Publication Information

{'id': 'https://openalex.org/W2004016651', 'doi': 'https://doi.org/10.1074/jbc.274.17.11660', 'title': 'Arachidonic Acid Is Preferentially Metabolized by Cyclooxygenase-2 to Prostacyclin and Prostaglandin E2', 'display_name': 'Arachidonic Acid Is Preferentially Metabolized by Cyclooxygenase-2 to Prostacyclin and Prostaglandin E2', 'publication_year': 1999, 'publication_date': '1999-04-01', 'ids': {'openalex': 'https://openalex.org/W2004016651', 'doi': 'https://doi.org/10.1074/jbc.274.17.11660', 'mag': '2004016651', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10206978'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.274.17.11660', 'pdf_url': 'http://www.jbc.org/article/S0021925819734796/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819734796/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5087809350', 'display_name': 'Thomas G. Brock', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas G. Brock', 'raw_affiliation_strings': ['From the Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109'], 'affiliations': [{'raw_affiliation_string': 'From the Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066534752', 'display_name': 'Robert McNish', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert W. McNish', 'raw_affiliation_strings': ['From the Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109'], 'affiliations': [{'raw_affiliation_string': 'From the Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5084604101', 'display_name': 'Marc Peters‐Golden', 'orcid': 'https://orcid.org/0000-0002-9768-0262'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Marc Peters-Golden', 'raw_affiliation_strings': ['From the Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109'], 'affiliations': [{'raw_affiliation_string': 'From the Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109', 'institution_ids': ['https://openalex.org/I27837315']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 15.158, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 295, 'citation_normalized_percentile': {'value': 0.999796, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '274', 'issue': '17', 'first_page': '11660', 'last_page': '11666'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12910', 'display_name': 'Eicosanoids and Hypertension Pharmacology', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/prostaglandin-h2', 'display_name': 'Prostaglandin H2', 'score': 0.5378913}, {'id': 'https://openalex.org/keywords/prostanoid', 'display_name': 'Prostanoid', 'score': 0.5314763}, {'id': 'https://openalex.org/keywords/thromboxane-b2', 'display_name': 'Thromboxane B2', 'score': 0.4181875}], 'concepts': [{'id': 'https://openalex.org/C2779689624', 'wikidata': 'https://www.wikidata.org/wiki/Q410251', 'display_name': 'Cyclooxygenase', 'level': 3, 'score': 0.9500943}, {'id': 'https://openalex.org/C2778078955', 'wikidata': 'https://www.wikidata.org/wiki/Q407699', 'display_name': 'Arachidonic acid', 'level': 3, 'score': 0.8202263}, {'id': 'https://openalex.org/C2781128415', 'wikidata': 'https://www.wikidata.org/wiki/Q412050', 'display_name': 'Prostacyclin', 'level': 2, 'score': 0.7492886}, {'id': 'https://openalex.org/C2777956040', 'wikidata': 'https://www.wikidata.org/wiki/Q416554', 'display_name': 'Prostaglandin E2', 'level': 2, 'score': 0.7104118}, {'id': 'https://openalex.org/C2780664492', 'wikidata': 'https://www.wikidata.org/wiki/Q209717', 'display_name': 'Prostaglandin', 'level': 2, 'score': 0.6873534}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.60151243}, {'id': 'https://openalex.org/C2780978440', 'wikidata': 'https://www.wikidata.org/wiki/Q416567', 'display_name': 'Prostaglandin H2', 'level': 4, 'score': 0.5378913}, {'id': 'https://openalex.org/C2778266237', 'wikidata': 'https://www.wikidata.org/wiki/Q962217', 'display_name': 'Prostanoid', 'level': 3, 'score': 0.5314763}, {'id': 'https://openalex.org/C2777198256', 'wikidata': 'https://www.wikidata.org/wiki/Q4860325', 'display_name': 'Prostaglandin E', 'level': 2, 'score': 0.46398973}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.44897288}, {'id': 'https://openalex.org/C2776785769', 'wikidata': 'https://www.wikidata.org/wiki/Q412212', 'display_name': 'Thromboxane', 'level': 3, 'score': 0.44626188}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4205041}, {'id': 'https://openalex.org/C2781080829', 'wikidata': 'https://www.wikidata.org/wiki/Q3009646', 'display_name': 'Thromboxane B2', 'level': 3, 'score': 0.4181875}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3708458}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3567876}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.262411}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.15636879}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.14878234}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.08959231}], 'mesh': [{'descriptor_ui': 'D016718', 'descriptor_name': 'Arachidonic Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015232', 'descriptor_name': 'Dinoprostone', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D011464', 'descriptor_name': 'Epoprostenol', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011451', 'descriptor_name': 'Prostaglandin-Endoperoxide Synthases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016718', 'descriptor_name': 'Arachidonic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051546', 'descriptor_name': 'Cyclooxygenase 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015232', 'descriptor_name': 'Dinoprostone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004790', 'descriptor_name': 'Enzyme Induction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011464', 'descriptor_name': 'Epoprostenol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019084', 'descriptor_name': 'Fluorescent Antibody Technique, Indirect', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D017737', 'descriptor_name': 'Macrophages, Peritoneal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017737', 'descriptor_name': 'Macrophages, Peritoneal', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D017737', 'descriptor_name': 'Macrophages, Peritoneal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011451', 'descriptor_name': 'Prostaglandin-Endoperoxide Synthases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011451', 'descriptor_name': 'Prostaglandin-Endoperoxide Synthases', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.274.17.11660', 'pdf_url': 'http://www.jbc.org/article/S0021925819734796/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10206978', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.274.17.11660', 'pdf_url': 'http://www.jbc.org/article/S0021925819734796/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1470445811', 'https://openalex.org/W1491383197', 'https://openalex.org/W1500692723', 'https://openalex.org/W1540849804', 'https://openalex.org/W1553386677', 'https://openalex.org/W1554644961', 'https://openalex.org/W1564614506', 'https://openalex.org/W1571961338', 'https://openalex.org/W1573038981', 'https://openalex.org/W1848812703', 'https://openalex.org/W1966423878', 'https://openalex.org/W1987175676', 'https://openalex.org/W1993507501', 'https://openalex.org/W1994443052', 'https://openalex.org/W1997364548', 'https://openalex.org/W2011951102', 'https://openalex.org/W2013414651', 'https://openalex.org/W2019328429', 'https://openalex.org/W2019774786', 'https://openalex.org/W2021304625', 'https://openalex.org/W2021835061', 'https://openalex.org/W2030109883', 'https://openalex.org/W2039376197', 'https://openalex.org/W2041299660', 'https://openalex.org/W2052366609', 'https://openalex.org/W2055687230', 'https://openalex.org/W2059785252', 'https://openalex.org/W2063184509', 'https://openalex.org/W2077177475', 'https://openalex.org/W2088269247', 'https://openalex.org/W2120580301', 'https://openalex.org/W2122067835', 'https://openalex.org/W2125471714', 'https://openalex.org/W2149233326', 'https://openalex.org/W2228384319', 'https://openalex.org/W2399773764', 'https://openalex.org/W4313333716', 'https://openalex.org/W585162930', 'https://openalex.org/W654929682', 'https://openalex.org/W79262202'], 