Plasmid P1 RepA Is Homologous to the F Plasmid RepE Class of Initiators

Name: Work Video:
Duration: 3 min 30 s
Suveena Sharma; Bangalore K. Sathyanarayana; Jeremy G. Bird; Joel R. Hoskins; Byung Kook Lee; Sue Wickner
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2945, 3015, 3023, 3028, 3036, 3162, 3185, 3187, 3200, 3206, 3227, 3245, 3292, 3297, 3324, 3350, 3437, 3470, 3502, 3560, 3564, 3567, 3573, 3602, 3626, 3673, 3698, 3710, 3724, 3727, 3742, 3825, 3844, 3950, 4022, 4066, 4161, 4169, 4204, 4219, 4253, 4352, 4522], 'converted': [19, 206, 1606, 1625], 'by': [20, 48, 134, 207, 235, 321, 402, 495, 529, 625, 746, 839, 1043, 1045, 1056, 1134, 1304, 1461, 1560, 1644, 1655, 1740, 1759, 1805, 1915, 1964, 2341, 3094, 3211, 3228, 3340, 3402, 3735, 4012, 4069, 4175, 4258, 4454, 4527, 4546], 'molecular': [21, 208, 1196, 1466, 2411, 4470], 'chaperones': [22, 209, 849, 1197], 'into': [23, 210], 'active': [25, 212, 670, 771, 888, 1145, 1184], 'monomer': [26, 213, 671, 768, 1182, 1251, 1485, 2137, 2144, 2360, 2417, 2969, 2979], 'that': [27, 41, 52, 96, 137, 214, 228, 239, 283, 324, 392, 672, 1115, 1130, 1290, 1375, 1506, 2290, 2700, 2729, 2786, 2795, 3082, 3100, 3147, 3348, 3389, 3526, 3592, 3606, 3659, 3679, 3715, 3748, 3761, 3833, 4043, 4055, 4090, 4099, 4124, 4140, 4277, 4364, 4401, 4431], 'binds': [28, 98, 215, 285, 555, 3084, 3102, 3839, 3848, 3941, 4142, 4197, 4473], 'binding': [30, 77, 104, 112, 217, 264, 291, 299, 602, 626, 676, 838, 990, 1042, 1133, 1553, 1804, 1914, 2813, 3033, 3045, 3157, 3209, 3225, 3231, 3397, 3401, 3409, 3439, 3472, 3478, 3504, 3510, 3706, 3765, 3970, 3981, 4002, 4033, 4063, 4078, 4107, 4202, 4231, 4239, 4248, 4281, 4321, 4335, 4344, 4368, 4379, 4406, 4436, 4446, 4453, 4481, 4518, 4524, 4543], 'sites.': [31, 218], 'Although': [32, 219, 890, 3372], 'the': [33, 65, 73, 81, 85, 99, 103, 109, 115, 121, 127, 135, 144, 151, 220, 252, 260, 268, 272, 286, 290, 296, 302, 308, 314, 322, 331, 338, 431, 435, 443, 451, 458, 463, 469, 491, 514, 519, 523, 535, 541, 548, 565, 604, 612, 617, 666, 677, 742, 770, 783, 844, 882, 894, 973, 1047, 1103, 1113, 1124, 1139, 1181, 1190, 1237, 1286, 1310, 1317, 1355, 1363, 1420, 1429, 1440, 1491, 1513, 1596, 1651, 1899, 1907, 1976, 2067, 2075, 2121, 2148, 2155, 2160, 2169, 2176, 2180, 2189, 2194, 2216, 2235, 2250, 2267, 2273, 2295, 2322, 2328, 2343, 2353, 2357, 2364, 2367, 2394, 2404, 2410, 2414, 2421, 2455, 2460, 2468, 2512, 2516, 2523, 2574, 2612, 2619, 2625, 2679, 2683, 2688, 2708, 2713, 2723, 2776, 2836, 2850, 2853, 2859, 2890, 2925, 2943, 2950, 3008, 3073, 3076, 3089, 3108, 3151, 3155, 3169, 3179, 3190, 3204, 3222, 3237, 3253, 3315, 3333, 3363, 3379, 3385, 3419, 3427, 3532, 3536, 3540, 3544, 3551, 3594, 3617, 3656, 3660, 3680, 3693, 3696, 3699, 3716, 3719, 3738, 3744, 3755, 3762, 3774, 3778, 3781, 3786, 3790, 3818, 3828, 3834, 3841, 3845, 3850, 3876, 3887, 3891, 3896, 3904, 3908, 3943, 3947, 3958, 3962, 3965, 3977, 3983, 3987, 3990, 3994, 4004, 4035, 4039, 4047, 4057, 4083, 4087, 4091, 4101, 4118, 4122, 4128, 4131, 4147, 4151, 4154, 4177, 4199, 4206, 4211, 4228, 4234, 4238, 4243, 4247, 4278, 4287, 4291, 4299, 4310, 4314, 4318, 4325, 4356, 4370, 4382, 4385, 4395, 4402, 4408, 4417, 4421, 4428, 4438, 4457, 4466, 4469, 4475, 4479, 4503, 4512, 4516, 4537, 4548], 'sequence': [34, 221, 563, 1409, 2465, 2577, 4180, 4184], 'not': [38, 225, 477, 1109, 1407, 1415, 2475, 2802, 3392, 3938, 4110, 4136, 4554], 'homologous': [39, 168, 226, 355], 'to': [40, 79, 143, 169, 227, 266, 330, 356, 434, 518, 556, 603, 652, 669, 887, 901, 967, 1101, 1121, 1144, 1242, 1244, 1301, 1346, 1439, 1447, 1454, 1471, 1487, 1512, 1519, 1607, 1626, 2014, 2111, 2131, 2142, 2262, 2402, 2451, 2571, 2592, 2595, 2602, 2639, 2642, 2673, 2760, 2768, 2941, 2962, 2971, 2981, 3018, 3071, 3085, 3104, 3252, 3376, 3406, 3628, 3655, 3686, 3737, 3743, 3822, 3840, 3849, 3934, 3942, 3971, 4003, 4034, 4076, 4082, 4146, 4198, 4205, 4309, 4369, 4407, 4437, 4456, 4474], 'F': [43, 230, 977, 1281, 1475, 2333, 2358, 2598, 2922], 'RepE,': [45, 232, 972, 2334, 2789, 3881], 'we': [46, 233, 545, 1427, 2453, 2834, 3171, 4030, 4041, 4073, 4113, 4296], 'found': [47, 234, 3605, 3627, 4042], 'using': [49, 236, 1595, 1768, 1997, 2016, 2147, 2193, 2241, 2286, 2393, 2466, 2845, 2889, 3216, 3233, 3442, 3475, 3507, 4009], 'fold-recognition': [50, 237, 2613], 'programs': [51, 238, 2589, 2614], 'shares': [54, 241], 'structural': [55, 242, 2916], 'homology': [56, 243, 1359, 1410, 2150, 2156], 'with': [57, 108, 120, 244, 295, 307, 680, 1053, 1285, 1411, 1419, 1474, 1988, 2066, 2120, 2140, 2234, 2266, 2431, 2459, 2583, 2600, 2608, 2618, 2687, 2707, 2766, 2924, 3330, 