Publication Information

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1821, 2628, 2675, 2752, 2898, 2929, 3002, 3105, 3177, 3509, 3628, 3668, 3707, 3722, 4016, 4054, 4056, 4117], 'high': [33, 273, 597, 650, 697, 1786, 2296, 2329, 3047, 3197, 3445, 3574], 'resolution': [34, 78, 274, 318, 3468, 3576], 'separation': [35, 275, 1782, 3384, 3519, 3584], 'highly': [37, 277, 2494, 2506, 3684, 3723], 'sulfated,': [38, 278], 'heparin-derived': [39, 90, 279, 330, 2508, 3392, 3463, 4007], 'oligosaccharides.': [40, 91, 280, 331, 1700, 2247, 2306, 2496], 'Simultaneous': [41, 281], 'detection': [42, 97, 217, 282, 337, 457, 3605], 'by': [43, 283, 1362, 1803, 2458, 2586, 2794, 2866, 3262, 3354, 3655, 4033, 4065, 4094], 'UV': [44, 92, 284, 332, 3513, 3613, 3647], 'absorbance': [45, 285, 2795, 2801], 'and': [46, 64, 87, 147, 209, 234, 286, 304, 327, 387, 449, 474, 683, 701, 733, 786, 933, 1073, 1267, 1297, 1397, 1412, 1415, 1484, 1598, 1703, 1745, 1750, 1774, 1791, 1988, 2325, 2410, 2493, 2515, 2549, 2653, 2673, 2704, 2713, 2742, 2781, 2838, 2912, 2946, 2954, 2973, 3024, 3134, 3139, 3148, 3266, 3340, 3352, 3389, 3425, 3453, 3502, 3537, 3545, 3568, 3577, 3611, 3645, 3726, 3894, 3897, 3913, 4026, 4031, 4042, 4059, 4070, 4073], 'electrospray': [47, 287, 594, 647, 1394, 2131, 2894], 'ionization-mass': [48, 288], '(ESI-MS)': [50, 290], 'provides': [51, 291, 1769, 2315], 'important': [52, 292, 881], 'structural': [53, 116, 293, 356, 481, 830, 1286, 1386, 3185], 'information': [54, 294, 2517], 'on': [55, 161, 295, 401, 1529, 1741, 2311, 2518, 2686, 2812, 3663], 'oligosaccharide': [57, 297, 1376, 2064, 2256, 2578, 3144, 3318, 3335, 3518, 4092], 'components': [58, 298], 'this': [60, 189, 300, 429, 1358, 3111, 3178, 3350], 'mixture.': [61, 301], 'Highly': [62, 302], 'sensitive': [63, 303], 'easily': [65, 305, 1777], 'interpretable': [66, 306], 'spectra': [67, 307, 2848, 2932, 2956, 3547, 3725, 3791, 3801, 3924], 'were': [68, 308, 2558, 2684, 2718, 2768, 2792, 2809, 2849, 2957, 2965, 2995, 3029, 3378, 3506], 'post-column': [71, 311, 2379, 2405, 2992, 3026, 3887, 4105], 'addition': [72, 312, 2406, 2993, 3027, 3888, 4047, 4106], 'tributylamine': [74, 314], 'acetonitrile.': [76, 316, 3429], 'High': [77, 317], 'mass': [79, 205, 230, 319, 445, 470, 586, 639, 1074, 1991, 2847, 2955, 3680, 3923], 'afforded': [81, 174, 321, 414, 3572], 'elemental': [82, 322], 'composition': [83, 323], 'many': [85, 325, 793, 1256, 1822], 'known': [86, 164, 326, 404, 3321], 'previously': [88, 328, 2594], 'unknown': [89, 329], 'combination': [94, 334, 1263], 'with': [95, 180, 222, 335, 420, 462, 1779, 1831, 1843, 1933, 1984, 2053, 2291, 2334, 2384, 2590, 2621, 2731, 2882, 2902, 3189, 3450, 3466, 3488, 3608, 3620, 3693, 3792, 4100], 'MS': [96, 216, 336, 456, 1545, 1804, 1969, 2292, 2988, 3452, 3489, 3579], 'led': [98, 338], 'identification': [101, 117, 341, 357], 'arising': [104, 344], 'from': [105, 123, 345, 363, 828, 1482, 2534, 2543, 2560, 2582, 2695, 3247, 3349, 3589, 4019], 'original': [107, 347], 'non-reducing': [108, 131, 348, 371, 628, 681], 'end': [109, 349], '(NRE)': [110, 350], 'heparin': [113, 135, 167, 186, 353, 375, 407, 426, 684, 747, 785, 835, 1483, 2451, 2521, 2577, 2585, 2618, 2875, 3143, 3170, 3586], 'chain.': [114, 136, 354, 376], 'The': [115, 355, 480, 1473, 2497, 2642, 2669, 2723, 2734, 2789, 2893, 3430, 3633, 3774, 4046, 4085, 4104], 'these': [119, 171, 359, 411, 773, 1258, 1887, 2320, 2444], 'provided': [121, 361, 3485, 4119], 'sequence': [122, 362, 702, 2065, 2516, 3336], 'reading': [125, 365], 'frame': [126, 366], 'that': [127, 181, 367, 421, 2130], 'begins': [128, 368], 'at': [129, 369, 2328, 2639, 2659, 2755, 2796, 2799, 2803, 2886, 3015, 3031, 3557, 3615], 'terminus': [132, 372], 'Interestingly,': [137, 377], '16': [138, 378], 'NRE': [139, 172, 379, 412], 'are': [141, 157, 381, 397, 763, 775, 934, 1799, 1820, 2323, 2326, 2982, 3044, 3631, 3666, 4097], 'observed,': [142, 382], 'having': [143, 203, 228, 383, 443, 468, 3325, 3717], 'both': [144, 384, 2512, 2721, 3386, 3573, 3640], 'an': [145, 148, 385, 388, 1281, 2385, 2813, 2852, 3011, 3327, 3411, 3426, 3554], 'even': [146, 386, 3328], 'odd': [149, 389], 'number': [150, 390, 3329, 3713], 'saccharide': [152, 226, 392, 466, 1291, 3331], 'residues,': [153, 393], 'most': [154, 394, 490, 1692, 4086, 4121], 'which': [156, 396, 1819], 'not': [158, 398, 2488, 3315], 'predicted': [159, 399], 'based': [160, 400, 3662], 'biosynthesis': [162, 402], 'or': [163, 403, 743, 2050, 3700], 'pathways': [165, 405], 'catabolism.': [168, 408], 'Quantification': [169, 409], 'number-averaged': [176, 416], 'molecular': [177, 417, 735, 1794, 1838, 2513, 3048, 3108, 3116], 'weight': [178, 418, 736, 1795, 1839, 2514, 3049, 3109, 3117], 'consistent': [179, 419], 'expected': [182, 422, 4011], 'for': [183, 196, 220, 423, 436, 460, 493, 1284, 1385, 1695, 1770, 2662, 2764, 3448, 3659], 'pharmaceutical': [185, 425], 'used': [187, 427, 578, 631, 765, 1973, 2252, 2441, 2763, 2940, 3104, 3410], 'analysis.': [190, 430], 'Molecular': [191, 431], 'ions': [192, 432, 2928, 3716, 3796, 4080], 'could': [193, 433], 