Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

Name: Work Video:
Duration: 3 min 30 s
Audrey Minden; Anning Lin; Martin McMahon; Carol A. Lange; Benoît Dérijard; Roger J. Davis; Gary L. Johnson; Michael Karin
{'id': 'https://openalex.org/W2005900169', 'doi': 'https://doi.org/10.1126/science.7992057', 'title': 'Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK', 'display_name': 'Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK', 'publication_year': 1994, 'publication_date': '1994-12-09', 'ids': {'openalex': 'https://openalex.org/W2005900169', 'doi': 'https://doi.org/10.1126/science.7992057', 'mag': '2005900169', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7992057'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.7992057', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054787277', 'display_name': 'Audrey Minden', 'orcid': 'https://orcid.org/0000-0002-4500-5740'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Audrey Minden', 'raw_affiliation_strings': ['Department of Pharmacology, Program in Biomedical Sciences, School of Medicine, University of California at San Diego, La Jolla, CA 92093-0636, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Program in Biomedical Sciences, School of Medicine, University of California at San Diego, La Jolla, CA 92093-0636, USA.', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066195792', 'display_name': 'Anning Lin', 'orcid': 'https://orcid.org/0000-0003-2754-5134'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anning Lin', 'raw_affiliation_strings': ['Department of Pharmacology, Program in Biomedical Sciences, School of Medicine, University of California at San Diego, La Jolla, CA 92093-0636, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Program in Biomedical Sciences, School of Medicine, University of California at San Diego, La Jolla, CA 92093-0636, USA.', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003652463', 'display_name': 'Martin McMahon', 'orcid': 'https://orcid.org/0000-0003-2812-1042'}, 'institutions': [{'id': 'https://openalex.org/I4210123531', 'display_name': 'Merck (Japan)', 'ror': 'https://ror.org/0292awh62', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I164928964', 'https://openalex.org/I4210123531']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Martin McMahon', 'raw_affiliation_strings': ['DNAX Institute of Molecular and Cellular Biology, Palo Alto, CA 94304-1104, USA.', 'Merck'], 'affiliations': [{'raw_affiliation_string': 'Merck', 'institution_ids': ['https://openalex.org/I4210123531']}, {'raw_affiliation_string': 'DNAX Institute of Molecular and Cellular Biology, Palo Alto, CA 94304-1104, USA.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051915371', 'display_name': 'Carol A. Lange', 'orcid': 'https://orcid.org/0000-0003-2751-3976'}, 'institutions': [{'id': 'https://openalex.org/I3019586173', 'display_name': 'National Jewish Health', 'ror': 'https://ror.org/016z2bp30', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019586173']}, {'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carol Lange-Carter', 'raw_affiliation_strings': ['Division of Basic Sciences, National Jewish Center for Immunology &amp; Respiratory Medicine, Denver, CO 80206, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Basic Sciences, National Jewish Center for Immunology &amp; Respiratory Medicine, Denver, CO 80206, USA.', 'institution_ids': ['https://openalex.org/I3019586173', 'https://openalex.org/I921990950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106035072', 'display_name': 'Benoît Dérijard', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I166722992', 'display_name': 'University of Massachusetts Chan Medical School', 'ror': 'https://ror.org/0464eyp60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I166722992']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Benoit Dérijard', 'raw_affiliation_strings': ['Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01805, USA.'], 'affiliations': [{'raw_affiliation_string': 'Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01805, USA.', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I166722992']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028742170', 'display_name': 'Roger J. Davis', 'orcid': 'https://orcid.org/0000-0002-0130-1652'}, 'institutions': [{'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I166722992', 'display_name': 'University of Massachusetts Chan Medical School', 'ror': 'https://ror.org/0464eyp60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I166722992']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Roger