Localization of Metallocarboxypeptidase D in AtT-20 Cells

Name: Work Video:
Duration: 3 min 30 s
Oleg Varlamov; Francis J. Eng; Elena G. Novikova; Lloyd D. Fricker
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3291, 3294, 3297, 3333, 3336, 3357, 3370, 3374, 3383, 3389, 3392, 3416, 3426, 3468, 3476, 3531, 3673, 3695, 3722, 3740, 3744, 3750, 3758, 3790, 3794, 3810, 3818, 3822, 3829, 3870, 3875, 3897, 3907, 3912, 3919, 3936, 4016, 4093, 4116, 4146, 4161, 4166, 4171, 4178, 4181, 4190, 4202, 4210, 4225, 4241, 4268, 4272, 4292, 4298, 4304, 4317, 4323, 4332, 4359, 4390, 4400, 4414, 4419, 4427, 4447, 4450, 4456, 4472, 4477, 4485, 4497], 'cell': [21, 215, 1455, 1983, 2402, 2872, 3745], 'surface': [22, 216, 1456], 'TGN.': [25, 219, 3477], 'In': [26, 220, 1035, 1279, 1822, 3253, 3858, 4013, 4407], 'present': [28, 95, 132, 222, 289, 326, 1041, 1824, 1874, 4159, 4360], 'study,': [29, 223, 1825], 'intracellular': [31, 225, 1767, 1830, 1845, 3228], 'distribution': [32, 226, 1768, 1831, 1846, 3229, 4239, 4254], 'of': [33, 85, 123, 130, 140, 164, 185, 227, 279, 317, 324, 334, 358, 379, 417, 508, 523, 562, 646, 759, 815, 821, 831, 945, 961, 978, 1475, 1528, 1542, 1562, 1583, 1619, 1735, 1769, 1784, 1817, 1832, 1847, 1852, 1862, 1891, 2004, 2022, 2040, 2077, 2112, 2174, 2190, 2195, 2211, 2218, 2232, 2250, 2268, 2275, 2287, 2294, 2307, 2325, 2372, 2409, 2429, 2493, 2513, 2522, 2544, 2547, 2553, 2566, 2584, 2592, 2658, 2705, 2809, 2911, 2999, 3230, 3264, 3283, 3290, 3296, 3335, 3360, 3364, 3373, 3382, 3391, 3419, 3425, 3436, 3457, 3470, 3481, 3523, 3550, 3575, 3739, 3757, 3784, 3806, 3825, 3867, 3874, 3894, 3911, 4102, 4106, 4118, 4165, 4209, 4221, 4240, 4253, 4260, 4306, 4311, 4322, 4389, 4413, 4449, 4494, 4505], 'CPD': [34, 53, 93, 112, 141, 165, 180, 228, 247, 287, 306, 335, 359, 374, 1039, 1153, 1384, 1443, 1476, 1514, 1544, 1553, 1736, 1772, 1833, 1863, 1886, 2032, 2052, 2078, 2326, 2558, 2745, 3146, 3245, 3668, 3717, 3871, 3908, 4299], 'was': [35, 229, 1004, 1773, 2187, 2208, 2229, 2247, 2265, 2284, 2304, 2404, 2454, 2475, 2488, 2517, 2540, 2570, 2608, 2615, 2641, 3054, 3106, 3268, 3273, 3287, 3332, 3351, 3525, 3747, 3815, 3864, 4314, 4329, 4397, 4441, 4453], 'examined': [36, 230, 1843, 3055, 3197], 'AtT-20': [38, 150, 232, 344, 1630, 1793, 1951, 2373, 2677, 2777, 2962, 3063, 3395, 3504, 3597, 3677, 3833, 4234, 4263, 4279], 'cells,': [39, 151, 233, 345, 3834], 'mouse': [41, 235, 2051, 2117], 'anterior': [42, 236], 'pituitary-derived': [43, 237], 'corticotroph.': [44, 238], 'CPD-containing': [45, 74, 239, 268, 2766, 4172, 4203, 4269], 'compartments': [46, 240, 2767, 3272, 4270], 'were': [47, 241, 1509, 1940, 1985, 1996, 2010, 2171, 2327, 2351, 2377, 2383, 2629, 2661, 2681, 2708, 2711, 2734, 2781, 2817, 2836, 2868, 2880, 2915, 2948, 2964, 2973, 3008, 3020, 3070, 3153, 3185, 3210, 3238, 3248, 3259, 3320, 3367, 3443, 3466, 3484, 3491, 3579, 3587, 3719, 3774, 3787, 3842, 3881, 4023, 4108, 4281, 4342], 'isolated': [48, 242, 3720, 4200], 'using': [49, 243, 1834, 1953, 1987, 2332, 2635, 2667, 2739, 2840, 2952, 3056, 3847, 3904, 4231, 4346], 'antibodies': [50, 244, 2319, 2350, 2555, 3175, 3241, 3820, 3848, 3868, 3905, 4129, 4296, 4347, 4444], 'to': [51, 166, 245, 360, 511, 587, 663, 751, 956, 1512, 1551, 1572, 1867, 2030, 2072, 2142, 2185, 2203, 2245, 2262, 2282, 2302, 2329, 2339, 2353, 2532, 2556, 2631, 2663, 2669, 2737, 2742, 2827, 2838, 2842, 2875, 2950, 2955, 3092, 3143, 3173, 3242, 3279, 3446, 3530, 3672, 3821, 3849, 3869, 3896, 3906, 3935, 4015, 4130, 4218, 4224, 4258, 4291, 4297, 4344, 4445, 4484], 'cytosolic': [54, 248, 1401, 1404, 2075, 2323, 2335, 2560, 3823, 4300], 'tail.': [55, 249, 1402, 2561, 4301], 'The': [56, 73, 250, 267, 490, 644, 943, 1403, 1473, 1766, 2028, 2070, 2105, 2183, 2401, 2452, 2472, 2534, 2605, 2729, 2833, 2878, 2946, 3275, 3478, 3572, 4187, 4353], 'immunopurified': [57, 251], 'vesicles': [58, 75, 252, 269, 1525, 1570, 3292, 3495, 3535, 4008], 'contained': [59, 77, 253, 271], 'TGN': [60, 98, 189, 254, 292, 383, 1459, 1479, 1685, 3393, 3427, 3772, 3937, 4017, 4211], 'proteins': [61, 186, 255, 380, 1387, 1895, 2628, 2673, 2901, 3366, 3696, 3786, 4196, 4212, 4223], '(TGN38,': [62, 256], 'furin,': [63, 257], 'syntaxin': [64, 258, 2227, 3928], '6)': [65, 259], 'but': [66, 103, 260, 297, 2046], 'not': [67, 158, 261, 352, 1774, 2048, 4158, 4198, 4216, 4247, 4256, 4336, 4460], 'lysosomal': [68, 262], 'or': [69, 263, 517, 1858, 1901, 2024, 2618, 2746, 2792, 2803, 2845, 2892, 2941, 2958, 3034, 3068, 3101, 3147, 3246, 3428, 3462, 3472, 3793, 3804, 4275, 4351], 'plasma': [70, 264, 3532, 3766, 4155, 4191], 'membrane': [71, 265, 1415, 3762, 3767, 4156, 4192, 4195, 4222], 'proteins.': [72, 266, 2104], 'neuropeptide-processing': [78, 272], 'enzymes': [79, 273, 1418, 1501, 1532], 'adrenocorticotropic': [81, 275], 'hormone,': [82, 276], 'product': [84, 278, 4368], 'proopiomelanocortin': [86, 280, 1627], 'proteolysis.': [87, 281, 400], 'Electron': [88, 282], 'microscopic': [89, 283, 1838], 'analysis': [90, 284, 2666], 'revealed': [91, 285], 'within': [96, 187, 290, 381, 4026], 'immature': [100, 191, 294, 385, 1569, 1587, 1876, 3340, 3430, 3498, 3939], 'secretory': [101, 168, 192, 295, 362, 386, 590, 976, 1517, 1524, 1588, 1790, 1869, 1877, 1903, 2671, 3285, 3499, 3552, 3577, 3851, 3879, 3940, 4028, 