Publication Information

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2590], 'only': [347, 753, 1664, 2489], 'fair': [348], 'point': [350], 'out': [351, 2221], 'medication–poison': [354], 'sequence': [355], 'one-way': [359], 'street,': [360], 'cures': [368, 644, 985], 'times': [371], 'present.': [374], 'Aureolus': [375], 'Phillipus': [376], 'Theostratus': [377], 'Bombastus': [378], 'von': [379], 'Hohenheim': [380], '(1493–1541),': [381], 'immortalized': [382], 'Paracelsus,9': [384], 'reasoned': [385], '"All': [387], 'substances': [388], 'poisons;': [390], 'none': [393], 'poison."': [398], 'Paracelsus': [399, 442], 'thought': [400], 'it': [402, 667, 998, 1087, 1169, 1237, 1293, 2544], 'dose': [404, 436, 1205, 1217], 'alone': [405, 437, 1771, 2339], 'differentiated': [407], 'remedy,': [412], 'thereby': [413, 2104], 'preempting': [414], '500': [416], 'years': [417, 471, 1242, 1757, 2442], 'what': [418, 1412], 'we': [419, 2706], 'now': [420, 1027, 1488], 'true,': [424], 'predictable,': [425], 'intrinsic': [427, 1409, 2137, 2170], 'hepatotoxicity.10': [428], 'His': [429, 1747, 2076], 'dictum': [430], '"Dosis': [431], 'sola': [432], 'facit': [433], 'veneum"': [434], '("the': [435], 'makes': [438], 'poison")': [440], 'use': [445, 1029, 1311], 'mercury': [447], 'treat': [449, 1060, 1719], 'syphilis,': [450], 'he': [453, 970, 1109, 1112, 1124, 1589, 1635, 1715, 1781, 1872, 1961, 2133, 2141, 2542, 2552, 2665], 'denounced': [455], 'his': [457, 855, 1487, 1617, 1623, 1637, 1694, 1738, 1768, 1773, 1776, 1783, 1788, 1797, 1842, 1855, 1870, 1884, 1903, 1913, 2059, 2070, 2145, 2619, 2660, 2671, 2692, 2700, 2792, 2816], 'day': [458], 'nonetheless': [461, 1136], 'remained': [462, 2666], 'therapy': [464], 'choice': [466], 'next': [469], '300': [470, 836, 1723], 'until': [472, 1152, 1481], "Erlich's": [473], 'discovery': [474], 'arsenic-derived': [476], 'arsphenamine': [477, 1368], '(Salvarsan)': [478], '1910.11': [480], 'Many': [481], 'modern': [482, 2121], 'starting': [489], 'neuromuscular': [492], 'blocking': [493], 'agents': [494], 'followed': [496, 1761], 'naturally': [497, 2370], 'Claude': [499], "Bernard's": [500], 'famous': [501, 2715], 'experiments': [502], 'curare,12': [504], 'alkaloid': [507], 'found': [508], 'South': [511], 'American': [512, 1986], 'vine': [513], 'Chondrodendron': [514], 'tomentosum': [515], 'said': [518], 'brought': [522], 'Europe': [524], 'first': [525, 1216, 1287, 1324, 1342, 1361, 1748], 'Sir': [527], 'Walter': [528], 'Raleigh.': [529], 'host': [531], 'antitumor': [533], 'antibiotics': [534], 'clinical': [537, 2626], 'oncologic': [538], 'today,': [540, 669], 'all': [541, 1076, 1514, 2423, 2637], '"natural"': [544], 'products13,': [545], '14': [546], '(mostly': [547], 'plants,': [548, 726], 'fungi,': [549], 'bacteria),': [551], 'lends': [552, 2118], 'support': [553], "Paracelsus'": [555], 'hypothesis': [556], 'includes': [560], 'asparaginase,': [561], 'bacterial': [563], 'enzyme;': [564], 'etoposide,': [565], 'semisynthetic': [567], 'derivative': [568], 'podophyllotoxin': [570], 'stems': [573], 'roots': [575], 'mayapple': [578], '(Podophyllum': [579], 'peltatum);': [580], 'irinotecan,': [581], 'isolated': [582, 628], 'Chinese': [585, 749], 'ornamental': [586], 'tree': [587, 602], 'Camptotheca': [588], 'acuminata;': [589], 'paclitaxel,': [590], 'taxine': [592], 'obtained': [594], 'bark': [597], 'Pacific': [600], 'yew': [601], 