Title: Solubility enhancement of low soluble biologically active compounds—temperature and cosolvent dependent inclusion complexation
Abstract: The solubility enhancement of biologically active compounds was analysed in dependence on temperature, amount of cosolvents and on β-cyclodextrin as complexing agent. The analysis was performed for the systemic fungicide triflumizole (TF), a poorly water soluble compound. All parameters lead to an improvement of the solubility, the largest effect was obtained for host–guest complexation with β-cyclodextrin. Generally, the combination of cosolvents and β-cyclodextrin does not increase the solubility of the compound, because cosolvents destabilize the inclusion complex. At higher cosolvent concentrations the solubility of TF is mainly determined by the solubility of the free non-complexed compound in the solvent mixtures. Raising temperature enhances the solubility in any cases. It could be shown that the temperature dependence of the solubility of TF is controlled by the solubility in the solvent mixtures and not by the inclusion reaction.
Publication Year: 2003
Publication Date: 2003-04-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 29
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