'related_works': ['https://openalex.org/W3152104195', 'https://openalex.org/W3141276219', 'https://openalex.org/W3092357696', 'https://openalex.org/W2080832417', 'https://openalex.org/W2055553905', 'https://openalex.org/W2048596499', 'https://openalex.org/W2035637315', 'https://openalex.org/W2009996567', 'https://openalex.org/W2005674313', 'https://openalex.org/W1973421340'], 'abstract_inverted_index': {'The': [0, 132, 191, 323, 565, 581, 733, 755, 813, 877, 2060, 2764, 2803, 3053, 3417, 3540, 3652, 4120, 4903, 5700], 'two': [1, 33, 177, 192, 224, 368, 608, 1881, 2381, 3054, 3789, 4052, 4428, 4555], 'cyclooxygenase': [2, 193, 387, 594], 'isoforms,': [3, 194, 4697], 'cyclooxygenase-1': [4, 55, 123, 171, 195, 246, 314, 362], 'and': [5, 56, 76, 112, 180, 196, 247, 267, 303, 371, 416, 443, 466, 482, 487, 685, 697, 713, 726, 750, 770, 844, 870, 939, 949, 959, 1029, 1071, 1103, 1121, 1125, 1134, 1205, 1219, 1229, 1320, 1324, 1335, 1364, 1400, 1416, 1485, 1539, 1563, 1609, 1698, 1810, 1838, 1933, 1969, 2022, 2024, 2080, 2089, 2117, 2242, 2311, 2386, 2439, 2442, 2453, 2474, 2484, 2548, 2565, 2628, 2668, 2727, 2755, 2778, 2811, 2817, 2877, 2954, 2965, 2969, 2996, 3011, 3032, 3047, 3098, 3118, 3186, 3203, 3267, 3284, 3368, 3371, 3379, 3518, 3529, 3571, 3792, 3847, 3855, 3884, 3949, 3998, 4151, 4194, 4211, 4290, 4344, 4358, 4406, 4452, 4562, 4593, 4671, 4881, 4890, 4908, 4925, 5015, 5062, 5091, 5129, 5184, 5233, 5245, 5262, 5269, 5313, 5336, 5349, 5375, 5389, 5405, 5443, 5464, 5556, 5583, 5641, 5643, 5668, 5705, 5714], 'cyclooxygenase-2,': [6, 197], 'both': [7, 198, 762, 767, 2665, 2957, 3515, 3995, 5280, 5334, 5635], 'metabolize': [8, 199], 'arachidonic': [9, 48, 63, 156, 200, 239, 254, 347, 383, 421], 'acid': [10, 157, 201, 348, 384, 389, 391, 399, 422, 1105, 1582], 'to': [11, 21, 94, 138, 152, 172, 202, 212, 285, 329, 343, 363, 692, 722, 745, 759, 794, 805, 808, 854, 868, 890, 941, 945, 991, 1005, 1067, 1075, 1096, 1119, 1207, 1210, 1366, 1376, 1510, 1718, 1758, 1852, 1923, 1964, 1982, 2008, 2027, 2039, 2153, 2166, 2373, 2435, 2508, 2582, 2624, 2638, 2690, 2697, 2725, 2783, 2840, 2881, 2993, 3115, 3355, 3406, 3463, 3485, 3490, 3551, 3559, 3599, 3640, 3755, 3778, 3787, 3797, 3971, 4042, 4063, 4086, 4178, 4319, 4335, 4340, 4355, 4362, 4418, 4432, 4570, 4667, 4784, 4885, 4914, 4935, 4964, 4994, 5021, 5059, 5095, 5138, 5191, 5214, 5231, 5507, 5525, 5580, 5622, 5630, 5662, 5702, 5720], 'prostaglandin': [12, 74, 92, 95, 113, 136, 139, 181, 203, 265, 283, 286, 304, 327, 330, 372, 382, 599, 603], 'H2,': [13, 204], 'which': [14, 183, 205, 374, 607, 796, 1045, 2663, 3096, 3642, 3724, 3876], 'is': [15, 206, 591, 678, 705, 714, 797, 829, 888, 989, 2037, 2292, 2361, 3243, 3324, 3696, 3743, 4144, 4314, 4329, 4350, 4375, 4392, 4439, 4448, 4517, 4610, 4910, 5212, 5236], 'subsequently': [16, 207, 5591], 'processed': [17, 208], 'by': [18, 145, 170, 209, 336, 361, 569, 593, 801, 831, 845, 883, 894, 1092, 1156, 1288, 1327, 1340, 1357, 1529, 1605, 1667, 1708, 1742, 1812, 1832, 1840, 1862, 1912, 1944, 2066, 2169, 2269, 2338, 2512, 2530, 2553, 2866, 2889, 2895, 2934, 3220, 3301, 3411, 3601, 3633, 3667, 3677, 3842, 3941, 4324, 4372, 4693, 4801, 5051, 5393, 5499], 'downstream': [19, 210, 4364, 4785], 'enzymes': [20, 211, 948, 3351, 4059, 4079, 4097, 4336, 4360, 4887], 'the': [22, 26, 32, 37, 107, 160, 173, 188, 213, 217, 223, 228, 298, 351, 364, 379, 575, 585, 702, 706, 738, 783, 809, 817, 824, 832, 835, 839, 846, 895, 899, 934, 967, 984, 995, 1007, 1052, 1136, 1147, 1589, 1656, 1662, 1709, 1725, 1743, 1853, 1877, 1880, 1928, 1934, 1939, 1966, 1972, 2004, 2030, 2084, 2141, 2157, 2183, 2191, 2202, 2205, 2273, 2286, 2342, 2355, 2397, 2436, 2450, 2458, 2480, 2497, 2560, 2585, 2602, 2608, 2671, 2684, 2702, 2711, 2730, 2750, 2860, 2867, 2922, 2938, 2982, 3001, 3014, 3102, 3224, 3237, 3305, 3318, 3332, 3345, 3356, 3387, 3392, 3395, 3480, 3533, 3608, 3708, 3713, 3781, 3803, 3868, 3873, 3878, 3978, 4043, 4066, 4072, 4087, 4102, 4137, 4147, 4153, 4163, 4179, 4192, 4213, 4288, 4295, 4309, 4356, 4367, 4396, 4401, 4412, 4419, 4423, 4427, 4442, 4454, 4554, 4565, 4604, 4613, 4668, 4701, 4788, 4797, 4802, 4805, 4892, 5086, 5224, 5237, 5240, 5455, 5494, 5501, 5510, 5518, 5551, 5563, 5575, 5593, 5596, 5600, 5603, 5613, 5628, 5637], 'various': [23, 214], 'prostanoids.': [24, 215], 'In': [25, 216, 446, 908, 994, 1577, 2486, 2904, 3029, 3715, 3769, 3955, 3982, 4346, 5121], 'present': [27, 218, 903], 'study,': [28, 219, 997, 3717, 3984, 4313], 'we': [29, 220, 998, 3385, 3718, 3988, 4285], 'asked': [30, 221], 'if': [31, 122, 222, 313, 1039, 2146, 3041, 3761], 'isoforms': [34, 225, 609, 764, 791, 2960, 4094, 4430, 4556], 'differ': [35, 226, 4293, 4433, 4571], 'in': [36, 106, 117, 155, 227, 297, 308, 346, 472, 485, 584, 613, 681, 695, 860, 904, 930, 963, 966, 976, 1146, 1227, 1232, 1234, 1259, 1266, 1296, 1496, 1518, 1566, 1655, 1691, 1807, 1892, 1909, 1958, 1960, 2075, 2077, 2156, 2182, 2214, 2264, 2293, 2297, 2333, 2362, 2366, 2371, 2601, 2646, 2657, 2745, 2786, 2795, 2846, 2856, 2872, 2906, 3009, 3024, 3088, 3174, 3188, 3215, 3244, 3248, 3255, 3269, 3296, 3325, 3505, 3510, 3532, 3542, 3647, 3694, 3766, 3824, 3828, 3859, 3867, 3943, 3977, 3994, 4026, 4033, 4045, 4048, 4057, 4068, 4074, 4089, 4106, 4122, 4132, 4146, 4156, 4181, 4207, 4294, 4305, 4316, 4331, 4380, 4395, 4414, 4434, 4572, 4612, 4917, 4929, 4933, 4958, 4962, 4989, 4992, 5016, 5019, 5057, 5093, 5293, 5354, 5397, 5513, 5517, 5627, 5646], 'profile': [38, 119, 229, 310, 878, 968, 1940, 2036, 2714, 3104, 3335, 3454, 3782, 3839, 3861, 4076, 4183, 4296, 4416, 5502, 5618], 'of': [39, 67, 100, 110, 134, 162, 176, 230, 258, 291, 301, 325, 353, 367, 414, 430, 577, 587, 606, 708, 720, 735, 741, 753, 757, 819, 826, 834, 841, 849, 866, 872, 875, 879, 898, 969, 1034, 1037, 1051, 1099, 1112, 1138, 1149, 1159, 1263, 1353, 1611, 1638, 1643, 1703, 1711, 1714, 1727, 1737, 1745, 1825, 1846, 1879, 1941, 2003, 2029, 2062, 2108, 2132, 2149, 2159, 2178, 2185, 2193, 2204, 2280, 2288, 2349, 2357, 2383, 2399, 2401, 2562, 2587, 2590, 2604, 2686, 2835, 2862, 2900, 2912, 2924, 2989, 3017, 3062, 3074, 3105, 3231, 3239, 3312, 3320, 3349, 3389, 3394, 3409, 3426, 3455, 3482, 3493, 3535, 3569, 3616, 3654, 3733, 3783, 3830, 3845, 3852, 3870, 3872, 3980, 4104, 4139, 4149, 4166, 4209, 4297, 4302, 4311, 4369, 4398, 4404, 4422, 4607, 4615, 4618, 4690, 4774, 4804, 4906, 4921, 5127, 5239, 5243, 5252, 5284, 5290, 5341, 5400, 5457, 5496, 5503, 5520, 5529, 5536, 5548, 5553, 5571, 5577, 5595, 5602, 5605, 5615, 5619, 5639], 'prostanoids': [40, 164, 231, 355, 686, 1053, 1080, 1942, 2063, 2110, 2732, 3736, 5707], 'that': [41, 232, 823, 905, 988, 1054, 1081, 1089, 2040, 2101, 2445, 2466, 2496, 2607, 2655, 2695, 2720, 2808, 2949, 3112, 3341, 3352, 3687, 3720, 3935, 4055, 4115, 4136, 4174, 4191, 4287, 4328, 4337, 4383, 4508, 4811, 5226, 5493, 5531, 5568, 5708], 'ultimately': [42, 233], 'arise': [43, 234, 3863], 'from': [44, 159, 235, 350, 420, 589, 688, 1010, 1057, 1084, 1408, 1792, 1986, 2096, 2111, 2212, 2641, 2735, 2944, 3078, 3128, 3440, 3488, 3538, 3621, 3665, 3674, 3690, 3705, 3737, 3864, 3960, 4077, 4092, 4109, 4116, 4127, 4203, 4796, 5651], 'their': [45, 236, 1833, 3956, 4298, 4435, 4573], 'action': [46, 237, 840, 960, 1015, 4803], 'on': [47, 238, 432, 574, 701, 782, 1016, 1131, 1242, 1461, 2389, 2449, 2457, 2572, 2578, 3366, 3374, 3391, 3698, 4308, 4451, 4889, 5440], 'acid.': [49, 78, 240, 269, 1827], 'Resident': [50, 241, 1152], 'peritoneal': [51, 242, 393, 1002, 1157], 'macrophages': [52, 243, 1003], 'contained': [53, 244, 1889, 2664], 'only': [54, 142, 245, 333, 717, 2829, 2853, 2932, 3002, 3081, 3632, 3678, 3744, 3804], 'synthesized': [57, 248, 1943, 2670], '(from': [58, 249], 'either': [59, 250, 1011, 1230, 1511, 2234, 2303, 3441, 5448], 'endogenous': [60, 251, 1987, 2112, 2219, 3136, 3158, 3442, 3561], 'or': [61, 252, 602, 1013, 1240, 1248, 1513, 1601, 1630, 1751, 2252, 2321, 2543, 2559, 3092, 3177, 3258, 3347, 3447, 3588, 3613, 4519, 4937, 4996, 5023, 5164, 5452], 'exogenous': [62, 91, 135, 253, 282, 326, 1704, 1738, 2226, 2254, 2323, 3143, 3165, 3448], 'acid)': [64, 255], 'a': [65, 82, 153, 256, 273, 344, 412, 427, 884, 913, 931, 964, 1143, 1260, 1341, 1542, 1816, 