'be': [194, 434, 690, 1776], 'assigned': [195, 435, 3652], 'as': [198, 200, 438, 440, 766, 815, 1479, 1785, 2592, 2941, 2966, 3067, 3173, 3180, 3260, 3900, 4050], 'large': [199, 439, 1367, 1712, 2492, 3390, 3712], 'tetradecasaccharide,': [202, 442], '4625': [207, 447], 'Da': [208, 233, 448, 473], 'net': [211, 236, 451, 476], 'charge': [212, 237, 452, 477, 4017], '–32.': [214, 454], 'Furthermore,': [215, 455, 3333], 'was': [218, 458, 2533, 2542, 2564, 2580, 2619, 2645, 2650, 2657, 2671, 2701, 2707, 2727, 2740, 2762, 2864, 2896, 2939, 3171], 'demonstrated': [219, 459], 'up': [223, 463], '30': [225, 465, 2640], 'units': [227, 467, 2802], '>10,000': [232, 472], '–60.': [239, 479], 'elucidation': [482, 1287, 1387], 'carbohydrates': [485], 'remains': [486], 'one': [487, 3334], 'difficult': [491, 692, 1800, 2288], 'challenges': [492, 825], 'chemists,': [494], 'often': [495, 883, 939], 'requiring': [496], 'application': [498], 'multiple': [500, 2841], 'analytical': [501], 'approaches': [502, 1694], '(1.Davies': [503], 'J.G.': [504], 'Henrissat': [505], 'B.': [506, 563, 1058, 1326, 1869, 1912, 2353, 2429, 2461], 'Biochem.': [507, 540, 710, 1022, 1347], 'Soc.': [508, 1151, 2475, 3874, 3994], 'Trans.': [509], '2002;': [510, 711, 724, 872, 2476], '30:': [511], '291-297Crossref': [512], 'PubMed': [513, 530, 544, 557, 569, 714, 727, 758, 858, 928, 955, 974, 994, 1026, 1046, 1090, 1108, 1157, 1180, 1196, 1210, 1243, 1314, 1352, 1439, 1455, 1468, 1521, 1560, 1593, 1613, 1636, 1663, 1684, 1906, 1921, 1949, 1963, 2024, 2041, 2094, 2111, 2146, 2169, 2183, 2210, 2230, 2282, 2357, 2374, 2433, 2479, 2609, 3097, 3129, 3163, 3229, 3283, 3309, 3372, 3404, 3479, 3530, 3742, 3769, 3829, 3861, 3949, 3981], 'Google': [514, 533, 547, 560, 572, 717, 730, 761, 861, 877, 903, 931, 958, 977, 997, 1029, 1049, 1071, 1093, 1111, 1139, 1160, 1183, 1199, 1213, 1246, 1317, 1339, 1355, 1428, 1442, 1458, 1471, 1502, 1524, 1563, 1596, 1616, 1639, 1666, 1687, 1864, 1879, 1909, 1924, 1952, 1966, 2027, 2044, 2097, 2114, 2149, 2172, 2186, 2213, 2233, 2285, 2360, 2377, 2403, 2436, 2482, 2612, 3100, 3132, 3166, 3232, 3286, 3312, 3375, 3407, 3482, 3533, 3745, 3772, 3817, 3832, 3849, 3864, 3882, 3937, 3952, 3969, 3984, 4002], 'Scholar,': [515, 534, 548, 561, 718, 862, 904, 959, 998, 1050, 1094, 1112, 1140, 1161, 1184, 1200, 1214, 1318, 1340, 1429, 1443, 1459, 1503, 1564, 1617, 1640, 1667, 1865, 1910, 1953, 2028, 2098, 2150, 2173, 2187, 2214, 2273, 2361, 3075, 3287, 3746, 3818, 3833, 3850, 3865, 3938, 3953, 3970, 3985], '2.Cataldi': [516], 'T.R.': [517], 'Campa': [518], 'C.': [519, 1035, 1303, 1650, 1852, 1867, 1871, 2197, 2222, 2598, 3272, 3361, 3395, 3470, 3521, 3756], 'de': [520], 'Benedetto': [521], 'G.E.': [522], "Fresenius'": [523], 'J.': [524, 917, 968, 988, 1130, 1149, 1174, 1186, 1202, 1224, 1348, 1419, 1462, 1493, 1574, 1630, 1657, 1915, 1939, 1955, 2005, 2075, 2163, 2175, 2204, 2276, 2351, 2368, 2427, 2472, 3085, 3088, 3297, 3300, 3398, 3473, 3524, 3763, 3806, 3809, 3823, 3872, 3926, 3929, 3943, 3992], 'Anal.': [525, 539, 1009, 1021, 1103, 1191, 1205, 1434, 1450, 1608, 1872, 1944, 1958, 2141, 2178, 2268, 2396, 3737, 3842, 3856, 3962, 3976], 'Chem.': [526, 868, 919, 1010, 1104, 1192, 1206, 1435, 1451, 1609, 1873, 1945, 1959, 2142, 2179, 2269, 2397, 2474, 3738, 3843, 3857, 3963, 3977], '2000;': [527, 541, 1023, 1240, 1590, 2021, 2091, 2279, 3826, 3946], '368:': [528], '739-758Crossref': [529], 'Scopus': [531, 545, 558, 570, 715, 728, 759, 859, 875, 901, 929, 956, 975, 995, 1027, 1047, 1069, 1091, 1109, 1137, 1158, 1181, 1197, 1211, 1244, 1315, 1337, 1353, 1426, 1440, 1456, 1469, 1500, 1522, 1561, 1594, 1614, 1637, 1664, 1685, 1862, 1877, 1907, 1922, 1950, 1964, 2025, 2042, 2095, 2112, 2147, 2170, 2184, 2211, 2231, 2283, 2358, 2375, 2401, 2434, 2480, 2610, 3098, 3130, 3164, 3230, 3284, 3310, 3373, 3405, 3480, 3531, 3743, 3770, 3815, 3830, 3847, 3862, 3880, 3935, 3950, 3967, 3982, 4000], '(208)': [532], '3.Koketsu': [535], 'M.': [536, 1018, 1513, 1677, 1679, 2367, 2463], 'Linhardt': [537, 852, 865, 1007, 1019, 1040, 1063, 1131, 1147, 1172, 1227, 1308, 1331, 1343, 1577, 1628, 2008, 2078, 2161, 2266, 2603, 3086, 3157, 3223, 3277, 3298, 3366, 3396, 3471, 3522], 'R.J.': [538, 749, 807, 853, 866, 1008, 1020, 1041, 1064, 1132, 1148, 1173, 1228, 1309, 1332, 1344, 1578, 1629, 2009, 2079, 2162, 2267, 2604, 3059, 3087, 3120, 3158, 3224, 3278, 3299, 3367, 3397, 3472, 3523], '283:': [542, 1024], '136-145Crossref': [543, 1025], '(45)': [546, 559, 1028], '4.Packer': [549], 'N.H.': [550], 'Harrison': [551], 'M.J.': [552, 1894, 3871, 3991], 'Electrophoresis.': [553], '1998;': [554, 855, 1105, 1610, 1681, 2143, 3160, 3226, 3739, 3858, 3978], '19:': [555, 725], '1872-1882Crossref': [556], '5.Mulloy': [562], 'Mol.': [564], 'Biotechnol.': [565], '1996;': [566, 971, 991, 1465, 1874], '6:': [567], '241-265Crossref': [568], '(16)': [571], 'Scholar).': [573, 731, 823, 878, 1356, 1472, 1880, 1925, 1967, 2045, 2234, 2483, 2613, 3101, 3167, 3233, 3408, 3483, 3534, 3773, 3883], 'Glycosaminoglycans': [574], '(GAGs),': [575], '1The': [576], 'abbreviations': [577, 630], 'are:': [579, 