Publication Information

{'id': 'https://openalex.org/W2006607885', 'doi': 'https://doi.org/10.1371/journal.pone.0062839', 'title': 'Use of Natural Products as Chemical Library for Drug Discovery and Network Pharmacology', 'display_name': 'Use of Natural Products as Chemical Library for Drug Discovery and Network Pharmacology', 'publication_year': 2013, 'publication_date': '2013-04-25', 'ids': {'openalex': 'https://openalex.org/W2006607885', 'doi': 'https://doi.org/10.1371/journal.pone.0062839', 'mag': '2006607885', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23638153', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3636197'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0062839', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0062839&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0062839&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008573611', 'display_name': 'Jiangyong Gu', 'orcid': 'https://orcid.org/0000-0002-3654-2640'}, 'institutions': [{'id': 'https://openalex.org/I4391768055', 'display_name': 'State Key Laboratory of Rare Earth Materials Chemistry and Application', 'ror': 'https://ror.org/04vgnd506', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I20231570', 'https://openalex.org/I4391768055']}, {'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiangyong Gu', 'raw_affiliation_strings': ['Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Material Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, PR China.'], 'affiliations': [{'raw_affiliation_string': 'Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Material Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, PR China.', 'institution_ids': ['https://openalex.org/I4391768055', 'https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075725401', 'display_name': 'Yuanshen Gui', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210116048', 'display_name': 'Beijing National Laboratory for Molecular Sciences', 'ror': 'https://ror.org/02601yx74', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210116048']}, {'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I4391768055', 'display_name': 'State Key Laboratory of Rare Earth Materials Chemistry and Application', 'ror': 'https://ror.org/04vgnd506', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I20231570', 'https://openalex.org/I4391768055']}, {'id': 'https://openalex.org/I52158045', 'display_name': 'China Agricultural University', 'ror': 'https://ror.org/04v3ywz14', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I52158045']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuanshen Gui', 'raw_affiliation_strings': ['Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Material Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, P. R. China', 'Institute of Science and Technology, China Agricultural University, Beijing, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Material Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, P. R. China', 'institution_ids': ['https://openalex.org/I4210116048', 'https://openalex.org/I20231570', 'https://openalex.org/I4391768055']}, {'raw_affiliation_string': 'Institute of Science and Technology, China Agricultural University, Beijing, P. R. China', 'institution_ids': ['https://openalex.org/I52158045']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045796734', 'display_name': 'Lirong Chen', 'orcid': 'https://orcid.org/0000-0002-7302-5458'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I4391768055', 'display_name': 'State Key Laboratory of Rare Earth Materials Chemistry and Application', 'ror': 'https://ror.org/04vgnd506', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I20231570', 'https://openalex.org/I4391768055']}, {'id': 'https://openalex.org/I4210116048', 'display_name': 'Beijing National Laboratory for Molecular Sciences', 'ror': 'https://ror.org/02601yx74', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210116048']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lirong Chen', 'raw_affiliation_strings': ['Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Material Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Material Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, P. R. China', 'institution_ids': ['https://openalex.org/I20231570', 'https://openalex.org/I4391768055', 'https://openalex.org/I4210116048']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100887791', 'display_name': 'Gu Yuan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210116048', 'display_name': 'Beijing National Laboratory for Molecular Sciences', 'ror': 'https://ror.org/02601yx74', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210116048']}, {'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I4391768055', 