'Taxus': [603], 'brevifolia': [604], '(now': [605], 'synthetically);': [607], 'vincristine': [608], 'vinblastine,': [610], 'vinca': [611], 'alkyloids': [612], 'Madagascar': [615], 'periwinkle': [616], 'Catharanthus': [617], 'roseus;': [618], 'anthracyclines': [621], 'bleomycin,': [622], 'dactinomycin,': [623], 'daunorubicin,': [624], 'mitomycin,': [625], 'others': [627], 'various': [630], 'Streptomyces': [631], 'species,': [632], 'name': [634], 'few.': [637], 'proclivity': [639], 'humans': [641], 'seek': [643], 'ills': [647], 'worlds': [650], 'nature': [652, 984], 'alchemy': [654], 'appears': [655], 'strong': [660], 'universal': [662], 'among': [663, 2088], 'ancients': [665], 'judging': [670], 'content': [673], 'documents': [676], 'survived': [679], 'clay': [681], 'tablet,': [682], 'papyrus,': [683], 'silk,': [684], 'parchment': [686], 'Mesopotamia,': [688], 'Egypt,': [689], 'China,': [690], 'Europe,': [692], 'respectively.': [693], 'Egyptian': [695], 'Papyrus': [696], 'Ebers,': [697], 'dating': [698], '1500': [700], 'BCE,': [701, 825], 'set': [702], 'forth': [703], '811': [704], 'prescriptions': [705], 'form': [708], 'salves,': [710], 'plasters,': [711], 'poultices;': [713], 'snuffs,': [714], 'inhalations,': [715], 'gargles;': [717], 'fumigations,': [719], 'suppositories,': [720], 'enemas—all': [722], 'minerals,': [725], 'so-called': [728, 993], '"organic"': [729], 'material': [730], '"plumbs': [732], 'depths': [734], 'human': [736, 2747], 'credulity"15': [737], 'does': [739], 'bear': [741, 2416], 'description': [742], 'here.': [743], 'extensive': [745, 2071], 'Materia': [746], 'Medica': [747], 'medicine16': [750], '(itself': [751], 'predated': [752], 'medicine': [756, 802, 809, 975, 1596, 1650], 'Babylon': [758], 'Egypt)': [760], 'well-documented': [762], '(over': [763], '1200': [764], 'drugs)': [765], 'centuries': [768, 1053], 'between': [769, 1304, 1408, 2136, 2157, 2212, 2458], '1100': [770], 'BCEand': [771], '659': [772], 'CE,': [773], 'Wu': [776], 'Shi': [777], 'Er': [778], 'Fang': [779], 'Herbals': [782], 'Shennong': [784], 'Tang,': [786], 'Indian': [790], 'Ayurvedic': [791], 'System17,': [792], '18': [793], 'Gyu-zhi': [797], '8th': [799], 'century': [800, 844], 'CETibetan': [801], 'based.': [804], 'Plainly,': [805], 'physic': [806], 'Western': [808], 'began': [810, 1336, 1902], 'Greeks': [813], 'Romans': [815], 'described': [817, 971], 'Hippocratic': [820], 'writings': [821, 929], 'approximately': [823, 1004], '400': [824], 'contributions': [829], 'both': [831], 'philosopher-scientist': [833], 'Theophrastus': [834], '(approximately': [835], 'BCE)': [837], 'peripatetic': [840], 'physician': [841], 'Dioscorides': [842], '(1st': [843], 'CE),': [845], 'well': [847, 1259], 'Claudius': [850], 'Galen': [851], '(131–201': [852], 'CE)': [853], 'complex': [856], '"galenicals."': [860], 'During': [861, 1322, 1375, 1775], 'Dark': [863], 'Ages,': [866], 'remedial': [868], 'expertise': [869], 'Greco-Roman': [871], 'civilization': [872], 'preserved': [874], 'monasteries': [877], 'England,': [879], 'Ireland,': [880], 'France,': [881], 'Germany': [883], 'promoted': [886], 'Arabs,': [889], 'exemplified': [891], 'magnum': [894], 'opus': [895], 'Persian': [898, 923], 'physician,': [899, 932, 2625], 'philosopher,': [900, 933], 'poet': [902], 'Abu': [903], 'Ali': [904], 'al-Husain': [905], 'ibn': [906, 908], 'Abdallah': [907], 'Sina': [909], '(981–1037': [910], 