SNARE assembly and disassembly exhibit a pronounced hysteresis

Name: Work Video:
Duration: 3 min 30 s
Dirk Fasshauer; Wolfram Antonin; Vinod Subramaniam; Reinhard Jahn
{'id': 'https://openalex.org/W2003813143', 'doi': 'https://doi.org/10.1038/nsb750', 'title': 'SNARE assembly and disassembly exhibit a pronounced hysteresis', 'display_name': 'SNARE assembly and disassembly exhibit a pronounced hysteresis', 'publication_year': 2002, 'publication_date': '2002-01-14', 'ids': {'openalex': 'https://openalex.org/W2003813143', 'doi': 'https://doi.org/10.1038/nsb750', 'mag': '2003813143', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11786917'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nsb750', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S139253143', 'display_name': 'Nature Structural & Molecular Biology', 'issn_l': '1545-9985', 'issn': ['1545-9985', '1545-9993'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://pure.mpg.de/pubman/item/item_599701_3/component/file_2214539/599701.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080159031', 'display_name': 'Dirk Fasshauer', 'orcid': 'https://orcid.org/0000-0002-1040-4282'}, 'institutions': [{'id': 'https://openalex.org/I4210131661', 'display_name': 'Max Planck Institute for Biophysical Chemistry', 'ror': 'https://ror.org/03e76ya46', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210131661']}, {'id': 'https://openalex.org/I149899117', 'display_name': 'Max Planck Society', 'ror': 'https://ror.org/01hhn8329', 'country_code': 'DE', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I149899117']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Dirk Fasshauer', 'raw_affiliation_strings': ['Research Group of Structural Biochemistry, MPI for biophysical chemistry, Max Planck Society'], 'affiliations': [{'raw_affiliation_string': 'Research Group of Structural Biochemistry, MPI for biophysical chemistry, Max Planck Society', 'institution_ids': ['https://openalex.org/I4210131661', 'https://openalex.org/I149899117']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031568773', 'display_name': 'Wolfram Antonin', 'orcid': 'https://orcid.org/0000-0003-4669-379X'}, 'institutions': [{'id': 'https://openalex.org/I149899117', 'display_name': 'Max Planck Society', 'ror': 'https://ror.org/01hhn8329', 'country_code': 'DE', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I149899117']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Wolfram Antonin', 'raw_affiliation_strings': ['Department of Neurobiology, MPI for Biophysical Chemistry, Max Planck Society'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurobiology, MPI for Biophysical Chemistry, Max Planck Society', 'institution_ids': ['https://openalex.org/I149899117']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049383907', 'display_name': 'Vinod Subramaniam', 'orcid': 'https://orcid.org/0000-0001-6712-7266'}, 'institutions': [{'id': 'https://openalex.org/I149899117', 'display_name': 'Max Planck Society', 'ror': 'https://ror.org/01hhn8329', 'country_code': 'DE', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I149899117']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Vinod Subramaniam', 'raw_affiliation_strings': ['Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society', 'institution_ids': ['https://openalex.org/I149899117']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5077214003', 'display_name': 'Reinhard Jahn', 'orcid': 'https://orcid.org/0000-0003-1542-3498'}, 'institutions': [{'id': 'https://openalex.org/I149899117', 'display_name': 'Max Planck Society', 'ror': 'https://ror.org/01hhn8329', 'country_code': 'DE', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I149899117']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Reinhard Jahn', 'raw_affiliation_strings': ['Department of Neurobiology, MPI for Biophysical Chemistry, Max Planck Society'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurobiology, MPI for Biophysical Chemistry, Max Planck Society', 'institution_ids': ['https://openalex.org/I149899117']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 5.016, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 193, 'citation_normalized_percentile': {'value': 0.999806, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '9', 'issue': '2', 'first_page': '144', 'last_page': '151'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10407', 'display_name': 'Lipid Membrane Structure and Behavior', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.9852, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/snare-complex', 'display_name': 'SNARE complex', 'score': 0.77204627}], 'concepts': [{'id': 'https://openalex.org/C2908790754', 'wikidata': 'https://www.wikidata.org/wiki/Q279694', 'display_name': 'SNARE complex', 'level': 4, 'score': 0.77204627}, {'id': 'https://openalex.org/C103038307', 'wikidata': 'https://www.wikidata.org/wiki/Q6556360', 'display_name': 'Lipid bilayer fusion', 'level': 3, 'score': 0.65794975}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.63782513}, {'id': 'https://openalex.org/C158525013', 'wikidata': 'https://www.wikidata.org/wiki/Q2593739', 'display_name': 'Fusion', 'level': 2, 'score': 0.50859535}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.5041462}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46050307}, {'id': 'https://openalex.org/C102931765', 'wikidata': 'https://www.wikidata.org/wiki/Q189673', 'display_name': 'Dissociation (chemistry)', 'level': 2, 'score': 0.44930202}, {'id': 'https://openalex.org/C204328495', 'wikidata': 'https://www.wikidata.org/wiki/Q847556', 'display_name': 'Protein folding', 'level': 2, 'score': 0.4406178}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.41655442}, {'id': 'https://openalex.org/C8010536', 'wikidata': 