632], 'GAG,': [580, 633], 'glycosaminoglycan;': [581, 634], 'LC,': [582, 635], 'liquid': [583, 599, 636, 652, 1788, 3903, 4052], 'chromatography;': [584, 600, 637, 653], 'MS,': [585, 638], 'spectrometry;': [587, 640], 'MALDI-TOF,': [588, 641], 'matrix-assisted': [589, 642, 1398], 'laser': [590, 643, 1399], 'desorption/ionization': [591, 644, 1400], 'time-of-flight;': [592, 645], 'ESI-MS,': [593, 646], 'ionization-MS;': [595, 648], 'HPLC,': [596, 649], 'performance': [598, 651, 1787], 'RPIP,': [601, 654], 'ion-pairing;': [603, 656], 'TrBA,': [604, 657], 'tributylammonium': [605, 658, 2999], 'acetate;': [606, 659, 3424], 'dp,': [607, 660], 'degree': [608, 661], 'polymerization;': [610, 663], 'GlcA,': [611, 664], 'glucuronic': [612, 665], 'acid;': [613, 616, 666, 669], 'IdoA,': [614, 667], 'iduronic': [615, 668], 'GlcN,': [617, 670], 'glucosamine;': [618, 671], 'HexN,': [619, 672], 'hexosamine;': [620, 673], 'P,': [621, 674], 'pyranose;': [622, 675], 'S,': [623, 676], 'sulfo;': [624, 677], 'Ac,': [625, 678], 'acetyl;': [626, 679], 'NRE,': [627, 680], 'end.1The': [629], 'end.': [682], 'particular,': [686], 'have': [687, 1248, 1402, 1527, 1689, 2438, 2454, 3346], 'proven': [688], 'extremely': [691], 'analyze': [694], 'because': [695, 1805, 3193], 'negative': [698, 2899, 3603], 'charge,': [699], 'polydispersity,': [700], 'heterogeneity': [703], '(6.Esko': [704], 'J.D.': [705, 2391, 3808, 3928], 'Selleck': [706], 'S.B.': [707, 2275], 'Annu.': [708], 'Rev.': [709, 1422, 1496], '71:': [712], '435-471Crossref': [713], '(1226)': [716], '7.Rabenstein': [719], 'D.L.': [720, 2469], 'Nat.': [721], 'Prod.': [722], 'Rep.': [723], '312-331Crossref': [726], '(698)': [729], 'Heparin': [732, 2574], 'low': [734, 3115, 3440, 3542, 4109], 'heparins,': [737], 'prepared': [738, 1534, 2581], 'controlled': [741, 1537, 2048, 2587, 3590], 'chemical': [742, 782, 1743, 2051], 'enzymatic': [744, 1538, 2049, 2588], 'fragmentation': [745], '(8.Linhardt': [748, 3119], 'Gunay': [750, 1053, 1321, 3121], 'N.S.': [751, 1054, 1322, 3122], 'Sem.': [752, 3123], 'Thromb.': [753, 3124], 'Hemost.': [754, 3125], '1999;': [755, 898, 1918, 2038, 2108, 2354, 2371, 3126], '25:': [756, 3127], '5-15Crossref': [757, 3128], '(38)': [760, 3131], 'Scholar),': [762, 978, 1014, 1030, 1072, 2378, 2404], 'widely': [764], 'clinical': [767], 'anticoagulants.': [768], 'Despite': [769], 'their': [770, 781, 1413, 1807], 'medical': [771], 'importance,': [772], 'drugs': [774], 'relatively': [776, 1366, 3196], 'uncharacterized': [777], 'terms': [779], 'structure.': [783], 'Moreover,': [784], 'structurally': [788, 3045], 'related': [789], 'heparan': [790, 1485, 3042], 'sulfate': [791], 'exhibit': [792], 'additional': [794], 'biological': [795], 'activities,': [796], 'making': [797, 1727, 2331], 'them': [798, 2332], 'great': [800], 'interest': [801], 'new': [803], 'drug': [804], 'discovery': [805], '(9.Linhardt': [806, 3058], 'Toida': [808, 962, 982, 1055, 1121, 1225, 1323, 1575, 2006, 2076, 3060], 'T.': [809, 961, 963, 981, 983, 1056, 1122, 1226, 1324, 1576, 2007, 2077, 2348, 2363, 2365, 3061], 'Witczak': [810, 3062], 'Z.B.': [811, 3063], 'Nieforth': [812, 3064], 'K.A.': [813, 1037, 1305, 2600, 3065, 3274, 3363], 'Carbohydrates': [814, 3066], 'Drugs.': [816, 3068], 'Marcel': [817, 3069], 'Dekker,': [818, 3070], 'Inc.,': [819, 3071], 'New': [820, 942, 3072], 'York1997:': [821, 3073], '277-341Google': [822, 3074], 'Numerous': [824], 'can': [826, 1775, 3703], 'arise': [827], 'investigation': [831], 'biologically': [833, 880], 'active': [834], 'oligosaccharides,': [836, 3686, 4008], 'particularly': [837, 2121], 'those': [838, 1480], 'recognition': [840], 'systems': [841], 'involving': [842], 'specific': [843, 3142], 'protein-carbohydrate': [844], 'interactions': [845, 4072], '(10.Hileman': [846, 3151, 3217], 'R.E.': [847, 1171, 1627, 2160, 3077, 3152, 3218, 3289], 'Fromm': [848, 3153, 3219], 'J.R.': [849, 3154, 3220], 'Weiler': [850, 3080, 3155, 3221, 3292], 'J.M.': [851, 3081, 3156, 3222, 3293], 'BioEssays.': [854, 3159, 3225], '20:': [856, 3161, 3227], '156-167Crossref': [857, 3162, 3228], '(514)': [860, 3165, 3231], '11.Capilla': [863], 'I.': [864, 965, 985, 1656, 2203, 3762], 'Angew.': [867], 'Int.': [869], 'Ed.': [870], 'Engl.': [871], '41:': [873], '390-412Crossref': [874], '(1524)': [876], 'Such': [879], 'contain': [884, 3323], 'rare': [885], 'sequences': [886, 1977, 3202], '(12.Rosenberg': [887], 'R.D.': [888, 1642, 2189, 2471, 3748, 3841, 3961], 'Lam': [889], 'L.': [890, 1644, 2191, 2465, 3750], 'Proc.': [891, 1080, 1233, 1550, 1583, 2014, 2084], 'Natl.': [892, 1081, 1234, 1551, 1584, 2015, 2085], 'Acad.': [893, 1082, 1235, 1552, 1585, 2016, 2086], 'Sci.': [894, 1083, 1236, 1553, 1586, 2017, 2087, 3090, 3302], 'U.': [895, 1084, 1237, 1515, 1554, 1587, 2018, 2088], 'S.': [896, 908, 1085, 1238, 1555, 1588, 2019, 2089], 'A.': [897, 906, 914, 970, 990, 1033, 1086, 1239, 1301, 1431, 1464, 1511, 1556, 1589, 1646, 1654, 1659, 1917, 2020, 2090, 2193, 2201, 2206, 2218, 2278, 2342, 2370, 2596, 3079, 3270, 3291, 3359, 3400, 3475, 3526, 3752, 3760, 3765, 3811, 3822, 