashford, D. A., Alafi, C. D., Gamble, V. M., Mackay, D. J. G., Rademacher, T. W., Williams, P. J., Dwek, R. A., Barclay, A. N., Davis, S. J., Somoza, C., Ward, H. A. & Williams, A. F. (1993) Site specific glycosylation of recombinant rat and human soluble CD4 variants expressed in Chinese hamster ovary cells. J. Biol. Chem. 268, 3260. Blanken, W. M. & van den Eijnden, D. H. (1985) Biosynthesis of terminal Galα1→Galβ→4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaiminide α→3-galactosyltransferase from calf thymus. J. Biol Chem. 260, 12927. Bogman, M. J. J. T., Berden, J. H. M., Cornelissen, I. M. H. A., Maass, C. N. & Koene, R. A. P. (1982) The role of complememt in the induction of acute antibody-mediated vasculitis of rat skin grafts in the mouse. Am. J. Pathol. 109, 97. Bogman, M. J. J. T., Berden, J. H. M., Hagemann, F. H. M., Maass, C. N. & Koene, R. A. F. (1980) Patterns of vascular damage in the antibody-mediated rejection of skin xeno-grafts in the mouse. Am. J. Pathol. 100, 727. Borrebaeck, C. A. K., Malmborg, C. & Ohlin, M. (1993) Does endogenous glycosylation prevent the use of mouse monoclonal antibodies as cancer therapeutics Immunology Today 14, 477. Cairns, T., Hammelmann, W., Gray, D., Welsh, K. & Larson, G. (1994) Enzymatic removal from various tissues of the galactose α1,3galactose target antigen of human anti-species antibodies. Transplant. Proc. (in press). Cooper, D. K. C., Good, A. H., Koren, E., Oriol, R.. Malcolm, A. J., Ippolito, R. M., Neethling, F. A., Ye, Y., Romano, E. & Zuhdi, N. (1993a) Identification of a-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man. Transplant. Immunol. 1, 198. Cooper, D. K. C., Good, A. H., Ye, Y., Koren, E., Oriol, P., Ippolito, R. M., Malcolm, A. J., Neethling, F. A., Romano, E. & Zuhdi, N. (1993b) Specific intravenous carbohydrate therapy: A new approach to the inhibition of antibody mediated rejection following ABO incompatible allografting and discordant xenografts. Transplant. Proc. 25, 377. Cooper, D. K. C., Ye, Y., Kehoe, M., Niekrasz, M., Rolf, L. L., Martin, M., Baker, I., Kosanke, S., Zuhdi, N., Worsley, G. & Romano, E. (1992) A novel approach to “neutralization” of preformed antibodies: cardiac allotransplantation across the ABO blood group barrier as a paradigm of discordant transplantation. Transplant. Proc. 24, 566. Cooper, D. K. C., Ye, Y., Rolf, L. L. Jr. & Zuhdi, N. (1991b) The pig as a potential organ donor for man. In: D. K. C. Cooper, E. Kemp, K. Reemtsma & D. J. G. White eds., Xenotransplantation. Springer-Verlag, Heidelberg , p. 481. Dabkowski, P. L., Angus, P. W., Bishara, N., Sandrin, M. S., Hardy, K. J., Jones, R. McL. & McKenzie, I. F. C. (1994) The removal of antibodies against Gal(al-3)Gal epitope from human plasma prolongs perfusion of rat liver. Transplantation (submitted). Dabkowski, P. L., Vaughan, H. A., McKenzie, I. F. C. & Sandrin, M. S. (1993) Characterisation of the pig a(I-3) galactose transferase - Implications for xenotransplantation. Transplant. Proc. 25, 2921. Eguchi, Y., Itoh, T. & Tomizawa, J. (1991) Antisense RNA. Annu. Rev. Biochem.60, 631. Galili, U.,1993) Evolution and pathophysiology of the human natural anti-α-galactosyl IgG (anti-Gal) antibody. Springer Semin, Immunopathol. 