3360, 3424, 3461, 3493, 3531, 3587, 3611, 3632, 3648, 3773, 3785, 4018, 4143, 4181, 4216, 4218, 4286, 4306, 4337, 4359, 4375, 4389, 4420, 4500], 'RepE': [58, 66, 158, 245, 253, 345, 1279, 1291, 1361, 1412, 1441, 1477, 1521, 2015, 2073, 2146, 2190, 2236, 2251, 2268, 2326, 2359, 2469, 2510, 2596, 2609, 2623, 2643, 2692, 2695, 2714, 2769, 2857, 2923, 2978, 3591, 3768, 3831, 3838, 4160], 'built': [60, 247], 'model': [62, 94, 130, 249, 281, 317, 1481, 1498, 2134, 2184, 2258, 2412, 2422, 2684, 2763, 2779, 2964, 3077, 3145, 3524, 3697, 3746, 4275, 4429], 'based': [63, 149, 250, 336, 1489], 'on': [64, 150, 251, 337, 1351, 1490, 2035, 2188, 2243, 2361, 2544], 'crystal': [67, 152, 254, 339, 1492, 2323, 2354, 2715, 2854, 2974], 'structure.': [68, 255], 'We': [69, 256, 1468, 2526, 3202, 3571, 3604, 3932, 3967], 'constructed': [70, 257, 1594, 3172, 3572], 'mutants': [71, 86, 138, 258, 273, 325, 1563, 1614, 1652, 1684, 2940, 3046, 3404, 3575, 4316], 'in': [72, 89, 140, 259, 276, 327, 387, 442, 484, 490, 507, 564, 634, 647, 661, 773, 1038, 1051, 1106, 1185, 1283, 1551, 1766, 1863, 1980, 2116, 2420, 2511, 2949, 3048, 3066, 3175, 3178, 3189, 3197, 3256, 3353, 3378, 3395, 3426, 3448, 3513, 3543, 3576, 3599, 3652, 3670, 3683, 3703, 3718, 3895, 3997, 4127, 4298, 4317, 4404, 4414, 4502], 'two': [74, 261, 1318, 1343, 1347, 2166, 2217, 2524, 2793, 3111, 3177, 3577, 3815, 3884], 'predicted': [75, 95, 145, 262, 282, 332, 2590, 3180, 3191, 3375, 3405, 4430], 'domains': [78, 265, 1299, 1319, 1344, 2794, 3025], 'test': [80, 267, 3072, 3168, 3935, 4294], 'model.': [82, 269], 'As': [83, 270, 3242], 'expected,': [84, 271], 'were': [87, 274, 1469, 1532, 1543, 1555, 1593, 1605, 1624, 1642, 1653, 1685, 1757, 1764, 1861, 1891, 1901, 1968, 1978, 1995, 2174, 2239, 2339, 2474, 2636, 2671, 3318, 3820, 4074, 4173, 4256, 4366], 'defective': [88, 139, 275, 326], 'binding.': [92, 279], 'The': [93, 124, 129, 280, 311, 316, 639, 655, 766, 1031, 1097, 1342, 1497, 1647, 1729, 2060, 2106, 2126, 2183, 2211, 2230, 2397, 2719, 2915, 2932, 3021, 3031, 3040, 3757, 3814, 4138, 4167], 'first': [100, 287, 2709, 3775, 3842, 3905, 3959, 3984, 4036, 4148, 4168, 4207, 4235, 4288, 4311, 4326, 4357, 4371, 4386, 4439, 4458, 4476, 4513], 'half': [101, 117, 288, 304, 3776, 3788, 3889, 3906, 3960, 3985, 3992, 4037, 4085, 4149, 4236, 4245, 4289, 4312, 4514], 'site': [105, 292, 459, 537, 3158, 3226, 3963, 3995, 4006, 4059, 4103, 4152, 4203, 4240, 4249, 4410, 4519], 'through': [106, 118, 293, 305, 460, 1903, 3110, 3159, 4328, 4373], 'interactions': [107, 119, 294, 306, 461, 2947, 3115, 4329, 4374], 'C-terminal': [110, 297, 1298, 3024, 3164, 3192, 3763, 3835, 3897, 4279, 4333, 4377], 'domain': [113, 300, 2808, 3766, 3783, 3836, 3847, 4282, 4322, 4336, 4423], 'second': [116, 303, 3787, 3851, 3888, 3991, 4084, 4119, 4155, 4170, 4244, 4418], 'N-terminal': [122, 309, 3161, 3181, 3545, 3552, 3720, 3782, 3846, 3877, 4319, 4422], 'domain.': [123, 310, 4380], 'experiments': [125, 312, 1554, 3098], 'supported': [126, 133, 313, 320], 'prediction.': [128, 315], 'was': [131, 318, 1499, 1524, 1663, 1707, 1734, 1910, 2012, 2063, 2108, 2129, 2185, 2254, 2282, 2291, 2400, 2615, 2758, 3092, 3422, 3440, 3459, 3473, 3491, 3505, 3582, 3623, 4007, 4016, 4050, 4064, 4093, 4108, 4214, 4251, 4447, 4450, 4498, 4520, 4525, 4544], 'further': [132, 319, 4156], 'observation': [136, 323, 4139], 'dimerization': [141, 328], 'map': [142, 329], 'subunit': [146, 333], 'interface': [147, 334], 'region,': [148, 335], 'structure': [153, 340, 1493, 2123, 2171, 2192, 2253, 2324, 2355, 2371, 2690, 2855, 2975, 3758, 3829], 'pPS10': [155, 342, 1137, 2083, 2368, 2437, 2844, 2866, 3016], 'RepA,': [156, 343, 2332, 2436, 2438, 2787, 3176, 3384], 'family': [159, 346, 846, 2470, 2514], 'member.': [160, 347], 'These': [161, 348, 3344, 4462], 'results': [162, 349, 1504, 3345, 3387, 3645, 3691, 4463], 'suggest': [163, 350, 3347, 3714], 'structurally': [167, 354, 1437, 1510, 2797], 'initiators,': [171, 358], 'including': [172, 359], 'those': [173, 360, 1376], 'F,': [175, 362], 'R6K,': [176, 363, 1367, 2079, 2277, 2630, 2840, 3014], 'pSC101,': [177, 364, 1180, 1368, 2080, 2278, 2631, 2841, 3012], 'pCU1,': [178, 365, 1369, 2081, 2279, 2632, 2842, 3013], 'pPS10,': [179, 366, 1370, 2634], 'pFA3,': [180, 367, 1371], 'pGSH500,': [181, 368], 'Rts1,': [182, 369], 'RepHI1B,': [183, 370], 'RepFIB,': [184, 371], 'RSF1010.': [186, 373], 'A': [374, 1815, 1865, 2772, 4507], 'large': [375], 'class': [376, 1442, 1449, 1457, 1514], 'circular': [378], 'double-stranded': [379, 1961, 3219, 3973, 4225, 4509], 'plasmids': [381, 502, 788, 960, 2629], 'contain': [382], 'multiple': [383, 