Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2007069042', 'doi': 'https://doi.org/10.1016/j.vaccine.2004.11.003', 'title': 'Protein modifications in the plant secretory pathway: current status and practical implications in molecular pharming', 'display_name': 'Protein modifications in the plant secretory pathway: current status and practical implications in molecular pharming', 'publication_year': 2004, 'publication_date': '2004-12-15', 'ids': {'openalex': 'https://openalex.org/W2007069042', 'doi': 'https://doi.org/10.1016/j.vaccine.2004.11.003', 'mag': '2007069042', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15734039'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.vaccine.2004.11.003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S27359860', 'display_name': 'Vaccine', 'issn_l': '0264-410X', 'issn': ['0264-410X', '1873-2518'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5062032522', 'display_name': 'Loı̈c Faye', 'orcid': 'https://orcid.org/0009-0001-1231-3253'}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I62396329', 'display_name': 'Université de Rouen Normandie', 'ror': 'https://ror.org/03nhjew95', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I4210105918', 'https://openalex.org/I62396329']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Loïc Faye', 'raw_affiliation_strings': ['CNRS UMR 6037-IFRMP 23-GDR 2590, Université de Rouen-Bâtiment de Biologie (extension), Blvd de Broglie, 76821 Mont Saint Aignan Cedex, France.'], 'affiliations': [{'raw_affiliation_string': 'CNRS UMR 6037-IFRMP 23-GDR 2590, Université de Rouen-Bâtiment de Biologie (extension), Blvd de Broglie, 76821 Mont Saint Aignan Cedex, France.', 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I62396329']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051342023', 'display_name': 'Aurélia Boulaflous', 'orcid': 'https://orcid.org/0000-0003-1378-2569'}, 'institutions': [{'id': 'https://openalex.org/I62396329', 'display_name': 'Université de Rouen Normandie', 'ror': 'https://ror.org/03nhjew95', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I4210105918', 'https://openalex.org/I62396329']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Aurelia Boulaflous', 'raw_affiliation_strings': ['CNRS UMR 6037-IFRMP 23-GDR 2590, Université de Rouen-Bâtiment de Biologie (extension), Blvd de Broglie, 76821 Mont Saint Aignan Cedex, France.'], 'affiliations': [{'raw_affiliation_string': 'CNRS UMR 6037-IFRMP 23-GDR 2590, Université de Rouen-Bâtiment de Biologie (extension), Blvd de Broglie, 76821 Mont Saint Aignan Cedex, France.', 'institution_ids': ['https://openalex.org/I62396329', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008334437', 'display_name': 'Meriem Benchabane', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I43406934', 'display_name': 'Université Laval', 'ror': 'https://ror.org/04sjchr03', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I43406934']}, {'id': 'https://openalex.org/I62396329', 'display_name': 'Université de Rouen Normandie', 'ror': 'https://ror.org/03nhjew95', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I4210105918', 'https://openalex.org/I62396329']}], 'countries': ['CA', 'FR'], 'is_corresponding': False, 'raw_author_name': 'Meriem Benchabane', 'raw_affiliation_strings': ['CNRS UMR 6037, IFRMP 23, GDR 2590, Université de Rouen-Bâtiment de biologie (extension), Blvd de Broglie, 76821 Mont Saint Aignan Cedex, France', 'CRH/INAF, Département de phytologie, Pavillon de l’INAF, Université Laval, Sainte-Foy, Que., Canada G1K 7P4'], 'affiliations': [{'raw_affiliation_string': 'CNRS UMR 6037, IFRMP 23, GDR 2590, Université de Rouen-Bâtiment de biologie (extension), Blvd de Broglie, 76821 Mont Saint Aignan Cedex, France', 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I62396329']}, {'raw_affiliation_string': 'CRH/INAF, Département de phytologie, Pavillon de l’INAF, Université Laval, Sainte-Foy, Que., Canada G1K 7P4', 'institution_ids': ['https://openalex.org/I43406934']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000417594', 'display_name': 'Véronique Gomord', 'orcid': 'https://orcid.org/0000-0001-7062-9136'}, 'institutions': [{'id': 'https://openalex.org/I62396329', 'display_name': 'Université de Rouen Normandie', 'ror': 'https://ror.org/03nhjew95', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I4210105918', 'https://openalex.org/I62396329']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Véronique Gomord', 'raw_affiliation_strings': ['CNRS UMR 6037-IFRMP 23-GDR 2590, Université de Rouen-Bâtiment de Biologie (extension), Blvd de Broglie, 76821 Mont Saint Aignan Cedex, France.'], 