15, 155. Galili, U., Clark, M. R., Shohet, S. B., Buehler, J. & Macher, B. A. (1987) Evolutionary relationship between the natural anti-Gal antibody and the Galα(l, 3)Gal epitope in primates. Proc. Natl Acad. Sci USA 84, 1369. Galili, U., Macher, B. A., Buehler, J. & Shohet, S. B. (1985) Human natural anti-α-galactosyl IgG. II The specific recognition of α(1-3) linked galactose residues. J. Exp. Med. 162, 573. Galili, U., Rachmilewitz, E. A., Peleg, A. & Flechner, I. (1984) A unique natural human IgG antibody with anti-α-galactosyl specificity. J. Exp. Med. 160, 1519. Galili, U., Shohet, S. B., Kobrin, E., Stults, C. L. M. & Macher, B. A. (1988) Man, apes, and Old World monkeys differ from other mammals in the expression of α-galactosyl epitopes on nucleated cells. J. Biol. Chem. 263, 17755. Galili, U. & Swanson, K. (1991) Gene sequences suggest inactivation of α-l,3-galactosyl-transferase in catarrhines after the divergence of apes from monkeys. Proc. Natl. Acad. Sci. USA 88, 7401. Gautreau, C., Cardoso, J., Jeyaraj, P., Houssin, D. & Weill, B. (1993) Relationship between human natural anti-A, anti-B alloantibodies and anti-pig xenoantibodies. Transplant. Proc. 25, 389. Geller, R. L., Bach, F. H., Turman, M. A., Turman, M. A., Casali, P. & Platt, J. L. (1993) Evidence that polyreactive antibodies are deposited in rejected discordant xenografts. Transplantation 55, 168. Good, A. H., Cooper, D. K. C., Malcolm, A. J., Ippolito, R. M., Koren, E., Neethling, F. A., Ye, Y., Zuhdi, N. & Lamontagne, L. R. (1992) Identification of carbohydrate structures that bind antiporcine antibodies: Implications for discordant xenografting in humans. Transplant. Proc. 24, 558. Holgersson, J., Cairns, T. D. H., Karlsson, E. C., Backer, A. E., Breimer, M. E., Taube, D. H., Welsh, K. & Samuelsson, B. E. (1992) Carbohydrate specificity of human immunoglobulin-M antibodies with pig lymphocytotoxic activity Transplant. Proc. 24, 605. Ikematsu, S., Kaname, T. Ozawa, M., Yonezawa, S., Sato, E., Uehara, F., Obama, H., Yamamura, K. & Muramatsu, T. (1993) Transgenic mouse lines with ectopic expression of α-1,3-galactosyltransferase: production and characteristics. Glycobiology 3, 575. Jozìasse, D. H., Sharper, N. L., Kim, D., Van den Eijnden, D. H. & Sharper, J. H. (1992) Murine α1,3-Galactosytransferase a single gene locus specifies four isoforms of the enzyme by alternative splicing. J. Biol. Chem. 267, 5534. Joziasse, D. H., Shaper, J. H, Jabs, E. W. & Sharper, N. L. (1991) Characterization of an α1,3-galactosyltransferase homologue on human chromosome 12 that is organised as a processed pseudogene. J. Biol. Chem. 266, 6991. Joziasse, D. H., Sharper, J. H., Van den Eijnden, D. H., van Tunen, A. J. & Sharper, N. L. (1989) Bovine α1,3-Galactosytransferase: isolation and characterization of a cDNA clone. Identification of homologous sequences in human genomic DNA. J. Biol. Chem. 264, 14290. Karlsson, E., Cairns, T., Holgersson, J., Welsh, K. & Samulesson, B. (1993) Pig to human xenotransplantation, confirmation of the major target epitope of preformed human natural IgG and IgM anti-pig terminal galactoseα 1,3 galactose. Glycoconj. J. 10, 297 (abstr.). Koren, E., Neethling, F. A., Ye, Y., Niekrasz, M., Baker, J., Martin, M., Zuhdi, N. & Cooper, D. K. C. (1992) Heterogeneity of performed human antipig xenogeneic antibodies. Transplant. Proc. 24, 598. Larsen, R. D., Rajan, V. P., Ruff, M. M., Kukowska-Latallo, J., Cummings, R. D. & Lowe, J. B. (1989) Isolation of a cDNA encoding a murine UDPgalactose:β-D-galactosyl- 1,4-N-acetyl-D-glucosaminide α:-1,3-galactosyltransferase: Expression cloning by gene transfer. Proc. Natl Acad Sci. USA 86, 8227. Larsen, R. D., Rivera-Marrero, C. A., Ernst, L. K., Cummings, R. D. & Lowe, J. B. (1990) Frameshift and non sense mutations in a human genomic sequence homologous to a murine UDP-Gal:β-D-Gal 1,4-D-GlcNAcα 1,3-galactosyltransferase cDNA. J. Biol. Chem. 265, 7055. Lattine, D., Vitiello, D. M., Sachs, D. H. & Sykes, M. (1994) Tolerance to discordant xeno-grafts: I Sharing of human natural antibody determinants on miniature swine bone marrow and endothelial cells. Transplantation 57, 238. Makowka, L., Wu, G. D., Hoffman, A., Podesta, L., Sher, L., Tuso, P. J., Chapman, F. A., Cosenza, C., Yasunaga, C. & Cramer, D. V. (1994) Immunohistopathologic lesions associated with the rejection of a pig-to-human liver xenograft. Transplant. Proc. (in press). McKenzie, I. F. C. (1969) Antibodies and organ transplantation: A study of the role of humoral antibodies in allograft and xenograft rejection. PhD thesis. The University of Melbourne. McKenzie, I. F. C., Stocker, J., Ting, A. & Morris, P. J. (1968) Human lymphocytotoxic and hemagglutinating activity against sheep and pig cells. Lancet 2, 386. McKenzie, I. F. C., Xing, P., Vaughan, H. A., Prenzoska, J., Dabkowski, P. L. & Sandrin, M. S. (1994) Distribution of the Major Xenoantigen (Gal(al-3)Gal) for Pig to Human Xenografts. Transplant Immunol. 2, 81. Niekrasz, M., Ye, Y., Rolf, L. L. & Zuhdi, N. (1992) The pig as a potential donor for man. Transplant. Proc. 24, 625. Platt, J. L. & Bach, F. H. (1991) Discordant xenografting: challenges and controversies. Current Opinions in Immunology 3, 735. Platt, J. L., Fischel, R. J., Matas, A. J., Reif, S. A., Bolman, R. M. & Bach, F. H. (1991) Immunopathology of hyperacute rejection in swine to primate model. Transplantation, 52, 214. Platt, J. L., & Holznaecht, Z. E. (1994) Porcine platelet antigens recognized by human xenoreactive natural antibodies. Transplantation 57, 327. Platt, J. L., Lindman, B. J., Chen, H., Spitalnik, S. L. & Bach, F. H. (1990a) Endothelial cell antigens recognized by xenoreactive human natural antibodies. Transplantation 50, 817. Platt, J. L., Vercellotti, G. M., Dalmasso, A. P., Matas, A. J., Bolman, R. M., Najarian, J. S. & Bach, F.H. (1990b) Transplantation of discordant xenografts: a review of progress. Immunology Today, 11, 450. Ramasamy, R. (1994) Is malaria linked to the adherence of a-galactosyl epitopes in Old World primates Immunology Today 15, 140. Ratner, A. J., Canhui, H., Pepino, P., Sanchez, J. A., Edwards, N., Watkins, J. F., Xu, H., Reemtsma, K., Rose, E. A. & Berger, C. (1992) Lymphocyte xenoantigens recognised by preformed antibodies. Transplant. Proc. 24, 583. Sandrin, M. S., Dabkowski, P. L., Henning, M. M., Mouhthouris, E. & McKenzie, I. F. C. (1994a) The isolation and