2070, 2620], 'repeated': [384, 632], 'sequences,': [385], 'iterons,': [386, 606], 'their': [388, 497, 1379, 4331, 4376], 'origins': [389], 'specifically': [393, 3251], 'bind': [394, 653, 966, 1243, 1345, 1378, 3629, 4324], 'encoded': [396], 'initiator': [398, 432, 474, 515, 551, 955, 974, 1032, 1105, 1239, 1364, 1445, 1451, 1517, 2076, 2274, 2472, 2626, 2837, 2928, 2959, 3009], 'proteins': [399, 475, 956, 1365, 1377, 1460, 1518, 1733, 2077, 2232, 2275, 2473, 2627, 2838, 2851, 2929, 2960, 3010, 3205, 3317, 3662, 3681, 4552], '(recently': [400], 'reviewed': [401], 'del': [403], 'Solar': [404, 409], 'et': [405, 2732], 'al.,': [406], 'Ref.': [407], '1del': [408], 'G.': [410, 1156], 'Giraldo': [411, 1159], 'R.': [412, 418, 1158, 1160, 2373, 2379, 2876], 'Ruiz-Echevarria': [413], 'M.J.': [414, 2048, 2559], 'Espinosa': [415], 'M.': [416, 809, 823, 1009, 1150, 1253, 1261, 1327, 1390, 1777, 2091, 2306, 2487, 2651, 2741, 2900, 2990, 3799, 3860, 3917], 'Diaz-Orejas': [417, 1157, 2378, 2875], 'Microbiol.': [419], 'Mol.': [420, 575, 593, 997, 1226, 1263, 2050, 2561], 'Biol.': [421, 576, 594, 755, 825, 916, 940, 1063, 1162, 1227, 1264, 1578, 2051, 2384, 2562, 2820], 'Rev.': [422], '1998;': [423, 1265, 1789], '62:': [424], '434-464Crossref': [425], 'PubMed': [426, 580, 598, 695, 710, 731, 763, 803, 815, 872, 926, 950, 1003, 1026, 1073, 1092, 1172, 1214, 1231, 1268, 1337, 1400, 1588, 1677, 1701, 1724, 1792, 2055, 2101, 2206, 2316, 2388, 2497, 2566, 2661, 2751, 2828, 2884, 2910, 3000, 3127, 3140, 3287, 3309, 3809, 3870, 3927], 'Google': [427, 583, 599, 698, 713, 734, 764, 804, 816, 829, 875, 929, 953, 1006, 1029, 1076, 1095, 1175, 1217, 1234, 1271, 1340, 1403, 1591, 1680, 1704, 1727, 1795, 2058, 2104, 2209, 2319, 2391, 2500, 2569, 2664, 2754, 2829, 2887, 2913, 3003, 3128, 3143, 3290, 3312, 3812, 3873, 3930], 'Scholar).': [428, 600, 735, 765, 876, 1030, 1096, 1176, 1235, 1341, 1705, 1728, 2059, 2105, 2210, 2501, 2665, 2830, 2914, 3004, 3313, 3813, 3874, 3931], 'Binding': [429, 512, 1800, 3734, 3740], 'protein': [433, 516, 642, 975, 1857, 1949, 2191, 2252, 2288, 2456, 2586], 'essential': [440, 479], 'step': [441], 'initiation': [444, 2953], 'theta-type': [446], 'triggers': [450], 'assembly': [452], 'complex': [456, 1284], 'at': [457, 1874, 1896, 1955, 1973, 3418, 4094, 4210], 'between': [462, 1316, 1360, 2215, 2522, 3558, 3565, 3725, 4159], 'initiator,': [465], 'host': [466], 'proteins,': [467, 1446, 1452], 'DNA.': [472, 654, 2972, 3090], 'Plasmid': [473], 'are': [476, 487, 780, 1119, 1744, 2418, 2796, 3026, 3038, 3051, 3646, 3729], 'only': [478, 3883], 'for': [480, 782, 790, 836, 984, 1040, 2409, 2937, 3320, 3676, 3731, 3957, 4056, 4100], 'replication,': [482], 'but': [483, 1189, 4046, 4483], 'most': [485], 'cases': [486], 'also': [488, 503, 608, 961, 3624, 3713, 4109, 4464], 'involved': [489, 2948, 3394], 'control': [492, 510, 520, 536, 637], 'autoregulating': [496], 'gene': [498], 'expression.': [499], 'Additionally,': [500], 'some': [501, 3671], 'possess': [504], 'iterons': [505, 969, 1381, 3819], 'located': [506, 615, 4126], 'separate': [508, 3944], 'copy': [509, 527, 623, 636], 'loci.': [511], 'simultaneously': [517], 'locus': [521], 'regulates': [525, 622], 'number': [528, 624], 'mechanism': [531], 'involving': [532, 4330], 'pairing': [533], 'iterons.In': [540], 'work': [542, 2246], 'presented': [543], 'here': [544], 'have': [546, 1128, 4434], 'studied': [547], 'five': [557], 'direct': [558], 'repeats': [559, 619], '19-bp': [562, 1287, 3739, 3978], '(2Abeles': [568], 'A.L.': [569, 3117], 'Snyder': [570], 'K.M.': [571], 'Chattoraj': [572, 3132], 'D.K.': [573, 586, 3133], 'J.': [574, 703, 718, 754, 798, 810, 857, 915, 939, 1062, 1161, 1225, 1255, 1262, 1333, 1396, 1577, 1670, 2049, 2097, 2198, 2312, 2493, 2560, 2657, 2747, 2819, 2879, 2906, 2996, 3122, 3272, 3302, 3805, 3866, 3923], '1984;': [577], '173:': [578], '307-324Crossref': [579], 'Scopus': [581, 696, 711, 732, 873, 927, 951, 1004, 1027, 1074, 1093, 1173, 1215, 1232, 1269, 1338, 1401, 1589, 1678, 1702, 1725, 1793, 2056, 2102, 2207, 2317, 2389, 2498, 2567, 2662, 2752, 2885, 2911, 3001, 3141, 3288, 3310, 3810, 3871, 3928], '(121)': [582], 'Scholar,': [584, 699, 714, 805, 817, 930, 1007, 1077, 1218, 2042, 3129], '3Chattoraj': [585], 'Schneider': [587], 'T.D.': [588], 'Prog.': [589], 'Nucleic': [590, 3134], 'Acids': [591, 3135], 'Res.': [592, 3136], '1997;': [595, 1089], '57:': [596], '145-186Crossref': [597], 'By': [601], 'represses': [609], 'transcription': [610], 'from': [611, 1526, 1534, 1545, 2294, 2611, 2728], 'repA': [613, 791], 'promoter,': [614], 'within': [616, 2678], 'it': [621, 