J. Davis', 'raw_affiliation_strings': ['Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01805, USA.'], 'affiliations': [{'raw_affiliation_string': 'Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01805, USA.', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I166722992']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047612906', 'display_name': 'Gary L. Johnson', 'orcid': 'https://orcid.org/0000-0003-2867-0551'}, 'institutions': [{'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}, {'id': 'https://openalex.org/I3019586173', 'display_name': 'National Jewish Health', 'ror': 'https://ror.org/016z2bp30', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019586173']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gary L. Johnson', 'raw_affiliation_strings': ['Division of Basic Sciences, National Jewish Center for Immunology &amp; Respiratory Medicine, Denver, CO 80206, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Basic Sciences, National Jewish Center for Immunology &amp; Respiratory Medicine, Denver, CO 80206, USA.', 'institution_ids': ['https://openalex.org/I921990950', 'https://openalex.org/I3019586173']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5056315342', 'display_name': 'Michael Karin', 'orcid': 'https://orcid.org/0000-0002-2758-6473'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael Karin', 'raw_affiliation_strings': ['Department of Pharmacology, Program in Biomedical Sciences, School of Medicine, University of California at San Diego, La Jolla, CA 92093-0636, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Program in Biomedical Sciences, School of Medicine, University of California at San Diego, La Jolla, CA 92093-0636, USA.', 'institution_ids': ['https://openalex.org/I36258959']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 38.981, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1092, 'citation_normalized_percentile': {'value': 0.97521, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '266', 'issue': '5191', 'first_page': '1719', 'last_page': '1723'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11533', 'display_name': 'Melanoma and MAPK Pathways', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11533', 'display_name': 'Melanoma and MAPK Pathways', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10274', 'display_name': 'Synthesis and biological activity', 'score': 0.9884, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9882, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.79050756}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.6386801}, {'id': 'https://openalex.org/C137361374', 'wikidata': 'https://www.wikidata.org/wiki/Q6714442', 'display_name': 'MAP kinase kinase kinase', 'level': 4, 'score': 0.62165934}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6036948}, {'id': 'https://openalex.org/C132149769', 'wikidata': 'https://www.wikidata.org/wiki/Q899651', 'display_name': 'Mitogen-activated protein kinase', 'level': 3, 'score': 0.5486579}, {'id': 'https://openalex.org/C90934575', 'wikidata': 'https://www.wikidata.org/wiki/Q6593810', 'display_name': 'Mitogen-activated protein kinase kinase', 'level': 4, 'score': 0.5015371}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46515566}, {'id': 'https://openalex.org/C2776362946', 'wikidata': 'https://www.wikidata.org/wiki/Q424374', 'display_name': 'Epidermal growth factor', 'level': 3, 'score': 0.43118653}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.41959918}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.38490695}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.24426386}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.14882895}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.14639324}], 'mesh': [{'descriptor_ui': 'D017871', 'descriptor_name': 'Calcium-Calmodulin-Dependent Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D048728', 'descriptor_name': 'MAP Kinase Kinase Kinase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018631', 'descriptor_name': 'ras Proteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D016475', 'descriptor_name': '3T3 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017871', 'descriptor_name': 'Calcium-Calmodulin-Dependent Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004815', 'descriptor_name': 'Epidermal Growth Factor', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004815', 'descriptor_name': 'Epidermal Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011905', 'descriptor_name': 'Genes, ras', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048031', 'descriptor_name': 