characterisation of cDNA encoding the pig α(1,3)galactosyl transferase, encoding the major xenoepitope recognised by naturally occurring human antibodies. Xenotransplantation (in press). Sandrin, M. S., Vaughan, H. A., Dabkowski, P. L. & McKenzie, I. F. C. (1993a) Anti-pig antibodies in serum react predominantly with Galα(1,3)Gal epitopes. Proc. Natl. Acad. Sci. USA 90, 11391. Sandrin, M. S., Vaughan, H. A., Dabkowski, P. L. & McKenzie, I. F. C. (1993b) Studies on Human Naturally Occurring antibodies to Pig Xenoantigens. Transplant. Proc. 25, 2917. Sandrin, M. S., Vaughan, H. A. & McKenzie, I.F.C. (1994b) Identification of Gal(α1,3)Gal as the major epitope for pig-to-human vascularised xenografts. Transplantation Reviews 8, 134. Scaapherder, A. F. M., Daha, M. R., van der Woude, F. J., Bruijn, J. A. & Gooszen, H. G. (1993) IgM, IgG and IgA antibodies in human sera directed against porcine islets of Langerhans. Transplantation 56, 1576. Symons, R. H. (1992) Small catalytic RNAs. Annu. Rev. Biochem. 61, 641. Thall, A. & Galili, U. (1990) Distribution of Galα1→3Galβl→3GlcNAc residues on secreted mammalian glycoproteins (thyroglobulin, fibrinogen, and immunoglobulin G) as measured by a sensitive solid-phase radioimmunoassay. Biochemistry 29, 3959. Tuso, P. J., Cramer, D. V., Middleton, Y. D., Kearns-Jonker, M., Yasunaga, C., Cosenza, C. A., Davis, W. C., Wu, G. D. & Makowka, L. (1993) Pig aortic endothelial cell antigens recognised by human IgM natural antibodies Transplantation 56, 651. Vaughan, H. A., Dabkowski, P. L., McKenzie, I. F. C. & Sandrin, M. S. (1993) Biochemical analysis of the major pig xenoantigens recognized by humans. Transplant. Proc. 25, 2919. Vaughan, H. A., Loveland, B. E. & Sandrin, M. S. (1994b) Galα(1,3)Gal is the major xenoepitope expressed on pig endothelial cells recognised by naturally occurring cyto- toxic human antibodies. Transplantation (in press). Vaughan, H. A., McKenzie, I. F. C., & Sandrin, M. S. (1994b) Biochemical studies of pig xenoantigens detected by naturally occurring human antibodies. Transplantation (in press). Watkins, W. M. (1980) Biochemistry and genetics of the ABO, Lewis, and P blood group systems. Adv. Hum. Genet. 10, 1. Watts, J. McK., Douglas, M. C., Dudley, H. A. F., Gurr, F. W. & Owen, J. A. (1967) Heterologous Liver perfusions in acute liver failure. Brit. Med. J. 2, 341. Welsh, K. I., Taube, D. H., Thick, M., Palmer, A., Stevens, N. & Binns, R. (1991) Human antibodies to pig determinants and their association with hyperacute rejection. In: D. K. C. Cooper, E. Kemp, K. Reemtsma & D. J. G. White eds. Xenotransplantation. Springer-Verlag, Heidelberg , p. 501. Yamamoto, F., Clausen, H., White, T., Marken, J. & Hakomori, S. (1990) Molecular genetic basis of the histo-blood group ABO system. Nature 345, 229. Yang, Q., Bollinger, R. R. & De Buysscher, E. V. (1992) Xenoantigens expressed on swine erythrocytes, lymphoblastoid cells, and endothelial cells. Transplant. Proc. 24, 593. Citing Literature Volume141, Issue1October 1994Pages 169-190 ReferencesRelatedInformation
Publication Year: 1994
Publication Date: 1994-10-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 308
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot