Publication Information

{'id': 'https://openalex.org/W2004566597', 'doi': 'https://doi.org/10.1002/ijc.11637', 'title': 'High incidence of renal tumours in vitamins A and E synthesis workers: A new cause of occupational cancer?', 'display_name': 'High incidence of renal tumours in vitamins A and E synthesis workers: A new cause of occupational cancer?', 'publication_year': 2004, 'publication_date': '2004-01-02', 'ids': {'openalex': 'https://openalex.org/W2004566597', 'doi': 'https://doi.org/10.1002/ijc.11637', 'mag': '2004566597', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/14712501'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/ijc.11637', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.11637', 'source': {'id': 'https://openalex.org/S5382288', 'display_name': 'International Journal of Cancer', 'issn_l': '0020-7136', 'issn': ['0020-7136', '1097-0215'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.11637', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072922609', 'display_name': 'Richard J. 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The authors certify that they have not entered into any agreement that could interfere with their access to the data on the research, nor upon their ability to analyse the data independently, to prepare articles, and to publish them.', 'Service de Médecine du Travail, Adisséo, Commentry, France', 'The first two authors contributed equally to this work.'], 'affiliations': [{'raw_affiliation_string': 'Dr. Marie-Noelle Carrette is employed by the Adisséo company as occupational physician. 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'about': [21, 87, 1322], '11/100,000': [22], 'person-years': [23], 'in': [24, 36, 43, 225, 239, 282, 297, 303, 323, 354, 358, 371, 373, 449, 468, 473, 481, 486, 505, 552, 579, 584, 588, 595, 600, 661, 673, 712, 797, 806, 840, 870, 916, 957, 978, 985, 994, 1012, 1024, 1039, 1050, 1068, 1093, 1105, 1137, 1160, 1162, 1178, 1187, 1230, 1283, 1294, 1371, 1375], 'industrial': [25], 'countries': [26], 'and': [27, 42, 58, 82, 128, 146, 203, 308, 314, 333, 401, 416, 437, 444, 459, 471, 484, 586, 619, 623, 651, 666, 689, 715, 766, 814, 873, 882, 903, 969, 1022, 1056, 1088, 1168, 1182, 1207, 1243, 1364, 1374, 1386, 1393, 1396], 'increasing': [29], 'as': [30, 493, 1016, 1143, 1145, 1303], 'result': [32, 1136], 'both': [34, 967], 'increases': [35, 273], 'prevalence': [38, 1215], 'risk': [40, 177, 1300], 'factors': [41, 98, 148], 'use': [44, 339], 'diagnostic': [46], 'imaging': [47], 'procedures.2,': [48], '3': [49, 460, 485, 587, 690, 1208, 1218], 'Main': [50], 'histological': [51], 'subtypes': [52], 'include': [53], 'clear-cell': [54, 126, 231, 257, 458, 664, 688, 950, 968], '(75%),': [55], 'papillary': [56, 130, 242, 461, 676, 970], '(10%)': [57], 'chromophobe': [59], '(5%)': [60], 'RCC.': [61, 462, 739, 971, 1097], 'Complete': [62], 'surgical': [63], 'resection': [64], 'considered': [66], 'to': [67, 120, 143, 151, 167, 196, 227, 249, 386, 725, 735, 744, 763, 775, 784, 820, 824, 887, 932, 942, 992, 1026, 1031, 1034, 1079, 1119, 1196, 1267, 1277, 1296, 1316], 'be': [68, 144, 782, 821, 1091, 1109, 1268, 1292], 'curative': [69], 'localised': [71], 'RCC': [72, 83, 103, 140, 232, 258, 295, 320, 366, 394, 988, 1028, 1059, 1142, 1157, 1299], 'but': [73, 748, 838], '30%': [74], 'patients': [76, 427, 433, 470, 576, 613, 627, 662, 1385], 'have': [77, 185, 395, 913, 1197], 'metastatic': [78], 'disease': [79, 