4243], 'granules': [102, 296, 591, 1518, 1589, 1791, 3286, 3341, 3355, 3414, 3452, 3483, 3500, 3553, 3578, 3941, 4029], 'virtually': [105, 299], 'absent': [106, 300], 'from': [107, 116, 301, 310, 395, 504, 653, 1160, 1623, 2391, 2519, 2643, 3322, 3475, 3710, 3832], 'mature': [108, 167, 302, 361, 819, 1516, 1523, 1789, 1868, 3551, 3576, 4027], 'granules,': [109, 303], 'suggesting': [110, 304, 1149], 'actively': [114, 308], 'removed': [115, 309], 'regulated': [118, 312, 1900, 2862, 2909], 'pathway': [119, 148, 313, 342, 977, 2672, 3852, 4244], 'during': [120, 314, 3809], 'process': [122, 316, 3469], 'granule': [124, 318], 'maturation.': [125, 319], 'A': [126, 320, 696, 1967], 'second': [127, 321, 965], 'major': [128, 322, 556], 'finding': [129, 323, 655, 4188], 'study': [133, 327, 4361], 'soluble': [137, 331, 1771, 1780, 1849, 2036], 'truncated': [138, 332, 1850, 1860], 'form': [139, 333, 1851, 1861], 'secreted': [143, 337, 2859, 2900], 'mainly': [144, 338], 'via': [145, 339, 2860], 'constitutive': [147, 341, 1902], 'indicating': [152, 346, 1812, 3801, 3890, 4151, 4249, 4500], 'lumenal': [155, 349, 1815], 'domain': [156, 350, 1397, 1816], 'does': [157, 351, 2047], 'contain': [159, 353, 1389, 1526, 2768, 4271], 'signals': [160, 354], 'for': [161, 355, 520, 707, 958, 1911, 2360, 2379, 2477, 2504, 2537, 2572, 2654, 2687, 2702, 2789, 2794, 2801, 2895, 2917, 2923, 2934, 2981, 2987, 3010, 3044, 3072, 3108, 3133, 3164, 3187, 4285, 4466], 'sorting': [163, 357, 1820], 'granules.': [169, 363], 'Taken': [170, 364], 'together,': [171, 365], 'these': [172, 366, 1499, 2005, 3482, 3534, 3707, 3785, 3807], 'data': [173, 367, 2018], 'are': [174, 368, 393, 405, 824, 1786, 1864, 1873, 2020, 3547, 4003, 4142, 4157, 4197], 'consistent': [175, 369, 3376, 3592, 4176], 'with': [176, 370, 559, 2050, 2387, 2550, 2578, 2581, 2621, 2683, 2692, 2713, 2724, 2785, 2821, 2883, 2887, 2920, 2929, 2942, 2975, 3013, 3022, 3031, 3167, 3190, 3198, 3240, 3377, 3593, 3699, 3714, 3817, 3828, 4006, 4092, 4128, 4170, 4177, 4283, 4295, 4409, 4443], 'proposal': [178, 372, 1884], 'participates': [181, 375], 'processing': [184, 378, 492, 561, 650, 1417, 1531, 1561, 1582, 1679, 1890], 'vesicles.': [193, 387, 1878], 'Most': [388], 'peptide': [389, 510, 649, 1416, 1530, 1557, 2111, 2152, 2337], 'hormones': [390], 'neurotransmitters': [392], 'produced': [394], 'larger': [396, 1625, 4498], 'precursors': [397, 404, 4274], 'by': [398, 414, 496, 1394, 1519, 1998, 2342, 2542, 2610, 2646, 2903, 3048, 3343, 3844], 'limited': [399], 'Initially,': [401], 'prohormone': [403, 422, 430], 'processed': [406, 947, 2151, 4367], 'at': [407, 2397, 2480, 2507, 2575, 2674, 3075, 3127, 3325, 3356, 3388, 3415, 3453, 3721], 'multiple': [408], 'basic': [409, 501], 'amino': [410, 502], 'acid': [411], 'cleavage': [412], 'sites': [413], 'family': [416], 'endoproteases': [418], 'collectively': [419], 'known': [420, 547], 'as': [421, 548, 1007, 1420, 1550, 2014, 2364, 2748], 'convertases': [423, 1534], '(PC)': [424], '1The': [425], 'abbreviations': [426], 'used': [427, 2359, 2378, 3702, 3865, 4357], 'are:': [428], 'PC,': [429], 'convertase;': [431], 'CPE,': [432, 817, 1538, 3234, 4103], 'carboxypeptidase': [433, 436, 549, 557, 966], 'E;': [434], 'CPD,': [435, 3700, 3826], 'D;': [437], 'PAM,': [438], 'peptidylglycine-α-amidating': [439, 1423], 'monooxygenase;': [440], 'TGN,': [441, 1449, 1568, 3375], 'trans-Golgi': [442], 'network;': [443], 'ACTH,': [444], 'adrenocorticotrophic': [445], 'hormone;': [446], 'POMC,': [447], 'proopiomelanocortin;': [448], 'PBS,': [449, 2357, 2389, 2693, 2714, 2884, 2930, 2976, 3084, 3161], 'phosphate-buffered': [450], 'saline;': [451], 'ER,': [452], 'endoplasmic': [453], 'reticulum.': [454], '(1Steiner': [455], 'D.F.': [456, 679, 722, 773, 845], 'Smeekens': [457], 'S.P.': [458], 'Ohagi': [459], 'S.': [460, 601, 634, 1248, 1657, 3600, 3989, 4039], 'Chan': [461], 'S.J.': [462], 'J.': [463, 796, 867, 887, 986, 1027, 1053, 1073, 1093, 1179, 1228, 1297, 1317, 1364, 1464, 1486, 1666, 1706, 1721, 1750, 1801, 1924, 1960, 2083, 2125, 2159, 2754, 3305, 3308, 3398, 3401, 3507, 3510, 3558, 3561, 3609, 3628, 3651, 3683, 3953, 3975, 3987, 4375], 'Biol.': [464, 797, 888, 987, 1074, 1094, 1125, 1180, 1211, 1270, 1298, 1318, 1345, 1365, 1433, 1646, 1722, 1751, 1803, 1925, 2060, 2084, 2126, 2160, 3310, 3403, 3512, 3563, 3630, 3653, 3993, 4376], 'Chem.': [465, 798, 889, 988, 1075, 1095, 1181, 1299, 1319, 1366, 1723, 1752, 1926, 2085, 2127, 2161, 4377], '1992;': [466, 1804, 3654], '267:': [467], '23435-23438Abstract': [468], 'Full': [469, 802, 804, 893, 895, 992, 994, 1079, 1081, 1099, 1101, 1185, 1187, 1303, 1305, 1323, 1325, 1370, 1372, 1608, 1727, 1756, 1758, 1930, 1932, 2089, 2091, 2131, 2133, 2165, 4381], 'Text': [470, 803, 805, 894, 896, 993, 995, 1080, 1082, 1100, 1102, 1186, 1188, 1304, 1306, 1324, 1326, 1371, 1373, 1609, 1728, 1757, 1759, 1931, 1933, 2090, 2092, 2132, 2134, 2166, 4382], 'PDF': [471, 806, 897, 996, 1083, 1103, 1189, 1307, 1327, 1374, 1610, 1729, 1760, 1934, 2093, 2135, 2167, 4383], 'PubMed': [472, 485, 536, 573, 606, 620, 639, 691, 734, 785, 807, 857, 874, 898, 923, 938, 997, 1032, 1058, 1084, 1104, 1129, 1144, 1190, 1215, 1232, 1253, 1274, 1308, 1328, 1349, 1375, 1438, 1470, 1492, 1611, 1651, 1672, 1697, 1712, 1730, 1761, 1807, 1935, 2065, 2094, 2136, 2168, 2760, 3314, 3407, 3516, 3567, 3615, 3634, 3657, 3689, 3957, 3979, 3998, 4044, 4063, 4082, 4384], 'Google': [473, 488, 539, 576, 609, 623, 642, 694, 737, 788, 810, 860, 877, 901, 926, 941, 1000, 1033, 1059, 1087, 1107, 1132, 1147, 1193, 1218, 1235, 1256, 1277, 1311, 1331, 1352, 1378, 1441, 1471, 1493, 1614, 1654, 1675, 1700, 1713, 1731, 1764, 1810, 1938, 2068, 2097, 2139, 2169, 2761, 3317, 3410, 3519, 3570, 3618, 3637, 3660, 3690, 3960, 3982, 4001, 4047, 4066, 4085, 4385], 'Scholar,': [474, 540, 577, 610, 624, 789, 861, 878, 902, 927, 1060, 1088, 1108, 1133, 1194, 1236, 1257, 1312, 1332, 1353, 1655, 1701, 1714, 3619, 3638, 3961, 3983, 4048, 4067], '2Seidah': [475], 'N.G.': [476], 'Chretien': [477], 'M.': [478, 1222, 1595, 1640, 4052], 'Day': [479, 1113, 1138, 1199], 'R.': [480, 1022, 1048, 1114, 1139, 1200], 'Biochimie.': [481], '1994;': [482, 1029, 1055, 1709, 2757, 3954], '76:': [483], '197-209Crossref': [484], 'Scopus': [486, 537, 574, 607, 621, 640, 692, 735, 786, 808, 858, 875, 899, 924, 939, 998, 1085, 1105, 1130, 1145, 1191, 1216, 1233, 1254, 1275, 1309, 1329, 1350, 1376, 1439, 1612, 1652, 1673, 1698, 1762, 1808, 1936, 2066, 2095, 2137, 3315, 3408, 3517, 3568, 3616, 3635, 3658, 3958, 3980, 3999, 4045, 4064, 4083], '(382)': [487], 'Scholar).': [489, 542, 579, 643, 695, 738, 811, 942, 1001, 1034, 1278, 1379, 1442, 1472, 1615, 1732, 1765, 1981, 2069, 2140, 2762, 3411, 3520, 3571, 3661, 3691, 4386], 'subsequent': [491], 'step': [493], 'mediated': [495], 'carboxypeptidases,': [497], 'which': [498, 3319, 3421, 3546, 3590, 3930, 4022], 'remove': [499], 'acids': [503], 'C': [506], 'terminus': [507], 'generate': [512], 'either': [513, 1898, 2743, 2782, 2843, 2938, 2956, 3066, 3099, 3144, 3243, 4348], 'bioactive': [515], 'product,': [516], 'precursor': [519, 1626, 2149, 2771], 'formation': [522, 3381], 'C-terminal': [525, 2074, 2110, 2206, 2322, 2559], 'amide': [526], 'group': [527], '(3Fricker': [528, 565], 'L.D.': [529, 566, 593, 671, 714, 765, 795, 837, 880, 916, 985, 1092, 1122, 1137, 1208, 1263, 1296, 1316, 1338, 1363, 1431, 1463, 1485, 1749, 1923, 2058, 2082, 2124, 3682, 4031], 'Annu.': [530, 567], 'Rev.': [531, 568], 'Physiol.': [532, 569], '1988;': [533, 570, 3631], '50:': [534, 571], '309-321Crossref': [535, 572], '(311)': [538, 575], '4$$Google': [541, 578], 'E': [544], '(CPE,': [545], 'H': [550], 'enkephalin': [552], 'convertase)': [553], 'involved': [558], 'many': [563, 1043, 1527], 'peptides': [564, 948, 4475], 'Within': [580], 'several': [581, 1407, 2007], 'tissues,': [582], 'CPE': [583, 647, 701, 742, 2114, 2747, 2957, 3148, 3247, 4019], 'has': [584, 971, 1155], 'been': [585, 972, 1156, 1738, 3932], 'localized': [586, 3671, 3934], 'peptide-containing': [589], '(5Fricker': [592, 4030], 'Snyder': [594, 4032], 'S.H.': [595, 4033], 'Proc.': [596, 629, 1243, 4034], 'Natl.': [597, 630, 1244, 4035], 'Acad.': [598, 631, 1245, 4036], 'Sci.': [599, 632, 1246, 1466, 1488, 1708, 2756, 3685, 4037], 'U.': [600, 633, 1247, 4038], 'A.': [602, 635, 865, 1249, 1603, 1716, 2154, 4040, 4370], '1982;': [603, 4041], '79:': [604, 4042], '3886-3890Crossref': [605, 4043], '(257)': [608, 4046], '6Docherty': [611], 'K.': [612, 1020, 1046, 1062, 1168, 1359, 1661, 1663, 1665, 1919, 3604, 3606, 3608], 'Hutton': [613, 4057], 'J.C.': [614, 4058], 'FEBS': [615], 'Lett.': [616], '1983;': [617], '162:': [618], '137-141Crossref': [619], '(63)': [622], '7Hook': [625], 'V.Y.H.': [626], 'Loh': [627], 'Y.P.': [628], '1984;': [636], '81:': [637], '2776-2780Crossref': [638], '(110)': [641], 'involvement': [645], 'evident': [652], 'fat/fat': [657, 832], 'mice': [658, 833], 'have': [659, 1737, 1841, 3663, 3931], 'reduced': [661], 'ability': [662], 'convert': [664], 'proinsulin': [665, 1584], 'into': [666, 1788, 1942, 1950], 'insulin': [667], '(8Naggert': [668, 711, 762, 834], 'J.K.': [669, 712, 763, 835, 3947], 'Fricker': [670, 713, 764, 794, 836, 915, 984, 1091, 1121, 1136, 1207, 1262, 1295, 1315, 1337, 1362, 1430, 1462, 1484, 1748, 1922, 2057, 2081, 2123, 3681], 'Varlamov': [672, 715, 766, 838, 909, 1111, 1197, 1428, 2055], 'O.': [673, 716, 767, 791, 839, 910, 1112, 1198, 1429, 1461, 1483, 2056, 2120, 3680, 4075], 'Nishina': [674, 717, 768, 840], 'P.M.': [675, 718, 769, 841], 'Rouille': [676, 719, 770, 842], 'Y.': [677, 720, 771, 843, 1261, 1336], 'Steiner': [678, 721, 772, 844], 'Carroll': [680, 723, 774, 846], 'R.J.': [681, 724, 775, 847], 'Paigen': [682, 725, 776, 848], 'B.J.': [683, 726, 777, 849], 'Leiter': [684, 727, 778, 792, 850, 883, 913, 1119, 1205, 2121], 'E.H.': [685, 728, 779, 793, 851, 884, 914, 1120, 1206, 2122], 'Nat.': [686, 729, 780, 852], 'Genet.': [687, 730, 781, 853], '1995;': [688, 731, 782, 854, 989, 1076, 1182, 1250, 1300], '10:': [689, 732, 783, 855, 1436, 2063], '135-142Crossref': [690, 733, 784, 856], '(610)': [693, 736, 787, 859], 'missense': [697], 'mutation': [698, 710, 754], 'gene': [702, 761], 'molecular': [705], 'basis': [706], 'fat': [709], 'Although': [739, 1559, 1854], 'full-length': [741, 1857, 3715], 'protein': [743, 747, 1003, 1011, 1282, 2042, 2118], 'translated,': [745], 'inactive': [749], 'due': [750, 4217, 4257], 'point': [753], 'coding': [757], 'region': [758, 3675], '9Varlamov': [790], '1996;': [799, 871, 890, 1096, 1320, 1753, 2086, 2128], '271:': [800, 