Title: Failure of <i>N</i>‐Acetylcysteine to reduce alpha amanitin toxicity
Abstract: Abstract Acetaminophen undergoes toxic conversion in the liver to a free‐radical intermediary which binds to glutathione. N ‐Acetylcysteine acts as a glutathione precursor when natural stores are depleted, and is an effective antidote for acetaminophen overdose. Mushrooms containing amatoxins (such as Amanita phalloides ) may undergo similar toxic conversion. However, in our amatoxin‐poisoned mouse model, N ‐acetylcysteine (1.2 g kg −1 ) produced no change in survival or hepatic enzyme elevation compared to control animals. We conclude that N ‐acetylcysteine has no clinical role in the treatment of Amanita phalloides ingestion.
Publication Year: 1992
Publication Date: 1992-04-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 39
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