'display_name': 'State Key Laboratory of Rare Earth Materials Chemistry and Application', 'ror': 'https://ror.org/04vgnd506', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I20231570', 'https://openalex.org/I4391768055']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Gu Yuan', 'raw_affiliation_strings': ['Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Material Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Material Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, P. R. China', 'institution_ids': ['https://openalex.org/I4210116048', 'https://openalex.org/I20231570', 'https://openalex.org/I4391768055']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058555512', 'display_name': 'Huizhe Lu', 'orcid': 'https://orcid.org/0000-0003-1061-9387'}, 'institutions': [{'id': 'https://openalex.org/I4391768055', 'display_name': 'State Key Laboratory of Rare Earth Materials Chemistry and Application', 'ror': 'https://ror.org/04vgnd506', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I20231570', 'https://openalex.org/I4391768055']}, {'id': 'https://openalex.org/I4210116048', 'display_name': 'Beijing National Laboratory for Molecular Sciences', 'ror': 'https://ror.org/02601yx74', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210116048']}, {'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I52158045', 'display_name': 'China Agricultural University', 'ror': 'https://ror.org/04v3ywz14', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I52158045']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hui-Zhe Lu', 'raw_affiliation_strings': ['Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Material Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, P. R. China', 'Institute of Science and Technology, China Agricultural University, Beijing, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Material Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, P. R. China', 'institution_ids': ['https://openalex.org/I4391768055', 'https://openalex.org/I4210116048', 'https://openalex.org/I20231570']}, {'raw_affiliation_string': 'Institute of Science and Technology, China Agricultural University, Beijing, P. R. China', 'institution_ids': ['https://openalex.org/I52158045']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103940920', 'display_name': 'Xiaojie Xu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I4391768055', 'display_name': 'State Key Laboratory of Rare Earth Materials Chemistry and Application', 'ror': 'https://ror.org/04vgnd506', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I20231570', 'https://openalex.org/I4391768055']}, {'id': 'https://openalex.org/I4210116048', 'display_name': 'Beijing National Laboratory for Molecular Sciences', 'ror': 'https://ror.org/02601yx74', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210116048']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaojie Xu', 'raw_affiliation_strings': ['Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Material Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Material Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, P. R. China', 'institution_ids': ['https://openalex.org/I20231570', 'https://openalex.org/I4391768055', 'https://openalex.org/I4210116048']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 18.546, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 386, 'citation_normalized_percentile': {'value': 0.999898, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '8', 'issue': '4', 'first_page': 'e62839', 'last_page': 'e62839'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Drug Discovery Methods', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10211', 'display_name': 'Computational Drug Discovery Methods', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10252', 'display_name': 'Microbial Natural Products and Biosynthesis', 'score': 0.9932, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10887', 'display_name': 'Bioinformatics and Genomic Networks', 'score': 0.9902, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chemical-space', 'display_name': 'Chemical space', 'score': 0.9093468}, {'id': 'https://openalex.org/keywords/natural-product', 'display_name': 'Natural product', 'score': 0.7698028}, {'id': 'https://openalex.org/keywords/cheminformatics', 'display_name': 'Cheminformatics', 'score': 0.42756477}], 'concepts': [{'id': 'https://openalex.org/C99726746', 'wikidata': 'https://www.wikidata.org/wiki/Q906396', 'display_name': 'Chemical space', 'level': 3, 'score': 0.9093468}, {'id': 'https://openalex.org/C74187038', 'wikidata': 'https://www.wikidata.org/wiki/Q1418791', 