Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2003985632', 'doi': 'https://doi.org/10.1056/nejm199810083391504', 'title': 'Bilateral Orchiectomy with or without Flutamide for Metastatic Prostate Cancer', 'display_name': 'Bilateral Orchiectomy with or without Flutamide for Metastatic Prostate Cancer', 'publication_year': 1998, 'publication_date': '1998-10-08', 'ids': {'openalex': 'https://openalex.org/W2003985632', 'doi': 'https://doi.org/10.1056/nejm199810083391504', 'mag': '2003985632', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9761805'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejm199810083391504', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJM199810083391504?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJM199810083391504?articleTools=true', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5012074439', 'display_name': 'Mario A. Eisenberger', 'orcid': 'https://orcid.org/0000-0002-8787-3271'}, 'institutions': [{'id': 'https://openalex.org/I4210150714', 'display_name': 'Johns Hopkins Hospital', 'ror': 'https://ror.org/05cb1k848', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436', 'https://openalex.org/I4210150714']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mario A. Eisenberger', 'raw_affiliation_strings': ['Johns Hopkins Hospital, Baltimore'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins Hospital, Baltimore', 'institution_ids': ['https://openalex.org/I4210150714']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070922234', 'display_name': 'Brent A. Blumenstein', 'orcid': 'https://orcid.org/0000-0003-1338-2370'}, 'institutions': [{'id': 'https://openalex.org/I4210165553', 'display_name': 'SWOG Cancer Research Network', 'ror': 'https://ror.org/05n6zrm60', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210165553']}, {'id': 'https://openalex.org/I4210101190', 'display_name': 'Cancer Research And Biostatistics', 'ror': 'https://ror.org/01575p865', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210101190']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brent A. Blumenstein', 'raw_affiliation_strings': ['Southwest Oncology Group Statistical Center, Seattle'], 'affiliations': [{'raw_affiliation_string': 'Southwest Oncology Group Statistical Center, Seattle', 'institution_ids': ['https://openalex.org/I4210165553', 'https://openalex.org/I4210101190']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014213335', 'display_name': 'E. David Crawford', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'E. David Crawford', 'raw_affiliation_strings': ['University of Colorado, Denver'], 'affiliations': [{'raw_affiliation_string': 'University of Colorado, Denver', 'institution_ids': ['https://openalex.org/I921990950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111688208', 'display_name': 'Gary J. Miller', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gary Miller', 'raw_affiliation_strings': ['University of Colorado, Denver'], 'affiliations': [{'raw_affiliation_string': 'University of Colorado, Denver', 'institution_ids': ['https://openalex.org/I921990950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111538289', 'display_name': 'David G. McLeod', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I92664306', 'display_name': 'Walter Reed Army Institute of Research', 'ror': 'https://ror.org/0145znz58', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I106965489', 'https://openalex.org/I1304082316', 'https://openalex.org/I1330347796', 'https://openalex.org/I2802581893', 'https://openalex.org/I4210088792', 'https://openalex.org/I92664306']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David G. McLeod', 'raw_affiliation_strings': ['Walter Reed Army Medical Center, Washington, D.C.'], 'affiliations': [{'raw_affiliation_string': 'Walter Reed Army Medical Center, Washington, D.C.', 'institution_ids': ['https://openalex.org/I92664306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021904320', 'display_name': 'Patrick J. Loehrer', 'orcid': 'https://orcid.org/0000-0002-1532-4660'}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}, {'id': 'https://openalex.org/I2802849423', 'display_name': 'University Medical Center', 'ror': 'https://ror.org/036pt7h44', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802849423']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Patrick J. Loehrer', 'raw_affiliation_strings': ['Indiana University Medical Center, Indianapolis'], 'affiliations': [{'raw_affiliation_string': 'Indiana University Medical Center, Indianapolis', 'institution_ids': ['https://openalex.org/I55769427', 'https://openalex.org/I2802849423']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061697254', 'display_name': 'George Wilding', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210103341', 'display_name': 'University of Wisconsin Carbone Cancer Center', 'ror': 'https://ror.org/01e4byj08', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799905417', 'https://openalex.org/I4210103341', 'https://openalex.org/I4210132596']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'George Wilding', 'raw_affiliation_strings': ['University of Wisconsin Clinical Cancer Center, Madison'], 'affiliations': [{'raw_affiliation_string': 'University of Wisconsin Clinical Cancer Center, Madison', 