448], 'at': [80, 107, 380, 409, 705, 928, 1110], 'diagnosis': [81, 410, 1305], 'responsible': [85], '95,000': [88], 'deaths': [89], 'per': [90], 'year': [91, 1181], 'world-wide.1': [92], 'Little': [93], 'known': [95, 150], 'regarding': [96, 846], 'etiological': [97], 'RCC.2,': [100], '4': [101, 438, 624], 'Familial': [102], 'syndromes': [104], 'are': [105, 115, 141, 149, 171, 211, 718, 885, 1253], 'estimated': [106, 541], 'less': [108], 'than': [109, 559, 727, 1221], '5%;': [110], '2': [112, 602, 620, 746, 1251], 'main': [113, 173], 'conditions': [114], 'von': [116], 'Hippel-Lindau': [117], 'disease,': [118], 'related': [119, 734, 774, 823], 'tumour-suppressor': [122], 'VHL': [123, 221, 264, 656, 695, 973], 'gene,': [124], 'RCC;': [127, 1213], 'hereditary': [129], 'RCC,': [131, 665, 1312], 'caused': [132], 'by': [133, 369, 403, 441, 520, 720, 1005, 1114, 1123], 'c-MET': [135, 235], 'proto-oncogene.5': [136], 'Most': [137], 'cases': [138, 318, 483], 'thought': [142], 'sporadic': [145, 230], 'many': [147, 852], 'increase': [152, 1139], 'risk.': [154, 1326], 'Tobacco': [155], 'smoking,': [156], 'obesity': [157], '(particularly': [158], 'among': [159, 501], 'women),': [160], 'high': [161, 629, 995, 1100, 1144], 'blood': [162, 630], 'pressure': [163], 'and/or': [164], 'medication': [165], 'prescribed': [166], 'treat': [168], 'this': [169, 270, 326, 506, 860, 890, 1240, 1284, 1323], 'condition': [170], 'established,': [174], 'although': [175], 'modest,': [176], 'factors.6,': [178], '7,': [179], '8': [180], 'A': [181, 382, 581, 639, 714, 1087], 'number': [182, 293, 514, 529], 'reports': [184], 'also': [186, 1382], 'pointed': [187], 'out': [188, 608, 953], 'potential': [190, 758, 777, 848, 1325], 'nephrocarcinogenic': [191], 'effect': [192], 'occupational': [194, 1007, 1077], 'exposure': [195, 248, 762, 996, 1033, 1078], 'trichloroethylene,': [197], 'gasoline,': [198], 'petroleum': [199], 'products,': [200], 'asbestos,': [201], 'cadmium': [202], 'iron': [204], 'processing': [205], 'fumes;': [206], 'corresponding': [207], 'epidemiological': [208, 751, 1263], 'studies,': [209], 'however,': [210, 1126], 'sometimes': [212, 866], 'controversial.9,': [213], '10,': [214], '11,': [215], '12': [216], 'Somatic': [217], 'inactivation': [218], 'gene': [222], 'found': [224, 660, 672, 977, 1195], 'up': [226], '70%': [228], 'whereas': [233], 'somatic': [234, 265, 696, 974], 'mutations': [236], 'only': [237, 749, 1217], 'occur': [238, 984, 1082], '13%': [240], 'tumours.13,': [243], '14,': [244], '15,': [245], '16': [246], 'Prolonged': [247], 'trichloroethylene': [250, 281, 990], 'during': [251, 508, 856, 1083], 'metal': [252], 'machining': [253], 'associated': [255], 'with': [256, 393, 663, 675, 989], 'harbouring': [259], 'a': [260, 277, 298, 343, 374, 435, 590, 757, 776, 786, 801, 1017, 1051, 1069, 1115, 1127, 1151, 1198, 1271, 1287], 'specific': [261, 700], 'pattern': [262], 'mutations;': [266], 'identification': [268], 'putative': [271], 'mechanism': [272], 'probability': [275], 'causative': [278, 787], 'role': [279, 788], 'RCC.12,': [283], '17': [284], 'We': [285, 1329, 1381], 'recently': [286], 'were': [287, 321, 428, 439, 445, 491, 577, 604, 614, 731, 926, 946, 1194, 1210], 'made': [288], 'aware': [289], 'an': [291, 347, 793, 929, 1044, 1138, 1262], 'unexpected': [292], 'occurring': [296], 'French': [299, 546, 563], 'factory': [300, 327, 918], 'that': [301, 328, 574, 730, 780, 863, 945, 1076, 