3825, 3931, 3942, 3945], '76:': [899], '1218-1222Crossref': [900], '(231)': [902], '13.Kinoshita': [905], 'Yamada': [907], 'Haslam': [909], 'S.M.': [910], 'Morris': [911, 1506], 'H.R.': [912, 1507, 3839, 3959], 'Dell': [913, 1510], 'Sugahara': [915], 'K.': [916, 1079, 1165, 1222, 1230, 1549, 1572, 1580, 1621, 1669, 2003, 2011, 2073, 2081, 2154, 2346], 'Biol.': [918], '1997;': [920, 1177, 1349, 1633, 2166, 2227, 2430, 3877, 3997], '272:': [921], '19656-19665Abstract': [922], 'Full': [923, 925, 3094, 3306], 'Text': [924, 926, 3095, 3307], 'PDF': [927, 3096, 3308], '(100)': [930], 'Scholar)': [932, 1247, 1597, 1688, 2286, 2437, 3133, 3313], 'present': [935, 2498, 2520], 'only': [936], 'minute,': [938], 'picomole': [940], 'quantities.': [941], 'derivatization': [943], 'methods': [944], '(14.Drummond': [945], 'K.J.': [946], 'Yates': [947], 'E.A.': [948], 'Turnbull': [949, 1223, 1573, 2004, 2074], 'J.E.': [950, 1188, 1941], 'Proteomics.': [951], '2001;': [952, 1193, 1207, 1903, 1946, 1960, 2180], '1:': [953], '304-310Crossref': [954], '(29)': [957], '15.Imanari': [960], 'Koshiishi': [964, 984], 'Toyoda': [966, 986], 'H.': [967, 987, 1671, 1675, 2344, 3869, 3989], 'Chromatogr.': [969, 989, 1463, 1658, 1916, 2205, 2277, 2352, 2369, 2428, 3399, 3474, 3525, 3764, 3810, 3824, 3930, 3944], '720:': [972, 992, 1466], '275-293Crossref': [973, 993], '(106)': [976, 996], 'chromatography': [979, 1789, 3150, 3265], '(15.Imanari': [980], '16.Rice': [999], 'K.G.': [1000, 2259], 'Kim': [1001, 1061, 1119, 1329, 2260], 'Y.S.': [1002, 1062, 1114, 1330, 2261], 'Grant': [1003, 2262], 'A.C.': [1004, 2263], 'Merchant': [1005, 2264], 'Z.M.': [1006, 2265], '1985;': [1011, 2270], '150:': [1012, 2271], '325-331Google': [1013, 2272], 'electrophoresis-based': [1015], 'separations': [1016, 2683], '(3.Koketsu': [1017], 'NMR': [1031, 3356], '(17.Pervin': [1032, 1300, 2595, 3269, 3358], 'Gallo': [1034, 1302, 2597, 3271, 3360], 'Jandik': [1036, 1304, 2599, 3273, 3362], 'Han': [1038, 1306, 2601, 3275, 3364], 'X.J.': [1039, 1307, 2602, 3276, 3365], 'Glycobiology.': [1042, 1065, 1133, 1310, 1333, 1680, 2605, 3279, 3368], '1995;': [1043, 1066, 1311, 1334, 1452, 1859, 2606, 3280, 3369, 3812, 3844, 3932, 3964], '5:': [1044, 1312, 2607, 3281, 3370], '83-95Crossref': [1045, 1313, 2608, 3282, 3371], '(195)': [1048, 1316, 2611, 3285, 3374], '18.Yang': [1051, 1319], 'H.O.': [1052, 1320], 'Kuberan': [1057, 1325], 'Yu': [1059, 1127, 1327], 'G.L.': [1060, 1328], '10:': [1067, 1335], '1033-1040Crossref': [1068, 1336], '(61)': [1070, 1338], '(19.Juhasz': [1076, 1546], 'P.': [1077, 1547], 'Biemann': [1078, 1229, 1548, 1579, 2010, 2080], '1994;': [1087, 1423, 1497, 1557], '91:': [1088, 1558], '4333-4337Crossref': [1089, 1559], '(147)': [1092, 1562], '20.Chai': [1095], 'W.G.': [1096, 1601, 2134, 3730], 'Luo': [1097, 1602, 2135, 3731], 'J.L.': [1098, 1603, 2136, 3732, 3853, 3973], 'Lim': [1099, 1604, 2137, 3733], 'C.K.': [1100, 1605, 2138, 3734], 'Lawson': [1101, 1606, 2139, 3735], 'A.M.': [1102, 1607, 2140, 3736], '70:': [1106, 1611, 2144, 3740, 3859, 3979], '2060-2066Crossref': [1107, 1612, 2145, 3741], '(102)': [1110, 1615, 2148, 3744], '21.Kim': [1113], 'Ahn': [1115], 'M.Y.': [1116], 'Wu': [1117, 2466], 'S.J.': [1118], 'D.H.': [1120], 'Teesch': [1123], 'L.M.': [1124, 1146], 'Park': [1125], 'Y.': [1126], 'G.': [1128, 1220, 1570, 1648, 1848, 2001, 2030, 2071, 2100, 2195, 3754], 'Lin': [1129], '1988;': [1134], '8:': [1135, 1682, 3878, 3998], '869-877Crossref': [1136], '(40)': [1138], '22.Lamb': [1141], 'D.J.': [1142, 1461], 'Wang': [1143], 'H.M.': [1144], 'Mallis': [1145], 'Am.': [1150, 2473, 3873, 3993], 'Mass': [1152, 1175, 1378, 1420, 1494, 1631, 1857, 1901, 2164, 3875, 3995], 'Spectrom.': [1153, 1176, 1421, 1495, 1632, 1858, 1902, 2165, 3876, 3996], '1992;': [1154, 3091, 3303], '3:': [1155], '797-803Crossref': [1156], '(39)': [1159], '23.Siegel': [1162, 1618, 2151], 'M.M.': [1163, 1619, 2152], 'Tabei': [1164, 1620, 2153], 'Kagan': [1166, 1622, 2155], 'M.Z.': [1167, 1623, 2156], 'Vlahov': [1168, 1624, 2157], 'I.R.': [1169, 1625, 2158], 'Hileman': [1170, 1626, 2159], '32:': [1178, 1634, 2167], '760-772Crossref': [1179, 1635, 2168], '(31)': [1182, 1638, 2171], '24.Zaia': [1185], 'McClellan': [1187, 1940], 'Costello': [1189, 1203, 1448, 1942, 1956, 2176], 'C.E.': [1190, 1204, 1449, 1943, 1957, 2177], '73:': [1194, 1208, 1947, 1961, 2181], '6030-6039Crossref': [1195, 1948], '(92)': [1198, 1951], '25.Zaia': [1201, 1954, 2174], '233-239Crossref': [1209, 1962, 2182], '(134)': [1212, 1965, 2185], '26.Shriver': [1215, 1565], 'Z.': [1216, 1566, 1997, 2032, 2067, 2102], 'Raman': [1217, 1567, 1998, 2033, 2068, 2103], 'R.': [1218, 1232, 1568, 1582, 1999, 2013, 2034, 2036, 2069, 2083, 2104, 2106], 'Venkataraman': [1219, 1569, 2000, 2070], 'Drummond': [1221, 1571, 2002, 2072], 'Sasisekharan': [1231, 1581, 2012, 2035, 2082, 2105], '97:': [1241, 1591, 2022, 2092], '10365-10370Crossref': [1242, 1592, 2023, 2093], '(112)': [1245, 1595, 2026, 2096], 'been': [1249, 1403, 1690, 1972, 2440, 2455, 2489, 3347, 3779], 'past': [1253], 'solve': [1255], 'structures.': [1260], 'A': [1261, 