2782, 3390, 3585, 3607, 4393], 'group': [628], 'nine': [630, 4186], 'similar': [631, 1295, 1438, 1511, 2798, 2832, 3685, 4338, 4360, 4390], 'sequences': [633, 1648], 'locus.': [638], 'purified': [640, 1559, 1686, 3203], 'exists': [643], 'as': [644, 963, 970, 1247, 1665, 1687, 1709, 1738, 1746, 1772, 1858, 1950, 2327, 2477, 2858, 3053, 3246, 3393, 3398, 3446, 3480, 3512, 3823, 4262, 4340, 4392, 4531], 'solution': [648], 'unable': [651, 4075], 'action': [656], 'DnaJ': [658, 3296], 'DnaK': [660, 895, 1048, 3298], 'ATP-dependent': [663, 848], 'reaction': [664, 743, 1541, 1809, 1918, 3258], 'converts': [665], 'capable': [674], 'iteron': [679, 1131, 1186, 1246, 1288, 2237, 2269, 3255, 3328, 3665, 3779, 3791, 3892, 3909, 3949, 4134, 4397], 'high': [681, 2603], 'affinity': [682, 3334, 3364, 3615, 3636, 3956, 4049, 4092, 4145, 4339, 4391], '(4Wickner': [683, 1689], 'S.H.': [684, 1690, 1718], 'Proc.': [685, 721, 862, 1016, 1082, 1204, 1691, 1782, 3277], 'Natl.': [686, 722, 863, 1017, 1083, 1205, 1692, 1783, 3278], 'Acad.': [687, 723, 864, 1018, 1084, 1206, 1693, 1784, 3279], 'Sci.': [688, 724, 865, 1019, 1085, 1207, 1694, 1785, 3280], 'U.': [689, 725, 866, 1020, 1086, 1208, 1695, 1786, 3281], 'S.': [690, 701, 716, 726, 753, 821, 851, 853, 867, 914, 934, 938, 1021, 1087, 1209, 1572, 1576, 1668, 1696, 1781, 1787, 3266, 3268, 3282, 3300], 'A.': [691, 727, 868, 1022, 1088, 1152, 1210, 1697, 1788, 2381, 3283], '1990;': [692, 826, 1000, 1698], '87:': [693, 1699], '2690-2694Crossref': [694, 1700], '(70)': [697, 1703], '5Wickner': [700], 'Hoskins': [702, 717, 856, 935, 1573, 1669, 3271, 3301], 'McKenney': [704, 719, 858, 1671, 3273, 3303], 'K.': [705, 720, 807, 819, 859, 1061, 1257, 1331, 1394, 1672, 2095, 2310, 2491, 2655, 2745, 2904, 2994, 3274, 3304, 3803, 3864, 3921], 'Nature.': [706, 1673, 3305], '1991;': [707, 728, 1674, 3306], '350:': [708, 1675, 3307], '165-167Crossref': [709, 1676, 3308], '(158)': [712, 1679, 3311], '6Wickner': [715], '88:': [729], '7903-7907Crossref': [730], '(138)': [733], 'GrpE': [736, 779, 983], 'required': [738, 781, 3674, 4067], 'under': [739, 3482, 4264, 4533], 'conditions': [740], 'where': [741, 2172], 'limited': [745], 'slow': [747], 'nucleotide': [748], 'exchange': [749], '(7Skowyra': [750], 'D.': [751, 855, 1199, 2024, 2533, 3270], 'Wickner': [752, 913, 937, 1575, 1780], 'Chem.': [756, 917, 941, 1064, 1163, 1579, 2821], '1993;': [757], '268:': [758], '25296-25301Abstract': [759], 'Full': [760, 921, 923, 945, 947, 1068, 1070, 1167, 1169, 1583, 1585, 2825], 'Text': [761, 922, 924, 946, 948, 1069, 1071, 1168, 1170, 1584, 1586, 2826], 'PDF': [762, 925, 949, 1072, 1171, 1587, 2827], 'form': [772], 'vivo,': [774], 'since': [775], 'DnaK,': [776, 981], 'DnaJ,': [777, 980], 'stable': [784], 'maintenance': [785], 'promoter': [792], 'repression': [793], '(8Bukau': [794], 'B.': [795, 2200, 2872], 'Walker': [796], 'G.C.': [797], 'Bacteriol.': [799, 811, 2880, 3123], '1989;': [800, 812, 2822, 3124], '171:': [801, 813, 3125], '6030-6038Crossref': [802], '9Tilly': [806], 'Yarmolinsky': [808, 822], '6025-6029Crossref': [814], '10Tilly': [818], 'Sozhamannan': [820], 'New': [824, 1535], '2:': [827], '812-817PubMed': [828], 'Scholar).In': [830], 'vitro': [831, 1039, 1767], 'can': [833, 2783], 'be': [834, 1417, 1436, 2442, 2581, 2640, 2784, 3377, 3407], 'activated': [835, 1037, 4011, 4080], 'ClpA,': [840, 1851, 1943, 4013], 'member': [842], 'Clp/Hsp100': [845], '(11Wickner': [850], 'Gottesman': [852, 3267], 'Skowyra': [854, 3269], 'Maurizi': [860, 1778, 3275], 'M.R.': [861, 1712, 1779, 3276], '1994;': [869, 1023, 1721, 3137, 3284], '91:': [870, 1024, 3285], '12218-12222Crossref': [871, 3286], '(323)': [874, 3289], 'In': [877, 1424, 2165, 3875, 4071, 4426, 4536], 'this': [878, 1425, 2669, 4295, 4347], 'case,': [879], 'activation': [880, 987, 3339, 3369, 3677, 4068], 'conversion': [883, 1140], 'dimers': [886, 900, 964, 1143, 1751, 2338], 'monomers.': [889, 971], 'both': [891, 2507, 3210, 3704, 3752, 4367], 'ClpA': [892, 1706, 1753, 3263, 3341, 3425, 3462, 3467, 3494, 3499, 3675, 4217, 4501], 'chaperone': [896, 1049, 1098, 1117, 3260], 'system': [897, 1050, 1099], 'convert': [898], 'monomers,': [902], 'they': [903, 2800, 4365], 'recognize': [904], 'different': [905], 'regions': [906, 2167, 3650], '(12Hoskins': [909], 'J.R.': [910, 936, 1574, 1775], 'Kim': [911, 1717], 'S.Y.': [912, 932, 1570], '2000;': [918, 2052, 2203, 2563], '275:': [919], '35361-35367Abstract': [920], '(68)': [928], '13Kim': [931], 'Sharma': [933, 1571], '2002;': [942, 1065, 1580], '277:': [943, 1066, 1581], '44778-44783Abstract': [944, 1582], '(39)': [952, 1590], 