891, 1097, 1321, 1754, 2087, 2129], '13981-13986Abstract': [801, 2130], '(80)': [809, 2138], 'Despite': [812], 'absence': [814], 'functional': [816], 'forms': [820, 1734, 1783, 1872, 2039], 'numerous': [822], 'neuropeptides': [823, 1564], 'detectable': [825, 1543], 'brain': [827], 'other': [829, 1413, 1894], 'tissues': [830, 1044, 1745], '10Rovere': [862], 'C.': [863, 1068, 1174], 'Viale': [864], 'Nahon': [866], 'Kitabgi': [868], 'P.': [869, 906, 3971], 'Endocrinology.': [870, 919, 934, 4059], '137:': [872], '2954-2958Crossref': [873], '(124)': [876], '11Fricker': [879], 'Berman': [881], 'Y.L.': [882], 'Devi': [885], 'L.A.': [886], '30619-30624Abstract': [892], '(138)': [900], '12Udupi': [903], 'V.': [904], 'Gomez': [905], 'Song': [907], 'L.': [908, 983, 1090, 1294, 1314, 1593, 1747, 2080, 3621, 3945, 4056], 'Reed': [911], 'J.T.': [912], 'Greeley': [917], 'G.H.J.': [918], '1997;': [920, 935, 1126, 1212, 1229, 1648, 1669, 3612, 3995], '138:': [921, 936], '1959-1963Crossref': [922], '(58)': [925], '13Cain': [928], 'B.M.': [929], 'Wang': [930], 'W.': [931, 1116, 1135, 1202], 'Beinfeld': [932], 'M.C.': [933], '4034-4037Crossref': [937], '(51)': [940, 1146], 'presence': [944, 2808, 3334], 'correctly': [946], 'indicates': [949], 'an': [951, 3433, 3449, 3454, 3460, 3703, 4463], 'additional': [952, 3329, 4464], 'enzyme': [953], 'able': [955], 'compensate': [957], 'deficiency': [960], 'CPE.': [962], 'Recently,': [963], 'designated': [967], 'identified': [973, 1739, 1997], 'bovine': [979, 1742, 2113, 3003, 3119], 'pituitary': [980], 'glands': [981], '(14Song': [982, 1293], '270:': [990, 1077, 1183, 1301, 3977], '25007-25013Abstract': [991, 1302], '(140)': [999, 1310], 'This': [1002], 'independently': [1005], 'gp180,': [1008, 3231], 'duck': [1010, 1014, 1036, 1383, 2031, 2103, 2744, 2959, 3145, 3244, 3716], 'binds': [1013], 'hepatitis': [1015], 'B': [1016, 2264, 4139], 'virus': [1017], 'particles': [1018], '(15Kuroki': [1019, 1045], 'Cheung': [1021, 1047], 'Marion': [1023, 1049], 'P.L.': [1024, 1050], 'Ganem': [1025, 1051, 1071, 1177, 1360, 1920], 'D.': [1026, 1052, 1072, 1178, 1361, 1921], 'Virol.': [1028, 1054], '68:': [1030, 1056], '2091-2096Crossref': [1031, 1057], 'rat,': [1038, 1162, 1381], '16Kuroki': [1061], 'Eng': [1063, 1169], 'F.': [1064, 1070, 1170, 1176, 1220], 'Ishikawa': [1065, 1171], 'T.': [1066, 1172, 1659, 1964, 3303, 3602], 'Turck': [1067, 1173], 'Harada': [1069, 1175], '15022-15028Abstract': [1078, 1184], '(119)': [1086, 1192], '17Song': [1089, 1313], '28884-28889Abstract': [1098, 1322, 1755, 2088], '(71)': [1106, 1330, 1763, 2096], '18Xin': [1109, 1195], 'X.': [1110, 1196, 1259, 1334], 'Dong': [1115, 1201], 'Bridgett': [1117, 1203], 'M.M.': [1118, 1204, 1240], 'DNA': [1123, 1209, 1268, 1343], 'Cell': [1124, 1210, 1269, 1344, 1465, 1487, 1707, 1802, 2755, 3309, 3402, 3511, 3562, 3629, 3652, 3684], '16:': [1127, 1213], '897-909Crossref': [1128, 1214], '(75)': [1131, 1217], '19Dong': [1134], 'Neuroscience.': [1140], '1999;': [1141, 1271, 1346, 1435, 2062], '89:': [1142], '1301-1317Crossref': [1143], 'Scholar)': [1148, 1494, 1939, 2098, 2170], 'broad': [1151, 3345], 'function.': [1152], 'cDNA': [1154], 'cloned': [1157], 'sequenced': [1159], 'human,': [1161], 'duck,': [1163], 'Drosophila,': [1164], 'Aplysia': [1166], '(16Kuroki': [1167], 'Scholar,20Tan': [1219], 'Rehli': [1221], 'Krause': [1223], 'S.W.': [1224], 'Skidgel': [1225], 'R.A.': [1226], 'Biochem.': [1227, 3974], '327:': [1230], '81-87Crossref': [1231], '(61)': [1234], '21Settle': [1237], 'S.H.J.': [1238], 'Green': [1239], 'Burtis': [1241], 'K.C.': [1242], '92:': [1251], '9470-9474Crossref': [1252], '(43)': [1255], '22Fan': [1258, 1333], 'Qian': [1260, 1335], 'Akalal': [1264, 1339], 'D.B.': [1265, 1340], 'Nagle': [1266, 1341], 'G.T.': [1267, 1342], '18:': [1272, 1347], '121-132Crossref': [1273, 1348], '(14)': [1276, 1351], 'general,': [1280], 'highly': [1284, 3542], 'conserved': [1285], 'among': [1286], 'species,': [1287], 'shows': [1289, 4430], 'similar': [1290, 4238, 4491], 'enzymatic': [1291], 'properties': [1292], '23Eng': [1354], 'F.J.': [1355, 1427, 1915, 2054], 'Novikova': [1356, 1916], 'E.G.': [1357, 1917], 'Kuroki': [1358, 1918], '1998;': [1367, 1467, 1489, 1927, 3686], '273:': [1368, 1928], '8382-8388Abstract': [1369, 1929], '(50)': [1377, 1937], 'Human,': [1380], 'cDNAs': [1385], 'encode': [1386], 'three': [1390, 2025, 2385, 2617, 2819, 2927], 'carboxypeptidase-like': [1391], 'domains,': [1392], 'followed': [1393, 3047], 'transmembrane': [1396], '58-residue': [1400], 'tail': [1405, 2076, 2207, 2324, 2336, 3824], 'contains': [1406, 1819, 4183], 'consensus': [1408], 'routing': [1409], 'motifs': [1410], 'found': [1411, 3269, 3526, 4025, 4417], 'integral': [1414], 'such': [1419], 'furin': [1421, 1481, 2205], 'monooxygenase': [1424], '(PAM)': [1425], '(24Eng': [1426, 2053], 'Mol.': [1432, 1645, 1692, 2059, 3992], 'Cell.': [1434, 1604, 1647, 2061, 3994], '35-46Crossref': [1437, 2064], '(42)': [1440, 2067], '(25Varlamov': [1460, 1482, 3679], '111:': [1468, 1490, 3687], '877-885Crossref': [1469, 1491, 3688], 'co-localization': [1474, 4091], 'endoprotease': [1480], 'supports': [1495], 'hypothesis': [1497], 'two': [1500, 2023], 'may': [1502, 1680, 3422], 'function': [1503], 'same': [1506, 2623, 3138], 'pathway.': [1507], 'We': [1508, 