'CE),19': [911], 'who': [912, 941, 1182, 1353, 1515, 2368, 2647], 'known': [914, 943, 1874], 'Avicenna,': [916], 'Prince': [918], 'Physicians,': [920], 'empire;': [924], 'voluminous': [928], 'rabbi': [935], 'Moses': [936], 'ben': [937], 'Maimon': [938], '(1135–1204': [939], 'CE),20': [940], 'Rambam': [945], 'Maimonides.': [947], 'tempting': [950], 'dismiss': [952], 'old': [956], 'simply': [957], 'collections': [959], 'potentially': [961], 'dangerous': [962], 'nostrums': [963], 'placebos,': [965], 'Voltaire': [967], 'hinted': [968], 'when': [969, 1108, 1283, 1367, 1483, 2268], 'art': [973], 'means': [978], '"amusing': [980], 'patient': [982, 1352, 2305], 'while': [983, 1691], 'disease."': [987], 'Despite': [988], 'contemporary': [990, 1859], 'penchant': [991], '"alternative"': [994], '"complementary"': [996], 'medicine,': [997, 1049, 1940], 'salutary': [1000], 'note': [1002], '80%': [1005], "world's": [1008], 'inhabitants': [1009], 'still': [1010, 1370, 2112, 2414], 'rely': [1011], 'mainly': [1012], 'traditional': [1014, 1048], 'medicines': [1015], 'primary': [1018], 'care.21': [1020], 'Also,': [1021], 'many': [1022, 1120, 1471, 2000, 2207, 2568], 'important': [1025, 2256, 2470], 'medications': [1026], 'countries': [1032], 'discovered': [1034, 2488], 'direct': [1037], 'result': [1038], 'isolating': [1040], 'active': [1042], 'principles': [1043], 'plants': [1045], 'over': [1051, 1722, 1763, 2440], 'has': [1054, 2173, 2389, 2493, 2560], 'us': [1056], 'malaria,': [1061], 'pain,': [1062], 'heart': [1063], 'failure,': [1064], 'dysrhythmias,': [1065], 'hypertension,': [1066], 'infection,': [1067], 'depression,': [1068], 'cancer,': [1069], 'and,': [1070, 2281], 'course,': [1072], 'constipation.22': [1073], 'Yet': [1074, 1473], 'apparent': [1078], 'perspicacity': [1079], 'healers': [1082], 'apothecaries': [1084], 'old,': [1086], 'difficult': [1089], 'them': [1091], 'recognize': [1093], 'toxic': [1095], 'remedies.': [1099], 'Alexander': [1100], 'Great': [1102], 'came': [1103, 1753], 'close': [1104, 2824], 'mark': [1107], 'complained': [1110], '"dying': [1114], 'treatment': [1117, 1457], 'too': [1119], 'doctors."': [1121], '(In': [1122], 'truth,': [1123], 'probably': [1125], 'died': [1126], 'alcoholic': [1128], 'pancreatitis!)': [1129], 'come': [1132], 'surprise': [1135], 'learn': [1138], 'phenomenon': [1141], 'hepatitis': [1143, 1192], 'due': [1144, 2433], 'drug': [1146, 1284, 1319, 1334, 1440, 1459, 1751, 2042, 2200, 2216, 2311, 2374, 2492], 'sensitivity': [1147, 2585], 'firmly': [1150], 'established': [1151, 1493], 'mid-20th': [1154], 'century.': [1155, 1542], 'Lowell': [1158], 'Lectures': [1159], 'Boston,': [1162], 'Massachusetts,': [1163], 'March': [1165], '1947,23': [1166], 'Himsworth': [1167], 'felt': [1168], 'necessary': [1170], 'present': [1172], '37-year-old': [1177], 'woman': [1178], 'suffering': [1179], 'thyrotoxicosis': [1181], 'severe': [1185, 2484], 'illness': [1186], 'indistinguishable': [1189], 'infective': [1191, 1727], 'characterized': [1195], 'fever,': [1197], 'jaundice,': [1198], 'hepatomegaly': [1200], 'after': [1201, 1645, 1897, 2403, 2490, 2699], 'second': [1203, 1537, 1736, 2689], 'test': [1204], 'aminothiazole': [1207], '(a': [1210], 'transient': [1211], 'fever': [1212], 'had': [1218, 1238, 1267, 1354, 1654], 'disregarded).': [1220], 'At': [1221], 'time': [1223, 1272, 1777, 2050, 2845], "Himsworth's": [1225], 'practice,': [1226], 'hepatotoxicity': [1228, 