1081, 1131], 'specialised': [302], 'vitamin': [304, 306, 381, 580, 596, 713], 'A,': [305], 'E': [307, 597, 716, 1089], 'methionine': [309], 'synthesis.': [310, 598], 'Between': [311], 'March': [312, 450], '1994': [313, 372, 1049], 'October': [315], '2002,': [316], '10': [317], 'detected': [322, 368, 927, 1061, 1141], 'workers': [324, 1011], 'from': [325, 384, 542, 562, 646, 653, 681, 1225, 1399], 'currently': [329], 'employs': [330], '612': [331], 'men': [332, 392, 606, 1167, 1206], '116': [334], 'women.': [335], 'Because': [336], 'vinyl': [341, 764], 'chloride,': [342], 'well-documented': [344], 'liver': [345], 'carcinogen,': [346], 'annual': [348, 513], 'abdominal': [349], 'ultrasonography': [350, 400, 999, 1045, 1155], 'was': [351, 367, 411, 421, 466, 479, 499, 518, 534, 555, 560, 593, 634, 642, 659, 671, 679, 708, 976, 1046, 1060, 1066, 1158, 1216], 'progressively': [352], 'introduced': [353, 805, 915], 'worker': [355], 'medical': [356, 1320], 'surveillance': [357], 'end': [360], '1980s.': [363], 'The': [364, 463, 512, 527, 549, 808, 879, 922], 'first': [365, 1015, 1180], 'chance': [370], '48-year-old': [375], 'man,': [376], 'who': [377], 'had': [378, 628], 'worked': [379], 'synthesis': [383, 717, 747, 803, 1084], '1979': [385], '1988.': [387], 'To': [388, 1042], 'date,': [389, 1043], '9': [390, 469, 482, 575, 685, 1203], 'further': [391, 591, 1260], 'been': [396, 836, 844, 914, 1001, 1275], 'discovered': [397, 1067], 'through': [398], 'systematic': [399, 893, 1124, 1132], 'confirmed': [402], 'CT-scan': [404], '[Table': [405, 569], 'I].': [406], 'Mean': [407], 'age': [408, 1172, 1233], '52.3': [412], '±': [413, 423], '7.8': [414], 'years': [415], 'mean': [417, 1171], 'diameter': [418], 'tumour': [420, 454, 465], '2.9': [422], '1.0': [424], 'cm.': [425], 'All': [426, 489], 'successfully': [429], 'operated': [430], 'upon': [431], '(6': [432, 687], 'underwent': [434], 'nephrectomy': [436], 'treated': [440], 'conservative': [442], 'surgery)': [443], 'free': [446], '2003.': [451], 'Review': [452], 'slides': [455], 'identified': [456], '7': [457], 'renal': [464, 531, 1064, 1199], 'unique': [467], 'multifocal': [472], '1': [474, 487, 750, 1063], 'patient.': [475], 'Nuclear': [476], 'grade': [477], '(Fuhrman)': [478], '1–2': [480], 'case.': [488], 'tumours': [490, 686, 944, 956, 981], 'classified': [492], 'pT1N0M0.': [494], 'Standardized': [495], 'ratio': [497], '(SIR)': [498], 'calculated': [500, 535], 'subjects': [503, 516, 1193], 'employed': [504, 517, 578, 594, 711], 'firm': [507, 522, 554], 'period': [510], '1994–2002.': [511], 'provided': [519, 753], 'same': [525], 'period.': [526], 'expected': [528, 561, 1224], 'cancer': [533, 547, 1227], 'using': [536, 1154], 'national': [538], 'rates': [540, 565, 1282], 'data': [544, 1229], 'registries.18': [548], 'SIR': [550], 'observed': [551, 966, 1104], '13.1': [556], 'times': [557, 1219], 'higher': [558, 1220], 'population': [564, 1107], '(95%': [566], 'CI:': [567], '6.28–24.10)': [568], 'II].': [570], 'Occupational': [571], 'history': [572], 'showed': [573], 'synthesis:': [582], '6': [583, 1205], 'fabrication': [585], 'maintenance;': [589], 'patient': [592, 633, 935], 'Workers': [599, 710], 'these': [601], 'occupations': [603], 'essentially': [605], '(434': [607], '441': [610], 'persons).': [611], 'Six': [612], 'smokers': [615, 618], '(4': [616], 'heavy': [617], 'light': [621], 'smokers)': [622], 'nonsmokers.': [625], 'Five': [626], 