Beneficial effects of once‐daily liraglutide, a human glucagon‐like peptide‐1 analogue, on cardiovascular risk biomarkers in patients with Type 2 diabetes

Name: Work Video:
Duration: 3 min 30 s
J.P. Courrèges; Tina Vilsbøll; Milan Zdravković; T Le-Thi; Thure Krarup; O. Schmitz; Rob H.A. Verhoeven; Ingrid Bugáňová; Sten Madsbad
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[57], 'may': [58, 378], 'also': [59], 'beneficial': [61], 'effects': [62, 291, 455], 'on': [63, 68, 79, 292], 'the': [64, 75, 149, 155, 165, 197, 215, 226, 380, 388, 559, 657], 'myocardium': [65], '[3]': [66], 'endothelial': [69], '[4].': [71], 'We': [72, 554, 680], 'present': [73], 'here': [74], 'effect': [76], 'biomarkers': [80, 217, 363, 435], 'for': [81, 145, 209, 214, 406, 411, 488, 502, 506, 515, 685], 'diabetes,': [89, 432], 'as': [90, 522], 'exploratory': [92], 'endpoint': [93, 199], 'from': [94], 'broader': [96], 'clinical': [97, 122, 309], 'study.': [98], 'The': [99, 113, 192, 256, 415], 'design': [100], 'non-cardiovascular': [102], 'biomarker': [103], 'results': [104, 449], 'this': [106, 690], 'study': [107, 193, 303], 'been': [109, 495], 'described': [110], 'previously': [111, 158], '[1].': [112, 328, 357], 'trial': [114, 546], 'was': [115, 194, 202, 278, 304, 547], 'carried': [116], 'out': [117], 'accordance': [119], 'good': [121], 'practice.': [123], 'Briefly,': [124], '165': [125], 'were': [131, 157, 230, 271, 288, 354], 'randomized': [132], 'to': [133, 422, 446, 451, 557], 'either': [134], 'placebo': [135], 'or': [136, 141, 525], '0.65': [137], 'mg,': [138], '1.25': [139], 'mg': [140, 143], '1.9': [142], '14': [146], 'weeks.': [147], 'Across': [148], 'four': [150], 'treatment': [151, 274, 290], 'arms,': [152], '17–23%': [153], 'subjects': [156, 167, 324], 'treated': [159, 325], 'diet': [161], 'exercise': [163], 'remaining': [166], 'oral': [169], 'glucose-lowering': [170], 'agents.': [171], 'Subjects': [172], 'had': [173], 'mean': [175, 184], 'body': [176, 321], 'mass': [177], 'index': [178], '(BMI)': [179], '28.9–31.2': [181], 'kg/m2': [182], 'glycated': [185], 'haemoglobin': [186], '(HbA1c)': [187], 'at': [188, 205, 338, 349], 'randomization': [189, 221], '8.1–8.5%.': [191], 'powered': [195, 204], 'against': [196], 'primary': [198], 'HbA1c,': [200], 'but': [201, 281], 'not': [203], '80%': [207], 'level': [208], 'difference': [211], '20%': [213], 'discussed': [218], 'here.': [219], 'At': [220], 'end': [223], 'study,': [225], 'following': [227, 273, 560], 'additional': [228], 'parameters': [229], 'assessed:': [231], 'adiponectin,': [232, 295], 'leptin,': [233, 296], 'high-sensitivity': [234], 'C-reactive': [235], 'protein': [236], '(hs-CRP),': [237], 'interleukin': [238], '6': [239], '(IL-6),': [240], 'tumour': [241], 'necrosis': [242], 'factor': [243], 'alpha': [244], '(TNF-α),': [245], 'plasminogen': [246], 'activator': [247], 'inhibitor': [248], '1': [249], '(PAI-1)': [250], 'B-type': [252], 'natriuretic': [253], 'peptide': [254], '(BNP).': [255], 'data': [257], 'are': [258, 361, 365, 403, 444, 471], 'presented': [259], 'Table': [261], '1.': [262], 'A': [263], 'significant': [264], 'decrease': [265], 'PAI-1': [267, 358, 376], 'BNP': [269, 392], 'levels': [270, 293, 377, 402, 426], 'observed': [272], 'liraglutide.': [276, 301], 'There': [277, 287], 'non-significant,': [280], 'dose-dependent,': [282], 'reduction': [283, 319], 'hs-CRP': [285, 360], 'levels.': [286], 'no': [289], 'IL-6': [297], 'TNF-α': [299], 'This': [302, 545], 'part': [305], 'larger': [308], 'trial,': [310], 'which': [311], 'showed': [312], 'significantly': [313, 355], 'improved': [314], 'glycaemic': [315], 'control': [316], 'weight': [322], 'In': [329], 'addition,': [330], 'systolic': [331], 'pressure': [333], '(reduction': [334, 346], '8': [336], 'mmHg': [337], '1.90': [339, 350], 'mg/day': [340, 351], 'vs.': [341, 352], 'placebo)': [342, 353], 'plasma': [344], 'triglycerides': [345], '22%': [348], 'reduced': [356], 'inflammatory': [362], 'disease': [373], '[5].': [374], 'Elevated': [375], 'suppress': [379], 'fibrinolytic': [381], 'process': [382], 'thereby': [384], 'be': [385], 'development': [389], 'atherosclerosis.': [391], 'marker': [395], 'left': [397], 'ventricular': [398], 'dysfunction': [399], 'elevated': [401], 'markers': [405], 'diseases,': [408], 'particular': [410], 'heart': [412], 'failure': [413], '[6].': [414], 'findings': [416], 'suggest': [417], 'liraglutide,': [419], 'when': [420], 'used': [421], 'regulate': [423], 'improves': [433], 'certain': [434], 'risk.': [440], 'Large': [441], 'prospective': [442], 'trials': [443], 'needed': [445], 'confirm': [447], 'these': [448, 454], 'assess': [452], 'whether': [453], 'translate': [456], 'into': [457], 'diabetes.': [467], 'MZ': [468], 'TL-T': [470], 'employed': [472], 'by': [473, 497, 549], 'hold': [475], 'stocks': [476], 'Novo': [478, 498, 530, 550], 'Nordisk': [479, 499, 551], 'A/S.': [480], 'TK': [481], 'member': [484, 511], 'advisory': [486, 513], 'boards': [487, 514], 'Eli': [489], 'Lilly': [490], 'Merck.': [492], 'TV': [493], 'has': [494, 520], 'reimbursed': [496], 'MSD': [501, 516], 'attending': [503], 'symposia,': [504], 'speaking,': [507], 'Novartis.': [518], 'SM': [519], 'served': [521], 'consultant': [524], 'advisor': [526], 'to:': [527], 'Novartis': [528], 'Pharmaceuticals,': [529], 'Nordisk,': [531], 'Merck-Sharp': [532], 'Dome,': [534], 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