'affiliations': [{'raw_affiliation_string': 'CNRS UMR 6037-IFRMP 23-GDR 2590, Université de Rouen-Bâtiment de Biologie (extension), Blvd de Broglie, 76821 Mont Saint Aignan Cedex, France.', 'institution_ids': ['https://openalex.org/I62396329', 'https://openalex.org/I1294671590']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045176518', 'display_name': 'Dominique Michaud', 'orcid': 'https://orcid.org/0000-0002-5177-1142'}, 'institutions': [{'id': 'https://openalex.org/I43406934', 'display_name': 'Université Laval', 'ror': 'https://ror.org/04sjchr03', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I43406934']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Dominique Michaud', 'raw_affiliation_strings': ['CRH/INAF, Département de phytologie, Pavillon de l’INAF, Université Laval, Sainte-Foy, Que., Canada G1K 7P4'], 'affiliations': [{'raw_affiliation_string': 'CRH/INAF, Département de phytologie, Pavillon de l’INAF, Université Laval, Sainte-Foy, Que., Canada G1K 7P4', 'institution_ids': ['https://openalex.org/I43406934']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3500, 'currency': 'USD', 'value_usd': 3500, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.206, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 218, 'citation_normalized_percentile': {'value': 0.985816, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '23', 'issue': '15', 'first_page': '1770', 'last_page': '1778'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12856', 'display_name': 'Production of Recombinant Pharmaceuticals in Plants', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12856', 'display_name': 'Production of Recombinant Pharmaceuticals in Plants', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12477', 'display_name': 'Immunotoxin Therapy for Cancer Treatment', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10240', 'display_name': 'Elicitor Signal Transduction for Metabolite Production', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/plant-molecular-farming', 'display_name': 'Plant Molecular Farming', 'score': 0.567724}, {'id': 'https://openalex.org/keywords/molecular-pharming', 'display_name': 'Molecular Pharming', 'score': 0.565764}, {'id': 'https://openalex.org/keywords/glycosylation-engineering', 'display_name': 'Glycosylation Engineering', 'score': 0.513663}, {'id': 'https://openalex.org/keywords/secretory-protein', 'display_name': 'Secretory protein', 'score': 0.4903076}], 'concepts': [{'id': 'https://openalex.org/C2777313579', 'wikidata': 'https://www.wikidata.org/wiki/Q898365', 'display_name': 'Glycosylation', 'level': 2, 'score': 0.6376779}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5278841}, {'id': 'https://openalex.org/C156399914', 'wikidata': 'https://www.wikidata.org/wiki/Q7444454', 'display_name': 'Secretory protein', 'level': 3, 'score': 0.4903076}, {'id': 'https://openalex.org/C6492254', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretory pathway', 'level': 4, 'score': 0.4642414}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.46378908}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.43353596}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.36390162}, {'id': 'https://openalex.org/C49039625', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretion', 'level': 2, 'score': 0.34133333}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.25892025}, {'id': 'https://openalex.org/C119062480', 'wikidata': 'https://www.wikidata.org/wiki/Q83181', 'display_name': 'Golgi apparatus', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D010940', 'descriptor_name': 'Plant Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D010944', 'descriptor_name': 'Plants', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006031', 'descriptor_name': 'Glycosylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010447', 'descriptor_name': 'Peptide Hydrolases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010447', 'descriptor_name': 'Peptide Hydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010940', 'descriptor_name': 'Plant Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D010940', 'descriptor_name': 'Plant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010944', 'descriptor_name': 'Plants', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010944', 'descriptor_name': 'Plants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.vaccine.2004.11.003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S27359860', 'display_name': 'Vaccine', 'issn_l': '0264-410X', 