'pressure.': [631], 'One': [632], 'obese': [635], '(BMI:': [636], '39': [637], 'kg/m2).': [638], 'genetic': [640], 'study': [641, 752, 842, 1129, 1242, 1264, 1273, 1290, 1373], 'performed': [643, 845, 1047], 'after': [644], 'approval': [645], 'our': [647, 1106, 1244], 'local': [648], 'Ethics': [649], 'Committee': [650], 'consent': [652], 'patients.': [654], 'No': [655, 972], 'germline': [657, 669], 'mutation': [658, 670, 975], 'no': [667, 839, 934, 1057], 'MET': [668], 'those': [674], 'tumours.': [677], 'DNA': [678], 'extracted': [680], 'paraffin-embedded': [682], 'blocks': [683], 'papillary);': [691], 'none': [692], 'bore': [693], 'any': [694], 'mutation;': [697], 'notably,': [698], '"trichloroethylene-target': [701], 'hot-spot"': [702], '(nucleotide': [703], '454': [704], 'codon': [706], '81)17': [707], 'unmodified.': [709], 'exposed': [719], 'inhalation': [721, 872], 'or': [722], 'skin': [723, 874], 'contact': [724, 875], 'more': [726], '60': [728], 'chemicals': [729, 1037, 1080], 'not': [732, 772, 1135], 'previously': [733, 773, 825], 'occurrence': [737, 1095], 'Vinyl': [740], 'chloride': [741, 765], 'slight': [754], 'support': [755], 'link': [759], 'between': [760, 1239], 'long-time': [761], 'cancer.10': [768], 'Among': [769], 'substances': [771], 'carcinogenic': [778], 'impact': [779], 'could': [781, 1108], 'suspected': [783], 'play': [785], '"Chloracetal': [790], 'C5"': [791], '(C5H13ClO2),': [792], 'intermediate': [794], 'chemical': [795], 'produced': [796], 'course': [799], 'proprietary': [802], 'procedure': [804, 862], '1981.': [807], 'molecular': [809, 959], 'structure': [810], 'chloracetal': [812], 'C5': [813, 834], 'some': [815], 'its': [817, 847], 'metabolites': [818], 'seem': [819], 'closely': [822], 'demonstrated': [826, 837, 1130], 'carcinogens.': [827], 'In': [828, 850], 'vitro': [829], 'mutagenic': [830], 'activity': [831], 'Chloracetal': [833], 'has': [835, 843, 936, 1000, 1274], 'vivo': [841], 'carcinogenicity.': [849], 'addition,': [851], 'technical': [853], 'problems': [854], 'occurred': [855], 'start-up': [858], 'new': [861, 1324], 'required': [864], 'numerous,': [865], 'emergency,': [867], 'interventions,': [868], 'resulting': [869], 'frequent': [871], 'workers.': [878], 'above-mentioned': [880], 'time': [881], 'place': [883], 'circumstances': [884], 'insufficient': [886], 'definitely': [888], 'incriminate': [889], 'substance;': [891], 'nevertheless,': [892], 'preventive': [894, 1018], 'measures': [895], '(use': [896], 'protective': [898], 'boiler': [899], 'suit,': [900], 'respiratory': [901], 'mask': [902], 'gloves': [904], 'all': [906, 1010], 'direct': [907], 'interventions': [908], 'on': [909, 1255], 'production': [911], 'line)': [912], 'since': [919, 1048, 1249], '1990s.': [921], 'RCCs': [923], 'we': [924, 965], 'report': [925], 'early': [930, 1304], 'stage:': [931], 'date': [933], 'died': [937], 'because': [938], 'them.': [940], 'Contrary': [941], 'trichloroethylene-related': [943], 'almost': [947], 'exclusively': [948], 'type,': [951], '42': [952], '44': [955], 'work': [960], 'Brauch': [962], 'et': [963], 'al.17,': [964], 'analysed': [980], 'while': [982], 'they': [983], '75%': [986], '(up': [991], '88%': [993], 'levels).17': [997], 'Abdominal': [998], 'now': [1002], 'strongly': [1003], 'recommended': [1004], 'physician': [1008], 'factory,': [1014], '(early': [1019], 'detection)': [1020], 'measure': [1021], 'second': [1023, 1189], 'order': [1025, 1295], 'analyse': [1027], 