Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2004577240', 'doi': 'https://doi.org/10.1007/bf00508904', 'title': 'Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in Vivo using an inhibitor of the aromatic amino acid decarboxylase', 'display_name': 'Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in Vivo using an inhibitor of the aromatic amino acid decarboxylase', 'publication_year': 1972, 'publication_date': '1972-01-01', 'ids': {'openalex': 'https://openalex.org/W2004577240', 'doi': 'https://doi.org/10.1007/bf00508904', 'mag': '2004577240', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/4404948'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/bf00508904', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S159534381', 'display_name': 'Naunyn-Schmiedeberg s Archives of Pharmacology', 'issn_l': '0028-1298', 'issn': ['0028-1298', '1432-1912'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5038932065', 'display_name': 'Arvid Carlsson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I881427289', 'display_name': 'University of Gothenburg', 'ror': 'https://ror.org/01tm6cn81', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I881427289']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'A. Carlsson', 'raw_affiliation_strings': ['Department of Pharmacology, University of Göteborg, Göteborg, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Göteborg, Göteborg, Sweden', 'institution_ids': ['https://openalex.org/I881427289']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103726562', 'display_name': 'James N. Davis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I881427289', 'display_name': 'University of Gothenburg', 'ror': 'https://ror.org/01tm6cn81', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I881427289']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'J. N. Davis', 'raw_affiliation_strings': ['Department of Pharmacology, University of Göteborg, Göteborg, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Göteborg, Göteborg, Sweden', 'institution_ids': ['https://openalex.org/I881427289']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030926549', 'display_name': 'W. Kehr', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I881427289', 'display_name': 'University of Gothenburg', 'ror': 'https://ror.org/01tm6cn81', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I881427289']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'W. Kehr', 'raw_affiliation_strings': ['Department of Pharmacology, University of Göteborg, Göteborg, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Göteborg, Göteborg, Sweden', 'institution_ids': ['https://openalex.org/I881427289']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056609874', 'display_name': 'Margit Lindqvist', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I881427289', 'display_name': 'University of Gothenburg', 'ror': 'https://ror.org/01tm6cn81', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I881427289']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Margit Lindqvist', 'raw_affiliation_strings': ['Department of Pharmacology, University of Göteborg, Göteborg, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Göteborg, Göteborg, Sweden', 'institution_ids': ['https://openalex.org/I881427289']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5077426898', 'display_name': 'Colin Atack', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I881427289', 'display_name': 'University of Gothenburg', 'ror': 'https://ror.org/01tm6cn81', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I881427289']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'C. V. Atack', 'raw_affiliation_strings': ['Department of Pharmacology, University of Göteborg, Göteborg, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Göteborg, Göteborg, Sweden', 'institution_ids': ['https://openalex.org/I881427289']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3390, 'currency': 'EUR', 'value_usd': 4390, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 22.233, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 704, 'citation_normalized_percentile': {'value': 0.995059, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '275', 'issue': '2', 'first_page': '153', 'last_page': '168'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13551', 'display_name': 'Physiology and Pathophysiology of Carnosine', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13551', 'display_name': 'Physiology and Pathophysiology of Carnosine', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12770', 'display_name': 'Amino Acid Transport and Metabolism in Health and Disease', 'score': 0.995, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12267', 'display_name': 'Effects of Ketogenic Diet on Health', 'score': 0.9915, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/decarboxylase-inhibitor', 'display_name': 'Decarboxylase inhibitor', 'score': 0.788116}, {'id': 'https://openalex.org/keywords/hydroxylation', 'display_name': 'Hydroxylation', 'score': 0.61053216}, {'id': 'https://openalex.org/keywords/neuroprotection', 'display_name': 'Neuroprotection', 'score': 0.475582}], 'concepts': [{'id': 'https://openalex.org/C58824617', 'wikidata': 'https://www.wikidata.org/wiki/Q421186', 'display_name': 'Aromatic L-amino acid decarboxylase', 'level': 3, 'score': 0.9368695}, {'id': 'https://openalex.org/C2776165026', 'wikidata': 'https://www.wikidata.org/wiki/Q188017', 'display_name': 'Tyrosine', 'level': 2, 'score': 0.79383373}, {'id': 'https://openalex.org/C159167319', 'wikidata': 'https://www.wikidata.org/wiki/Q420766', 'display_name': 'Tyrosine hydroxylase', 'level': 3, 'score': 0.78851366}, {'id': 'https://openalex.org/C2908591018', 