1840, 3662], 'previously': [1510, 1775, 1909, 3501, 3664, 3933, 4024], 'unable': [1511], 'detect': [1513], 'light': [1520], 'microscopy.': [1521], 'As': [1522, 4462], '(prohormone': [1533], '1': [1535, 2354, 2420, 2435, 2505, 2511, 2725, 2997, 3011, 3045, 3134], '2,': [1537], 'PAM),': [1539], 'lack': [1541], 'this': [1546, 3778, 4251], 'compartment': [1547, 4095, 4173], 'raised': [1548, 2107], 'doubts': [1549], 'whether': [1552, 2765, 2856, 4267], 'can': [1554], 'participate': [1555], 'processing.': [1558], 'some': [1563, 4431], 'begins': [1565, 1585, 3387], 'appear': [1571], 'be': [1573, 1681], 'most': [1575, 3873, 3910, 4412], 'productive': [1576], 'proteolytic': [1577, 2775, 4277], 'compartments.': [1578], 'For': [1579, 2002, 2316, 3204, 3706, 3812], 'example,': [1580], 'β-cells': [1591], '(26Orci': [1592], 'Ravazzola': [1594, 4051], 'Storch': [1596], 'M.J.': [1597], 'Anderson': [1598], 'R.G.W.': [1599], 'Vassalli': [1600], 'J.D.': [1601], 'Perrelet': [1602], '1987;': [1605], '49:': [1606], '865-868Abstract': [1607], '(243)': [1613], 'Also,': [1616], 'generation': [1618], 'ACTH': [1620, 2143, 2844, 4350, 4356, 4391, 4415, 4474, 4495], 'β-endorphin': [1622, 2145], '(POMC)': [1628], 'cells': [1631, 1794, 1952, 2374, 2678, 2710, 2730, 2778, 2816, 2865, 2879, 2914, 2963, 3007, 3064, 3209, 3396, 3505, 3556, 3598, 3678, 3711, 4235, 4280], 'post-TGN': [1635], 'event': [1636], '(27Fernandez': [1637], 'C.J.': [1638], 'Haugwitz': [1639], 'Eaton': [1641], 'B.': [1642, 3646, 3965], 'Moore': [1643], 'H.H.': [1644], '8:': [1649, 3996], '2171-2185Crossref': [1650], '(53)': [1653, 1674, 3617], '28Tanaka': [1656], 'Yora': [1658, 3601], 'Nakayama': [1660, 3603], 'Inoue': [1662, 3605], 'Kurosumi': [1664, 3607], 'Histochem.': [1667, 3610], 'Cytochem.': [1668, 3611], '45:': [1670, 3613], '425-436Crossref': [1671, 3614], 'Scholar),': [1676, 1811, 3318, 4002, 4086], 'although': [1677, 4426], 'POMC': [1678, 2772, 4325, 4364, 4429, 4506], 'initiated': [1682], '(29Schnabel': [1686], 'E.': [1687, 3644], 'Mains': [1688, 1704, 1719, 1799, 2157, 2177, 2752, 4373], 'R.E.': [1689, 1705, 1720, 1800, 2158, 2753, 4374], 'Farquhar': [1690], 'M.G.': [1691], 'Endocrinol.': [1693], '1989;': [1694], '3:': [1695], '1223-1235Crossref': [1696], '(148)': [1699], '30Milgram': [1702], 'S.L.': [1703, 1796, 2751], '107:': [1710, 2758], '737-745Crossref': [1711, 2759], '31Zhou': [1715], 'Bloomquist': [1717, 2155, 4371], 'B.T.': [1718, 2156, 4372], '1993;': [1724, 2162, 4079, 4378], '268:': [1725, 2163, 4379], '1763-1769Abstract': [1726, 2164, 4380], 'Soluble': [1733], 'various': [1741, 2670, 3850, 4242], 'rat': [1744, 2101], '(17Song': [1746, 2079], 'examined.': [1776], 'Interestingly,': [1777], 'both': [1778, 1871, 1994, 2034, 2100, 2148, 3837, 4363], 'membrane-associated': [1782, 2038], 'PAM': [1785, 1818], 'packaged': [1787], '(32Milgram': [1795], 'Johnson': [1797], 'R.C.': [1798], '117:': [1805], '717-728Crossref': [1806], '(103)': [1809], 'information.': [1821], 'we': [1826, 3701, 4122, 4469], 'further': [1827, 4114, 4205], 'characterized': [1828], 'immunoisolation': [1835, 2362, 2539, 2829, 3704, 4120, 4229, 4293], 'electron': [1837, 3202, 3206, 3235], 'approaches.': [1839], 'CPD.': [1853, 2960, 4186], 'neither': [1855], 'efficiently': [1865, 4199], 'routed': [1866], 'vesicles,': [1870, 3431], 'These': [1879, 3412, 3494], 'findings': [1880], 'strongly': [1881], 'support': [1882], 'functions': [1887], 'prohormones': [1892], 'transit': [1897], 'pathways.': [1904], 'gp180': [1905, 2376, 2640, 2780, 3067, 3742, 3876, 3913, 4094, 4214, 4261], 'gp170': [1907, 2680, 2857, 2867, 3069], 'constructs': [1908, 1995], 'described': [1910, 2015, 2365, 2603, 2749, 2831, 3502], 'baculovirus': [1912], 'expression': [1913, 1945], '(23Eng': [1914], 'subcloned': [1941], 'pcDNA3': [1944], 'vector': [1946], '(Invitrogen)': [1947], 'transfected': [1949, 3062, 3713], 'standard': [1955, 2344, 3093], 'calcium': [1956], 'phosphate': [1957], 'procedure': [1958, 2363, 2830, 4230, 4294], '(33Sambrook': [1959], 'Fritsch': [1961], 'E.F.': [1962], 'Maniatis': [1963], 'Molecular': [1965], 'Cloning:': [1966], 'Laboratory': [1968, 1975], 'Manual.': [1969], '2nd': [1970], 'Ed.': [1971], 'Cold': [1972, 1977], 'Spring': [1973, 1978], 'Harbor': [1974], 'Press,': [1976], 'Harbor,': [1979], 'NY1989Google': [1980], 'Stable': [1982], 'lines': [1984], 'selected': [1986, 2011], '0.6': [1988], 'mg/ml': [1989, 2355], 'Geneticin': [1990], '(G418).': [1991], 'Cells': [1992, 2382, 2972, 3019, 3152], 'expressing': [1993, 2375, 2679, 2779, 2866, 3065], 'Western': [1999, 2664, 2904, 3845], 'blot': [2000, 2665, 3846], 'analysis.': [2001], 'each': [2003, 2659], 'constructs,': [2006], 'positive': [2008], 'clones': [2009], 'analyzed': [2013, 2848, 2902, 3843], 'below;': [2016], 'shown': [2019], 'representative': [2021], 'separate': [2026], 'clones.': [2027], 'antiserum': [2029, 2071, 2106, 2184, 2202, 2244, 2261, 2301, 2741, 2954, 3142], 'recognizes': [2033, 2099, 2115, 4362], '(i.e.gp170': [2043], 'gp180)': [2045], 'cross-react': [2049], 'against': [2108, 2226, 2320, 4349, 4355], '(9Varlamov': [2119], 'Antisera': [2141], 'recognize': [2147], '(31Zhou': [2153, 4369], 'gift': [2173, 2189, 2210, 2231, 2249, 2267, 2286, 2306], 'Dr.': [2175, 2191, 2212, 2236, 2251, 2269, 2288, 2308], 