'JNK Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019950', 'descriptor_name': 'Mitogen-Activated Protein Kinase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009414', 'descriptor_name': 'Nerve Growth Factors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009414', 'descriptor_name': 'Nerve Growth Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016716', 'descriptor_name': 'PC12 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019908', 'descriptor_name': 'Proto-Oncogene Proteins c-raf', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018631', 'descriptor_name': 'ras Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.7992057', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7992057', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1486631729', 'https://openalex.org/W1502098090', 'https://openalex.org/W1543993582', 'https://openalex.org/W1572416479', 'https://openalex.org/W1766643663', 'https://openalex.org/W1799809595', 'https://openalex.org/W1906271222', 'https://openalex.org/W1911507086', 'https://openalex.org/W1935382092', 'https://openalex.org/W1948328269', 'https://openalex.org/W1969785844', 'https://openalex.org/W1971334343', 'https://openalex.org/W1977302628', 'https://openalex.org/W1977472414', 'https://openalex.org/W1978798502', 'https://openalex.org/W1983501834', 'https://openalex.org/W1984903682', 'https://openalex.org/W1987428363', 'https://openalex.org/W1992494265', 'https://openalex.org/W1993657069', 'https://openalex.org/W1994975139', 'https://openalex.org/W1999157780', 'https://openalex.org/W2000082154', 'https://openalex.org/W2001013796', 'https://openalex.org/W2003962192', 'https://openalex.org/W2006650852', 'https://openalex.org/W2009338295', 'https://openalex.org/W2012928252', 'https://openalex.org/W2024026979', 'https://openalex.org/W2026778256', 'https://openalex.org/W2026951979', 'https://openalex.org/W2042260090', 'https://openalex.org/W2051538397', 'https://openalex.org/W2057126981', 'https://openalex.org/W2058015528', 'https://openalex.org/W2069132844', 'https://openalex.org/W2073423744', 'https://openalex.org/W2077880395', 'https://openalex.org/W2077993951', 'https://openalex.org/W2078011486', 'https://openalex.org/W2078856910', 'https://openalex.org/W2092109378', 'https://openalex.org/W2143678301', 'https://openalex.org/W2158608327', 'https://openalex.org/W2764496980'], 'related_works': ['https://openalex.org/W2349470516', 'https://openalex.org/W2082355820', 'https://openalex.org/W2025745100', 'https://openalex.org/W2022135311', 'https://openalex.org/W1998487776', 'https://openalex.org/W1967218150', 'https://openalex.org/W1964975312', 'https://openalex.org/W1605227383', 'https://openalex.org/W1553356293', 'https://openalex.org/W1502707514'], 'abstract_inverted_index': {'Growth': [0], 'factors': [1], 'activate': [2], 'mitogen-activated': [3], 'protein': [4, 71], 'kinases': [5, 10, 14], '(MAPKs),': [6], 'including': [7], 'extracellular': [8], 'signal-regulated': [9], '(ERKs)': [11], 'and': [12, 74, 124], 'Jun': [13], '(JNKs).': [15], 'Although': [16], 'the': [17, 30, 109, 125], 'signaling': [18], 'cascade': [19], 'from': [20], 'growth': [21, 44, 49], 'factor': [22, 45, 50, 63], 'receptors': [23], 'to': [24, 33, 85, 90, 121, 131], 'ERKs': [25], 'is': [26, 36], 'relatively': [27], 'well': [28], 'understood,': [29], 'pathway': [31], 'leading': [32, 120, 130], 'JNK': [34, 41, 58, 91, 97, 132], 'activation': [35, 59, 87, 98, 102], 'more': [37], 'obscure.': [38], 'Activation': [39], 'of': [40, 111], 'by': [42, 60, 118, 128], 'epidermal': [43], '(EGF)': [46], 'or': [47, 77], 'nerve': [48], '(NGF)': [51], 'was': [52, 66], 'dependent': [53], 'on': [54], 'H-Ras': [55], 'activation,': [56, 92, 123], 'whereas': [57, 93], 'tumor': [61], 'necrosis': [62], 'α': [64], '(TNF-α)': [65], 'Ras-independent.': [67], 'Ras': [68], 'activates': [69], 'two': [70, 112], 'kinases,': [72], 'Raf-1': [73, 82, 119], 'MEK': [75], '(MAPK,': [76], 'ERK,': [78], 'kinase)': [79], 'kinase': [80], '(MEKK).': [81], 'contributes': [83], 'directly': [84], 'ERK': [86, 101, 122], 'but': [88, 99], 'not': [89], 'MEKK': [94, 129], 'participated': [95], 'in': [96], 'caused': [100], 'only': [103], 'after': [104], 'overexpression.': [105], 'These': [106], 'results': [107], 'demonstrate': [108], 'existence': [110], 'distinct': [113], 'Ras-dependent': [114], 'MAPK': [115], 'cascades—one': [116], 'initiated': [117, 127], 'other': [126], 'activation.': [133]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2005900169', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-12-15T10:41:20.824208', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