'institution_ids': ['https://openalex.org/I4210103341']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078044804', 'display_name': 'Kathy Sears', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210165553', 'display_name': 'SWOG Cancer Research Network', 'ror': 'https://ror.org/05n6zrm60', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210165553']}, {'id': 'https://openalex.org/I4210101190', 'display_name': 'Cancer Research And Biostatistics', 'ror': 'https://ror.org/01575p865', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210101190']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kathy Sears', 'raw_affiliation_strings': ['Southwest Oncology Group Statistical Center, Seattle'], 'affiliations': [{'raw_affiliation_string': 'Southwest Oncology Group Statistical Center, Seattle', 'institution_ids': ['https://openalex.org/I4210165553', 'https://openalex.org/I4210101190']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051370459', 'display_name': 'Daniel J. Culkin', 'orcid': 'https://orcid.org/0000-0002-6740-5841'}, 'institutions': [{'id': 'https://openalex.org/I49332381', 'display_name': 'University of Oklahoma Health Sciences Center', 'ror': 'https://ror.org/0457zbj98', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I49332381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel J. Culkin', 'raw_affiliation_strings': ['University of Oklahoma Health Science Center, Oklahoma City'], 'affiliations': [{'raw_affiliation_string': 'University of Oklahoma Health Science Center, Oklahoma City', 'institution_ids': ['https://openalex.org/I49332381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015887484', 'display_name': 'Ian M. Thompson', 'orcid': 'https://orcid.org/0000-0003-0833-952X'}, 'institutions': [{'id': 'https://openalex.org/I2799567722', 'display_name': 'Wilford Hall Medical Center', 'ror': 'https://ror.org/025m0q735', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330347796', 'https://openalex.org/I2799567722', 'https://openalex.org/I2802362820', 'https://openalex.org/I4210089612', 'https://openalex.org/I4210102105', 'https://openalex.org/I4210119345']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ian M. Thompson', 'raw_affiliation_strings': ['Brook Army Med. Ctr.-Wilford Hall M.'], 'affiliations': [{'raw_affiliation_string': 'Brook Army Med. Ctr.-Wilford Hall M.', 'institution_ids': ['https://openalex.org/I2799567722']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057703401', 'display_name': 'Anton J. Bueschen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32389192', 'display_name': 'University of Alabama at Birmingham', 'ror': 'https://ror.org/008s83205', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32389192']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anton J. Bueschen', 'raw_affiliation_strings': ['University of Alabama at Birmingham, Birmingham'], 'affiliations': [{'raw_affiliation_string': 'University of Alabama at Birmingham, Birmingham', 'institution_ids': ['https://openalex.org/I32389192']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5113758730', 'display_name': 'Bruce A. Lowe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bruce A. Lowe', 'raw_affiliation_strings': ['Oregon Health Sciences University, Portland'], 'affiliations': [{'raw_affiliation_string': 'Oregon Health Sciences University, Portland', 'institution_ids': ['https://openalex.org/I165690674']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 12, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 35.508, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 857, 'citation_normalized_percentile': {'value': 0.999922, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '339', 'issue': '15', 'first_page': '1036', 'last_page': '1042'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11146', 'display_name': 'Hormonal and reproductive studies', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11235', 'display_name': 'Statistical Methods in Clinical Trials', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2613', 'display_name': 'Statistics and Probability'}, 'field': {'id': 'https://openalex.org/fields/26', 'display_name': 'Mathematics'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/flutamide', 'display_name': 'Flutamide', 'score': 0.9756242}, {'id': 'https://openalex.org/keywords/orchiectomy', 'display_name': 'Orchiectomy', 'score': 0.82620597}], 'concepts': [{'id': 'https://openalex.org/C2778313021', 'wikidata': 'https://www.wikidata.org/wiki/Q418669', 'display_name': 'Flutamide', 'level': 5, 'score': 0.9756242}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.87329125}, {'id': 'https://openalex.org/C2781440318', 'wikidata': 'https://www.wikidata.org/wiki/Q1806228', 'display_name': 'Orchiectomy', 'level': 2, 'score': 0.82620597}, {'id': 'https://openalex.org/C2779322244', 'wikidata': 'https://www.wikidata.org/wiki/Q574820', 'display_name': 'Antiandrogen', 'level': 4, 'score': 0.8079622}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.74987936}, {'id': 'https://openalex.org/C126894567', 'wikidata': 'https://www.wikidata.org/wiki/Q105650', 'display_name': 'Urology', 'level': 1, 'score': 0.67229176}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.5938878}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.5818443}, {'id': 'https://openalex.org/C2778468042', 'wikidata': 