1285, 1410, 1460, 1567, 1752, 2201, 2296, 2375, 2432], 'chlorinated': [1230], 'hydrocarbons': [1231], 'chloroform)': [1233], 'recognized24': [1235], '(although': [1236], 'taken': [1239, 1355], 'almost': [1240, 2060], '50': [1241], 'do': [1244], 'so25),': [1245], 'risk': [1247], 'liver': [1249, 1306, 1918, 2046, 2101, 2279, 2485, 2734], 'kidney': [1251], 'necrosis': [1252], 'phosphorus': [1255], 'arsenic': [1257], 'known,26': [1260], 'fatality': [1263], 'mushroom': [1265], 'appreciated': [1269], 'since': [1270], 'Roman': [1275], 'Empire,27': [1276], 'least.': [1278], 'certain': [1282], 'recognized': [1288], 'entity,': [1291], "Bang's": [1297], 'observation': [1298], '177428': [1300], 'association': [1303, 1915], 'disease': [1307], 'arsenic,': [1309], 'fashionable': [1315], 'then': [1316], 'cosmetic.': [1321], 'half': [1325, 1538], '20th': [1328, 1381, 1541], 'incidental': [1330], 'occurrences': [1331], 'hepatic': [1333], 'injury': [1335, 2102, 2244, 2275, 2486], 'noticed,': [1339], 'like': [1340], 'idiosyncratic': [1346, 2139], 'reaction': [1347], 're-exposure': [1349], 'cinchophen': [1356], 'gout,29': [1358], '12': [1362], 'cases': [1363], 'drug-induced': [1365, 2100, 2269], 'cholestasis30': [1366], 'being': [1371], 'prescribed': [1372], 'syphilis.': [1374], 'third': [1377], 'quarter': [1378], 'practitioners': [1383], 'noticed': [1384], 'increasing': [1387], 'number': [1388], 'injured': [1391], 'liver,': [1393, 2294], 'they': [1395], 'published': [1396, 2696], 'observations': [1398], 'reports': [1401], 'small': [1404], 'series.': [1405], 'distinction': [1407], 'Hippocrates': [1413], 'called': [1414], 'idiosyncrasy,': [1415], 'referring': [1416], "person's": [1419], 'own': [1420, 1700], 'peculiar': [1421], '(constitution': [1422], 'ιδιoς': [1423], '(idios)': [1424], "one's": [1425], 'self,': [1426], 'συν': [1427], '(syn)': [1428], 'together,': [1429], 'κρασις': [1430], '(crasis)': [1431], 'mixture)': [1432], 'acknowledged': [1434], 'hepatotoxic': [1439], 'reactions': [1441, 2043, 2156, 2271], 'extended': [1443], 'include': [1445], 'cholestasis,': [1446, 2250], 'steatosis,': [1447], 'tumors.': [1450], 'Studies': [1451], 'mechanisms,': [1454], 'prevention,': [1455], 'monitoring': [1464], 'regulatory': [1466], 'agencies': [1467], 'enfranchised': [1469], 'field': [1475, 1675], 'lacked': [1476], 'cohesion,': [1477], 'systemization,': [1478], 'leadership': [1480], '1978,': [1482], 'publication': [1485], 'landmark': [1489, 2737, 2742, 2746], 'monograph': [1490], 'hepatotoxicity31': [1492], 'Hyman': [1494, 1508], 'J.': [1495], 'Zimmerman': [1496, 1827, 2634, 2757], 'doyen,': [1499], 'guru,': [1500], 'oracle,': [1501], 'high': [1503, 2180], 'priest': [1504], 'realm.': [1507], 'Joseph': [1509], 'Zimmerman,': [1510], '"Hy"': [1512], 'knew': [1516], 'him': [1517, 1802, 2094, 2649], '(Fig.': [1518, 2017], '1),': [1519], 'most': [1524, 2037], 'beloved': [1525], 'respected': [1527], 'members': [1528], 'founding': [1531], 'elite': [1532], 'hepatology': [1534], 'twinkling': [1544], 'eye,': [1545], 'warm': [1546], 'disposition,': [1547], 'magnetic': [1548], 'charm,': [1549], 'signature': [1550], 'tie,': [1552], 'gravelly': [1553], 'voice,': [1554], 'Edward': [1556], 'G.': [1557], 'Robinson–like': [1558], 'countenance': [1559], 'stature': [1561], 'this': [1563, 2298, 2351, 2499, 2571, 2594], '"Little': [1564], 'Caesar"': [1565], 'unique': [1568, 2265], 