'Scholar).The': [954, 2755, 3144], 'several': [958, 1116], 'other': [959, 1303, 1421, 2724, 2926, 4178], 'exist': [962], 'yet': [965], 'plasmid,': [978], 'monomerization': [985, 1044], '(14Kawasaki': [991], 'Y.': [992, 1013, 1325, 1388, 2089, 2304, 2485, 2649, 2739, 2898, 2988, 3797, 3858, 3915], 'Wada': [993, 1010, 1328, 1391, 2092, 2307, 2488, 2652, 2742, 2901, 2991, 3800, 3861, 3918], 'C.': [994, 1011, 1154, 1329, 1392, 2093, 2308, 2375, 2489, 2653, 2743, 2902, 2992, 3801, 3862, 3919], 'Yura': [995, 1014], 'T.': [996, 1015, 1148], 'Gen.': [998], 'Genet.': [999], '220:': [1001], '277-282Crossref': [1002], '(69)': [1005, 2390], '15Ishiai': [1008], 'Kawasaki': [1012], '3839-3843Crossref': [1025], '(67)': [1028], 'RK2': [1035, 1104], 'either': [1046, 3262, 3976, 4547], 'combination': [1052], 'ClpB': [1054], 'or': [1055, 1250, 1453, 1854, 1946, 2114, 2676, 3295, 3415, 3431, 3456, 3465, 3488, 3497, 3937, 3989, 4242, 4493, 4550], 'ClpX': [1057], '(16Konieczny': [1058], 'I.': [1059, 1079], 'Liberek': [1060], '18483-18488Abstract': [1067], '(40)': [1075], '17Konieczny': [1078], 'Helinski': [1080], 'D.R.': [1081], '94:': [1090], '14378-14382Crossref': [1091], '(49)': [1094], 'used': [1100, 1550, 2130, 2401, 2527, 2759, 3047, 4114], 'activate': [1102], 'vivo': [1107], 'has': [1108, 2867, 3953], 'been': [1110, 2869], 'identified,': [1111, 2476], 'suggesting': [1112, 4089, 4363, 4400], 'possibility': [1114], 'systems': [1118], 'able': [1120, 1241, 1470], 'carry': [1122], 'out': [1123, 2284], 'reaction.': [1125], 'Recent': [1126], 'studies': [1127, 1273, 3050, 4345], 'suggested': [1129, 3678], 'facilitates': [1138], 'monomers': [1146, 2351], '(18Diaz-Lopez': [1147], 'Lages-Gonzalo': [1149], 'Serrano-Lopez': [1151], 'Alfonso': [1153], 'Rivas': [1155], '2003;': [1164, 2385, 2881], '278:': [1165], '18606-18616Abstract': [1166], '(50)': [1174], 'For': [1177], 'binding,': [1188, 1808, 3322], 'monomer-dimer': [1191], 'transition': [1192], 'independent': [1194], '(19Manen': [1198], 'Upegui-Gonzalez': [1200], 'L.C.': [1201], 'Caro': [1202], 'L.': [1203, 2030, 2539], '1992;': [1211], '89:': [1212], '8923-8927Crossref': [1213], '(42)': [1216], '20Ingmer': [1219], 'H.': [1220, 1321, 1384, 2085, 2300, 2481, 2645, 2735, 2894, 2984, 3793, 3854, 3911], 'Fong': [1221], 'E.L.': [1222], 'Cohen': [1223], 'S.N.': [1224], '1995;': [1228], '250:': [1229], '309-314Crossref': [1230], '(22)': [1233], 'Interestingly,': [1236], 'R6K': [1238, 2336, 2349, 2433], 'its': [1245], '(21Urh': [1252], 'Wu': [1254], 'Forest': [1256], 'Inman': [1258], 'R.B.': [1259, 2026, 2535], 'Filutowicz': [1260], '283:': [1266], '619-631Crossref': [1267], '(33)': [1270], 'Scholar).Structural': [1272], 'monomeric': [1276, 1495], 'mutant': [1277, 1856, 1948, 3316, 3661, 4551], 'demonstrated': [1289, 3832], 'consists': [1292], 'topologically': [1294], 'N-': [1296, 3022], 'related': [1300, 2641], 'each': [1302, 2362], 'internal': [1305], 'pseudo': [1306], '2-fold': [1307, 2017, 2528], 'symmetry,': [1308], 'despite': [1309], 'lack': [1311], 'amino': [1313, 2463, 2575, 2701, 2710, 2804], 'acid': [1314, 1358, 2464, 2576, 2702, 2711, 2805], 'similarity': [1315, 2521, 2917, 4158], '(22Komori': [1320, 1383, 2084, 2299, 2480, 2644, 2734, 2893, 2983, 3792, 3853, 3910], 'Matsunaga': [1322, 1385, 2086, 2301, 2482, 2646, 2736, 2895, 2985, 3794, 3855, 3912], 'F.': [1323, 1386, 2087, 2302, 2483, 2647, 2737, 2896, 2986, 3795, 3856, 3913], 'Higuchi': [1324, 1387, 2088, 2303, 2484, 2648, 2738, 2897, 2987, 3796, 3857, 3914], 'Ishiai': [1326, 1389, 2090, 2305, 2486, 2650, 2740, 2899, 2989, 3798, 3859, 3916], 'Miki': [1330, 1393, 2094, 2309, 2490, 2654, 2744, 2903, 2993, 3802, 3863, 3920], 'EMBO': [1332, 1395, 2096, 2311, 2492, 2656, 2746, 2905, 2995, 3804, 3865, 3922], '1999;': [1334, 1397, 2098, 2313, 2494, 2658, 2748, 2907, 2997, 3806, 3867, 3924], '18:': [1335, 1398, 2099, 2314, 2495, 2659, 2749, 2908, 2998, 3807, 3868, 3925], '4597-4607Crossref': [1336, 1399, 2100, 2315, 2496, 2660, 2750, 2909, 2999, 3808, 3869, 3926], '(77)': [1339, 1402, 2103, 2318, 2499, 2663, 2753, 2912, 3002, 3811, 3872, 3929], 'consecutive': [1348, 3112], 'major': [1349, 3113, 3152], 'grooves': [1350], 'one': [1352, 3086, 3105, 3188], 'face': [1353, 3087, 3106], 'helix.': [1356], 'Amino': [1357], 'pGSH500': [1373], 'suggests': [1374, 4157], 'respective': [1380], 'similarly': [1382, 2285, 2594], 'Scholar).P1': [1404], 'does': [1406, 4485], 'share': [1408, 2803], 'could': [1414, 2580], 'initially': [1416], 'aligned': [1418, 2013], 'initiators.': [1423], 'study': [1426], 'addressed': [1428], 'question': [1430], 'whether': [1432, 3936, 3951], 'might': [1435, 