1822, 2070, 2106, 2123, 2278, 2298, 2347, 2409, 2509, 2518, 2598, 3229, 3249, 3310, 3407, 3502, 3699, 3731, 3745, 3838, 3865, 4027, 4332, 4384, 4393, 4509, 4616, 4911, 4918, 5250, 5527, 5534, 5546, 5616, 5625, 5658], 'balance': [66, 257, 576, 1148, 2107, 3732, 4397, 5528, 5576], 'four': [68, 259, 2097, 2109, 2289, 2358, 3734], 'major': [69, 260, 3015, 3735], 'prostanoids:': [70, 261], 'prostacyclin,': [71, 262], 'thromboxane': [72, 263, 395, 458], 'A2,': [73, 264], 'D2,': [75, 266], '12-hydroxyheptadecatrienoic': [77, 268, 390, 1104], 'Prostaglandin': [79, 270], 'E2': [80, 140, 271, 331], 'was': [81, 120, 124, 141, 272, 311, 315, 332, 1586, 1653, 1665, 1675, 1706, 1740, 1849, 1860, 1907, 2064, 2122, 2143, 2369, 2447, 2454, 2505, 2526, 2536, 2550, 2692, 2706, 2742, 2752, 2757, 2864, 2886, 2930, 2977, 2985, 3044, 3403, 3421, 3431, 3457, 3461, 3546, 3596, 3631, 3939, 4111, 5055, 5135, 5188], 'minor': [83, 274, 2124, 2854, 3746], 'fifth': [84, 275, 2125, 3740], 'product,': [85, 276, 2126, 3397, 3747, 3880], 'although': [86, 277, 3628, 3748], 'these': [87, 278, 578, 2573, 3648, 3749, 3961, 5216, 5219, 5285, 5445, 5588], 'cells': [88, 279, 721, 1020, 1062, 1133, 1191, 1225, 1285, 1464, 1552, 1617, 1720, 1760, 2172, 2179, 2407, 2421, 2428, 2467, 2490, 2499, 2804, 2873, 2950, 3048, 3079, 3517, 3649, 3750, 3962, 3997, 4932, 4961, 5018, 5054], 'efficiently': [89, 280, 3404, 3597], 'converted': [90, 281, 2007, 2696, 2839, 3484, 3598], 'H2': [93, 137, 284, 328], 'E2.': [96, 114, 287, 305], 'By': [97, 288, 1060, 1884, 1918, 1990, 2393, 2461], 'contrast,': [98, 289, 1061, 2905, 3030, 3771, 4347], 'induction': [99, 150, 290, 341, 734, 858, 958, 1140, 2365, 2529, 2595, 3836, 4371, 5211, 5495], 'cyclooxygenase-2': [101, 130, 149, 292, 321, 340], 'with': [102, 127, 165, 293, 318, 356, 737, 1065, 1073, 1374, 1424, 1474, 1482, 1508, 1521, 1560, 1620, 1671, 1676, 1723, 1763, 1821, 1835, 1952, 1971, 2000, 2180, 2236, 2244, 2305, 2313, 2412, 2432, 2540, 2619, 2630, 2654, 2748, 2759, 2766, 2806, 2828, 2844, 2875, 2897, 2956, 2967, 2991, 3020, 3070, 3091, 3121, 3176, 3190, 3197, 3205, 3257, 3271, 3278, 3286, 3475, 3501, 3584, 3607, 3656, 3707, 3776, 3795, 3849, 4003, 4023, 5223, 5653], 'lipopol-': [103, 294], 'ysaccharide': [104, 295], 'resulted': [105, 296, 3008, 4025], 'preferential': [108, 174, 299, 365, 3843, 4402], 'production': [109, 161, 300, 352, 740, 2061, 2648, 2861, 3573, 3620, 3673, 3689, 3704, 3829, 3851, 4047, 4108, 4148, 4165, 4403, 4905, 5050, 5242, 5392, 5456], 'prostacyclin': [111, 179, 302, 370, 385, 467], 'This': [115, 306, 980, 2035, 2975, 3430, 4037], 'shift': [116, 154, 307, 345, 965, 1145, 3840, 3858, 4180, 4394, 4413], 'product': [118, 309, 707, 2276, 2345, 2704, 3227, 3308, 3420, 3860, 4075, 4182, 4415], 'accentuated': [121, 312, 3807], 'permanently': [125, 316, 760, 1068], 'inactivated': [126, 317, 2744], 'aspirin': [128, 319, 758, 1066, 1580], 'before': [129, 320, 4001], 'induction.': [131, 322, 4186], 'conversion': [133, 324], 'modestly': [143, 334], 'increased': [144, 335, 2190, 3487, 3577, 3623, 3662, 3671, 4164, 4927], 'lipopolysaccharide': [146, 337, 392, 731], 'treatment.': [147, 338, 4170], 'Thus,': [148, 339, 4771, 5387, 5516], 'leads': [151, 342], 'metabolism': [158, 349, 1036, 4323, 4349, 5570], 'several': [163, 354, 925, 1026, 1993], 'diverse': [166, 357], 'effects': [167, 186, 358, 377, 431, 781, 1130, 3365, 3373, 3388, 3636, 5286, 5439], 'as': [168, 359, 435, 598, 776, 778, 911, 1107, 1109, 1170, 1437, 1603, 1769, 2014, 2018, 2277, 2346, 2380, 2517, 2652, 2674, 2699, 2701, 2819, 2821, 2842, 2893, 3000, 3068, 3107, 3228, 3309, 3692, 3802, 4005, 4576, 4896, 5560, 5562], 'mediated': [169, 360, 592], 'synthesis': [175, 366, 586, 821, 2192, 2603, 2885, 2929, 3646, 3664, 3844, 3979, 4126, 5552, 5604, 5638, 5716], 'prostanoids,': [178, 369, 742], 'E2,': [182, 373], 'evoke': [184, 375, 1128, 5249, 5282, 5545], 'common': [185, 376, 4912, 5213, 5253], 'at': [187, 378, 1194, 1201, 1221, 1256, 1292, 1516, 1683, 3423, 4199, 4810, 5609], 'cellular': [189, 380, 441, 1639, 1984, 5254], 'level.': [190, 381], 'leukotriene': [386, 2087], 'hydroxyeicosatetraenoic': [388], 'macrophage': [394], 'phosphate-buffered': [396], 'saline': [397], 'acetylsalicylic': [398], 'tumor': [400], 'necrosis': [401], 'factor': [402], 'interleukin': [403], 'high': [404], 'pressure': [405], 'liquid': [406], 'chromatography': [407], 'enzyme': [408, 916, 1755], 'immunoassay': [409, 1756, 1844], 'Prostaglandins': [410], '(PGs)1are': [411], 'family': [413], 'intercellular': [415], 'intracellular': [417, 4443], 'messengers': [418], 'derived': [419, 687, 1009, 1056, 1083, 2734, 4091], '(AA).': [423], 'These': [424, 1018, 2661, 2826, 3635, 3810, 4171, 5490], 'mediators': [425, 4374, 4916], 'exert': [426], 'wide': [428, 4919], 'range': [429, 4920], 'processes': [433], 'such': [434, 4895], 'smooth': [436, 461, 5257, 5263], 'muscle': [437, 462, 5258, 5264], 'tone,': [438], 'vascular': [439, 4930], 'permeability,': [440], 'proliferation,': [442, 5265, 5713], 'inflammatory/immune': [444], 'function.': [445, 5272], 'many': [447, 5283, 5342], 'cases,': [448, 910], 'different': [449, 810, 880, 926, 946, 952, 3700, 4566, 4688, 4702], 'PGs': [450, 570, 588, 881, 2606, 2863, 3064, 3076, 3410, 4382, 4399, 5248, 5281, 5446, 5530, 5579, 5589], 'will': [451, 5573], 'have': [452, 3362, 3725, 3933, 4189, 5449, 5657], 'opposing': [453, 579], 'actions.': [454], 'For': [455, 1549, 1636, 4602], 'example,': [456, 4603], 'PGD2and': [457], '(TxA2)': [459], 'cause': [460, 469], 'contraction,': [463], 'whereas': [464, 1114, 2477, 2694, 2729, 3669, 3946, 4446, 4661], 'PGE2': [465, 1126, 2121, 2691, 2884, 2928, 3012, 3369, 3422, 3439, 3486, 3506, 3543, 3554, 3572, 3600, 3619, 3663, 3672, 3688, 3703, 3848, 3936, 3991, 4034, 4046, 4107, 4125, 4142, 4157, 4167, 4897, 4909, 4926, 5049, 5092, 5130, 5337, 5642, 5672], '(PGI2)': [468], 'relaxation': [470], '(reviewed': [471, 612, 5292, 5353], 'Refs.': [473, 614, 5294, 5355], '1Peters-Golden': [474], 'M.': [475, 477, 1174, 1276, 1446, 1772, 2044, 3891, 3915, 4013, 4265, 4460, 4584, 4622, 4647, 4706, 4818, 4864, 5030, 5065, 5149, 5408, 5478, 5682, 5688], 'Lipscomb': [476], 'Russell': [478], 'S.': [479, 3899, 3919, 3925, 4218, 4240, 4254, 4814, 4973, 5069, 5106, 5151, 5196, 5317, 5359, 5377, 5379, 5684], 'Lung': [480], 'Macrophages': [481], 'Dendritic': [483], 'Cells': [484, 1214, 1253, 1430, 2301, 3199, 3252, 3280], 'Health': [486], 'Disease.': [488], 'Marcel': [489, 4595], 'Dekker,': [490, 4596], 'Inc.,': [491, 4597], 'New': [492, 4598], 'York1997:': [493, 4599], '151-182Google': [494], 'Scholar,': [495, 513, 539, 632, 658, 3911, 4232, 4263, 4643, 4730, 4750, 4838, 4862, 5417], '2Vane': [496, 615], 'J.': [497, 531, 543, 616, 650, 662, 1183, 1272, 1278, 1447, 1781, 2053, 3926, 4009, 4015, 4221, 4234, 4272, 4471, 4498, 4531, 4590, 4654, 4715, 4732, 4735, 4755, 4823, 4847, 4872, 4946, 4951, 5004, 5034, 5036, 5071, 5072, 5100, 5108, 5141, 5143, 5411, 5480, 5678, 5689], 'Bakhle': [498, 617], 'Y.': [499, 618, 4487, 4624, 4645, 4649, 4710], 'Botting': [500, 619], 'R.': [501, 620, 1178, 1444, 1776, 2048, 4267, 4497, 4588, 4708, 4942, 4950, 4971, 4977, 5028, 5104, 5357, 5361, 5423, 5472, 5686], 'Annu.': [502, 621], 'Rev.': [503, 622, 5173, 5198, 5302, 5319], 'Pharmacol.': [504, 623], 'Toxicol.': [505, 624], '1998;': [506, 532, 545, 625, 651, 664, 3928, 4534], '38:': [507, 626, 4680], '97-120Crossref': [508, 627], 'PubMed': [509, 535, 553, 628, 654, 672, 1395, 1456, 3907, 4230, 4259, 4281, 4482, 4542, 4639, 4682, 4726, 4746, 4766, 4834, 4858, 4876, 4984, 5010, 5042, 5078, 5116, 5159, 5179, 5204, 5308, 5325, 5370, 5431, 5485, 5695], 'Scopus': [510, 536, 554, 629, 655, 673, 1396, 3908, 4260, 4483, 4543, 4640, 4683, 4727, 4747, 4767, 4835, 4859, 4877, 4985, 5011, 5043, 5079, 5117, 5160, 5180, 5205, 5309, 5326, 5371, 5486, 5696], '(2620)': [511, 630], 'Google': [512, 538, 556, 631, 657, 675, 1188, 1283, 1398, 1457, 1786, 2058, 3910, 3931, 4020, 4231, 4262, 4282, 4485, 4545, 4642, 4659, 4685, 4729, 4749, 4769, 4837, 4861, 4879, 4956, 4987, 5013, 5045, 5081, 5119, 5162, 5182, 5207, 5311, 5328, 5373, 5416, 5432, 5488, 5698], '3Dubois': [514, 633], 'R.N.': [515, 634], 