'display_name': 'Drug discovery', 'level': 2, 'score': 0.7996077}, {'id': 'https://openalex.org/C2779396153', 'wikidata': 'https://www.wikidata.org/wiki/Q901227', 'display_name': 'Natural product', 'level': 2, 'score': 0.7698028}, {'id': 'https://openalex.org/C103697762', 'wikidata': 'https://www.wikidata.org/wiki/Q4112105', 'display_name': 'Virtual screening', 'level': 3, 'score': 0.6385095}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.55713594}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.5525416}, {'id': 'https://openalex.org/C183696295', 'wikidata': 'https://www.wikidata.org/wiki/Q2487696', 'display_name': 'Biochemical engineering', 'level': 1, 'score': 0.48646042}, {'id': 'https://openalex.org/C117045392', 'wikidata': 'https://www.wikidata.org/wiki/Q4899215', 'display_name': 'Betweenness centrality', 'level': 3, 'score': 0.46371722}, {'id': 'https://openalex.org/C68762167', 'wikidata': 'https://www.wikidata.org/wiki/Q910164', 'display_name': 'Cheminformatics', 'level': 2, 'score': 0.42756477}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.36261755}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3576955}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.33627594}, {'id': 'https://openalex.org/C53811970', 'wikidata': 'https://www.wikidata.org/wiki/Q5062194', 'display_name': 'Centrality', 'level': 2, 'score': 0.30379474}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.24282369}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.22460225}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.10540569}, {'id': 'https://openalex.org/C33923547', 'wikidata': 'https://www.wikidata.org/wiki/Q395', 'display_name': 'Mathematics', 'level': 0, 'score': 0.09318349}, {'id': 'https://openalex.org/C114614502', 'wikidata': 'https://www.wikidata.org/wiki/Q76592', 'display_name': 'Combinatorics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001688', 'descriptor_name': 'Biological Products', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D055808', 'descriptor_name': 'Drug Discovery', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D010600', 'descriptor_name': 'Pharmacology', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D019295', 'descriptor_name': 'Computational Biology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D062313', 'descriptor_name': 'Databases, Pharmaceutical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004194', 'descriptor_name': 'Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017277', 'descriptor_name': 'Drug Approval', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014481', 'descriptor_name': 'United States', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014486', 'descriptor_name': 'United States Food and Drug Administration', 'qualifier_ui': 'Q000331', 'qualifier_name': 'legislation & jurisprudence', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0062839', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0062839&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/b9c3293fdad14871b4cbdac8630946af', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3636197', 'pdf_url': 'https://europepmc.org/articles/pmc3636197?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636197', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23638153', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0062839', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0062839&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W1493055596', 'https://openalex.org/W1525985997', 'https://openalex.org/W1543582423', 'https://openalex.org/W1544009106', 'https://openalex.org/W1969053334', 'https://openalex.org/W1969921890', 'https://openalex.org/W1971527053', 'https://openalex.org/W1973177531', 'https://openalex.org/W1976029010', 'https://openalex.org/W1983248350', 'https://openalex.org/W1989061197', 'https://openalex.org/W1990555250', 'https://openalex.org/W1992716708', 'https://openalex.org/W1994311174', 'https://openalex.org/W1994898147', 'https://openalex.org/W1996149494', 'https://openalex.org/W1999055742', 'https://openalex.org/W2014637600', 'https://openalex.org/W2018976898', 'https://openalex.org/W2022108422', 'https://openalex.org/W2022125914', 'https://openalex.org/W2025150565', 'https://openalex.org/W2027991790', 'https://openalex.org/W2028653544', 'https://openalex.org/W2031546822', 'https://openalex.org/W2032123459', 'https://openalex.org/W2033591223', 'https://openalex.org/W2034549041', 'https://openalex.org/W2035753075', 'https://openalex.org/W2042065803', 'https://openalex.org/W2054884372', 'https://openalex.org/W2061843861', 'https://openalex.org/W2062458432', 'https://openalex.org/W2065061109', 