4323], 'another': [1448], 'known': [1456], 'fold': [1462, 2593], 'prediction': [1463, 3080], 'analysis': [1464], 'modeling.': [1467], 'align': [1472, 2698], 'generate': [1479, 2403], 'bound': [1486, 2261, 2961, 2970, 2980, 3017, 3250, 3326, 3357, 3608, 3663, 4355, 4384, 4394], 'RepE.': [1496, 2125], 'tested': [1500, 3319, 3574, 3583, 3625], 'experimentally': [1501], 'our': [1503, 2846], 'indicate': [1505, 3388], 'which': [1520, 2635], 'belongs.EXPERIMENTAL': [1522], 'PROCEDURESMaterials—ATP': [1523], 'obtained': [1525, 1533, 1544, 2062, 2610], 'Roche': [1527], 'Applied': [1528], 'Science.': [1529], 'Restriction': [1530], 'endonucleases': [1531], 'England': [1536], 'BioLabs': [1537], 'polymerase': [1539], 'chain': [1540], 'reagents': [1542], 'PerkinElmer': [1546], 'Life': [1547], 'Sciences.': [1548], 'Oligonucleotides': [1549], 'synthesized': [1556], 'PAGE': [1558], 'Sigma': [1561], 'Genosys.Plasmids—Site-directed': [1562], 'wild-type': [1565, 4332, 4341, 4353, 4442, 4494, 4549], 'RepA-His6': [1568], '(13Kim': [1569], 'Scholar)': [1592, 2320, 2392, 2551, 2888], 'QuickChange': [1597], 'mutagenesis': [1598], 'kit': [1599], '(Stratagene).': [1600], 'His134': [1602], 'Gly156': [1604], 'Asn': [1608], 'Val,': [1610], 'respectively,': [1611], 'generating': [1612, 1628, 2256], 'point': [1613], 'RepA(H134N)': [1615], 'RepA(G156V).': [1617], 'Lys88,': [1618], 'Lys128,': [1619], 'Arg130,': [1620], 'Arg245,': [1621], 'Arg269': [1623], 'alanines,': [1627], 'RepA(K88A),': [1629], 'RepA(K128A),': [1630], 'RepA(R130A),': [1631, 3186], 'RepA(R245A),': [1632], 'RepA(R269A).': [1634], 'To': [1635, 3167, 4293], 'make': [1636, 3529], 'RepA(3M),': [1637], 'H134N,': [1638], 'G156V,': [1639], 'N142K': [1641], 'introduced': [1643], 'megaprimer': [1645], 'PCR.': [1646], 'all': [1650, 1732], 'verified': [1654], 'sequencing.': [1657], '[3H]oriP1': [1658, 1886], '(3590': [1661, 1889], 'cpm/fmol)': [1662, 1890], 'prepared': [1664, 1963], 'described': [1666, 1688, 1773, 3447, 3481, 4263, 4532], '(5Wickner': [1667, 3299], 'Scholar).Proteins—RepA': [1681], 'isolated': [1708], 'reported': [1710, 2479], '(23Maurizi': [1711], 'Thompson': [1713], 'M.W.': [1714], 'Singh': [1715], 'S.K.': [1716], 'Methods': [1719], 'Enzymol.': [1720], '244:': [1722], '314-331Crossref': [1723], '(136)': [1726], 'purity': [1730], 'greater': [1735], 'than': [1736, 3616, 3637, 3780, 3964, 4054, 4098, 4153, 4441], '95%': [1737], 'determined': [1739, 1758], 'SDS-PAGE.': [1741], 'Protein': [1742, 1755, 2201], 'concentrations': [1743, 1756, 3420, 4212], 'expressed': [1745], 'molar': [1747], 'amounts': [1748], 'hexamers.': [1754], 'Bradford': [1760], 'assay': [1761, 3215, 3232, 3445, 3479, 3511, 4261, 4530], '(Bio-Rad).': [1762], 'Proteins': [1763, 1860], '3H-labeled': [1765], 'succinimidyl': [1769], 'propionate,': [1770], 'N-[propionate-2,3-3H]': [1771], '(24Hoskins': [1774], 'Pak': [1776], '95:': [1790], '12135-12140Crossref': [1791], '(123)': [1794], 'Scholar).RepA': [1796], 'Activation': [1797], 'Assays—For': [1801], 'measuring': [1802, 1912], 'nitrocellulose': [1806, 1904, 3229, 3476, 3508], 'filter': [1807, 3230, 3477, 3509], 'mixtures': [1810, 1900, 1919], '(20': [1811, 1816, 1920], 'μl)': [1812, 1921], 'contained': [1813, 1922], 'Buffer': [1814, 1864, 1923], 'mm': [1817, 1822, 1825, 1828, 1834, 1837, 1926, 1929], 'Tris-HCl,': [1818], 'pH': [1819], '7.5,': [1820], '100': [1821, 1839, 1931], 'KCl,': [1823], '5': [1824, 1894, 1928], 'dithiothreitol,': [1826], '0.1': [1827], 'EDTA,': [1829], '10%': [1830, 3332], 'glycerol': [1831], '(v/v)),': [1832], '10': [1833, 1872, 1883, 1925, 1971], 'MgOAc,': [1835, 1927], '1': [1836, 3199, 3601], 'ATP,': [1838, 1930, 4540], 'μg/ml': [1840, 1932], 'bovine': [1841, 1933], 'serum': [1842, 1934], 'albumin,': [1843, 1935], '0.005%': [1844, 1936], 'Triton': [1845, 1868, 1937], 'X-100': [1846, 1869, 1938], '(v/v),': [1847, 1939], '0.5': [1848], 'pmol': [1849, 1941, 1959], 'indicated.': [1859, 1951], 'diluted': [1862], 'containing': [1866, 3221, 3236, 3666, 3975, 4117, 4227, 4511], '0.05%': [1867], '(v/v).': [1870], 'After': [1871, 1952, 1970], 'min': [1873, 1895, 1954, 1972], '24': [1875, 1956], '°C,': [1876, 1898, 1957, 1975], 'calf': [1877], 'thymus': [1878], '(1': [1880], 'μg)': [1881], 'fmol': [1884], 'added.': [1892, 1969], 'Following': [1893], '0': [1897, 1974], 'filtered': [1902], 'filters,': [1905], 'retained': [1908], 'radioactivity': [1909], 'measured.For': [1911], 'gel': [1916, 3213, 3443, 4259, 4528], 'retardation,': [1917], 'A,': [1924], '0.64': [1940], '20': [1953], '2.5': [1958], 'oligonucleotide,': [1962], 'annealing': [1965], 'complementary': [1966], 