Title: <b>Immunohistological differentiation of benign thyroid follicular cell tumors from malignant ones: Usefulness of anti‐peroxidase and JT‐95 antibodies</b>
Abstract: An immunohistological investigation using anti‐thyroid peroxidase (PO) and JT‐95 (JT) antibodies was conducted on surgical specimens of papillary carcinoma ( n = 12), follicular carcinoma ( n = 8), follicular adenoma with prominent papillary structure ( n = 12), follicular adenoma ( n = 8) and adenomatous goiter ( n = 8). In benign lesions, follicle‐forming and papillae‐forming epithelia showed positive staining with anti‐PO antibody. In 26 of 28 benign lesions, PO‐positive areas covered 50% or more of the cut surface area of the lesions. However in carcinomas, PO‐positive areas were non‐existent (13/20) or only focal (7/20) and the papillae did not stain. The incidence of JT‐positive cases was higher in papillary carcinomas (12/12) than in other lesions (13/36). JT‐positive areas were much wider than PO‐positive areas in papillary carcinomas, whereas in benign lesions, PO‐positive areas were wider than or at least roughly equal to, JT‐positive areas. Follicular carcinomas did not stain or stained only focally with these antibodies. In conclusion, these two antibodies seem useful in differentiating benign from malignant follicular cell tumors.
Publication Year: 1993
Publication Date: 1993-11-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 18
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