'https://www.wikidata.org/wiki/Q273976', 'display_name': 'Blockade', 'level': 3, 'score': 0.4921376}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.47251755}, {'id': 'https://openalex.org/C2779256933', 'wikidata': 'https://www.wikidata.org/wiki/Q58929', 'display_name': 'Castration', 'level': 3, 'score': 0.4132126}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.37260842}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.36411774}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.321236}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.117830575}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.04949382}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000601', 'qualifier_name': 'surgery', 'is_major_topic': True}, {'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D005485', 'descriptor_name': 'Flutamide', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D009919', 'descriptor_name': 'Orchiectomy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000601', 'qualifier_name': 'surgery', 'is_major_topic': True}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000601', 'qualifier_name': 'surgery', 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003131', 'descriptor_name': 'Combined Modality Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004311', 'descriptor_name': 'Double-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005485', 'descriptor_name': 'Flutamide', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D005485', 'descriptor_name': 'Flutamide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D012983', 'descriptor_name': 'Soft Tissue Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D012983', 'descriptor_name': 'Soft Tissue Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012983', 'descriptor_name': 'Soft Tissue Neoplasms', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D012983', 'descriptor_name': 'Soft Tissue Neoplasms', 'qualifier_ui': 'Q000601', 'qualifier_name': 'surgery', 'is_major_topic': False}, {'descriptor_ui': 'D016019', 'descriptor_name': 'Survival Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejm199810083391504', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJM199810083391504?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9761805', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejm199810083391504', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJM199810083391504?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.85, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 25, 'referenced_works': ['https://openalex.org/W116367892', 'https://openalex.org/W1766338896', 'https://openalex.org/W1976128207', 'https://openalex.org/W1991074325', 'https://openalex.org/W1994047807', 'https://openalex.org/W1998832426', 'https://openalex.org/W2000366267', 'https://openalex.org/W2010881564', 'https://openalex.org/W2014145760', 'https://openalex.org/W2038415989', 'https://openalex.org/W2038580248', 'https://openalex.org/W2040997484', 'https://openalex.org/W2047553398', 'https://openalex.org/W2068776149', 'https://openalex.org/W2069791479', 'https://openalex.org/W2074544671', 'https://openalex.org/W2108955823', 'https://openalex.org/W2125437092', 'https://openalex.org/W2139625866', 'https://openalex.org/W2155949904', 'https://openalex.org/W2175119831', 'https://openalex.org/W2412648589', 'https://openalex.org/W2496614195', 'https://openalex.org/W2617245288', 'https://openalex.org/W4253882649'], 'related_works': ['https://openalex.org/W3148026613', 'https://openalex.org/W3133552530', 'https://openalex.org/W2442094159', 'https://openalex.org/W2165611177', 'https://openalex.org/W2120032813', 'https://openalex.org/W2092991204', 'https://openalex.org/W2084638914', 'https://openalex.org/W2080966978', 'https://openalex.org/W2036335596', 'https://openalex.org/W2003985632'], 'abstract_inverted_index': {'Combined': [0], 'androgen': [1], 'blockade': [2], 'for': [3], 'the': [4, 25, 57], 'treatment': [5], 'of': [6, 11, 40], 'metastatic': [7], 'prostate': [8], 'cancer': [9], 'consists': [10], 'an': [12], 'antiandrogen': [13, 26], 'drug': [14], 'plus': [15, 53, 63, 68], 'castration.': [16], 'In': [17, 56], 'a': [18], 'previous': [19], 'trial,': [20, 59], 'we': [21, 60], 'found': [22], 'that': [23, 35, 49], 'adding': [24], 'flutamide': [27, 62], 'to': [28], 'leuprolide': [29, 54], 'acetate': [30], '(a': [31], 'synthetic': [32], 'gonadotropin-releasing': [33], 'hormone': [34], 'results': [36], 'in': [37], 'medical': [38], 'ablation': [39], 'testicular': [41], 'function)': [42], 'significantly': [43], 'improved': [44], 'survival': [45], 'as': [46], 'compared': [47, 61], 'with': [48, 51, 66], 'achieved': [50], 'placebo': [52, 67], 'acetate.': [55], 'current': [58], 'bilateral': [64], 'orchiectomy': [65], 'orchiectomy.': [69]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2003985632', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 19}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 21}, {'year': 2019, 'cited_by_count': 26}, {'year': 2018, 'cited_by_count': 25}, {'year': 2017, 'cited_by_count': 20}, {'year': 2016, 'cited_by_count': 31}, {'year': 2015, 'cited_by_count': 49}, {'year': 2014, 'cited_by_count': 50}, {'year': 2013, 'cited_by_count': 51}, {'year': 2012, 'cited_by_count': 36}], 'updated_date': '2024-12-17T08:20:32.199173', 'created_date': '2016-06-24'}