'Richard': [2176, 2237], '(Johns': [2178], 'Hopkins': [2179], 'University,': [2180, 2240, 2256, 2312], 'Baltimore,': [2181], 'MD).': [2182], 'TGN38': [2186], 'Sharon': [2192], 'Milgram': [2193], '(University': [2194], 'North': [2196], 'Carolina,': [2197], 'Chapel': [2198], 'Hill,': [2199], 'NC),': [2200], 'Ruth': [2213], 'Angeletti': [2214], '(Albert': [2215, 2272, 2291], 'Einstein': [2216, 2273, 2292], 'College': [2217, 2274, 2293], 'Medicine,': [2219, 2276, 2295], 'New': [2220, 2257, 2296, 2313], 'York,': [2221, 2297], 'NY),': [2222, 2278, 2298], 'monoclonal': [2224, 2280], 'antibody': [2225, 2281, 3038], '6': [2228], 'Jason': [2233], 'Bock': [2234], 'Scheller': [2238, 3990], '(Stanford': [2239], 'Stanford,': [2241], 'CA),': [2242], 'PC1': [2246, 4021, 4107], 'Iris': [2252], 'Lindberg': [2253, 4076], '(Louisiana': [2254], 'State': [2255], 'Orleans,': [2258], 'LA),': [2259], 'cathepsin': [2263, 4131], 'Regina': [2270], 'Kuliawat': [2271], 'Bronx,': [2277], 'SNAP-25': [2283, 3764, 4135, 4141], 'Peter': [2289], 'Davies': [2290], 'calnexin': [2303, 3759, 4167], 'Ari': [2309], 'Helenius': [2310], '(Yale': [2311], 'Haven,': [2314], 'CT).': [2315], 'immunoisolation,': [2317, 3813], 'polyclonal': [2318], 'subjected': [2328, 2531, 2630, 2662, 2736, 2826, 2837, 2949, 4290, 4343], 'affinity': [2330, 2535, 2586, 3898, 4226], 'purification': [2331], 'glutathione': [2333], 'S-transferase-CPD': [2334], 'coupled': [2338, 3172], 'Sepharose': [2340], '4B': [2341], 'cyanogen': [2345], 'bromide': [2346], 'method': [2347], '(Sigma).': [2348], 'Affinity-purified': [2349], 'concentrated': [2352], 'below.': [2366], 'Typically,': [2367, 2510, 3736, 4100, 4320], 'six': [2368], 'confluent': [2369], '10-cm': [2370], 'plates': [2371], 'immunoisolation.': [2381, 2533, 4487], 'washed': [2384, 2616, 2690, 2712, 2818, 2881, 2926, 2974, 3021, 3155], 'times': [2386, 2457, 2620, 2820, 2928], 'cold': [2388, 2410, 2822], 'scraped': [2390], 'plates,': [2393], 'gently': [2395], 'pelleted': [2396], '700': [2398], '×': [2399, 2482], 'g.': [2400], 'pellet': [2403], 'resuspended': [2405], '4': [2407, 2491, 2576], 'ml': [2408, 2492, 2512], '0.25': [2411, 2524, 3791], 'm': [2412, 2495, 2527, 3727, 3792, 3796], 'sucrose,': [2413, 2528], '10': [2414, 2719], 'mm': [2415, 2421, 2424, 2597, 2720, 2726, 2944], 'HEPES,': [2416], 'pH': [2417, 2722, 3128], '7.4,': [2418], 'containing': [2419, 2595, 3024, 3114, 3140], 'EDTA,': [2422], '3': [2423, 2573], 'EGTA,': [2425], 'mixture': [2428, 4310], 'protease': [2430, 2601, 4312], 'inhibitors': [2431, 2602, 4313], '(1': [2432], 'μm': [2433, 2439, 2443, 2446, 2450], 'aprotonin,': [2434], 'mm4-(2-aminoethyl)benzenesulfonyl': [2436], 'fluoride,': [2437], '15': [2438, 2688, 2918, 2982, 2988], 'pepstatin': [2440], 'A,': [2441], '22': [2442], 'leupeptin,': [2444], '14': [2445], 'E-64,': [2447], '40': [2449], 'bestatin).': [2451], 'suspension': [2453], 'passed': [2455], 'five': [2456], 'through': [2458], '22-gauge': [2460], 'needle,': [2461], 'then': [2463, 2530, 2626, 2695, 2716, 2735, 2799, 2825, 2885, 2932, 2985, 3029, 3085, 3131, 3215, 3836, 4289], 'homogenized': [2464], 'tight-fitting': [2467], 'Dounce': [2468], 'homogenizer': [2469], '(25': [2470], 'strokes).': [2471], 'resulting': [2473, 2834], 'homogenate': [2474, 3746], 'centrifuged': [2476, 2498], '7': [2478], 'min': [2479, 2797, 2805, 2897, 2919, 2936, 2989, 3074, 3110, 3189], '1000': [2481, 3256], 'g': [2483], 'twice,': [2484], 'supernatant': [2487], 'layered': [2489], 'onto': [2490], '1.6': [2494, 2526, 3726, 3795], 'sucrose': [2496, 3731, 3797], 'SW41': [2501], 'rotor': [2502], '(Sorvall)': [2503], 'h': [2506, 2574, 2998, 3012, 3135, 3166, 4287], '200,000': [2508], '×g.': [2509], 'microsomal': [2515, 2568, 3751, 3779, 3830, 4333], 'fraction': [2516, 2569, 2660, 3752, 3780, 3831, 3921, 4148, 4334, 4402, 4421, 4458], 'collected': [2518], 'interface': [2521, 3723], 'resin': [2536, 2587, 2607, 3090], 'prepared': [2541], 'incubation': [2543], '100': [2545, 2551, 2582], 'μl': [2546, 2583, 2594], 'Pansorbin': [2548, 2606, 3814], '(Calbiochem)': [2549], 'μg': [2552], 'affinity-purified': [2554, 3819], 'An': [2562, 3328], 'aliquot': [2563], '(300': [2564], 'μl)': [2565], 'incubated': [2571, 2696, 2784, 2933, 3030, 3107, 3132, 3163, 3827], '°C': [2577], 'gentle': [2579], 'agitation': [2580], 'final': [2590], 'volume': [2591], '500': [2593], '140': [2596], 'NaCl': [2598], 'above.': [2604, 2832], 'recovered': [2609, 3748, 3776, 3882, 3917, 4109, 4144, 4330, 4398, 4454], 'low': [2611, 3358, 3417], 'speed': [2612], 'centrifugation': [2613], 'four': [2619], 'buffer,': [2624], 'vesicle-associated': [2627], 'detergent': [2633], 'elution': [2634], '1%': [2636, 2649, 3218], 'Triton': [2637, 2992], 'X-100.': [2638], 'IgG-associated': [2639], 'eluted': [2642], 'beads': [2645], 'boiling': [2647], 'SDS': [2650], 'gel': [2651], 'loading': [2652], 'buffer': [2653], '5': [2655, 2890, 2943], 'min.': [2656], 'Aliquots': [2657], 'antisera': [2668, 2841, 3016, 4354], '1:1000': [2675], 'dilution.': [2676], 'labeled': [2682, 2916, 4282], '[35S]Met': [2684, 2786, 4284], '(100': [2685, 2787], 'μCi/ml)': [2686, 2788], 'min,': [2689, 2983], 'twice': [2691, 2882], "Dulbecco's": [2698], 'modified': [2699], "Eagle's": [2700], 'medium': [2701], 'different': [2703, 3281], 'periods': [2704], 