'Abramson': [516, 635], 'S.B.': [517, 636], 'Crofford': [518, 637, 5679], 'L.': [519, 638, 5680], 'Gupta': [520, 639], 'R.A.': [521, 640], 'Simon': [522, 641], 'L.S.': [523, 642], 'Van': [524, 643], 'De': [525, 644], 'Putte': [526, 645], 'L.B.A.': [527, 646], 'Lipsky': [528, 647], 'P.E.': [529, 648], 'FASEB': [530, 649], '12:': [533, 652, 5365], '1063-1073Crossref': [534, 653], '(2231)': [537, 656], '4Bjorkman': [540, 659], 'D.': [541, 660, 1274, 4011, 4677, 5098, 5194, 5315, 5421], 'Am.': [542, 661, 1277, 4014, 5035, 5172, 5197, 5301, 5318], 'Med.': [544, 663, 5426], '105:': [546, 665], '8S-12SAbstract': [547, 666], 'Full': [548, 550, 667, 669, 1453, 4227, 4278, 4477, 4479, 4537, 4539, 4721, 4723, 4741, 4743, 4761, 4763, 4829, 4831, 4853, 4855, 5367], 'Text': [549, 551, 668, 670, 1454, 4228, 4279, 4478, 4480, 4538, 4540, 4722, 4724, 4742, 4744, 4762, 4764, 4830, 4832, 4854, 4856, 5368], 'PDF': [552, 671, 1455, 4229, 4280, 4481, 4541, 4725, 4745, 4765, 4833, 4857, 5369], '(75)': [555, 674], 'Scholar).': [557, 676, 1189, 1458, 1787, 2059, 4021, 4283, 4503, 4601, 4686, 4770, 5046, 5082, 5120, 5208, 5329, 5386, 5433, 5489, 5699], 'Similarly,': [558, 1902, 5047], 'TxA2increases,': [559], 'but': [560, 1895, 1904, 2082, 2197, 3727, 4030, 4547, 5665], 'PGI2': [561, 1120, 1124, 2012, 2726, 2816, 3010, 3367, 3791, 3846, 4405, 4901, 4907, 4924, 5090, 5128, 5232, 5244, 5335, 5388, 5582, 5640], 'inhibits,': [562], 'platelet': [563], 'aggregation.': [564], 'net': [566], 'effect': [567, 5451], 'evoked': [568], 'may,': [571, 5498], 'ultimately,': [572], 'depend': [573], 'forces.': [580], 'initial': [582], 'step': [583, 3975], 'AA': [590, 793, 837, 867, 1090, 1118, 1705, 1731, 1985, 2006, 2079, 2142, 2189, 2640, 2688, 2724, 2838, 2984, 3043, 3443, 3449, 3666, 4117, 4322, 4794, 5230, 5572], '(COX,': [595], 'also': [596, 2455, 2506, 2978, 3643, 3661, 4559, 5185, 5278], 'known': [597], 'H': [600], 'synthase': [601, 3507, 3544, 3937, 3948, 3951, 3992, 4035, 4158, 4609, 4898], 'endoperoxide': [604], 'synthase),': [605], 'are': [610, 690, 1055, 1082, 2285, 2354, 3236, 3317, 4198, 4215, 5221, 5277], 'recognized': [611], 'COX-1': [677, 689, 787, 938, 1012, 1058, 1070, 1093, 1377, 1512, 1891, 1921, 1945, 2134, 2206, 2213, 2534, 2667, 2736, 2741, 2995, 3082, 3726, 4193, 4289, 4325, 4438, 5523], 'expressed': [679, 716, 4216], 'constitutively': [680], 'most': [682, 3418], 'cell': [683, 886, 906, 1599, 1660, 1689, 2610, 2642, 3465, 3519, 3958, 3999, 4386, 4619], 'types,': [684], 'thought': [691, 889], 'be': [693, 891, 921, 1142, 2597, 2719, 3116, 3340, 3685, 4506], 'important': [694], 'gastric': [696, 784], 'renal': [698], 'homeostasis.': [699, 5538], 'COX-2,': [700, 736, 1047, 1407, 1514, 1906, 2426, 2626, 2669, 2883, 3067, 3729, 3780, 5664], 'other': [703, 2731, 4175, 4363, 4789, 5274], 'hand,': [704, 4790], 'an': [709, 974, 1049, 2160, 2898, 3825, 4378], 'immediate': [710], 'early': [711], 'gene': [712], 'rapidly': [715], 'after': [718, 1997], 'exposure': [719], 'hormones,': [723], 'mitogenic': [724], 'stimuli,': [725], 'inflammatory': [727, 3944, 4373, 4915, 5511, 5521, 5597], 'mediators,': [728, 5522, 5540], 'like': [729, 5541], 'bacterial': [730, 5542], '(LPS).': [732], 'resultant': [739], 'can': [743, 1127, 2612, 3751, 4388, 5709, 5717], 'contribute': [744, 4041, 5719], 'parturition,': [746], 'inflammation,': [747, 5711], 'pain,': [748], 'fever,': [749], 'certain': [751], 'types': [752, 4620], 'cancer.': [754], 'ability': [756, 5629], 'inactivate': [761, 1069, 2994, 3798], 'COX': [763, 790, 850, 862, 1385, 1882, 2009, 2072, 2591, 2776, 2798, 2959, 3357, 3396, 3816, 3832, 3879, 4093, 4429, 4703], 'indiscriminately': [765], 'explains': [766], 'its': [768, 779, 4775], 'analgesic': [769], 'anti-inflammatory': [771], 'properties,': [772], 'through': [773, 786, 3818, 5287, 5331, 5435, 5599], 'COX-2': [774, 857, 940, 957, 1014, 1077, 1115, 1139, 1401, 1898, 2364, 2402, 2433, 2446, 2471, 2503, 2594, 2721, 2756, 2830, 2869, 2999, 3645, 3801, 3835, 4185, 4195, 4291, 4348, 4370, 4447, 4791, 5210, 5227, 5497, 5569, 5632, 5704], 'inhibition,': [775], 'well': [777, 1108, 2700, 2820, 5561], 'damaging': [780], 'mucosa,': [785], 'inhibition.': [788], 'Both': [789, 4923, 5247], 'convert': [792, 3753], 'PGH2,': [795, 869, 1038, 3691], 'then': [798, 956, 982, 1072, 1216, 1417, 1506, 2162, 2878, 3152, 3201, 3282], 'acted': [799], 'upon': [800], 'discrete': [802], 'PG': [803, 811, 820, 828, 901, 927, 978, 1027, 1150, 2647, 2713, 3334, 3784, 4069, 4567, 5504], 'synthases': [804, 902, 928, 1028, 3370, 3375, 4568], 'give': [806, 4338], 'rise': [807, 1095, 4339], 'species.': [812], 'current': [814, 996, 2583], 'model': [815, 919, 4301], 'for': [816, 937, 1198, 1433, 1487, 1547, 1555, 1680, 1876, 1954, 2128, 2238, 2307, 2414, 2425, 2470, 2621, 2710, 2761, 2771, 2789, 3133, 3155, 3182, 3194, 3263, 3275, 3331, 3477, 3586, 3658, 4065, 4124, 4162, 4411, 4553], 'regulation': [818], 'posits': [822], 'amount': [825, 3346], 'each': [827, 873, 1515, 3871], 'determined': [830, 892, 1339, 1604, 2894], 'availability': [833], 'substrate': [836], '(through': [838], 'phospholipases': [842], 'A2)': [843], 'total': [847, 977], 'mass': [848, 2589, 3817], 'protein': [851, 1336, 1354, 2403, 2504, 2592], 'present.': [852], 'According': [853, 2581, 4318, 5621], 'this': [855, 918, 1594, 1919, 1991, 3383, 3626, 3716, 3808, 3968, 3973, 3983, 4303, 4312, 4320, 4515, 5623], 'model,': [856, 4321, 5624], 'results': [859, 1087, 2095, 2137, 2271, 2340, 3038, 3222, 3303, 3758, 3811, 4053, 4172, 4310, 4549, 5220, 5491], 'more': [861, 864, 871, 2920, 4352], 'protein,': [863], 'processing': [865, 3393], 'type': [874, 887, 2611, 4387], 'PG.': [876], 'produced': [882, 2174, 2814, 2961], 'given': [885, 2253, 2322, 2609, 2812, 2879, 2951, 3131, 3153, 3462, 4315, 4385, 5189], 'primarily': [893], 'relative': [896], 'amounts': [897, 1098, 1111, 3026, 3568, 3869], 'distal': [900, 915, 947, 3354, 3874, 4058, 4078, 4096, 4886], 'type.': [907], 'simple': [909, 4409], 'when': [912, 924, 2140, 2615, 2981, 3459, 3580, 3772, 4210, 5133, 5186], 'single': [914, 932, 2519], 'predominates,': [917], 'may': [920, 1141, 3862, 4040, 4698, 4779, 4792, 5447, 5532], 'accurate.': [922], 'However,': [923, 2614, 2680, 3509, 3625, 4051, 4284], 'exist': [929], 'cell,': [933, 1929], 'opportunity': [935], 'exists': [936], 'selectively': [942, 3343], 'deliver': [943, 4780, 4883], 'PGH2': [944, 1739, 1753, 3400, 3460, 3483, 3595, 3622, 3675, 3754, 4110, 4128, 4327, 4781, 4884], 'thus': [950, 1031, 2955, 2997, 4152, 5444, 5718], 'produce': [951, 5706], 'PGs.': [953], 'If': [954], 'so,': [955], 'could': [961, 981], 'result': [962, 1137, 2586, 2794, 3823, 4368], 'PGs,': [970, 2841, 3790], 'rather': [971], 'than': [972, 2130, 2921, 3702, 4114, 4361, 5673], 'simply': [973, 4377], 'increase': [975, 2600, 3504, 3541, 3827, 4032, 4044, 4105, 4379, 5454], 'production.': [979, 2858, 3555], 'change': [983, 2201, 3866, 4038, 4067], 'integrated': [985], 'prostanoid': [986, 2163, 2282, 2351, 3233, 3314], 'signal': [987], 'delivered': [990], 'target': [992, 1132], 'cells.': [993, 1612, 2660, 4050], 'used': [999], 'intact': [1000], 'rat': [1001, 2367], '(PMs)': [1004], 'compare': [1006], 'products': [1008, 1829, 1994, 2028, 2196, 2207, 2673, 3016, 3106, 3456, 3536, 3785, 4090], 'AA.': [1017, 3738], 'primary': [1019], 'were': [1021, 1154, 1192, 1215, 1254, 1286, 1338, 1355, 1372, 1431, 1465, 1505, 1537, 1553, 1618, 1767, 1790, 1830, 1874, 1950, 1995, 2138, 2151, 2173, 2233, 2267, 2302, 2336, 2422, 2472, 2482, 2500, 2617, 2649, 2733, 2809, 2852, 3034, 3039, 3049, 3172, 3200, 3218, 3253, 3281, 3299, 3472, 3522, 3582, 3637, 3759, 3763, 3774, 3812, 3953, 4060, 4083, 5131], 'chosen': [1022], 'because': [1023, 3433, 3814, 4773], 'they': [1024], 'contain': [1025], 'would': [1030, 2718, 3339, 3969, 5544, 5590, 5634], 'allow': [1032], 'detection': [1033, 1426], 'selective': [1035, 2644, 2868], 'it': [1040, 2464, 2549, 3670], 'existed.': [1041], 'Freshly': [1042, 1871], 'isolated': [1043, 1238, 1872, 1948, 2103, 2216, 2659, 2676, 2908, 3109, 3413, 3435, 3528, 3564, 3604, 3722], 'PMs,': [1044, 2662, 2909, 3110, 3605, 3723, 3945, 3987, 4306], 'lack': [1046], 'provide': [1048], 'indication': [1050], 