2700, 2885, 3598], 'successful': [1262, 1405], 'detection,': [1265, 3514], 'separation,': [1266], 'spectral': [1268, 3681, 4040, 4062], 'techniques': [1269], 'might': [1270], 'provide': [1271, 1836], 'critical': [1273], 'advantage': [1274], 'understanding': [1276], 'GAG': [1277], 'structure.NMR': [1278], 'spectroscopy': [1279, 3357], 'invaluable': [1282], 'tool': [1283], 'GAGs,': [1289], 'affording': [1290, 3444, 3458, 3710, 3790], 'composition,': [1292], 'ring': [1293], 'conformation,': [1294], 'glycosidic': [1295], 'linkage,': [1296], 'sulfation': [1298], 'patterns': [1299], '27.Mikhailov': [1341], 'D.': [1342, 1652, 1914, 2199, 3758], 'Mayo': [1345], 'K.H.': [1346, 1505], '328:': [1350], '51-61Crossref': [1351], '(85)': [1354], 'Unfortunately,': [1357], 'technique': [1359, 1384, 2129], 'limited': [1361], 'requirement': [1364], 'amounts': [1368], '(10': [1369], 'nmol': [1370], '1': [1372, 2615, 2871, 3630], 'μmol)': [1373], 'pure': [1375], 'sample.': [1377], '(MS)': [1380], 'another': [1382], 'powerful': [1383], 'GAGs.': [1389], 'Soft': [1390], 'ionization': [1391, 1395, 2128, 2900], 'methods,': [1392], 'including': [1393], '(ESI)': [1396], '(MALDI),': [1401], 'amazingly': [1404], 'neutral': [1410], 'peptide': [1414, 1987], 'lipid': [1416], 'conjugates': [1417], '(28.Peter-Katalinic': [1418, 1492], '13:': [1424, 1498], '77-98Crossref': [1425, 1499], '(78)': [1427, 1501], '29.Fura': [1430], 'Leary': [1432], 'J.A.': [1433, 2395], '1993;': [1436, 1518, 1660, 2207, 3766], '65:': [1437], '2805-2811Crossref': [1438], '(115)': [1441], '30.Reinhold': [1444], 'V.N.': [1445], 'Reinhold': [1446], 'B.B.': [1447], '67:': [1453, 3845, 3965], '1772-1784Crossref': [1454], '(316)': [1457], '31.Harvey': [1460], '429-446Crossref': [1467], '(145)': [1470], 'polyanionic': [1476], 'GAG-oligosaccharides,': [1477], 'such': [1478, 1784, 1934, 2057], 'derived': [1481], 'sulfate,': [1486], 'still': [1488], 'its': [1490, 3195], 'infancy': [1491], '32.Khoo': [1504], 'McDowell': [1508], 'R.A.': [1509], 'Maccarana': [1512], 'Lindahl': [1514], 'Carbohydr.': [1516, 2225], 'Res.': [1517, 2226], '244:': [1519], '205-223Crossref': [1520], '(32)': [1523], 'Scholar).MS': [1525], 'studies': [1526], 'focused': [1528], 'polysaccharides.': [1541], 'MALDI': [1542, 1751], 'time-of-flight': [1543], '(TOF)': [1544], 'ESI-MS': [1599, 1702, 1761, 3604, 3664, 3708, 3784], '(20.Chai': [1600, 2133, 3729], '33.Col': [1641, 2188, 3747], 'Silverstro': [1643, 2190, 3749], 'Naggi': [1645, 2192, 3751], 'Torri': [1647, 2194, 3753], 'Baiocchi': [1649, 2196, 3755], 'Moltrasio': [1651, 2198, 3757], 'Cedro': [1653, 2200, 3759], 'Viano': [1655, 2202, 3761], '647:': [1661, 2208, 3767], '289-300Crossref': [1662, 2209, 3768], '(25)': [1665, 2212, 3771], '34.Takagaki': [1668], 'Munakata': [1670], 'Nakamura': [1672], 'W.': [1673, 2421], 'Matsuya': [1674], 'Majima': [1676], 'Endo': [1678], '719-724Crossref': [1683], '(15)': [1686], 'favored': [1693], 'GAG-derived': [1699, 1980, 2118, 2246, 2255], 'Both': [1701, 3021], 'MALDI-TOF-MS': [1704, 1728, 2054], 'enjoy': [1705], 'particular': [1706], 'advantages': [1707], 'polar': [1713], 'macromolecules.': [1714], 'In': [1715, 1759, 3884], 'MALDI,': [1716], 'major': [1718], 'ion': [1719, 1738, 2952, 3550, 3600, 3643, 3907, 4057, 4088], 'formed': [1720], 'typically': [1722], 'singly': [1724, 3794], 'charged': [1725, 2305, 2507, 3795], 'species,': [1726], 'well': [1729, 2835], 'suited': [1730], 'mixtures.': [1735], 'However,': [1736], 'yield': [1739], 'depends': [1740], 'nature': [1744], 'size': [1746, 3263], 'analyte,': [1749, 1768], 'sufficiently': [1753], 'energetic': [1754], 'damage': [1756], 'analyte.': [1758], 'contrast,': [1760], 'utilizes': [1762], 'flowing': [1764], 'stream': [1765], 'containing': [1766], 'very': [1771], 'gentle': [1772], 'ionization,': [1773], 'combined': [1778], 'on-line': [1780, 3451], 'liquid-phase': [1781], 'techniques,': [1783], '(HPLC)': [1790], 'capillary': [1792, 2908], 'electrophoresis.True': [1793], 'distributions': [1796, 1840], 'polysaccharides': [1798, 1826], 'measure': [1802], 'polydispersity': [1808], '(P': [1809, 3054], '=': [1810, 2880], 'MW/MN': [1811], '>': [1812, 1845, 3051], '1).': [1813], 'MALDI-TOF': [1814, 1892, 1936, 1968], 'synthetic': [1817], 'polymers,': [1818], 'respects': [1823], 'similar': [1824], '(e.g.': [1827], 'polydisperse,': [1828], 'long-chain': [1829], 'oligomers': [1830], 'distinct': [1832], 'repeating': [1833], 'units),': [1834], 'cannot': [1835], 'accurate': [1837], 'polymers': [1842], 'P': [1844], '1.2': [1846], '(35.Monstaudo': [1847], 'Montaudo': [1849], 'M.S.': [1850], 'Puglisi': [1851], 'Samperi': [1853], 'F.': [1854, 2340], 'Rapid': [1855, 1899], 'Commun.': [1856, 1900], '9:': [1860], '453-462Crossref': [1861], '(289)': [1863], '36.Jackson': [1866], 'Larsen': [1868], 'McEwen': [1870], '68:': [1875], '1303-1308Crossref': [1876], '(127)': [1878], 'Prior': [1881], 'fractionation': [1882], 'required': [1884, 2301, 2327, 3447], 'simplify': [1886], 'polydisperse': [1888, 3053], 'prior': [1890], '(37.Deery': [1893], 'Stimson': [1895], 'E.': [1896, 2418], 