'https://openalex.org/W2069944571', 'https://openalex.org/W2072722433', 'https://openalex.org/W2073476932', 'https://openalex.org/W2083411335', 'https://openalex.org/W2090102281', 'https://openalex.org/W2093265335', 'https://openalex.org/W2096541451', 'https://openalex.org/W2096864392', 'https://openalex.org/W2105668062', 'https://openalex.org/W2111859098', 'https://openalex.org/W2114212850', 'https://openalex.org/W2123531184', 'https://openalex.org/W2126662293', 'https://openalex.org/W2128404766', 'https://openalex.org/W2135732933', 'https://openalex.org/W2137052779', 'https://openalex.org/W2141474275', 'https://openalex.org/W2143613372', 'https://openalex.org/W2147798082', 'https://openalex.org/W2153478782', 'https://openalex.org/W2155142785', 'https://openalex.org/W2159887157', 'https://openalex.org/W2162128823', 'https://openalex.org/W2163305701', 'https://openalex.org/W2167141095', 'https://openalex.org/W2167944112', 'https://openalex.org/W2168775915', 'https://openalex.org/W2169678694', 'https://openalex.org/W2184417913', 'https://openalex.org/W4236641706', 'https://openalex.org/W4237095724', 'https://openalex.org/W4248107770'], 'related_works': ['https://openalex.org/W4387845407', 'https://openalex.org/W4382246684', 'https://openalex.org/W4212982662', 'https://openalex.org/W4207063555', 'https://openalex.org/W4207004502', 'https://openalex.org/W2907885506', 'https://openalex.org/W2902857455', 'https://openalex.org/W2601867172', 'https://openalex.org/W2160244398', 'https://openalex.org/W2022444336'], 'abstract_inverted_index': {'Background': [0], 'Natural': [1, 186], 'products': [2, 21, 38, 70, 82, 136, 150, 180, 187], 'have': [3, 188], 'been': [4], 'an': [5], 'important': [6], 'source': [7], 'of': [8, 27, 66, 86, 96, 125, 143, 168, 178], 'lead': [9, 88], 'compounds': [10, 109], 'for': [11, 122, 151], 'drug': [12, 152], 'discovery.': [13], 'How': [14], 'to': [15, 24, 52, 107, 119, 139], 'find': [16], 'and': [17, 43, 57, 71, 100, 113, 154, 175, 195], 'evaluate': [18], 'bioactive': [19], 'natural': [20, 31, 37, 69, 81, 97, 135, 149, 179], 'is': [22], 'critical': [23], 'the': [25, 54, 75, 93], 'achievement': [26], 'drug/lead': [28], 'discovery': [29, 153], 'from': [30], 'products.': [32], 'Methodology': [33], 'We': [34, 90], 'collected': [35], '19,7201': [36], 'structures,': [39], 'reported': [40], 'biological': [41, 176], 'activities': [42, 177], 'virtual': [44, 130], 'screening': [45, 131], 'results.': [46], 'Principal': [47], 'component': [48], 'analysis': [49], 'was': [50, 62, 104, 132, 181], 'employed': [51], 'explore': [53], 'chemical': [55, 76, 173, 190], 'space,': [56, 77], 'we': [58], 'found': [59, 101], 'that': [60, 80, 102], 'there': [61], 'a': [63, 123, 161], 'large': [64, 84, 111], 'portion': [65], 'overlap': [67], 'between': [68], 'FDA-approved': [72, 144], 'drugs': [73], 'in': [74, 172, 183], 'which': [78], 'indicated': [79], 'had': [83], 'quantity': [85], 'potential': [87, 148], 'compounds.': [89], 'also': [91], 'explored': [92], 'network': [94], 'properties': [95, 194], 'product-target': [98], 'networks': [99], 'polypharmacology': [103], 'greatly': [105], 'enriched': [106], 'those': [108], 'with': [110, 198], 'degree': [112], 'high': [114, 128], 'betweenness': [115], 'centrality.': [116], 'In': [117], 'order': [118], 'make': [120], 'up': [121], 'lack': [124], 'experimental': [126], 'data,': [127], 'throughput': [129], 'employed.': [133], 'All': [134], 'were': [137, 157], 'docked': [138], '332': [140], 'target': [141, 201], 'proteins': [142], 'drugs.': [145], 'The': [146], 'most': [147], 'their': [155], 'indications': [156], 'predicted': [158], 'based': [159], 'on': [160], 'docking': [162], 'score-weighted': [163], 'prediction': [164], 'model.': [165], 'Conclusions': [166], 'Analysis': [167], 'molecular': [169], 'descriptors,': [170], 'distribution': [171], 'space': [174], 'conducted': [182], 'this': [184], 'article.': [185], 'vast': [189], 'diversity,': [191], 'good': [192], 'drug-like': [193], 'can': [196], 'interact': [197], 'multiple': [199], 'cellular': [200], 'proteins.': [202]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2006607885', 'counts_by_year': [{'year': 2024, 'cited_by_count': 40}, {'year': 2023, 'cited_by_count': 35}, {'year': 2022, 'cited_by_count': 33}, {'year': 2021, 'cited_by_count': 46}, {'year': 2020, 'cited_by_count': 51}, {'year': 2019, 'cited_by_count': 43}, {'year': 2018, 'cited_by_count': 41}, {'year': 2017, 'cited_by_count': 32}, {'year': 2016, 'cited_by_count': 22}, {'year': 2015, 'cited_by_count': 22}, {'year': 2014, 'cited_by_count': 17}, {'year': 2013, 'cited_by_count': 4}], 'updated_date': '2024-12-24T16:33:41.623772', 'created_date': '2016-06-24'}