'time.': [2706], 'Media': [2707], 'removed,': [2709], 'frozen': [2717], 'NaAc,': [2721], '5.5,': [2723], 'phenylmethylsulfonyl': [2727], 'fluoride.': [2728], 'media': [2733, 2894, 2940, 2947], 'immunoprecipitation': [2738, 2839, 2951, 4345], '(30Milgram': [2750], 'To': [2763, 2854, 2906, 3225, 3692, 4113, 4265, 4302], 'test': [2764, 4266], 'neuropeptide': [2770, 4273], 'its': [2774, 4366], 'fragments,': [2776, 4278], 'continuously': [2783], '8': [2790, 4286], 'h,': [2791, 2925, 3046], 'pulsed': [2793], 'only': [2795, 4088], '20': [2796, 3027, 3124, 3159], 'chased': [2800, 2922], '0': [2802], '90': [2804], 'unlabeled': [2810], 'Met.': [2811], 'Following': [2812], 'labeling,': [2814], 'PBS': [2823, 3023, 3050, 3126], 'fractions': [2835, 3885, 4127, 4480, 4489], 'β-endorphin,': [2846, 4446], 'on': [2849, 2870, 2966, 3098, 3596], '10%': [2850, 3115], 'polyacrylamide': [2851], 'Tricine': [2852], 'gels.': [2853], 'examine': [2855, 2907], 'pathway,': [2863], 'grown': [2869], '35-mm': [2871], 'culture': [2873], 'dishes': [2874], '90%': [2876], 'confluence.': [2877], 'treated': [2886], 'secretagogue': [2889], 'mm8-Br-cAMP': [2891], 'control': [2893, 2939, 3859, 4410, 4465], '30': [2896, 2935, 3073, 3109], 'blotting.': [2905], 'secretion': [2910], '[35S]Met-labeled': [2912], 'proteins,': [2913, 4018], '[35S]Met,': [2921], '2': [2924, 3165, 3188], '8-Br-cAMP.': [2945], 'Transfected': [2961], 'cultured': [2965], 'growth-supporting': [2967], 'glass': [2968], 'coverslips': [2969], '(Fisher': [2970], 'Scientific).': [2971], 'fixed': [2977, 3071, 3211], '4%': [2979, 3079], 'paraformaldehyde': [2980], 'permeabilized': [2986], '0.1%': [2991, 3122, 3157], 'X-100': [2993], 'PBS.': [2995], 'After': [2996, 3181], 'blocking': [3000, 3112, 3177], '3%': [3002], 'serum': [3004, 3120], 'albumin,': [3005, 3121], 'immunostained': [3009], 'primary': [3015], '(1:1000': [3017], 'dilution).': [3018], '0.2%': [3025, 3081], 'Tween': [3026, 3123, 3158], 'fluorescein-labeled': [3032], 'anti-mouse': [3033], 'rhodamine-labeled': [3035], 'anti-rabbit': [3036, 3174], 'secondary': [3037], '(Vector': [3039], 'Laboratories': [3040], 'Inc.,': [3041], '1:200': [3042], 'dilution)': [3043], 'extensive': [3049, 3182], 'washing.': [3051], 'Immunofluorescence': [3052], 'staining': [3053], 'Bio-Rad': [3058], 'confocal': [3059], 'microscope.': [3060, 3203], 'Stably': [3061], 'room': [3076], 'temperature': [3077], 'formaldehyde,': [3080], 'glutaraldehyde': [3082], 'dehydrated,': [3086], 'embedded': [3087, 3221], 'LR-White': [3089, 3223], 'according': [3091], 'procedure,': [3094], 'sectioned,': [3095], 'mounted': [3097], 'gold': [3100, 3170, 3257], 'nickel': [3102], 'grids.': [3103], 'Each': [3104], 'grid': [3105], 'solution': [3113, 3139, 3178], 'goat': [3116], 'serum,': [3117], '2.5%': [3118], '8.2,': [3129], '(final': [3149], 'dilution': [3150], '1:200).': [3151], 'extensively': [3154], '10-nm': [3168], 'colloidal': [3169], '(BioCell)': [3171], '(dilution': [3179], '1:10).': [3180], 'washes,': [3183], 'sections': [3184], 'stained': [3186], 'uranyl': [3191], 'acetate': [3192], '30%': [3194, 3738, 4164], 'ethanol': [3195], 'Jeol': [3200], '100CX': [3201], 'conventional': [3205], 'microscopy,': [3207], '2%': [3213], 'glutaraldehyde,': [3214], 'postfixed': [3216], 'OsO4': [3219], 'resin.': [3224, 4227], 'quantitate': [3226], 'gp170,': [3232], 'micrographs': [3236], 'immunogold-labeled': [3239], 'scanned': [3249], 'random': [3251], 'order.': [3252], 'total,': [3254], 'about': [3255, 3737], 'particles/grid': [3258], 'analyzed,': [3260], 'percentage': [3263], 'total': [3265, 3741, 4324], 'label': [3266], 'specific': [3271], 'determined.': [3274], 'main': [3276], 'morphological': [3277, 3330], 'criterion': [3278], 'distinguish': [3280], 'subclasses': [3282], 'size': [3289, 3295], 'dense': [3298, 3384, 3440, 3489, 3544, 3585], 'cores': [3299, 3441, 3490, 3586], '(34Tooze': [3300], 'S.A.': [3301, 3400, 3509, 3560], 'Flatmark': [3302], 'Tooze': [3304, 3399, 3508, 3559], 'Huttner': [3306], 'W.B.': [3307], '1991;': [3311, 4060], '115:': [3312], '1491-1503Crossref': [3313], '(185)': [3316], 'measured': [3321], 'negatives': [3323], 'taken': [3324], 'magnification': [3326], '×54,000.': [3327], 'criteria': [3331], 'lighter': [3337], 'core': [3338, 3385], 'surrounded': [3342], 'electron-lucid': [3346], 'peripheral': [3347], 'zone': [3348, 3350], '(this': [3349], 'much': [3352], 'broader': [3353], 'state': [3359, 3418, 3456], 'condensation).': [3361], 'Light': [3362], 'aggregates': [3363, 3386], 'condensing': [3365], 'observed': [3368], 'dilated': [3371], 'cisterns': [3372], 'previous': [3378, 3594], 'studies': [3379, 3595], 'level': [3390], '(35Tooze': [3397, 3506, 3557], '1986;': [3404, 3513, 3564], '103:': [3405, 3514, 3565], '839-850Crossref': [3406, 3515, 3566], '(158)': [3409, 3518, 3569], 'electron-dense': [3413], 'condensation,': [3420], 'represent': [3423], 'cross-sections': [3424], 'early': [3429], 'had': [3432, 3459, 3536], 'average': [3434, 3479, 3573], 'diameter': [3435], '280': [3437], 'nm': [3438, 3582], 'too': [3444], 'variable': [3445], 'accurately': [3447], 'determine': [3448, 3694], 'average.': [3450], 'Electron-dense': [3451], 'intermediate': [3455, 4479], 'condensation': [3458], 'ovoid': [3461], 'spherical': [3463, 3539], 'shape,': [3464], 