Title: Targeting protein kinase C epsilon or theta as a therapeutic strategy for insulin resistance
Abstract: Isoforms of the protein kinase C family are strong candidates for mediating the inhibitory effects of lipid oversupply on insulin action. These enzymes are lipid-activated, can interfere with insulin signal transduction, and several studies have highlighted an association between insulin resistance and chronic activation of specific protein kinase C isoforms, especially epsilon (ɛ) and theta (θ). The assessment of glucose homeostasis and lipid-induced insulin resistance in protein kinase C θ knockout mice has now demonstrated a key role for this isoform, although it is not yet clear whether its long-term inhibition would be beneficial. Potential approaches to block the action of specific PKC isoforms include pharmacological inhibitors, antisense oligonucleotides and bioactive peptides.
Publication Year: 2005
Publication Date: 2005-06-01
Language: en
Type: article
Indexed In: ['crossref']
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