'wikidata': 'https://www.wikidata.org/wiki/Q4795512', 'display_name': 'Decarboxylase inhibitor', 'level': 5, 'score': 0.788116}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.6792489}, {'id': 'https://openalex.org/C2776706248', 'wikidata': 'https://www.wikidata.org/wiki/Q181003', 'display_name': 'Tryptophan', 'level': 3, 'score': 0.664478}, {'id': 'https://openalex.org/C2781109383', 'wikidata': 'https://www.wikidata.org/wiki/Q898497', 'display_name': 'Hydroxylation', 'level': 3, 'score': 0.61053216}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5905684}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.50718784}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4703636}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.45106605}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.44946012}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4066535}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.34475943}, {'id': 'https://openalex.org/C2780304432', 'wikidata': 'https://www.wikidata.org/wiki/Q300989', 'display_name': 'Levodopa', 'level': 4, 'score': 0.31464726}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27190787}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.12627974}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D006899', 'descriptor_name': 'Mixed Function Oxygenases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014446', 'descriptor_name': 'Tyrosine 3-Monooxygenase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006916', 'descriptor_name': '5-Hydroxytryptophan', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006916', 'descriptor_name': '5-Hydroxytryptophan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000596', 'descriptor_name': 'Amino Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002262', 'descriptor_name': 'Carboxy-Lyases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002262', 'descriptor_name': 'Carboxy-Lyases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D002395', 'descriptor_name': 'Catecholamines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002395', 'descriptor_name': 'Catecholamines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004295', 'descriptor_name': 'Dihydroxyphenylalanine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004295', 'descriptor_name': 'Dihydroxyphenylalanine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006834', 'descriptor_name': 'Hydrazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006834', 'descriptor_name': 'Hydrazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006900', 'descriptor_name': 'Hydroxylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008781', 'descriptor_name': 'Methyltyrosines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008781', 'descriptor_name': 'Methyltyrosines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006899', 'descriptor_name': 'Mixed Function Oxygenases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014364', 'descriptor_name': 'Tryptophan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014364', 'descriptor_name': 'Tryptophan', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014365', 'descriptor_name': 'Tryptophan Hydroxylase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014365', 'descriptor_name': 'Tryptophan Hydroxylase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D014365', 'descriptor_name': 'Tryptophan Hydroxylase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014443', 'descriptor_name': 'Tyrosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014443', 'descriptor_name': 'Tyrosine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014446', 'descriptor_name': 'Tyrosine 3-Monooxygenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014446', 'descriptor_name': 'Tyrosine 3-Monooxygenase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/bf00508904', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S159534381', 'display_name': 'Naunyn-Schmiedeberg s Archives of Pharmacology', 'issn_l': '0028-1298', 'issn': ['0028-1298', '1432-1912'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/4404948', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6', 'score': 0.45}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 26, 'referenced_works': ['https://openalex.org/W1594099994', 'https://openalex.org/W1663605807', 'https://openalex.org/W1810814678', 'https://openalex.org/W1876328157', 'https://openalex.org/W1915581994', 'https://openalex.org/W1977761275', 'https://openalex.org/W1978702535', 'https://openalex.org/W2006759414', 'https://openalex.org/W2011381010', 'https://openalex.org/W2021432299', 'https://openalex.org/W2050526884', 'https://openalex.org/W2064127809', 'https://openalex.org/W2068381714', 'https://openalex.org/W2071330786', 'https://openalex.org/W2072270685', 'https://openalex.org/W2078978843', 'https://openalex.org/W2082800304', 'https://openalex.org/W2083303181', 'https://openalex.org/W2099269179', 'https://openalex.org/W2127920100', 'https://openalex.org/W2247301355', 'https://openalex.org/W2263555837', 'https://openalex.org/W2287714691', 'https://openalex.org/W2435000359', 'https://openalex.org/W2525550930', 'https://openalex.org/W4298917100'], 'related_works': ['https://openalex.org/W4211063015', 'https://openalex.org/W2911442568', 'https://openalex.org/W281333844', 'https://openalex.org/W2471823874', 'https://openalex.org/W2095172265', 'https://openalex.org/W2060598809', 'https://openalex.org/W2040456819', 'https://openalex.org/W2007214127', 'https://openalex.org/W2004577240', 'https://openalex.org/W1995881160'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2004577240', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-09-08T19:30:37.815811', 'created_date': '2016-06-24'}