'Chappell': [1897], 'C.G.': [1898, 3820, 3940], '15:': [1904], '2273-2283Crossref': [1905], '(48)': [1908], '38.Yeung': [1911], 'Mareeak': [1913], '852:': [1919], '573-581Crossref': [1920], '(66)': [1923], 'On-line': [1926, 2235, 2806], 'LC/ESI-MS': [1927], 'eliminates': [1928], 'time-consuming': [1929], 'fraction': [1930], 'collection,': [1931], 'associated': [1932, 3465, 4099], 'off-line': [1935, 3510], '(24.Zaia': [1938], 'has': [1970, 2487, 3182, 3778], 'also': [1971, 2237, 4010], 'determine': [1975], 'purified': [1979, 3348], 'basic': [1986], 'determining': [1989], 'peptide-oligosaccharide': [1994], '(26.Shriver': [1996, 2066], '39.Venkataraman': [2029, 2099], 'Shriver': [2031, 2101], 'Science.': [2037, 2107], '286:': [2039, 2109], '537-542Crossref': [2040, 2110], '(217)': [2043, 2113], 'By': [2046], 'combining': [2047], 'complexes,': [2058], 'it': [2059, 3181], 'possible': [2061], 'deduce': [2063], 'Scholar).ESI-MS': [2115], 'promising': [2122], 'due': [2123, 2293, 3548], 'relative': [2126], 'soft': [2127], 'offers': [2132], '40.Price': [2215], 'K.N.': [2216], 'Tuinman': [2217], 'Baker': [2219], 'D.C.': [2220, 3837, 3957], 'Chisena': [2221], 'Cysyk': [2223], 'R.L.': [2224], '303:': [2228], '303-311Crossref': [2229], '(51)': [2232], 'LC/MS': [2236], 'greatly': [2238], 'enhances': [2239], 'Strong': [2248], 'anion': [2249], 'exchange-HPLC': [2250], 'conventionally': [2251], 'fractionate': [2254], '(16.Rice': [2258], '41.Mohsin': [2274], '884:': [2280], '23-30Crossref': [2281], '(14)': [2284], 'interface': [2290, 2895], 'ionic': [2297], 'strength': [2298], 'phases': [2300], 'elute': [2303], 'multiply': [2304], '(RPIP)-HPLC,': [2309], 'relying': [2310], 'tetraalkyl': [2312], 'ammonium': [2313, 2714, 3423, 3538, 3562], 'salts,': [2314], 'excellent': [2316, 3578], 'chromatographic': [2317, 3575], 'resolution;': [2318], 'however,': [2319, 2486], 'reagents': [2322, 2338, 2994, 3505], 'non-volatile': [2324], 'concentrations,': [2330], 'incompatible': [2333], 'ESI-MS.': [2335], 'Volatile': [2336], '(42.Guan': [2339], 'Isii': [2341], 'Seno': [2343], 'Watanabe-Suzuki': [2345], 'Kumazuwa': [2347], 'Suzuki': [2349], 'O.': [2350], '731:': [2355], '155-165Crossref': [2356], '(33)': [2359], '43.Storm': [2362], 'Reemtsma': [2364], 'Jekel': [2366], '854:': [2372], '175-185Crossref': [2373], '(120)': [2376], 'removal': [2380, 3775], 'reagent': [2383, 3028, 3435, 4116], 'in-line': [2386], 'membrane': [2387], '(44.Conboy': [2388], 'J.J.': [2389], 'Henion': [2390, 3807, 3927], 'Martin': [2392], 'M.W.': [2393], 'Zweigenbaum': [2394], '1990;': [2398], '62:': [2399], '800-807Crossref': [2400], '(123)': [2402], 'sheath': [2408, 3902, 4051], 'liquid,': [2409], 'splitting': [2412], 'eluent': [2415, 2705, 2750], 'flow': [2416, 2757, 2888, 3016], '(45.Witters': [2417], 'Van': [2419, 2424], 'Donger': [2420], 'Esmans': [2422], 'E.L.': [2423], 'Onckelen': [2425], 'H.A.': [2426], '694:': [2431], '55-63Crossref': [2432], '(64)': [2435, 3406, 3481, 3532], 'all': [2439, 2550], 'overcome': [2443], 'problems.': [2445], 'Recently,': [2446], 'heparosan': [2447], '(an': [2448], 'unsulfated,': [2449], 'carboxyl-containing': [2450], 'analog)': [2452], 'successfully': [2456, 3780], 'analyzed': [2457], 'RPIP-HPLC/ESI-MS': [2459, 2501], '(46.Kuberan': [2460], 'Lech': [2462], 'Zhang': [2464], 'Z.L.': [2467], 'Beeler': [2468], 'Rosenberg': [2470], '124:': [2477], '8707-8718Crossref': [2478], '(152)': [2481], 'This': [2484, 3317], 'method,': [2485], 'sulfated': [2495, 3685], 'study': [2499, 3179], 'applies': [2500], 'obtain': [2511, 2921, 3516], 'polymer.EXPERIMENTAL': [2522], 'PROCEDURESMaterials—Bovine': [2523], 'lung': [2524, 2584, 3169, 3596], 'heparin,': [2525, 3192], 'sodium': [2526, 2634], 'salt': [2527], '(≥140': [2528], 'USP': [2529], 'units/mg,': [2530], '500,000': [2531], 'units)': [2532], 'Sigma.': [2535], 'Heparinase': [2536, 3102], '(heparin': [2537], 'lyase': [2538], 'I,': [2539], 'EC': [2540], '4.2.2.7)': [2541, 2627], 'IBEX': [2544], '(Montreal,': [2545], 'Canada).': [2546], 'Acetonitrile,': [2547], 'HPLC-grade,': [2548], 'other': [2551], 'chemicals,': [2552], 'purest': [2555], 'grade': [2556], 'available,': [2557], 'Aldrich.': [2561], 'Ultrapure': [2562], 'water': [2563], 'using': [2566, 2770, 2851, 2959, 3010, 3512, 3602, 3803], 'Milli-Q': [2568], 'system': [2569, 2774, 2818], '(Millipore,': [2570], 'Billerica,': [2571], 'MA).Preparation': [2572], 'Oligosaccharide': [2575], 'Mixtures—The': [2576], 'mixture': [2579, 2644, 2656, 2670, 3112, 3241, 3319, 3351], 'bovine': [2583, 3595], 'heparinase': [2591, 2625, 3592], 'described': [2593], 'Briefly,': [2614], 'mg': [2616], 'digested': [2620], '0.2': [2622], 'milliunits': [2623], '(EC': [2626], '200': [2629], 'μl': [2630, 2677], '50': [2632], 'mm': [2633, 2998], 'phosphate': [2635], 'buffer': [2636], '(pH': [2637], '7.0)': [2638], '°C.': [2641], 'reaction': [2643], 'incubated': [2646], 'until': [2647], 'digestion': [2649], '30%': [2651], 'complete,': [2652], 'then': [2654], 'boiled': [2658], '100': [2660, 2676], '°C': [2661, 2919], '2': [2663], 'min': [2664], 'inactivate': [2666], 