Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2005922438', 'doi': 'https://doi.org/10.1016/s0140-6736(85)92679-0', 'title': 'HYPOCHOLESTEROLAEMIA IN MALIGNANCY DUE TO ELEVATED LOW-DENSITY-LIPOPROTEIN-RECEPTOR ACTIVITY IN TUMOUR CELLS: EVIDENCE FROM STUDIES IN PATIENTS WITH LEUKAEMIA', 'display_name': 'HYPOCHOLESTEROLAEMIA IN MALIGNANCY DUE TO ELEVATED LOW-DENSITY-LIPOPROTEIN-RECEPTOR ACTIVITY IN TUMOUR CELLS: EVIDENCE FROM STUDIES IN PATIENTS WITH LEUKAEMIA', 'publication_year': 1985, 'publication_date': '1985-11-01', 'ids': {'openalex': 'https://openalex.org/W2005922438', 'doi': 'https://doi.org/10.1016/s0140-6736(85)92679-0', 'mag': '2005922438', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2865616'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0140-6736(85)92679-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S49861241', 'display_name': 'The Lancet', 'issn_l': '0140-6736', 'issn': ['0140-6736', '1474-547X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051883242', 'display_name': 'Sigurd Vitols', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802208705', 'display_name': 'Danderyds sjukhus', 'ror': 'https://ror.org/00hm9kt34', 'country_code': 'SE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802208705']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Sigurd Vitols', 'raw_affiliation_strings': ['Departments of Pharmacology and Medical Cell Genetics, Karolinska Institute, United Kingdom', 'Division of Clinical Hematology and Oncology, Department of Medicine, Huddinge Hospital, United Kingdom', 'Division of Hematology, Department of Medicine, Danderyd Hospital, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Department of Medicine, Danderyd Hospital, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I2802208705']}, {'raw_affiliation_string': 'Division of Clinical Hematology and Oncology, Department of Medicine, Huddinge Hospital, United Kingdom', 'institution_ids': []}, {'raw_affiliation_string': 'Departments of Pharmacology and Medical Cell Genetics, Karolinska Institute, United Kingdom', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046644939', 'display_name': 'Magnus Björkholm', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802208705', 'display_name': 'Danderyds sjukhus', 'ror': 'https://ror.org/00hm9kt34', 'country_code': 'SE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802208705']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Magnus Björkholm', 'raw_affiliation_strings': ['Departments of Pharmacology and Medical Cell Genetics, Karolinska Institute, United Kingdom', 'Division of Clinical Hematology and Oncology, Department of Medicine, Huddinge Hospital, United Kingdom', 'Division of Hematology, Department of Medicine, Danderyd Hospital, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Department of Medicine, Danderyd Hospital, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I2802208705']}, {'raw_affiliation_string': 'Division of Clinical Hematology and Oncology, Department of Medicine, Huddinge Hospital, United Kingdom', 'institution_ids': []}, {'raw_affiliation_string': 'Departments of Pharmacology and Medical Cell Genetics, Karolinska Institute, United Kingdom', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066284854', 'display_name': 'Gösta Gahrton', 'orcid': 'https://orcid.org/0000-0002-2596-6149'}, 'institutions': [{'id': 'https://openalex.org/I2802208705', 'display_name': 'Danderyds sjukhus', 'ror': 'https://ror.org/00hm9kt34', 'country_code': 'SE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802208705']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Gösta Gahrton', 'raw_affiliation_strings': ['Departments of Pharmacology and Medical Cell Genetics, Karolinska Institute, United Kingdom', 'Division of Clinical Hematology and Oncology, Department of Medicine, Huddinge Hospital, United Kingdom', 'Division of Hematology, Department of Medicine, Danderyd Hospital, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Division of Clinical Hematology and Oncology, Department of Medicine, Huddinge Hospital, United Kingdom', 'institution_ids': []}, {'raw_affiliation_string': 'Departments of Pharmacology and Medical Cell Genetics, Karolinska Institute, United Kingdom', 'institution_ids': []}, {'raw_affiliation_string': 'Division of Hematology, Department of Medicine, Danderyd Hospital, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I2802208705']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5051955118', 'display_name': 'Curt Peterson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802208705', 'display_name': 'Danderyds sjukhus', 'ror': 'https://ror.org/00hm9kt34', 'country_code': 'SE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802208705']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Curt Peterson', 'raw_affiliation_strings': ['Departments of Pharmacology and Medical Cell Genetics, Karolinska Institute, United Kingdom', 'Division of Clinical Hematology and Oncology, Department of Medicine, Huddinge Hospital, United Kingdom', 'Division of Hematology, Department of Medicine, Danderyd Hospital, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Department of Medicine, Danderyd Hospital, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I2802208705']}, {'raw_affiliation_string': 'Division of Clinical Hematology and Oncology, Department of Medicine, Huddinge Hospital, United Kingdom', 'institution_ids': []}, {'raw_affiliation_string': 'Departments of Pharmacology and Medical Cell Genetics, Karolinska Institute, United Kingdom', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 6830, 'currency': 'USD', 'value_usd': 6830, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.77, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 182, 'citation_normalized_percentile': {'value': 0.991168, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '326', 'issue': '8465', 'first_page': '1150', 'last_page': '1154'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12465', 'display_name': 'Lipid Metabolism in Cancer