'oligonucleotides,': [1967], 'samples': [1977], 'electrophoresed': [1979], '8%': [1981], 'polyacrylamide': [1982], 'Tris': [1983], 'borate/EDTA': [1984], 'gels': [1985], 'stained': [1987], 'SYBR': [1989], 'green': [1990], '(Molecular': [1991], 'Probes).': [1992], 'Band': [1993], 'intensities': [1994], 'quantified': [1996], '300-nm': [1998], 'transillumination': [1999], 'Eagle': [2002], 'Eye': [2003], 'II': [2004], '(Stratagene)': [2005], 'image': [2006, 3060, 3521, 4193, 4272, 4561], 'acquisition': [2007], 'system.Molecular': [2008], 'Modeling': [2009, 2271, 2446], 'RepA—RepA': [2011], 'recognition': [2018, 2529, 3182, 3193, 3381, 3541, 3707, 3878, 3898], 'programs,': [2019, 2530], 'bioinbgu': [2020, 2531], '3D-PSSM': [2022, 2553], '(25Fischer': [2023, 2532], 'Altman': [2025, 2534], 'Dunker': [2027, 2536], 'A.K.': [2028, 2537], 'Hunter': [2029, 2538], 'Klein': [2031, 2540], 'T.E.': [2032, 2541], 'Pacific': [2033, 2542], 'Symposium': [2034, 2543], 'Biocomputing.': [2036, 2545], 'World': [2037, 2546], 'Scientific,': [2038, 2547], 'Teaneck,': [2039, 2548], 'NJ2000:': [2040, 2549], '119-130Google': [2041, 2550], '26Kelley': [2043], 'L.A.': [2044, 2555], 'MacCallum': [2045, 2556], 'R.M.': [2046, 2557], 'Sternberg': [2047, 2558], '299:': [2053, 2564], '499-520Crossref': [2054, 2565], '(1120)': [2057, 2568], 'alignment': [2061, 2071, 2107, 2128, 2289, 2298, 2621, 2670, 2721, 2757, 2777, 2848, 2892], 'combined': [2064, 2616], 'manually': [2065, 2109, 2617], 'previously': [2068, 2296, 2478, 2637, 2868, 3247], 'published': [2069, 2297, 2891], 'adjusted': [2110, 2720], 'eliminate': [2112], 'breaks': [2113, 2675], 'insertions': [2115, 2677], 'secondary': [2117, 2680], 'structures': [2118, 2681], 'compared': [2119, 2686, 3968], 'x-ray': [2122, 2170, 2689], 'final': [2127, 2756], 'build': [2132, 2761], 'reference': [2141, 2767], 'automated': [2149], 'modeling': [2151, 2157], 'program,': [2152], 'modeler,': [2153], 'option': [2158], 'InsightII': [2161, 2242], 'program': [2162, 2178, 2195, 2395, 2398], '(Accelrys,': [2163], 'Inc.).': [2164], 'there': [2173, 4449], 'gaps,': [2175], 'modeler': [2177], 'inserted': [2179], 'corresponding': [2181], 'residues.': [2182], 'then': [2186, 2249], 'superimposed': [2187, 2231], 'Sheba': [2196], '(27Jung': [2197], 'Lee': [2199], 'Eng.': [2202], '13:': [2204], '535-543Crossref': [2205], '(100)': [2208], 'root': [2212], 'mean-squared': [2213], 'deviation': [2214], 'molecules': [2218], '1.1': [2220], 'Å': [2221], 'over': [2222], '191': [2223], '211': [2225], 'Cα': [2226], 'atoms': [2227], 'along': [2233], 'displayed': [2240], 'SGI': [2245], 'station': [2247], 'removed,': [2255], '23-bp': [2264], 'oligonucleotide': [2265, 3220, 4116, 4226, 4510], 'sequence.': [2270], 'pSP10': [2281], 'carried': [2283], 'slightly': [2292, 2727], 'modified': [2293], 'template.Illustrations': [2329], 'pi': [2337, 2350], 'made': [2340, 4174], 'superimposing': [2342], 'models': [2344, 2427, 2933, 3006], 'protomers': [2365], '(28Giraldo': [2372], 'Fernandez-Tornero': [2374], 'Evans': [2376], 'P.R.': [2377], 'Romero': [2380], 'Nat.': [2382], 'Struct.': [2383], '10:': [2386], '565-571Crossref': [2387], 'Sheba.': [2396], 'Molscript': [2399], 'ribbon': [2405], 'diagrams.The': [2406], 'atomic': [2407], 'coordinates': [2408], 'deposited': [2419], 'data': [2423, 2457, 2518, 3759], 'base': [2424, 2458], '(www.rcsb.org/pdb).': [2425], 'Molecular': [2426], 'DNA,': [2432, 3019, 3109, 3667], 'pi,': [2434], 'pSC101': [2435], 'pCU1': [2440], 'will': [2441], 'provided': [2443], 'upon': [2444], 'request.RESULTSMolecular': [2445], 'Bound': [2450], 'DNA—When': [2452], 'queried': [2454], 'blastp,': [2467], 'However,': [2502], 'Pfam': [2504, 2517], 'search': [2505], 'placed': [2506], 'Rep3': [2513], 'base,': [2519], 'indicating': [2520], 'proteins.': [2525], '(26Kelley': [2554], 'Scholar),': [2570], 'determine': [2572], 'if': [2573], 'identified': [2582], 'any': [2584], 'existing': [2585], 'folds.': [2587], 'Both': [2588, 3642, 4350], 'medium': [2601], 'confidence.': [2604], 'Alignment': [2605], 'shown': [2638, 3052], 'Manual': [2666], 'adjustments': [2667], 'done': [2672], 'avoid': [2674], 'when': [2685, 4112], '(Fig.': [2693, 2770, 2861, 3342, 3370, 3620, 3640, 4027, 4060, 4104, 4348, 4398, 4460], '1).': [2694], 'such': [2699], '71': [2703], 'aligns': [2706, 3586], 'structure,': [2716], 'residue': [2717], '15.': [2718], 'initiators': [2725], 'differs': [2726], 'Komori': [2731], 'al.': [2733], '2,': [2771, 2862], 'B).': [2774], 'From': [2775], 'seen': [2785, 4017], 'like': [2788], 'composed': [2791], 'although': [2799, 4305], 'do': [2801], 'homology.': [2806], 