'action.': [1059, 1151, 2737], 'treated': [1063, 2411, 2618, 2805, 3474, 3583], 'first': [1064, 3473], 'LPS': [1074, 1621, 2374, 2413, 2566, 2620, 2682, 2716, 2760, 2813, 2880, 2952, 3006, 3132, 3154, 3191, 3272, 3337, 3342, 3360, 3390, 3476, 3585, 3617, 3777, 3819, 3942, 4004, 4024, 4169, 4936, 4965], 'induce': [1076, 2625, 2882, 3779, 5631, 5703], 'demonstrate': [1078], 'those': [1079, 2167, 2478], 'COX-2.': [1085, 2580, 5557], 'Our': [1086, 5558], 'indicate': [1088, 2272, 2341, 3223, 3304, 5567], 'metabolized': [1091, 2026, 2689, 3405], 'gives': [1094], 'balanced': [1097, 4333], 'PGI2,': [1100, 2114, 2963, 4341], 'TxA2,': [1101, 2115, 2698, 3377, 4342], 'PGD2,': [1102, 2021, 2116, 3378, 3854, 4343], '(HHT)': [1106], 'smaller': [1110], 'PGE2,': [1113, 2020, 2728, 2818, 2966, 3057, 3570, 3742, 4150], 'preferentially': [1116, 2722, 4449, 4882, 5228], 'metabolizes': [1117, 2723, 5229], 'PGE2.': [1122, 3756, 3793, 3981, 4407, 5234, 5584], 'Because': [1123, 5209], 'similar': [1129, 2038, 2165, 3453], 'tissues,': [1135], 'dramatic': [1144], 'PMs': [1153, 1873, 1888, 1911, 1949, 2104, 2155, 2368, 2616, 2677, 2747, 2990, 3085, 3414, 3436, 3471, 3531, 3565, 3581, 3655, 3762, 3773], 'obtained': [1155, 2139, 3040, 3458, 3760], 'lavage': [1158], 'specific': [1160], 'pathogen-free,': [1161], 'female': [1162], 'Wistar': [1163], 'rats': [1164, 5139], '(Charles': [1165], 'River': [1166], 'Laboratories,': [1167], 'Portage,': [1168], 'MI)': [1169], 'described': [1171, 1269, 1438, 1770], 'previously': [1172, 1270, 1439, 2042, 4007], '(5Peters-Golden': [1173, 1771, 2043], 'McNish': [1175, 1773, 2045], 'R.W.': [1176, 1774, 2046], 'Hyzy': [1177, 1775, 2047], 'Shelly': [1179, 1777, 2049], 'C.': [1180, 1778, 2050, 5153, 5467], 'Toews': [1181, 1779, 2051], 'G.B.': [1182, 1780, 2052], 'Immunol.': [1184, 1782, 2054, 3927, 4499, 4655, 4952, 5038, 5362, 5412, 5481], '1990;': [1185, 1783, 2055, 4953, 4981], '144:': [1186, 1784, 2056, 4954], '263-270PubMed': [1187, 1785, 2057], 'Lavaged': [1190], 'centrifuged': [1193, 1217], '600': [1195], '×': [1196, 1223], 'g': [1197], '5': [1199, 1305, 3498], 'min': [1200, 1489, 1682], '4': [1202, 1333, 2801, 2824], '°C,': [1203, 1470, 1477], 'resuspended,': [1204], 'subjected': [1206], 'hypotonic': [1208], 'lysis': [1209], 'remove': [1211, 1965, 2784], 'contaminating': [1212], 'erythrocytes.': [1213], 'again': [1218, 3676], 'resuspended': [1220, 1806], '0.5': [1222, 1311, 1641, 1712], '106': [1224], 'ml−1': [1226], 'M199': [1228, 1567], 'maintained': [1231, 1957, 3764], 'suspension': [1233, 1959], 'Teflon': [1235, 1961], 'tubes': [1236], '(“freshly': [1237], 'cells”)': [1239], 'plated': [1241], '24-well': [1243], 'plates': [1244], '(for': [1245, 1251, 1748, 1754], 'metabolic': [1246, 4196, 4424], 'studies)': [1247], 'glass': [1249, 1462], 'slides': [1250], 'imaging).': [1252], 'incubated': [1255, 3086, 3187, 3268, 3775], '37': [1257, 1684, 1980, 2250, 2260, 2319, 2329, 2636, 3211, 3292], '°C': [1258], 'humidified': [1261], 'atmosphere': [1262], '5%': [1264], 'CO2': [1265], 'air.': [1267], 'As': [1268], '(6Wilborn': [1271, 4008], 'DeWitt': [1273, 4010, 4467], 'Peters-Golden': [1275, 1445, 4012, 4583, 5687], 'Physiol.': [1279, 4016], '1995;': [1280, 4017, 4474, 4718, 4826, 4850, 5482, 5692], '268:': [1281, 4018], 'L294-L301PubMed': [1282, 4019], 'Scholar),': [1284, 4546, 4660, 4880, 4957, 4988, 5014], 'disrupted': [1287], 'sonication': [1289], '(10': [1290, 1634], 'bursts': [1291], '20%': [1293], 'duty': [1294], 'cycle)': [1295], 'ice-cold': [1297], 'homogenizing': [1298], 'buffer': [1299], '(50': [1300], 'mmTris-HCl,': [1301], '25': [1302], 'mm': [1303, 1306, 1309, 1312, 1316], 'KCl,': [1304], 'MgCl2,': [1307], '1': [1308, 1315, 1556, 1590, 1677, 1900, 1916, 2772, 2890, 3183, 3264, 4561], 'dithiothreitol,': [1310], 'phenylmethylsulfonyl': [1313], 'fluoride,': [1314], 'leupeptin,': [1317], 'pH': [1318], '7.4)': [1319], 'separated': [1321, 1356, 1811, 2268, 2337, 3219, 3300], 'into': [1322, 4700], 'soluble': [1323], 'pelletable': [1325], 'fractions': [1326, 1894], 'centrifugation': [1328], '(100,000': [1329], '×g,': [1330], '30': [1331, 1471, 1488, 2935], 'min,': [1332, 1979, 2249, 2318, 2635, 3210, 3291], '°C);': [1334], 'concentrations': [1337], 'modified': [1342], 'Coomassie': [1343], 'Blue': [1344], 'dye': [1345], 'binding': [1346], 'assay': [1347], '(Pierce).': [1348], 'Samples': [1349], 'containing': [1350, 1498, 1568, 3080], '10': [1351, 2248, 2317, 3209, 3290], 'μg': [1352], 'SDS-polyacrylamide': [1358], 'gel': [1359], 'electrophoresis': [1360], 'under': [1361, 1804], 'reducing': [1362], 'conditions': [1363], 'transferred': [1365], 'nitrocellulose': [1367], 'membranes.': [1368], 'Following': [1369, 1459, 3556], 'blocking,': [1370], 'membranes': [1371, 1926, 1932], 'probed': [1373, 1507], 'antibodies': [1375, 1509, 5061], '(rabbit': [1378, 1402], 'polyclonal': [1379, 1403], 'raised': [1380, 1404], 'against': [1381, 1405], 'sheep': [1382, 5165], 'seminal': [1383], 'vesicle': [1384], '(7Smith': [1386], 'W.': [1387, 4244, 4944, 5169, 5298], 'Rollins': [1388], 'T.': [1389, 4466, 4495, 4526, 4582, 4816, 4868, 4870, 4999, 5067], 'Methods': [1390], 'Enzymol.': [1391], '1982;': [1392], '86:': [1393], '213-222Crossref': [1394], '(22)': [1397], 'Scholar))': [1399], 'murine': [1406], 'Cayman': [1409], 'Chemical': [1410], 'Co.,': [1411], 'Ann': [1412], 'Arbor,': [1413], 'MI;': [1414], '1:10,000)': [1415], 'peroxidase-conjugated': [1418], 'goat': [1419, 1502, 1531], 'anti-rabbit': [1420, 1532], 'secondary': [1421], 'antibody': [1422, 1533], '(1:5000)': [1423], 'ECL': [1425], '(Amersham': [1427], 'Pharmacia': [1428], 'Biotech).': [1429], 'prepared': [1432], 'indirect': [1434, 2394], 'immunofluorescent': [1435, 1913, 2395], 'microscopy': [1436, 1914], '(8Brock': [1440], 'T.G.': [1441], 'Paine': [1442], 'III,': [1443], 'Biol.': [1448, 4222, 4273, 4472, 4532, 4716, 4736, 4756, 4824, 4848, 5112, 5427], 'Chem.': [1449, 4223, 4274, 4473, 4533, 4717, 4737, 4757, 4825, 4849], '1994;': [1450, 4224, 4256, 4275], '269:': [1451, 4225, 4276], '22059-22066Abstract': [1452], 'mounting': [1460], 'slides,': [1463], 'fixed': [1466], 'using': [1467, 1490, 1541, 1795, 1815, 1867, 3514, 3549, 3985], 'methanol': [1468], '(−20': [1469, 1476], 'min),': [1472, 1479], 'permeabilized': [1473], 'acetone': [1475], '3': [1478, 2418, 2523, 2546, 2569], 'air-dried,': [1480], 'rehydrated': [1481], 'sterile': [1483, 1561], 'PBS,': [1484, 1562], 'blocked': [1486], '0.1%': [1491, 1522], '(w/v)': [1492], 'bovine': [1493, 1525], 'serum': [1494, 1526, 1573], 'albumin': [1495], 'PBS': [1497, 1519], '1%': [1499], '(v/v)': [1500], 'nonimmune': [1501], 'serum.': [1503], 'Preparations': [1504, 1536], '1:200': [1517], 'supplemented': [1520], 'fatty': [1523], 'acid-free': [1524], 'albumin,': [1527], 'followed': [1528], 'rhodamine-conjugated': [1530], '(1:200,': [1534], 'Sigma).': [1535], 'examined': [1538, 3386], 'photographed': [1540], 'Zeiss': [1543], 'Aristoplan': [1544], 'microscope': [1545], 'equipped': [1546], 'epifluorescence.': [1548], 'overnight': [1550, 1565, 1614, 2554, 2953, 3087, 3122, 3765], 'incubations,': [1551], 'adhered': [1554, 3173, 3254], 'h,': [1557, 1956, 2240, 2259, 2309, 2328, 3479], 'washed': [1558, 1963, 2753, 2810, 3202, 3283], 'twice': [1559], 'cultured': [1564, 1619], '10%': [1569, 2131], 'heat-inactivated': [1570], 'newborn': [1571], 'calf': [1572], '(Life': [1574], 'Technologies,': [1575], 'Inc.).': [1576], 'some': [1578, 1616, 2427, 5350, 5514, 5647], 'experiments,': [1579, 2488], '(acetylsalicylic': [1581], '(ASA);': [1583], '200': [1584], 'μm)': [1585, 1697, 2769, 3181, 3262, 3402], 'included': [1587, 1654, 1694], 'during': [1588, 1688, 1721, 1761], 'h': [1591, 2416, 2623, 2773, 2791, 3196, 3277, 3590, 3615, 3660], 'adherence': [1592, 1600], 'phase;': [1593], 'treatment': [1595, 2539, 2567, 2717, 2765, 3007, 3338, 3653, 3820, 4002], 'did': [1596, 1732, 2198, 2792, 3821], 'not': [1597, 1733, 1905, 2083, 2199, 2209, 2501, 2551, 2793, 3050, 3125, 3468, 3728, 3822, 4061, 4084, 4141, 4376, 5666], 'affect': [1598], 'survival,': [1602], 'trypan': [1606, 2492], 'blue': [1607, 2493], 'staining': [1608, 2468, 2479], 'visualization': [1610], 'During': [1613], 