Publication Information

{'id': 'https://openalex.org/W2003796402', 'doi': 'https://doi.org/10.1006/mgme.2000.3061', 'title': 'The Structure and Function of the Niemann–Pick C1 Protein', 'display_name': 'The Structure and Function of the Niemann–Pick C1 Protein', 'publication_year': 2000, 'publication_date': '2000-09-01', 'ids': {'openalex': 'https://openalex.org/W2003796402', 'doi': 'https://doi.org/10.1006/mgme.2000.3061', 'mag': '2003796402', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11001808'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1006/mgme.2000.3061', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S42433034', 'display_name': 'Molecular Genetics and Metabolism', 'issn_l': '1096-7192', 'issn': ['1096-7192', '1096-7206'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035205865', 'display_name': 'Yiannis A. Ioannou', 'orcid': 'https://orcid.org/0000-0001-6229-003X'}, 'institutions': [{'id': 'https://openalex.org/I98704320', 'display_name': 'Icahn School of Medicine at Mount Sinai', 'ror': 'https://ror.org/04a9tmd77', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1320796813', 'https://openalex.org/I98704320']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Yiannis A. Ioannou', 'raw_affiliation_strings': ['Department of Human Genetics, Department of Gene Therapy, Department of Gene Therapy and Molecular Medicine, Box 1498, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York, 10029'], 'affiliations': [{'raw_affiliation_string': 'Department of Human Genetics, Department of Gene Therapy, Department of Gene Therapy and Molecular Medicine, Box 1498, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York, 10029', 'institution_ids': ['https://openalex.org/I98704320']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5035205865'], 'corresponding_institution_ids': ['https://openalex.org/I98704320'], 'apc_list': {'value': 3570, 'currency': 'USD', 'value_usd': 3570, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.983, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 87, 'citation_normalized_percentile': {'value': 0.866751, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '71', 'issue': '1-2', 'first_page': '175', 'last_page': '181'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10945', 'display_name': 'Lysosomal Storage Disorders Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10945', 'display_name': 'Lysosomal Storage Disorders Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10835', 'display_name': 'Carbohydrate Chemistry and Synthesis', 'score': 0.9922, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9801, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/npc1', 'display_name': 'NPC1', 'score': 0.98684824}, {'id': 'https://openalex.org/keywords/membrane-topology', 'display_name': 'Membrane topology', 'score': 0.5731671}, {'id': 'https://openalex.org/keywords/positional-cloning', 'display_name': 'Positional cloning', 'score': 0.5613494}, {'id': 'https://openalex.org/keywords/patched', 'display_name': 'Patched', 'score': 0.41806453}, {'id': 'https://openalex.org/keywords/transport-protein', 'display_name': 'Transport protein', 'score': 0.41194323}], 'concepts': [{'id': 'https://openalex.org/C2778552423', 'wikidata': 'https://www.wikidata.org/wiki/Q14914279', 'display_name': 'NPC1', 'level': 4, 'score': 0.98684824}, {'id': 'https://openalex.org/C102747710', 'wikidata': 'https://www.wikidata.org/wiki/Q824237', 'display_name': 'Endosome', 'level': 3, 'score': 0.7805011}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6727656}, {'id': 'https://openalex.org/C119062480', 'wikidata': 'https://www.wikidata.org/wiki/Q83181', 'display_name': 'Golgi apparatus', 'level': 3, 'score': 0.63996303}, {'id': 'https://openalex.org/C24530287', 'wikidata': 'https://www.wikidata.org/wiki/Q424204', 'display_name': 'Transmembrane protein', 'level': 3, 'score': 0.60661703}, {'id': 'https://openalex.org/C534586', 'wikidata': 'https://www.wikidata.org/wiki/Q6815143', 'display_name': 'Membrane topology', 'level': 4, 'score': 0.5731671}, {'id': 'https://openalex.org/C118892022', 'wikidata': 'https://www.wikidata.org/wiki/Q7834587', 'display_name': 'Transmembrane domain', 'level': 3, 'score': 0.56746733}, {'id': 'https://openalex.org/C3020804800', 'wikidata': 'https://www.wikidata.org/wiki/Q5050812', 'display_name': 'Positional cloning', 'level': 4, 'score': 0.5613494}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5296975}, {'id': 'https://openalex.org/C2776879804', 'wikidata': 'https://www.wikidata.org/wiki/Q7630919', 