'enzyme.': [2668], 'freeze-dried': [2672], 'redissolved': [2674], 'double': [2679], 'distilled': [2680], 'water.Chromatographic': [2681], 'Conditions—HPLC': [2682], 'performed': [2685, 2769, 2865], 'a5-μm': [2687], 'Discovery': [2688], 'C18': [2689], 'column': [2690], '(4.6': [2691], '×': [2692], '250': [2693], 'mm)': [2694, 2712, 2717, 3571, 4112], 'Supelco': [2696], '(Bellefonte,': [2697], 'PA).': [2698], 'Eluent': [2699], 'water/acetonitrile': [2702, 2708], '(80:20),': [2703], 'B': [2706, 2751], '(35:65).': [2709], 'Tributylamine': [2710], '(15': [2711, 3570], 'acetate': [2715, 3000, 3539, 3563], '(50': [2716, 3564], 'added': [2719, 4020], 'eluents.': [2722], 'phase': [2725, 2884, 3414], 'pH': [2726, 3566], 'adjusted': [2728], '7.0': [2730], 'acetic': [2732, 4024], 'acid.': [2733], 'sample': [2735, 3023], '(20': [2736], 'μl,': [2737], '10': [2738, 2935], 'mg/ml)': [2739, 2872], 'injected,': [2741], 'linear': [2744], 'gradient': [2745, 2827, 3267, 3496, 3556], '(from': [2746], '0': [2747], '100%': [2749], '120': [2753], 'min)': [2754], 'rate': [2758, 2889, 3017], '0.5': [2760, 2891], 'ml/min': [2761], 'elution.Off-line': [2765], 'UV-LC': [2766], 'measurements': [2767, 2808], 'Shimadzu': [2772, 2778, 2783], 'HPLC': [2773, 2807, 3383], 'consisting': [2775, 2822], 'two': [2777], 'LC-10Ai': [2779], 'pumps': [2780], 'UV-visible': [2784], 'spectrophotometric': [2785], 'detector': [2786], '(Model': [2787], 'SPD-10A).': [2788], 'elution': [2790], 'profiles': [2791, 3497], 'monitored': [2793], '232': [2797, 3616], 'nm': [2798, 3617], '0.02': [2800], 'full': [2804, 2930, 2936], 'scale.': [2805], 'carried': [2810], 'out': [2811], 'Agilent': [2814, 2853, 2960, 3012], '1100': [2815, 2854], 'series': [2816, 2855], 'pumping': [2817], '(Agilent': [2819, 2860, 2977], 'Technologies,': [2820, 2861, 2978], 'Inc.)': [2821], 'G1312A': [2825], 'binary': [2826], 'pump,': [2828], 'G1322A': [2830], 'vacuum': [2831], 'degasser,': [2832], 'G1367A': [2834], 'plater': [2836], 'sampler,': [2837], 'GB65B': [2840], 'wave-length': [2842], 'UV/VIS': [2843], 'detector.Mass': [2844], 'Spectrometric': [2845], 'Conditions—ESI': [2846], 'Classic': [2856], 'G2445A': [2857], 'LC/MSD': [2858, 2969], 'trap': [2859, 2970], 'Inc.).': [2862, 2979], 'Optimization': [2863], 'direct': [2867], 'injection': [2868], '(6': [2869], 'μl/min,': [2870], 'trisulfated': [2874, 3200], 'disaccharide': [2876, 2927, 3201, 3248], '(Fig.': [2877, 3338, 3581], '1,': [2878], 'n': [2879], '0)': [2881], 'ml/min.': [2892], 'set': [2897], 'mode': [2901], 'skimmer': [2904], 'potential': [2905], '–19.7': [2906], 'V,': [2907, 2911], 'exit': [2909], '–48.4': [2910], 'source': [2914, 3009], 'temperature': [2916], '350': [2918], 'maximum': [2922], 'abundance': [2923], 'standard': [2926], 'scan': [2931], '(200–2200': [2933], 'Da,': [2934], 'scans/s).': [2937], 'Nitrogen': [2938], 'drying': [2943], '(12': [2944], 'liters/min)': [2945], 'nebulizing': [2947], 'gas': [2948], '(60': [2949], 'p.s.i.).': [2950], 'Total': [2951], 'chromatograms': [2953, 3648], 'processed': [2958], 'Chemstation': [2961], 'A.07.': [2962], 'Software': [2963], 'versions': [2964], 'follows:': [2967], '4.0': [2968], 'control': [2971], '5.0': [2972], 'Data': [2974], 'Analysis': [2975], '2.0': [2976], 'Monoisotopic': [2980], 'masses': [2981], 'reported': [2983], 'throughout': [2984], 'text.': [2986], 'For': [2987], 'simplification': [2989], 'experiments,': [2990], '(optimally': [2996], '5': [2997], '(TrBA)': [3001], 'CH3CN)': [3003], 'directly': [3004, 3904], 'infused': [3005], 'into': [3006], 'ESI': [3008], 'syringe': [3013], 'pump': [3014], '6': [3019], 'μl/min.': [3020], 'sprayed': [3030], 'same': [3033], 'time': [3034], 'ensure': [3036], 'in-source': [3037], 'mixing.RESULTS': [3038], 'AND': [3039], 'DISCUSSIONHeparin': [3040], '(and': [3041], 'sulfate)': [3043], 'diverse,': [3046], '(MWavg': [3050], '10,000),': [3052], '≈': [3055], '1.1–1.4)': [3056], '47.Edens': [3076, 3288], 'Al-Hakim': [3078, 3290], 'Rethwisch': [3082, 3294], 'D.G.': [3083, 3295], 'Fareed': [3084, 3296], 'Pharm.': [3089, 3301], '81:': [3092, 3304], '823-827Abstract': [3093, 3305], '(158)': [3099, 3311], 'reducing': [3106], 'prepare': [3114], 'heparins': [3118], 'facilitate': [3136], 'isolation': [3138], 'purification': [3140], 'components,': [3145], 'tedious': [3147], 'repetitive': [3149], 'Bovine': [3168], 'selected': [3172], 'starting': [3175], 'material': [3176], 'reduced': [3184], 'complexity,': [3186, 4041], 'when': [3187], 'compared': [3188], 'porcine': [3190], 'intestinal': [3191], 'proportion': [3198], 'structure': [3205], '→4)': [3206], '2-O-sulfo-α-l-idopyranosuronic': [3207], 'acid': [3208], '(1→4)': [3209, 3214], '2-deoxy-2-sulfamido-6-O-sulfo-α-d-glucopyranose': [3210], '(1→': [3211], '[→4)': [3212], 'α-l-IdoAp2S': [3213], 'α-d-GlcNpS6S': [3215], '(1→]': [3216], 'Controlled,': [3234], 'partial': [3235, 3688], '(30%),': [3236], 'yielded': [3239], 'comprised': [3242], 'primarily': [3243, 3326], 'ranging': [3246], '(degree': [3249], 'polymerization': [3251], '(dp)': [3252], '2)': [3253], 'larger': [3256], 'than': [3257], 