'incubation,': [1615], '(1': [1622, 1700, 1976, 2068, 2246, 2315, 2375, 2632, 3192, 3207, 3273, 3288], 'μg/ml),': [1623], 'TNF-α': [1624, 2513, 3657, 4938, 4997, 5024, 5134, 5406], '(100': [1625, 2514], 'ng/ml),': [1626, 1629, 2515], 'IL-1': [1627, 2531, 2544, 4995, 5022, 5096], '(5': [1628, 2532], 'polymyxin': [1631, 3094], 'B': [1632], 'sulfate': [1633], 'μg/ml).': [1635], 'prelabeling': [1637], 'lipids,': [1640], 'μCi': [1642, 1713], '[3H]AA': [1644, 1715, 1953, 2150, 2237, 2255, 2306, 2324], '(specific': [1645], 'activity,': [1646, 2777], '76–100': [1647], 'Ci/mmol,': [1648], 'NEN': [1649], 'Life': [1650], 'Science': [1651], 'Products)': [1652], 'incubation': [1657, 2555], 'medium.': [1658, 3768], 'Before': [1659], 'stimulation,': [1661], 'unincorporated': [1663, 1967], 'label': [1664], 'removed': [1666], 'washing': [1668, 2782], 'three': [1669, 2945, 3240, 3321, 3511], 'times': [1670, 3712], 'PBS.': [1672], 'Cell': [1673], 'stimulation': [1674, 1690, 1722, 1762, 2177, 3558, 3576], 'μm': [1678, 2891, 2902, 2916, 2936], 'A23187': [1679, 1975, 2181, 2245, 2257, 2314, 2326, 2631, 3206, 3287], '15': [1681, 1978, 2634], '°C.': [1685], 'Inhibitors': [1686], 'added': [1687], 'designated': [1692], 'experiments': [1693, 2099, 2576, 2947, 3513], 'NS-398': [1695, 2917], '(3': [1696], 'indomethacin': [1699, 2067], 'μm).': [1701], 'Metabolism': [1702, 1736], 'evaluated': [1707, 1741, 1861, 1875], 'addition': [1710, 1726, 1744], '(∼5': [1716], 'pm)': [1717], 'unlabeled': [1719, 1752, 1759], 'A23187;': [1724], 'additional': [1728], 'cold,': [1729], 'carrier': [1730], 'alter': [1734], 'results.': [1735], '0.1': [1746], 'μm[3H]PGH2': [1747], 'HPLC': [1749, 1814, 1998, 3609], 'analysis)': [1750, 1757], 'A23187.': [1764], 'Radiolabeled': [1765, 1828], 'eicosanoids': [1766, 1789], 'assayed': [1768], 'Briefly,': [1788], 'extracted': [1791], 'culture': [1793, 2410, 2780, 3123], 'medium': [1794, 2788, 3090], 'Sep-Pak': [1796], 'C18': [1797, 1819], 'cartridges': [1798], '(Waters': [1799], 'Associates,': [1800], 'Milford,': [1801], 'MA),': [1802], 'dried': [1803], 'nitrogen,': [1805], 'water:acetonitrile': [1808], '(2:1),': [1809], 'reverse-phase': [1813], 'Waters': [1817], 'μBondapak': [1818], 'column': [1820], 'mobile': [1823], 'phase': [1824], 'acetonitrile/water/trifluoroacetic': [1826], 'identified': [1831, 1996], 'coelution': [1834], 'authentic': [1836], 'standards': [1837], 'quantitated': [1839], 'on-line': [1841], 'radiodetection.': [1842], 'Enzyme': [1843], '(EIA)': [1845], 'conditioned': [1847, 2265, 2334, 3216, 3297], 'media': [1848, 2266, 2335, 3175, 3189, 3217, 3256, 3270, 3298], 'performed': [1850], 'according': [1851], "supplier's": [1854], 'instructions': [1855], '(Cayman': [1856], 'Chemicals).': [1857], 'Statistical': [1858], 'significance': [1859], 'paired': [1863, 4904, 5241], "Student's": [1864], 't': [1865], 'test': [1866], 'p': [1868], '<': [1869], '0.05.': [1870], 'presence': [1878, 2184], 'isoforms.': [1883], 'immunoblot': [1885], 'analysis,': [1886], 'fresh': [1887, 2154, 2746, 2848], 'abundant': [1890, 2456, 3419], 'membrane-containing': [1893], 'lacked': [1896, 3963], 'detectable': [1897, 1908, 2528, 3965], '(Fig.': [1899, 1915, 2091, 2417, 2522, 2545, 2568, 2800, 2823, 3497, 3591, 3650, 3680, 4081, 4118], 'A).': [1901, 2034, 2392, 2524, 2679, 3416, 3593], 'COX-1,': [1903, 3799, 4772, 5667], 'individual': [1910], 'B).': [1917, 2093, 2419, 2802, 3682], 'technique,': [1920], 'appeared': [1922, 2465], 'extensively': [1924], 'decorate': [1925], 'throughout': [1927, 4441], 'including': [1930, 2011, 5256, 5344, 5460, 5550], 'perinuclear': [1931, 2440], 'endoplasmic': [1935, 2459, 4669], 'reticulum.': [1936, 2460], 'To': [1937, 2738, 3381], 'determine': [1938], 'alone,': [1946, 2556], 'freshly': [1947, 2102, 2215, 2658, 2675, 2907, 3108, 3412, 3434, 3527, 3563, 3603, 3721], 'prelabeled': [1951, 2235, 2304], '2': [1955, 2092, 2239, 2308, 4099], 'tubes,': [1962], 'label,': [1968], 'stimulated': [1970, 2243, 2312, 2629, 3018, 3204, 3285], 'calcium': [1973], 'ionophore': [1974, 3445, 3557], 'μm,': [1977, 2247, 2316, 2633, 3208, 3289], '°C)': [1981, 2251, 2320, 2637], 'release': [1983, 2639], 'membrane': [1988, 4444], 'phospholipids.': [1989], 'method,': [1992], 'separation': [1999], 'approximately': [2001, 2384, 2833, 3491, 3578], '60%': [2002, 2845], 'released': [2005, 2837, 3065, 3077, 3437, 5089], 'metabolites,': [2010], '(detected': [2013, 2017], '6-keto-PGF1α),': [2015], 'TxA2': [2016, 3950], 'TxB2),': [2019], 'HHT': [2023, 2118, 2970, 3033], '30%': [2025, 3492, 3679], '5-lipoxygenase': [2031, 2085, 2195, 2703], 'pathway': [2032], '(Fig.2': [2033], 'reported': [2041, 4006], 'inhibited': [2065, 2865, 2888, 2931], 'μm),': [2069], 'nonselective': [2071, 2599], 'inhibitor,': [2073], 'resulting': [2074, 5396], 'increases': [2076], 'free': [2078], '12-HETE': [2081], 'products,': [2086, 3055], '(LT)B4': [2088], '5-HETE': [2090], 'Pooled': [2094, 2942], 'independent': [2098, 2946, 3512, 4202], 'indicated': [2100, 2948], 'generated': [2105, 2168, 3101, 3537], 'AA:': [2113], '(Table': [2119, 3027, 3083, 3450], 'I).': [2120, 3084, 3451], 'accounting': [2127], 'less': [2129, 2972, 4113, 5671], 'all': [2133, 2281, 2350, 2489, 2605, 2836, 3063, 3075, 3232, 3313, 3350, 3427, 3494, 3831, 4381, 5215], 'products.': [2135, 3833, 4299], 'Similar': [2136, 3037, 3757], 'supplied': [2144, 2187, 2986, 3045], 'exogenously;': [2145], 'trace': [2147], 'levels': [2148, 5126], 'provided': [2152], 'absence': [2158, 5519], 'agonist,': [2161], 'ratios': [2164, 2203], 'prelabeled,': [2170], 'A23187-stimulated': [2171], '(TableI).': [2175], 'Acute': [2176], 'exogenously': [2186, 3046], 'radiolabeled': [2188, 2194, 2687, 2983, 3042], 'significantly': [2200, 4928], '(data': [2208, 3124, 3467], 'shown).Table': [2210, 3126], 'IProducts': [2211], 'PMsProduct6-keto-PGF1αTxB2PGE2PGD2HHTFresh': [2217], 'PMsFrom': [2218], 'AA19.1': [2220], '(8.7)25.5': [2221], '(6.1)7.1': [2222], '(5.1)20.3': [2223], '(10.3)28.0': [2224], '(8.4)From': [2225], 'AA17.1': [2227], '(6.4)17.8': [2228], '(5.3)9.8': [2229], '(4.1)24.5': [2230], '(8.4)30.8': [2231], '(7.6)Cells': [2232], 'washed,': [2241, 2310, 2627, 3185, 3266], 'without': [2256, 2325, 3093, 3178, 3259], '(2': [2258, 2327], '°C).': [2261, 2330, 3212, 3293], 'Radioactive': [2262, 2331, 3213, 3294], 'metabolites': [2263, 2332, 3214, 3295], 'HPLC;': [2270, 2339, 3221, 3302], 'disintegrations/min': [2274, 2343, 3225, 3306, 3496], 'per': [2275, 2344, 3226, 3307], 'percentage': [2279, 2348, 3230, 3311], 'disintegrations/min.': [2283, 2352, 3234, 3315], 'Values': [2284, 2353, 3235, 3316], 'mean': [2287, 2356, 3238, 3319], 'experiments;': [2290, 2359, 3241, 3322], 'S.E.': [2291, 2360, 3242, 3323], 'parentheses.': [2294, 2363, 3245, 3326], 'Open': [2295, 3246], 'table': [2296, 3247], 'new': [2299, 2797, 3250], 'tab': [2300, 3251], 'pronounced': [2370, 2973], 'response': [2372, 4913, 4934, 4963, 4993, 5020, 5058, 5094, 5512, 5598], 'μg/ml,': [2376], '24': [2377, 2415, 2622, 2762, 2790, 3134, 3156, 3195, 3276, 3478, 3489, 3589, 3614, 3659], 'h),': [2378], 'appearing': [2379, 2516], 'bands': [2382], '69': [2385], '70': [2387], 'kDa': [2388], 'immunoblots': [2390], '(Fig.3': [2391], 'microscopy,': [2396], 'degree': [2398], 'expression': [2400, 2431, 2535, 5633], 'varied': [2404], 'greatly': [2405], 'among': [2406], 'within': [2408], 'Some': [2420], 'largely': [2423], 'negative': [2424], 'showed': [2429, 2444], 'intermediate': [2430], 'restricted': [2434], 'nuclear': [2437, 2451, 4455, 4672, 4798, 4893], 'envelope': [2438, 2452, 4456, 4673], 'membranes,': [2441, 2643], 'others': [2443], 'concentrated': [2448], 'Nomarski': [2462], 'optics,': [2463], 'greatest': [2469], 'spread': [2473], 'commonly': [2475], 'binucleate,': [2476], 'least': [2481, 4200, 5610], 'rounded': [2483, 2498], 'mononucleate.': [2485], 'parallel': [2487], 'excluded': [2491], 'dye,': [2494], 'indicating': [2495], 'dead.': [2502], 'induced': [2507, 2758, 3644, 3940], 'lesser': [2510], 'extent': [2511], '69-kDa': [2520], 'band': [2521], 'There': [2525], 'no': [2527, 3523, 5450], 'ng/ml).': [2533], 'unchanged': [2537], 'following': [2538, 2681, 2715, 3005, 3336, 3574, 4168, 4184], 