'always': [1570], 'recognizable,': [1571], 'matter': [1573], 'how': [1574], 'large': [1575], 'gathering.': [1577], 'Hy': [1578, 1670, 1826, 1880, 1901, 2032, 2633, 2729], 'born,': [1580], 'raised,': [1581], 'educated': [1583], 'Rochester,': [1585], 'New': [1586], 'York,': [1587], 'chance': [1593], 'study': [1595, 1721, 1954], 'balmy': [1599], 'clime': [1600], 'Stanford,': [1602], 'California,': [1603], 'unexpected': [1606], 'consolation': [1607], 'bonus': [1609], 'ethnic': [1612], '(Jewish)': [1613], 'quota': [1614], 'precluded': [1616], 'admission': [1618], 'medical': [1620, 1638, 2065], 'school': [1621], 'oft-snowbound': [1624], 'native': [1625], 'city.': [1626], 'Drafted': [1627], 'into': [1628, 2794], 'army': [1630, 1653], 'during': [1631, 1841], 'World': [1632, 1846], 'War': [1633, 1847], 'II,': [1634], 'completed': [1636], 'studies': [1639], 'reserve': [1642], 'commission.': [1643], 'Then,': [1644], 'superb': [1646], 'training': [1647], 'tropical': [1649], 'arranged,': [1655], 'vision,': [1659], 'insight,': [1660], 'planning': [1662], 'military': [1666, 1843, 1899], 'mind': [1667], 'can': [1668, 2165, 2224, 2333, 2377, 2705], 'exercise,': [1669], 'sent': [1672], 'hospital': [1676, 1910], 'France': [1678], 'Châlons-sur-Marne,': [1680], 'near': [1681], 'venue': [1683], 'Battle': [1686], 'Bulge.': [1689], 'There,': [1690], 'some': [1692], 'superiors': [1695], 'engaged': [1697], 'personal': [1701, 1743, 2818], 'evaluation': [1702], 'neuropsychiatric': [1705], 'fermentations': [1708], 'grape': [1711], 'barley,': [1714], 'free': [1717], 'soldiers': [1724], 'acute': [1726], 'hepatitis,': [1728], 'resulted': [1730], 'seminal': [1733], 'publication32': [1734], '(the': [1735], 'distinguished': [1739, 2135], 'bibliography)': [1740], 'commitment': [1744], 'hepatology.': [1746], 'article': [1749], 'just': [1754], 'few': [1756, 1967], 'later,33': [1758], '100': [1764], 'more': [1765, 2255, 2316, 2415], 'publications': [1766], 'chosen': [1769], 'topic': [1770], 'career.': [1774], 'army,': [1780], 'exploited': [1782], 'fondness': [1784], 'animals': [1786], 'disdain': [1789], 'pompous': [1791], 'authority': [1792], 'naming': [1794], 'dogs': [1798], 'Colonel,': [1799], 'gave': [1801], 'excuse': [1804], 'create': [1806], 'illusion': [1808], 'shouting': [1810], 'cussing': [1813], 'superior': [1816], 'officer': [1817], 'without': [1818], 'fear': [1819], 'retribution.': [1821], 'four': [1823], 'faces': [1824], '(July': [1828], '19,': [1829], '1944–July': [1830], '12,': [1831], '1999).Above': [1832], 'left:': [1833, 1868], 'Outside': [1834], '239th': [1836], 'General': [1837], 'Hospital': [1838], 'Châlons-sur-Marne': [1840], 'service': [1844, 1947], 'II': [1848], 'composite': [1851], 'picture': [1852], 'son': [1856, 2661], 'Philip': [1857, 2761], 'photographs.': [1860], 'Above': [1861], 'right:': [1862, 1879], 'Teaching': [1863], 'ward': [1865], 'rounds.': [1866], 'Below': [1867, 1878], 'For': [1869], 'sayings,': [1871], 'Chairman': [1876, 2015], 'Hy.': [1877, 2827], 'devoted': [1882, 2639], 'wife': [1885], 'Kitty,': [1886, 2646], 'here': [1887], 'shown': [1888, 2175], 'photograph': [1891], 'Ms.': [1893], 'Robin': [1894], 'Megibow.': [1895], 'Soon': [1896], 'leaving': [1898], 'service,': [1900], '50-year': [1904], 'attachment': [1905], "Veterans'": [1908, 1972], 'Affairs': [1909, 1973], 'system': [1911, 1974], 'cherished': 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