'https://www.wikidata.org/wiki/Q160398', 'display_name': 'Crystallography', 'level': 1, 'score': 0.4138468}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.401271}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.38493946}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.17439556}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C147789679', 'wikidata': 'https://www.wikidata.org/wiki/Q11372', 'display_name': 'Physical chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D017510', 'descriptor_name': 'Protein Folding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D033921', 'descriptor_name': 'Vesicular Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002942', 'descriptor_name': 'Circular Dichroism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004591', 'descriptor_name': 'Electrophoresis, Polyacrylamide Gel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011992', 'descriptor_name': 'Endosomes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011992', 'descriptor_name': 'Endosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019791', 'descriptor_name': 'Guanidine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019791', 'descriptor_name': 'Guanidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046911', 'descriptor_name': 'Macromolecular Substances', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011489', 'descriptor_name': 'Protein Denaturation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011489', 'descriptor_name': 'Protein Denaturation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017433', 'descriptor_name': 'Protein Structure, Secondary', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017433', 'descriptor_name': 'Protein Structure, Secondary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050765', 'descriptor_name': 'Qa-SNARE Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050683', 'descriptor_name': 'R-SNARE Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050600', 'descriptor_name': 'SNARE Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050825', 'descriptor_name': 'Synaptosomal-Associated Protein 25', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013696', 'descriptor_name': 'Temperature', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013816', 'descriptor_name': 'Thermodynamics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014508', 'descriptor_name': 'Urea', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014508', 'descriptor_name': 'Urea', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nsb750', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S139253143', 'display_name': 'Nature Structural & Molecular Biology', 'issn_l': '1545-9985', 'issn': ['1545-9985', '1545-9993'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/11858/00-001M-0000-0012-F454-A', 'pdf_url': 'https://pure.mpg.de/pubman/item/item_599701_3/component/file_2214539/599701.pdf', 'source': {'id': 'https://openalex.org/S4306400655', 'display_name': 'MPG.PuRe (Max Planck Society)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I149899117', 'host_organization_name': 'Max Planck Society', 'host_organization_lineage': ['https://openalex.org/I149899117'], 'host_organization_lineage_names': ['Max Planck Society'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11786917', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/11858/00-001M-0000-0012-F454-A', 'pdf_url': 'https://pure.mpg.de/pubman/item/item_599701_3/component/file_2214539/599701.pdf', 'source': {'id': 'https://openalex.org/S4306400655', 'display_name': 'MPG.PuRe (Max Planck Society)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I149899117', 'host_organization_name': 'Max Planck Society', 'host_organization_lineage': ['https://openalex.org/I149899117'], 'host_organization_lineage_names': ['Max Planck Society'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/7', 'score': 0.65, 'display_name': 'Affordable and clean energy'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1498832295', 'https://openalex.org/W1502422391', 'https://openalex.org/W1540559701', 'https://openalex.org/W1555714096', 'https://openalex.org/W1574626580', 'https://openalex.org/W1607355583', 'https://openalex.org/W1618106381', 'https://openalex.org/W170382783', 'https://openalex.org/W1822252127', 'https://openalex.org/W1905416680', 'https://openalex.org/W1984724306', 'https://openalex.org/W1991938283', 'https://openalex.org/W1998544609', 'https://openalex.org/W2010943743', 'https://openalex.org/W2016417523', 'https://openalex.org/W2021502092', 'https://openalex.org/W2027739701', 'https://openalex.org/W2027775552', 'https://openalex.org/W2033201989', 'https://openalex.org/W2045144602', 'https://openalex.org/W2045375596', 'https://openalex.org/W2045777307', 'https://openalex.org/W2047808133', 'https://openalex.org/W2049199355', 'https://openalex.org/W2052394407', 'https://openalex.org/W2081810556', 'https://openalex.org/W2085370553', 'https://openalex.org/W2093465143', 'https://openalex.org/W2114740719', 'https://openalex.org/W2118639186', 'https://openalex.org/W2131653836', 'https://openalex.org/W2147905210', 'https://openalex.org/W2151796887', 'https://openalex.org/W2217579908', 'https://openalex.org/W3135190686'], 'related_works': ['https://openalex.org/W99754648', 'https://openalex.org/W3005331642', 'https://openalex.org/W2902332755', 'https://openalex.org/W2156359383', 'https://openalex.org/W2097156513', 'https://openalex.org/W2043285409', 'https://openalex.org/W1987843188', 'https://openalex.org/W1980792982', 'https://openalex.org/W1975642381', 'https://openalex.org/W113080609'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2003813143', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-12-11T03:41:28.899134', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