'LPS,': [2541, 3100, 5543], 'TNF-α,': [2542, 3641], 'A),': [2547], 'altered': [2552, 2712, 3333], 'ASA': [2557, 2563, 2751, 2767, 2807, 2876, 2992, 3150, 3179, 3260, 3796], 'pretreatment,': [2558], 'combination': [2561], 'pretreatment': [2564], 'C).': [2570, 2825], 'Based': [2571], 'results,': [2574], 'subsequent': [2575], 'focused': [2577], 'LPS-induced': [2579], 'models,': [2584, 5124], 'elevated': [2588, 3120, 5056, 5132], 'via': [2593, 3066], 'should': [2596, 3684, 4505], 'make.': [2613], 'changes': [2645, 2855, 4056, 4073, 4088, 4155], 'readily': [2650, 3752], 'apparent,': [2651], 'compared': [2653, 2843, 3069], 'seen': [2656, 2980], 'active': [2666, 2958, 3003, 3805], 'same': [2672, 3103], '(Fig.4': [2678], 'treatment,': [2683, 3618], 'proportion': [2685, 3481], 'increased,': [2693], '5-HETE,': [2705], 'reduced.': [2707], 'One': [2708], 'explanation': [2709, 3330, 4410], 'address': [2739, 3382], 'this,': [2740], 'irreversibly': [2743], 'ASA,': [2749], 'away,': [2754], 'h.': [2763], '(200': [2768, 3180, 3261], 'alone': [2770, 4080], 'effectively': [2774], 'eliminated': [2775], 'continued': [2779], '(after': [2781], 'ASA)': [2785], 'LPS-free': [2787, 3089, 3767], 'significant': [2796, 3025, 3524, 3567, 3990, 4031], 'activity': [2799, 3348, 3545, 3938, 3993, 4138, 4159, 4663], 'predominantly': [2815, 2962], 'LTB4': [2822, 2857, 3119], 'cells,': [2827, 3019, 5348], 'active,': [2831], 'had': [2832, 3363], '85%': [2834], 'COX-1-containing': [2847], 'PMs.': [2849], 'Interestingly,': [2850], 'there': [2851, 3521, 4391], 'Finally,': [2859, 4687], 'inhibitor': [2870], 'NS-398;': [2871], 'pretreated': [2874], 'completely': [2887], 'NS-398,': [2892, 2937], 'EIA,': [2896], 'IC50': [2899, 2923], '0.12': [2901], 'NS-398.': [2903], '50%': [2910], 'inhibition': [2911], 'PGE2synthesis': [2913], 'required': [2914], '8.3': [2915], '(approximately': [2918], '70-fold': [2919], 'ASA-pretreated,': [2925], 'LPS-treated': [2926, 3129, 3530, 4049], 'cells);': [2927], '75%': [2933], 'highest': [2939], 'dose': [2940], 'tested.': [2941], 'data': [2943], 'TxB2,': [2964, 3853], 'PGD2': [2968, 3031, 3113, 3947, 4608], 'being': [2971, 3013, 3710], '(TableII).': [2974], 'pattern': [2976], 'generally': [2979], 'exogenously.': [2987], 'Pretreatment': [2988, 3794], 'leave': [2998], 'isoform': [3004], 'TxB2': [3021], 'occasionally': [3022], 'found': [3023, 3719, 3989, 4611], 'II).': [3028], 'barely': [3035], 'detectable.': [3036], 'acutely': [3051], 'stimulated.': [3052], 'PGI2and': [3056, 5048], 'constituted': [3058], '85.8': [3059], '±': [3060, 3072], '14.8%': [3061], '26.2': [3071], '13.9%': [3073], 'B,': [3095], 'binds': [3097], 'inactivates': [3099], 'except': [3111], 'tended': [3114], 'reduced': [3117, 3850], 'IIProducts': [3127], 'PMsProduct6-keto-PGF1αTxB2PGE2PGD2HHTPMs': [3130], 'hFrom': [3135, 3157], 'AA32.9': [3137], '(11.3)21.9': [3138], '(8.0)30.4': [3139], '(12)4.7': [3140], '(3.4)10.1': [3141], '(6.1)From': [3142], 'AA31.5': [3144], '(8.2)8.21': [3145], '(5.7)36.7': [3146], '(12)7.4': [3147], '(4.8)16.2': [3148], '(2.6)PMs': [3149], 'pretreated,': [3151], 'AA41.5': [3159], '(9.9)7.6': [3160], '(6.1)44.4': [3161], '(11)1.8': [3162], '(2.5)4.8': [3163], '(6.7)From': [3164], 'AA40.0': [3166], '(2.7)13.6': [3167], '(7.0)27.7': [3168], '(8.0)1.0': [3169], '(1.3)18.7': [3170], '(9.2)Cells': [3171], 'hr,': [3184, 3265], 'μg/ml)': [3193, 3274], '[3H]AA.': [3198, 3279], 'A': [3327, 3452, 3739, 3857, 4300, 4408], 'second': [3328], 'possible': [3329], 'changed': [3344], 'act': [3353], 'isozymes.': [3358], 'Specifically,': [3359], 'might': [3361], 'up-regulating': [3364], 'down-regulatory': [3372], 'giving': [3376], 'HHT.': [3380, 3856, 4345], 'possibility,': [3384], 'PGH2.': [3398, 3539, 3881], 'Exogenous': [3399, 3594], '(0.1': [3401], 'variety': [3408, 4617], '(Fig.5': [3415], 'about': [3424], '24%': [3425], 'recovered': [3428, 3495], 'product.': [3429], 'surprising': [3432, 3813], 'little': [3438], '(following': [3444], 'stimulation)': [3446], 'unfractionated': [3464], 'lysates': [3466, 3959, 4000], 'shown).': [3469], 'When': [3470], 'B),': [3499], 'consistent': [3500, 3606, 5222], 'slight': [3503], 'activity.': [3508, 4036], 'whole': [3516, 3996, 5122], 'lysates,': [3520], 'differences': [3525], 'between': [3526], 'profiles': [3534], 'further': [3547, 3638], 'assessed': [3548], 'EIAs': [3550], 'specifically': [3552], 'measure': [3553], 'liberate': [3560], 'AA,': [3562, 3706, 4130, 4691], 'made': [3566], 'acute': [3575], '2.5-fold': [3579], '6': [3587, 3592, 3612, 3681], 'untreated,': [3602], 'analysis.': [3610], 'After': [3611], 'significantly.': [3624], 'increase,': [3627], 'statistically': [3629], 'significant,': [3630], '30%.': [3634], 'extended': [3639], '3).': [3651, 4563], '3-fold,': [3668], 'It': [3683, 4504], 'noted': [3686, 4131, 4507], 'presented': [3693], 'Fig.6,': [3695], 'measured': [3697], 'scale': [3701, 4123], 'former': [3709], '8': [3711], 'latter.': [3714], 'make': [3730, 3972, 5669], 'prostanoid,': [3741], 'stark': [3770], 'shifted': [3786], 'emphasize': [3788, 5581], 'leaving': [3800], 'isoform,': [3806], 'change.': [3809], 'increasing': [3815], 'across-the-board': [3826], 'Instead,': [3834, 4390], 'caused': [3837], 'characterized': [3841], 'enzymes,': [3875], 'process': [3877], 'Indeed,': [3882, 5649], 'Oh-ishi': [3883, 3898, 3924], 'colleagues': [3885], '(9Matsumoto': [3886], 'H.': [3887, 3889, 3913, 3917, 4220, 4489, 4493, 4628, 4967, 5032, 5469], 'Naraba': [3888], 'Murakami': [3890], 'Kudo': [3892, 3922], 'I.': [3893, 3923, 4458], 'Yamaki': [3894], 'K.': [3895, 4242, 4248, 4630, 4651, 4866, 4948, 4969], 'Ueno': [3896, 3920], 'A.': [3897, 3921, 4255, 4586, 4975, 5001, 5147, 5167, 5296], 'Biochem.': [3900, 4634, 4871], 'Biophys.': [3901, 4635], 'Res.': [3902, 4980, 5382], 'Commun.': [3903], '1997;': [3904, 4500, 4758, 5075, 5113, 5428], '230:': [3905], '110-114Crossref': [3906], '(145)': [3909], '10Naraba': [3912], 'Maurakami': [3914], 'Matsumoto': [3916, 4266, 4707], 'Shimbara': [3918], '160:': [3929, 4501], '2974-2982PubMed': [3930], 'Scholar)': [3932, 5163, 5183], 'shown': [3934], 'activities': [3952], 'unaffected.': [3954], 'studies,': [3957], 'any': [3964], 'PGE2synthase': [3966, 4662], 'activity;': [3967], 'serve': [3970, 5506], 'enzymatic': [3974], 'rate-limiting': [3976, 4145], 'resident': [3986], 'Treatment': [4022], 'small': [4028, 4154], '(30%)': [4029], 'certainly': [4039], 'suggest': [4054, 4173, 5492], 'sufficient': [4062], 'account': [4064, 4161], 'profile.': [4070], 'First,': [4071, 4426], '5)': [4082], 'comparable': [4085], 'plus': [4095], '(Figs.': [4098], 'and4).': [4100], 'Second,': [4101, 4564], 'magnitude': [4103], 'much': [4112, 4351, 5670], '6).': [4119], 'difference': [4121, 4516], 'versus': [4129], 'Fig.': [4133], '6,': [4134], 'argues': [4135], 'COX,': [4140], 'synthase,': [4143], 'cannot': [4160], 'factors': [4176], 'contributed': [4177], 'Previous': [4187], 'researchers': [4188], 'suggested': [4190], 'pathways': [4197, 4214, 4292, 4704, 5276], 'partially': [4201], 'one': [4204], 'another,': [4205], 'particularly': [4206], 'terms': [4208], 'where': [4212], '(11Reddy': [4217], 'Herschman': [4219, 4753], '15473-15480Abstract': [4226], '12Masferrer': [4233], 'Zweifel': [4235], 'B.': [4236, 4491, 5410], 'Manning': [4237], 'P.': [4238, 4246], 'Hauser': [4239], 'Leahy': [4241], 'Smith': [4243, 4469, 4494, 4529, 4843], 'Isakson': [4245], 'Seibert': [4247], 'Proc.': [4249], 'Natl.': [4250], 'Acad.': [4251], 'Sci.': [4252], 'U.': [4253], '91:': [4257], '3228-3236Crossref': [4258], '(1293)': [4261], '13Murakami': [4264], 'Austen': [4268, 4711], 'K.F.': [4269, 4712], 'Arm': [4270, 4713], 'J.P.': [4271, 4714], '22269-22275Abstract': [4277], 'propose': [4286], 'relationship': [4304], 'based': [4307], 'Fig.7.': [4317], 'produces': [4326], 'directed': [4330], 'way': [4334], 'tightly': [4353], 'coupled': [4354], 'PGI2-': [4357], 'PGE2-synthesizing': [4359], 'enzymes.': [4365, 4425, 4786], 'Then': [4366], 'produce.': [4389], 'toward': [4400], 'relates': [4417], 'subcellular': [4420, 4436, 4574, 4777], 'distribution': [4421], 'appear': [4431, 4569], 'distribution.': [4437], 'dispersed': [4440], 'system,': [4445], 'accumulated': [4450], 