'issn': ['0264-410X', '1873-2518'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-01942853', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.science/hal-01942853', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15734039', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 68, 'referenced_works': ['https://openalex.org/W1482758805', 'https://openalex.org/W1750419609', 'https://openalex.org/W1860334080', 'https://openalex.org/W1893730694', 'https://openalex.org/W1968224363', 'https://openalex.org/W1973214902', 'https://openalex.org/W1976107624', 'https://openalex.org/W1978608343', 'https://openalex.org/W1985492583', 'https://openalex.org/W1991263759', 'https://openalex.org/W1991810608', 'https://openalex.org/W1993517499', 'https://openalex.org/W1996211163', 'https://openalex.org/W2002891661', 'https://openalex.org/W2013156671', 'https://openalex.org/W2016480316', 'https://openalex.org/W2018212967', 'https://openalex.org/W2019169932', 'https://openalex.org/W2024028932', 'https://openalex.org/W2027504235', 'https://openalex.org/W2029625075', 'https://openalex.org/W2035075241', 'https://openalex.org/W2035851443', 'https://openalex.org/W2036949542', 'https://openalex.org/W2038180030', 'https://openalex.org/W2038204573', 'https://openalex.org/W2038933967', 'https://openalex.org/W2039787380', 'https://openalex.org/W2040820986', 'https://openalex.org/W2042502086', 'https://openalex.org/W2047731143', 'https://openalex.org/W2055219332', 'https://openalex.org/W2063806420', 'https://openalex.org/W2065232854', 'https://openalex.org/W2066395560', 'https://openalex.org/W2082528610', 'https://openalex.org/W2091334328', 'https://openalex.org/W2099961816', 'https://openalex.org/W2102204014', 'https://openalex.org/W2103776223', 'https://openalex.org/W2113722221', 'https://openalex.org/W2117398821', 'https://openalex.org/W2123136958', 'https://openalex.org/W2128813939', 'https://openalex.org/W2132177439', 'https://openalex.org/W2135317393', 'https://openalex.org/W2139111319', 'https://openalex.org/W2141353547', 'https://openalex.org/W2144135799', 'https://openalex.org/W2147406558', 'https://openalex.org/W2148805317', 'https://openalex.org/W2163611993', 'https://openalex.org/W2165832011', 'https://openalex.org/W2166027547', 'https://openalex.org/W2167381455', 'https://openalex.org/W2171120420', 'https://openalex.org/W2255228899', 'https://openalex.org/W2313731949', 'https://openalex.org/W2324251256', 'https://openalex.org/W2337357147', 'https://openalex.org/W2338266679', 'https://openalex.org/W2416206049', 'https://openalex.org/W2416878139', 'https://openalex.org/W2504801128', 'https://openalex.org/W349823405', 'https://openalex.org/W4244888216', 'https://openalex.org/W4252043057', 'https://openalex.org/W625365729'], 'related_works': ['https://openalex.org/W4386845187', 'https://openalex.org/W4379054467', 'https://openalex.org/W3086093045', 'https://openalex.org/W2898878467', 'https://openalex.org/W2753518337', 'https://openalex.org/W2523520718', 'https://openalex.org/W2381607572', 'https://openalex.org/W2014853854', 'https://openalex.org/W2006943139', 'https://openalex.org/W1996694105'], 'abstract_inverted_index': {'Plants': [0], 'have': [1], 'become,': [2], 'over': [3], 'the': [4, 18, 25, 79, 87, 95], 'last': [5], 'ten': [6], 'years,': [7], 'a': [8], 'suitable': [9, 55], 'alternative': [10], 'to': [11, 45], 'microbial': [12], 'and': [13, 31, 36, 54, 69], 'animal': [14], 'cell': [15], 'factories': [16], 'for': [17, 51], 'production': [19, 33], 'of': [20, 29, 34, 57, 72, 90, 97], 'clinically-useful,': [21], 'therapeutic': [22, 59], 'proteins.': [23, 60], 'Besides': [24], 'well': [26], 'known': [27], 'advantage': [28], 'low-cost': [30], 'large-scale': [32], 'safe': [35], 'biologically': [37], 'active': [38], 'mammalian': [39], 'proteins,': [40], 'plants': [41], 'also': [42, 85], 'are': [43], 'able': [44], 'perform': [46], 'most': [47], 'post-translational': [48], 'maturations': [49], 'required': [50], 'biological': [52], 'activity': [53], 'pharmacokinetics': [56], 'recombinant': [58], 'In': [61], 'this': [62], 'short': [63], 'review': [64], 'we': [65], 'focus': [66], 'on': [67, 94], 'glycosylation': [68], 'proteolytic': [70], 'processing': [71], 'plant-made': [73], 'pharmaceuticals': [74], 'during': [75], 'their': [76], 'transport': [77], 'through': [78], 'plant': [80, 98], "cell's": [81], 'secretory': [82], 'pathway.': [83], 'We': [84], 'address': [86], 'practical': [88], 'implications': [89], 'these': [91], 'important': [92], 'processes': [93], 'effectiveness': [96], 'molecular': [99], 'pharming': [100], 'systems.': [101]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2007069042', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-09-19T21:00:53.104123', 'created_date': '2016-06-24'}