Pathogenesis', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12465', 'display_name': 'Lipid Metabolism in Cancer Pathogenesis', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11559', 'display_name': 'Role of Retinoic Acid in Biological Processes', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/low-density-lipoprotein', 'display_name': 'Low-density lipoprotein', 'score': 0.5188773}, {'id': 'https://openalex.org/keywords/cholesterol', 'display_name': 'Cholesterol', 'score': 0.516026}], 'concepts': [{'id': 'https://openalex.org/C43554185', 'wikidata': 'https://www.wikidata.org/wiki/Q425649', 'display_name': 'LDL receptor', 'level': 4, 'score': 0.6294566}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.6163233}, {'id': 'https://openalex.org/C2779399171', 'wikidata': 'https://www.wikidata.org/wiki/Q1483951', 'display_name': 'Malignancy', 'level': 2, 'score': 0.57877207}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.548648}, {'id': 'https://openalex.org/C2779620165', 'wikidata': 'https://www.wikidata.org/wiki/Q28749', 'display_name': 'Low-density lipoprotein', 'level': 3, 'score': 0.5188773}, {'id': 'https://openalex.org/C2780072125', 'wikidata': 'https://www.wikidata.org/wiki/Q28350', 'display_name': 'Lipoprotein', 'level': 3, 'score': 0.50603575}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4893517}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.47286627}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4599293}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.44712856}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.43896908}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.36448944}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.30472016}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.10701862}], 'mesh': [{'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D007938', 'descriptor_name': 'Leukemia', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D011973', 'descriptor_name': 'Receptors, LDL', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007938', 'descriptor_name': 'Leukemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007958', 'descriptor_name': 'Leukocyte Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008077', 'descriptor_name': 'Lipoproteins, LDL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008077', 'descriptor_name': 'Lipoproteins, LDL', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011973', 'descriptor_name': 'Receptors, LDL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0140-6736(85)92679-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S49861241', 'display_name': 'The Lancet', 'issn_l': '0140-6736', 'issn': ['0140-6736', '1474-547X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2865616', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.77}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W149198324', 'https://openalex.org/W1504037273', 'https://openalex.org/W1559382802', 'https://openalex.org/W1603925477', 'https://openalex.org/W1942583428', 'https://openalex.org/W195935352', 'https://openalex.org/W1965152367', 'https://openalex.org/W1965881785', 'https://openalex.org/W1968490374', 'https://openalex.org/W1982038456', 'https://openalex.org/W1995302429', 'https://openalex.org/W2004410658', 'https://openalex.org/W2006177647', 'https://openalex.org/W2009696383', 'https://openalex.org/W2014420470', 'https://openalex.org/W2023213027', 'https://openalex.org/W2044479039', 'https://openalex.org/W2052371783', 'https://openalex.org/W2060656087', 'https://openalex.org/W2076426515', 'https://openalex.org/W2101371464', 'https://openalex.org/W2151266356', 'https://openalex.org/W2156799866', 'https://openalex.org/W2171527056', 'https://openalex.org/W2188114435', 'https://openalex.org/W2207853819', 'https://openalex.org/W2279344163', 'https://openalex.org/W2396319142', 'https://openalex.org/W2401262240', 'https://openalex.org/W2407225179', 'https://openalex.org/W2423891322', 'https://openalex.org/W4255440954', 'https://openalex.org/W4302792529', 'https://openalex.org/W51597534', 'https://openalex.org/W74981159'], 'related_works': ['https://openalex.org/W760943593', 'https://openalex.org/W2345775285', 'https://openalex.org/W2320520566', 'https://openalex.org/W2187146142', 'https://openalex.org/W2061317455', 'https://openalex.org/W2027010109', 'https://openalex.org/W2014420470', 'https://openalex.org/W1981802108', 'https://openalex.org/W1977232940', 'https://openalex.org/W1891823817'], 'abstract_inverted_index': {'59': [0], 'patients': [1], 'with': [2, 37, 41, 65, 110], 'acute': [3, 16], 'leukaemia': [4, 77], 'were': [5], 'examined': [6], 'to': [7, 20, 33, 85, 106], 'see': [8], 'if': [9], 'hypocholesterolaemia,': [10], 'which': [11], 'is': [12], 'commonly': [13], 'found': [14, 32], 'in': [15, 76, 89], 'leukaemia,': [17], 'was': [18, 31], 'due': [19, 84], 'the': [21, 55, 66, 69, 90], 'high': [22, 44, 51, 94], 'low-density-lipoprotein': [23], '(LDL)-receptor': [24], 'activity': [25, 30, 46, 88], 'of': [26, 72, 98], 'leukaemic': [27, 73], 'cells.': [28, 74, 92], 'LDL-receptor': [29, 45, 87], 'be': [34, 83, 104], 'inversely': [35], 'correlated': [36], 'plasma-cholesterol': [38], 'concentration.': [39], 'Patients': [40], 'both': [42], 'a': [43, 50], 'per': [47], 'cell': [48], 'and': [49, 78, 96], 'white-blood-cell': [52], 'count': [53], 'had': [54], 'lowest': [56], 'cholesterol': [57, 61], 'concentrations.': [58], 'During': [59], 'chemotherapy,': [60], 'levels': [62], 'rose': [63], 'concomitantly': [64], 'disappearance': [67], 'from': [68], 'peripheral': [70], 'blood': [71], 'Hypocholesterolaemia': [75], 'other': [79], 'neoplastic': [80, 108], 'disorders': [81], 'may': [82], 'increased': [86], 'malignant': [91, 101], 'This': [93], 'uptake': [95], 'degradation': [97], 'LDL': [99], 'by': [100], 'cells': [102, 109], 'could': [103], 'utilised': [105], 'target': [107], 'LDL-bound': [111], 'chemotherapeutic': [112], 'agents.': [113]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2005922438', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-09-20T01:17:50.798705', 'created_date': '2016-06-24'}