'according': [1030], 'past': [1032], 'various': [1036], 'used': [1038], 'factory.': [1041], 'total': [1052], '435': [1054], 'employees': [1055], 'additional': [1058], '(however,': [1062], 'oncocytoma': [1065], '54-year-old': [1070], 'woman).': [1071], 'Our': [1072], 'preliminary': [1073], 'results': [1074], 'suggest': [1075], 'vitamins': [1086], 'may': [1090], 'involved': [1092], 'Nevertheless,': [1098], 'rate': [1102], '(13.1)': [1103], 'least': [1111], 'partially': [1112], 'explained': [1113], 'detection': [1116], 'bias': [1117], 'due': [1118], 'active': [1121], 'screening': [1122, 1133, 1152, 1241], 'ultrasonography;': [1125], 'recent': [1128], 'does': [1134], 'one': [1147], 'reported': [1148], 'here.': [1149], 'Indeed,': [1150], 'programme': [1153], 'established': [1159], '1996': [1161], 'Germany:': [1163], '9,959': [1164], 'volunteers': [1165], '(49%': [1166], '51%': [1169], 'women,': [1170], '61': [1173], 'years,': [1174], 'range': [1175], '40–94)': [1176], 'participated': [1177], '79%': [1183], 'returned': [1184], 'reexamination': [1186], 'year.19': [1190], 'Thirteen': [1191], '(0.1%)': [1192], 'mass': [1200], 'which': [1202], '(including': [1204], 'women)': [1209], 'histologically': [1211], 'proved': [1212], 'values': [1223], 'German': [1226], 'registry': [1228], 'given': [1232], 'group.': [1234], 'Of': [1235], 'course,': [1236], 'comparison': [1238], 'own': [1245], 'series': [1246], 'needs': [1247], 'caution': [1248], 'studies': [1252], 'based': [1254], 'different': [1256], 'reference': [1257], 'categories.': [1258], 'As': [1259], 'control,': [1261], 'going': [1266], 'conducted.': [1269], 'First,': [1270], 'cohort': [1272], 'designed': [1276], 'examine': [1278], 'cause-specific': [1280], 'mortality': [1281], 'population.': [1285], 'Second,': [1286], 'nested': [1288], 'case-control': [1289], 'will': [1291], 'conducted': [1293], 'precisely': [1297], 'characterise': [1298], 'factors.': [1301], 'However,': [1302], 'imperative': [1307], 'effective': [1309], 'treatment': [1310], 'it': [1313], 'crucial': [1315], 'promptly': [1317], 'inform': [1318], 'community': [1321], 'Yours': [1327], 'sincerely,': [1328], 'thank': [1330, 1383], 'Prof.': [1331, 1358, 1365], 'Jean-François': [1332], 'Foncin,': [1333], 'Dr.': [1334, 1337, 1340, 1343, 1346, 1349, 1352, 1355, 1361], 'Gérard': [1335, 1359], 'Barrat,': [1336], 'Christophe': [1338, 1405], 'Cavillon,': [1339], 'Rémy': [1341], 'Claude,': [1342], 'Bernard': [1344], 'Baudet,': [1345], 'Frédéric': [1347], 'Franck,': [1348], 'Agnès': [1350], 'Laplanche,': [1351], 'Rosette': [1353], 'Lidereau,': [1354], 'Henri': [1356], 'Pézerat,': [1357], 'Benoît,': [1360], 'Guy': [1362], 'Allègre': [1363], 'Marcel': [1366], 'Goldberg': [1367], 'their': [1369], 'help': [1370], 'preparation': [1377], 'article.': [1380], 'members': [1388], 'Medical': [1391], 'Department': [1392], 'Hygiene': [1395], 'Security': [1397], 'Commission': [1398], 'Adisséo.': [1400], 'Stéphane': [1401], 'Richard,': [1402], 'Marie-Noëlle': [1403], 'Carrette,': [1404], 'Béroud,': [1406], 'Sophie': [1407], 'Ferlicot,': [1408], 'Ellen': [1409], 'Imbernon,': [1410], 'Yuriko': [1411], 'Iwatsubo,': [1412], 'Hubert': [1413], 'Egloff,': [1414], 'Dominique': [1415], 'Sordet,': [1416], 'Jean-Michel': [1417], 'Salé': [1418]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2004566597', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-20T02:19:30.338806', 'created_date': '2016-06-24'}