'around': [4453, 4891], '(14Morita': [4457], 'Schindler': [4459], 'Regier': [4461, 4841], 'M.K.': [4462, 4842], 'Otto': [4463], 'J.C.': [4464], 'Hori': [4465], 'D.L.': [4468], 'W.L.': [4470, 4530, 4844], '270:': [4475, 4719, 4827, 4851], '10902-10908Abstract': [4476], '(512)': [4484], 'Scholar,15Zhang': [4486], 'Cao': [4488], 'Graf': [4490], 'Meekins': [4492], 'Phipps': [4496, 5422], '1053-1057Google': [4502], 'recent': [4510], 'study': [4511], 'has': [4512, 4577, 4664, 5437], 'questioned': [4513], 'whether': [4514], 'real': [4518], 'artifactual': [4520], '(16Spencer': [4521], 'A.G.': [4522], 'Woods': [4523], 'J.W.': [4524], 'Arakawa': [4525], 'Singer': [4527], 'I.I.': [4528], '273:': [4535], '9886-9893Abstract': [4536], '(296)': [4544], 'our': [4548], 'support': [4550], 'distinct': [4551, 4694], 'distributions': [4552], '(Fig.8,': [4557], 'see': [4558], 'Figs.': [4560], 'distribution,': [4575, 4778], 'been': [4578, 4665], 'recently': [4579], 'reviewed': [4580], '(17Brock': [4581], 'Szczeklik': [4585], 'Gryglewski': [4587], 'Vane': [4589], 'Eicosanoids,': [4591], 'Aspirin': [4592], 'Asthma.': [4594], '91-109Google': [4600], 'glutathione-requiring': [4605], 'form': [4606], 'cytoplasm': [4614], '(18Ujihara': [4621], 'Urade': [4623, 4709], 'Eguchi': [4625], 'N.': [4626], 'Hayashi': [4627], 'Ikai': [4629, 4650], 'Hayaishi': [4631, 4652], 'O.': [4632, 4653], 'Arch.': [4633], '1988;': [4636], '260:': [4637], '521-531Crossref': [4638], '(149)': [4641], '19Urade': [4644], 'Ujihara': [4646], 'Horiguchi': [4648], '1989;': [4656, 4679], '143:': [4657], '2982-2989PubMed': [4658], 'localized': [4666], 'reticulum': [4670], '(20Mukherjee': [4674], 'E.': [4675, 4820, 5102, 5145, 5419, 5476], 'Ghosh': [4676], 'Prostaglandins.': [4678], '557-563Crossref': [4681], '(6)': [4684], 'pools': [4689], 'liberated': [4692, 4795], 'phospholipase': [4695, 4807], 'A2': [4696, 4808], 'feed': [4699], '(21Murakami': [4705], '3239-3246Abstract': [4720], '(137)': [4728], '22Balsinde': [4731], 'Dennis': [4733], 'E.A.': [4734], '1996;': [4738, 4873, 5007], '271:': [4739], '6758-6765Abstract': [4740], '(342)': [4748], '23Reddy': [4751], 'S.T.': [4752], 'H.R.': [4754], '272:': [4759], '3231-3237Abstract': [4760], '(156)': [4768], 'diffuse': [4776], 'relatively': [4782], 'nonselectively': [4783], 'On': [4787], 'monopolize': [4793], 'envelope,': [4799, 4894], 'e.g.': [4800], '85-kDa': [4806], 'acting': [4809], 'site': [4812], '(24Glover': [4813], 'Bayburt': [4815], 'Jonas': [4817], 'Chi': [4819], 'Gelb': [4821], 'M.H.': [4822], '15359-15367Abstract': [4828], '(314)': [4836], '25Schievella': [4839], 'A.R.': [4840], 'Lin': [4845], 'L.-L.': [4846], '30749-30754Abstract': [4852], '(425)': [4860], '26Peters-Golden': [4863], 'Song': [4865], 'Marshall': [4867], 'Brock': [4869], '318:': [4874], '797-803Crossref': [4875], '(100)': [4878], 'located': [4888], 'and,': [4899, 5608], 'perhaps,': [4900], 'synthase.': [4902], 'settings.': [4922], 'endothelial': [4931, 5053], '(27Riedo': [4939], 'F.': [4940, 5026, 5474], 'Munford': [4941], 'Campbell': [4943], 'Reisch': [4945], 'Chien': [4947], 'Gerard': [4949], '3506-3512PubMed': [4955], 'ciliary': [4959], 'epithelial': [4960], '(28Helbig': [4966], 'Kittredge': [4968], 'Gurley': [4970], 'Thurau': [4972], 'Palestine': [4974], 'Nussen-blatt': [4976], 'Curr.': [4978], 'Eye': [4979], '9:': [4982], '501-505Crossref': [4983], '(17)': [4986], 'gingival': [4990], 'fibroblasts': [4991, 5650, 5676], '(29Modeer': [4998], 'Bengtsson': [5000], 'Rolla': [5002], 'G.': [5003, 5171, 5300], 'Clin.': [5005, 5073, 5690], 'Periodontol.': [5006], '23:': [5008], '927-933Crossref': [5009], '(56)': [5012], 'myometrial': [5017], '(30Hertelendy': [5025], 'Romero': [5027], 'Molnar': [5029], 'Todd': [5031], 'Baldassare': [5033], 'Reprod.': [5037], '1993;': [5039, 5156], '30:': [5040], '49-57Crossref': [5041], '(53)': [5044], 'aortic': [5052], 'xenoreactive': [5060], 'complement': [5063], '(31Bustos': [5064], 'Coffman': [5066], 'Saadi': [5068], 'Platt': [5070], 'Invest.': [5074, 5691], '100:': [5076], '1150-1158Crossref': [5077], '(76)': [5080], 'Inex': [5083], 'vivo': [5084], 'culture,': [5085], 'saphenous': [5087], 'vein': [5088], '(32Bishop-Bailey': [5097], 'Pepper': [5099], 'Haddad': [5101], 'Newton': [5103], 'Larkin': [5105], 'Mitchell': [5107], 'Arterioscler.': [5109], 'Thromb.': [5110], 'Vasc.': [5111], '17:': [5114], '1644-1648Crossref': [5115], '(58)': [5118], 'animal': [5123], 'plasma': [5125], 'administered': [5136], 'intravenously': [5137], '(33Fletcher': [5140], 'Collins': [5142], 'Graves': [5144], 'Luterman': [5146], 'Williams': [5148], 'Izenberg': [5150], 'Rodning': [5152], 'Ann.': [5154], 'Surg.': [5155], '217:': [5157], '668-674Crossref': [5158], '(34)': [5161, 5206, 5327], '(34Wheeler': [5166], 'Hardie': [5168, 5297], 'Bernard': [5170, 5299], 'Respir.': [5174, 5199, 5303, 5320], 'Dis.': [5175, 5200, 5304, 5321], '1992;': [5176, 5305], '145:': [5177, 5306], '632-639Crossref': [5178, 5307], '(38)': [5181, 5310], 'bleomycin': [5187], 'intratracheally': [5190], 'hamsters': [5192], '(35Chandler': [5193], 'Giri': [5195, 5316], '1983;': [5201, 5322], '128:': [5202, 5323], '71-76Crossref': [5203, 5324], 'experimental': [5217], 'systems,': [5218], 'thesis': [5225], 'What': [5235], 'impact': [5238], 'PGE2?': [5246], 'number': [5251, 5547], 'responses,': [5255, 5549], 'relaxation,': [5259], 'decreased': [5260, 5270, 5398], 'fibroblast': [5261, 5712], 'diminished': [5266], 'collagen': [5267, 5715], 'deposition,': [5268], 'leukocyte': [5271], 'Although': [5273], 'signaling': [5275], 'used,': [5279], 'receptor-mediated': [5288], 'elevation': [5289], 'cAMP': [5291, 5332, 5436, 5586], '34Wheeler': [5295], 'Scholar': [5312, 5374], '35Chandler': [5314], 'Also': [5330], 'signaling,': [5333, 5587], 'inhibit': [5338], 'activation-initiated': [5339], 'responses': [5340], 'leukocytes,': [5343], 'neutrophils,': [5345], 'macrophages,': [5346], 'mast': [5347], 'T': [5351], 'lymphocytes': [5352], '36Phipps': [5356], 'Stein': [5358], 'Roper': [5360], 'Today.': [5363], '1991;': [5364, 5413], '349-352Abstract': [5366], '(496)': [5372], '37Kunkel': [5376], 'Chensue': [5378], 'Adv.': [5380, 5424], 'Inflamm.': [5381], '1984;': [5383], '7:': [5384], '93-102Google': [5385], 'PGE2inhibit': [5390], 'cytokine': [5391], 'Th1-type': [5394, 5554, 5606], 'lymphocytes,': [5395, 5442], 'secretion': [5399], 'IL-2,': [5401], 'interferon-γ,': [5402], 'IL-8,': [5403], 'IL-12,': [5404], '(38Betz': [5407], 'Fox': [5409], '146:': [5414], '108-113PubMed': [5415], '39Fedyk': [5418], 'Brown': [5420], 'Exp.': [5425], '407:': [5429], '237-242Crossref': [5430], 'Signaling': [5434], 'variable': [5438], 'Th2-type': [5441, 5458, 5617], 'actually': [5453, 5508], 'cytokines,': [5459], 'IL-4,': [5461], 'IL-5,': [5462], 'IL-10,': [5463], 'IL-13': [5465], '(40Hilkens': [5466], 'Vermeulen': [5468], 'van': [5470], 'Neerven': [5471], 'Snijdewint': [5473], 'Wierenga': [5475], 'Kapsenberg': [5477], 'Eur.': [5479], '25:': [5483], '59-63Crossref': [5484], '(178)': [5487], 'shifting': [5500], 'secretion,': [5505], 'diminish': [5509], 'tissues.': [5515], 'serves': [5524], 'generate': [5526], 'maintain': [5533], 'level': [5535], 'system': [5537], 'Inflammatory': [5539], 'cytokines': [5555, 5607], 'data,': [5559], 'studies': [5564], 'cited': [5565], 'above,': [5566], 'tip': [5574], 'secreted': [5578], 'Via': [5585], 'begin': [5592], 'resolution': [5594], 'suppression': [5601], 'indirectly,': [5611], 'favor': [5612], 'development': [5614], 'cytokines.': [5620], 'defect': [5626], 'suppress': [5636, 5710], 'augment': [5644], 'inflammation': [5645], 'circumstances.': [5648], 'patients': [5652], 'idiopathic': [5654], 'pulmonary': [5655], 'fibrosis': [5656], 'severely': [5659], 'impaired': [5660], 'capacity': [5661], 'express': [5663], 'do': [5674], 'control': [5675], '(41Wilborn': [5677], 'Burdick': [5681], 'Kunkel': [5683], 'Strieter': [5685], '95:': [5693], '1861-1868Crossref': [5694], '(346)': [5697], 'failure': [5701], 'disease': [5721], 'progression.': [5722]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2004016651', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-13T16:20:42.406682', 'created_date': '2016-06-24'}