'display_name': 'Subcellular localization', 'level': 3, 'score': 0.4695585}, {'id': 'https://openalex.org/C2776925932', 'wikidata': 'https://www.wikidata.org/wiki/Q1755122', 'display_name': 'Neurodegeneration', 'level': 3, 'score': 0.4501264}, {'id': 'https://openalex.org/C144647389', 'wikidata': 'https://www.wikidata.org/wiki/Q423042', 'display_name': 'Membrane protein', 'level': 3, 'score': 0.44058233}, {'id': 'https://openalex.org/C2777994357', 'wikidata': 'https://www.wikidata.org/wiki/Q24781250', 'display_name': 'Patched', 'level': 4, 'score': 0.41806453}, {'id': 'https://openalex.org/C57581600', 'wikidata': 'https://www.wikidata.org/wiki/Q2449730', 'display_name': 'Transport protein', 'level': 2, 'score': 0.41194323}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.34474975}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.33562917}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.31191525}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.18535563}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.15816638}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.15211448}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.12759495}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.12719148}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C88498014', 'wikidata': 'https://www.wikidata.org/wiki/Q14859918', 'display_name': 'Hedgehog signaling pathway', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009542', 'descriptor_name': 'Niemann-Pick Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001693', 'descriptor_name': 'Biological Transport, Active', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077296', 'descriptor_name': 'Niemann-Pick C1 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009542', 'descriptor_name': 'Niemann-Pick Diseases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009542', 'descriptor_name': 'Niemann-Pick Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1006/mgme.2000.3061', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S42433034', 'display_name': 'Molecular Genetics and Metabolism', 'issn_l': '1096-7192', 'issn': ['1096-7192', '1096-7206'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11001808', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 47, 'referenced_works': ['https://openalex.org/W1275105234', 'https://openalex.org/W1507545655', 'https://openalex.org/W1515444383', 'https://openalex.org/W1517698792', 'https://openalex.org/W1545666239', 'https://openalex.org/W1549347094', 'https://openalex.org/W1562811405', 'https://openalex.org/W1658669968', 'https://openalex.org/W1965760487', 'https://openalex.org/W1976252335', 'https://openalex.org/W1976551834', 'https://openalex.org/W1980020885', 'https://openalex.org/W1982479470', 'https://openalex.org/W1994620081', 'https://openalex.org/W1998923213', 'https://openalex.org/W2002095792', 'https://openalex.org/W2002575581', 'https://openalex.org/W2006688645', 'https://openalex.org/W2026324678', 'https://openalex.org/W2026550373', 'https://openalex.org/W2039999119', 'https://openalex.org/W2044735117', 'https://openalex.org/W2045625322', 'https://openalex.org/W2046663694', 'https://openalex.org/W2049312906', 'https://openalex.org/W2056307910', 'https://openalex.org/W2056994384', 'https://openalex.org/W2060866593', 'https://openalex.org/W2064999742', 'https://openalex.org/W2067701179', 'https://openalex.org/W2068772709', 'https://openalex.org/W2081458493', 'https://openalex.org/W2084744450', 'https://openalex.org/W2094104389', 'https://openalex.org/W2096221379', 'https://openalex.org/W2097969661', 'https://openalex.org/W2132985208', 'https://openalex.org/W2134893181', 'https://openalex.org/W2136977521', 'https://openalex.org/W2153082254', 'https://openalex.org/W2157740023', 'https://openalex.org/W2163904086', 'https://openalex.org/W2166714339', 'https://openalex.org/W2171917168', 'https://openalex.org/W2189599899', 'https://openalex.org/W4234617857', 'https://openalex.org/W57019589'], 'related_works': ['https://openalex.org/W3203590990', 'https://openalex.org/W2605157816', 'https://openalex.org/W2517246299', 'https://openalex.org/W2471059767', 'https://openalex.org/W2169084634', 'https://openalex.org/W2038576114', 'https://openalex.org/W2003796402', 'https://openalex.org/W1993121378', 'https://openalex.org/W1985702872', 'https://openalex.org/W1826745675'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2003796402', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-18T22:23:13.265085', 'created_date': '2016-06-24'}