'detaching': [3471], 'already': [3473], 'detached': [3474], 'diameters': [3480, 3574], '170': [3485], 'nm,': [3486, 3589], 'their': [3488, 3584, 4276], '120': [3492], 'nm.': [3493], 'closely': [3496], 'resemble': [3497], 'Another': [3521], 'type': [3522, 4233], 'vesicle': [3524, 4486], 'close': [3528], 'proximity': [3529], 'membrane;': [3533], 'regular': [3538], 'shape': [3540], 'condensed': [3543], 'cores,': [3545], 'characteristic': [3548], 'features': [3549], 'endocrine': [3555], 'typically': [3580], '150': [3581], '110': [3588], '(28Tanaka': [3599], '36Matsuuchi': [3620], 'Buckley': [3622], 'K.M.': [3623], 'Lowe': [3624], 'A.W.': [3625], 'Kelly': [3626], 'R.B.': [3627], '106:': [3632], '239-251Crossref': [3633], '(55)': [3636], '37Koedam': [3639], 'J.A.': [3640], 'Cramer': [3641], 'E.M.': [3642], 'Briend': [3643], 'Furie': [3645, 3647], 'B.C.': [3648], 'Wagner': [3649], 'D.D.': [3650], '116:': [3655], '617-625Crossref': [3656], '(105)': [3659], 'demonstrated': [3665, 4236], 'endogenous': [3667], 'predominately': [3670], 'perinuclear': [3674], 'biochemically': [3693], 'co-localize': [3698], 'technique.': [3705], 'studies,': [3708], 'microsomes': [3709, 3895], 'stably': [3712], '(gp180)': [3718], '0.25m': [3730], 'layer': [3732], '(Fig.': [3733, 3753, 3781, 3799, 3854, 3886, 3922, 4009, 4096, 4136, 4149, 4174, 4403, 4422, 4434], '1A,': [3734], 'Ms).': [3735], '1B).': [3754, 3782], 'Similarly,': [3755], '20–30%': [3756, 4101], '(an': [3760], 'ER': [3761, 4182, 4194], 'protein),': [3763, 3768], '(a': [3765, 3771], 'syntaxin-6': [3770], 'protein)': [3773], 'None': [3783], 'detected': [3788], 'layers': [3798], '1B),': [3800], 'no': [3802, 4502], 'enrichment': [3803], 'loss': [3805], 'organelles': [3808, 4204], 'preparation.': [3811], 'precoated': [3816], 'bound': [3838, 3920, 4124, 4401, 4457], 'non-bound': [3840, 3884, 4111, 4126, 4147, 4340, 4420], 'materials': [3841, 4341], 'markers': [3853, 3880, 4245], '1C,': [3855, 3887, 3923, 4010, 4097], 'right': [3856, 4011, 4098, 4405], 'panels).': [3857, 4012], 'experiments,': [3860], 'when': [3861], 'rabbit': [3862], 'IgG': [3863], 'instead': [3866], 'tail,': [3872, 3909], 'immunoreactivity': [3877], 'left': [3888, 4424, 4436], 'panels),': [3889], 'nonspecific': [3892, 4219, 4307, 4432, 4467], 'binding': [3893, 4220, 4433], 'carrier': [3899], 'very': [3901], 'low.': [3902], 'When': [3903, 4438], '(typically': [3914], '>95%)': [3915], 'top).': [3924], 'Furin,': [3925], 'TGN38,': [3926], '6,': [3929], '(38Molloy': [3942], 'S.S.': [3943], 'Thomas': [3944, 3950], 'VanSlyke': [3946], 'Stenberg': [3948], 'P.E.': [3949], 'G.': [3951, 3967], 'EMBO': [3952], '13:': [3955], '18-23Crossref': [3956], '(420)': [3959], '39Luzio': [3962], 'J.P.': [3963, 4073], 'Brake': [3964], 'Banting': [3966], 'Howell': [3968], 'K.E.': [3969], 'Braghetta': [3970], 'Stanley': [3972], 'K.K.': [3973], '1990;': [3976], '97-102Crossref': [3978], '(258)': [3981], '40Bock': [3984], 'J.B.': [3985], 'Klumperman': [3986], 'Davanger': [3988], 'R.H.': [3991], '1261-1271Crossref': [3997], '(248)': [4000], 'exclusively': [4004, 4143], 'associated': [4005, 4169], 'gp180-containing': [4007], 'contrast': [4014], '41Guest': [4049], 'P.C.': [4050], 'Davidson': [4053], 'H.W.': [4054], 'Orci': [4055], '129:': [4061], '734-740Crossref': [4062], '(35)': [4065], '42Hornby': [4068], 'P.J.': [4069], 'Rosenthal': [4070], 'S.D.': [4071], 'Mathis': [4072], 'Vindrola': [4074], 'I.': [4077], 'Neuroendocrinology.': [4078], '58:': [4080], '555-563Crossref': [4081], '(27)': [4084], 'demonstrate': [4087], 'partial': [4090], 'panel).': [4099, 4406, 4437], '40–50%': [4105], 'fractions.': [4112], 'validate': [4115], 'specificity': [4117], 'our': [4119], 'technique,': [4121], 'probed': [4123], 'B,': [4132], 'calnexin,': [4133], '1C).': [4137], 'Cathepsin': [4138], '1C),': [4150, 4175], 'lysosomes': [4153], 'immunoisolates.': [4162], 'Approximately': [4163], 'expectation': [4179], 'newly': [4184], 'synthesized': [4185], 'suggests': [4206], 'co-sedimentation': [4208], 'Identical': [4228], 'wild': [4232], '(data': [4246, 4335, 4459], 'shown),': [4248], 'pattern': [4252], 'overexpression': [4259], 'cells.': [4264], 'reduce': [4303], 'possibility': [4305], 'proteolysis,': [4308, 4468], 'included': [4315], 'throughout': [4316], 'isolation': [4318], 'procedure.': [4319], '30–40%': [4321], 'POMC-derived': [4327], 'material': [4328, 4440, 4452], 'shown).': [4337, 4461], 'Pansorbin-bound': [4338], 'β-endorphin.': [4352], 'Typically': [4387], '70–80%': [4388], '(both': [4392], 'glycosylated': [4393], 'non-glycosylated': [4395], 'forms)': [4396], '2A,': [4404, 4423, 4435], 'experiments': [4408], 'IgG,': [4411], 'panel),': [4425], '30-kDa': [4428], 'immunoisolated': [4439], 'immunoprecipitated': [4442, 4471], 'bulk': [4448], 'β-endorphin-reactive': [4451], 'immunoreactive': [4473], 'homogenate,': [4478], 'microsomes,': [4482], 'prior': [4483], 'All': [4488], 'showed': [4490], 'relative': [4492], 'amounts': [4493], 'versus': [4496], 'peptides,': [4499], 'significant': [4503], 'proteolysis': [4504], 'o': [4507]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2003789671', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-08T13:05:20.575808', 'created_date': '2016-06-24'}
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