'tetradecasaccharide': [3258], '(dp14)': [3259, 3345], 'confirmed': [3261], 'exclusion': [3264], 'PAGE': [3268], '(data': [3314], 'shown).': [3316], 'residues.': [3332], 'predominates': [3337], '1),': [3339], 'disaccharides': [3341], '(dp2)': [3342], 'tetradecasaccharides': [3344], 'characterized': [3353], 'multidimensional': [3355], 'Scholar).Extensive': [3376], 'experiments': [3377], 'undertaken': [3379], 'optimize': [3381], 'small': [3387], '(dp2–dp6)': [3388], '(dp10–dp14)': [3391], '(48.Thanawiroon': [3394, 3469, 3520], '2003;': [3401, 3476, 3527], '1014:': [3402, 3477, 3528], '215-223Crossref': [3403, 3478, 3529], 'RPIP-HPLC': [3409, 3511, 3552], 'MS-friendly': [3412], 'including:': [3415], 'reagents,': [3418], 'tributylamine;': [3419], 'inorganic': [3421, 3500], 'salt,': [3422, 3501], 'organic': [3427, 3890, 3895, 3898], 'modifier,': [3428], 'choice': [3431], 'represents': [3436], 'compromise': [3438], 'between': [3439], 'alkyl': [3441, 3455], 'chain': [3442, 3456], 'length': [3443, 3457], 'volatility,': [3446], 'compatibility': [3449], 'longer': [3454], 'higher': [3459, 3650], 'on-column': [3460], 'retention': [3461, 3487], 'enhanced': [3467], 'TrBA': [3484, 3569, 4102, 4114], 'optimal': [3486], 'compatibility.': [3490], 'Organic': [3491], 'cosolvent,': [3492], 'solvent': [3493], 'pH,': [3494], 'temperature,': [3495], 'various': [3503, 3694], 'first': [3507], 'optimized,': [3508], 'efficient': [3517], 'Ammonium': [3535], 'formate': [3536], 'gradients': [3540], 'gave': [3541], 'peak': [3543, 3656, 4044], 'intensities': [3544], 'complicated': [3546], 'suppression.': [3551], 'acetonitrile': [3555, 4118], 'fixed': [3559], 'concentration': [3560, 4110], 'mm),': [3565], '7.0,': [3567], 'analyses': [3580], '2).Fig.': [3582], '2RPIP-HPLC': [3583], '(30%)': [3591], 'total': [3599, 3642], 'chromatogram': [3601, 3614, 3644], '(upper': [3606], 'trace)': [3607, 3619], 'peaks': [3609, 3623, 4089], 'numbered': [3610], '(lower': [3618], 'dp': [3621], 'corresponding': [3624], 'Fig.': [3629], 'shown.': [3632], 'inset': [3634], 'shows': [3635], 'expanded': [3637], 'view': [3638], 'dp16–dp28': [3654], 'counting.': [3657], 'Assignments': [3658], 'labeled': [3660], 'peaks,': [3661], 'spectra,': [3665, 4123], 'given': [3667], 'Table': [3669], 'I.View': [3670], 'Large': [3671], 'Image': [3672], 'Figure': [3673], 'ViewerDownload': [3674], 'Hi-res': [3675], 'image': [3676], 'Download': [3677], '(PPT)In': [3678], 'sulfo': [3691], 'groups': [3692], 'cations': [3695, 3777], '(i.e.': [3696], 'sodium,': [3697], 'potassium,': [3698], 'ammonium,': [3699], 'reagent)': [3702], 'pose': [3704], 'significant': [3705], 'problems': [3706], 'analysis,': [3709, 3886], 'pseudomolecular': [3715], 'different': [3718], 'm/z': [3719], 'values,': [3720], 'resulting': [3721], 'decreased': [3727], 'sensitivity': [3728], 'DNA': [3788, 3885], 'polyanion,': [3789], 'predominantly': [3793], 'closely': [3797], 'resembling': [3798], 'simpler': [3800], 'MALDI-MS': [3804], '(49.Cai': [3805, 3925], '703:': [3813, 3933], '667-692Crossref': [3814, 3934], '(307)': [3816, 3936], '50.Huber': [3819, 3939], 'Krajete': [3821, 3941], '870:': [3827, 3947], '413-424Crossref': [3828, 3948], '(55)': [3831, 3951], '51.Cheng': [3834, 3954], 'X.': [3835, 3955], 'Gale': [3836, 3956], 'Udseth': [3838, 3958], 'Smith': [3840, 3960], '586-593Crossref': [3846, 3966], '(83)': [3848, 3968], '52.Stephenson': [3851, 3971], 'Jr.,': [3852, 3972], 'McLuckey': [3854, 3974], 'S.A.': [3855, 3975], '3533-3544Crossref': [3860, 3980], '(119)': [3863, 3983], '53.Griffey': [3866, 3986], 'R.H.': [3867, 3987], 'Sasmor': [3868, 3988], 'Grieg': [3870, 3990], '155-160Crossref': [3879, 3999], '(36)': [3881, 4001], 'solvent,': [3891], 'reagent,': [3893], 'acids': [3896, 4021], 'bases,': [3899], 'within': [3905], 'source,': [3908], 'decreases': [3909], 'surface': [3911], 'tension': [3912], 'increases': [3914], 'volatility': [3916], 'electrosprayed': [3919], 'solution,': [3920], 'simplifying': [3921, 4039], 'Scholar).In': [4003], 'we': [4009], 'observe': [4013], 'reduction': [4015], 'states': [4018], '(formic': [4022], 'acid,': [4023], 'acid)': [4025], 'bases': [4027], '(ammonium': [4028], 'hydroxide,': [4029], 'piperidine,': [4030], 'imidazole)': [4032], 'influencing': [4034], 'proton': [4036], 'transfer': [4037], 'reactions,': [4038], 'enhancing': [4043], 'intensity.': [4045], 'CH3CN': [4049], 'resulted': [4053], 'improvement': [4055], 'intensity': [4058], 'substantial': [4061], 'simplification,': [4063], 'possibly': [4064], 'weakening': [4066], 'solventsolute': [4069], 'ion-counter-ion': [4071], 'subsequent': [4075], 'release': [4076], 'free': [4078], 'analyte': [4079], 'evaporation': [4083], 'process.': [4084], 'intense': [4087], 'each': [4091], 'caused': [4093], 'cation': [4095], 'adduction': [4096], 'always': [4098], 'adduct.': [4103], '(5': [4111], 'simplified': [4122], 'suppressing': [4124], 'Na+/NH4+': [4126], 'adduct': [4127]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2005517951', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-10T03:53:39.844026', 'created_date': '2016-06-24'}