'Each': [2807], 'contains': [2809], 'HTH': [2811, 3165], 'motif': [2814], '(29Brennan': [2815], 'R.G.': [2816], 'Matthews': [2817], 'B.W.': [2818], '264:': [2823], '1903-1906Abstract': [2824], 'Using': [2831], 'methods,': [2833], 'modeled': [2835, 2870], 'refined': [2847], 'template': [2860], 'C-F).': [2863], '(30Maestro': [2871], 'Sanz': [2873], 'J.M.': [2874], 'Fernandez-Tresguerres': [2877], 'E.': [2878], '185:': [2882], '1367-1375Crossref': [2883], '(34)': [2886], 'apparent.': [2931], 'provide': [2934], 'useful': [2935], 'tools': [2936], 'designing': [2938], 'site-directed': [2939, 3041, 3173], 'elucidate': [2942], 'protein-protein': [2944], 'protein-DNA': [2946, 3771], 'process': [2951], 'replication.Fig.': [2956], '2Models': [2957], 'DNA.A,': [2963], 'B,': [2973, 3451], 'C-F,': [3005], 'respectively.': [3020, 3030], 'blue': [3027], 'yellow,': [3029], 'helices,': [3034, 3708], 'α4': [3035, 3709], 'α4′,': [3037, 3900], 'red.': [3039], 'these': [3049, 3579, 3644, 3649, 3690], 'balls.View': [3054], 'Large': [3055, 3516, 4188, 4267, 4556], 'Image': [3056, 3517, 4189, 4268, 4557], 'Figure': [3057, 3518, 4190, 4269, 4558], 'ViewerDownload': [3058, 3519, 4191, 4270, 4559], 'Hi-res': [3059, 3520, 4192, 4271, 4560], 'Download': [3061, 3522, 4194, 4273, 4562], '(PPT)Site-directed': [3062], 'Mutants': [3064], 'Defective': [3065], 'Binding—We': [3068], 'next': [3069], 'wanted': [3070, 3933], 'validity': [3074, 3694, 4467], 'experimentally.': [3078], 'One': [3079], 'This': [3091], 'confirmed': [3093, 4346], 'previous': [3095], 'footprinting': [3097], 'showing': [3099], 'exclusively': [3103], 'groove': [3114, 3153], '(31Abeles': [3116], 'Reaves': [3118], 'L.D.': [3119], 'Austin': [3120], 'S.J.': [3121], '43-52Crossref': [3126], '32Papp': [3130], 'P.P.': [3131], '22:': [3138], '152-157Crossref': [3139], '(14)': [3142], 'predicts': [3146, 3525, 3747, 4276], 'should': [3149, 3528, 3750], 'contact': [3150, 3751, 3886, 3903], 'motif.': [3166], 'model,': [3170], 'mutations': [3174], 'helix,': [3183, 3194, 3899], 'RepA(K128A)': [3184, 3356, 3454], 'RepA(R245A)': [3195, 3325, 3416, 4432, 4455, 4484, 4490], '(indicated': [3196], 'Figs.': [3198, 3600], '2A).': [3201], 'measured': [3207, 3441, 3474, 3506, 4008, 4031], 'shift': [3214, 3444, 4260, 4529], '33-bp': [3218, 3972, 4224, 4508], 'consensus': [3224, 3254, 3979, 4005, 4200], 'replication.': [3241], 'control,': [3244], 'seen,': [3248], 'requiring': [3259], 'activation,': [3261], '(Ref.': [3264], '11Wickner': [3265], 'Scholar': [3291], 'Fig.': [3293, 3514, 3998], '3)': [3294], 'When': [3314, 4000, 4029, 4444], 'RepA(R130A)': [3323, 3413, 4351, 4383, 4487], 'about': [3331, 3361, 3612, 3633, 4051], 'wild': [3336, 3366, 3618, 3638, 3687], 'type': [3337, 3367, 3619, 3639], 'following': [3338, 4300], '3A).': [3343], 'strongly': [3346], 'Arg130': [3349], 'Arg245': [3351], 'participate': [3352], 'RepA-DNA': [3354, 4254], 'interactions.': [3355], 'oriP1': [3358, 3609, 3630], '60%': [3362, 3613], 'after': [3368], '3B).': [3371, 3621], 'Lys128': [3373], 'helix': [3382, 3879], 'biochemical': [3386], 'Arg130.Fig.': [3399], '3DNA': [3400], 'defective.A,': [3410], '(diamonds),': [3412, 3453], '(squares),': [3414, 3455], '(triangles),': [3417], 'indicated,': [3421], 'incubated': [3423, 3460, 3492, 4215, 4499], 'presence': [3428, 4504], '(closed': [3429, 4488, 4491, 4496], 'symbols)': [3430, 3434, 3464, 3496], 'absence': [3432, 4538], '(open': [3433, 3468, 3500], 'ATP': [3436], '"Experimental': [3449, 3483, 4265, 4534], 'Procedures."': [3450, 3484, 4535], 'RepA(K88A)': [3457, 3581], '(circles)': [3458], '(filled': [3463, 3495], 'without': [3466, 3498, 4220], 'symbols),': [3469, 3501], 'C,': [3485], '(diamonds)': [3487], 'RepA(R269A)': [3489, 3622], '(triangles)': [3490], '3B.View': [3515], '(PPT)The': [3523, 4274, 4563], 'contacts': [3530, 3593, 3772], 'phosphate': [3533, 3595], 'backbone': [3534], 'outside': [3538], 'helices': [3542], 'region': [3546, 3553, 3721], 'α2': [3548, 3723], '(residues': [3549, 3556, 3562, 3569], '87-89),': [3550], 'α2′': [3555], '204-206),': [3557], 'β3': [3559], 'β4': [3561], '170-173),': [3563], 'β3′': [3566, 3726], 'β4′': [3568, 3728], '266-269).': [3570], 'regions.': [3580], 'because': [3584], 'arginine': [3589], 'backbone,': [3596], 'R33': [3597], '(shown': [3598, 3996], '2).': [3603], 'lower': [3614, 3635, 4053, 4097, 4307], '25%': [3634], '3C).': [3641], 'consistent': [3647], 'being': [3651], 'close': [3653], 'proximity': [3654], 'DNA.The': [3657], 'observations': [3658], 'albeit': [3668], 'poorly': [3669], 'cases,': [3672], 'folded': [3682], 'conformations': [3684], 'type.': [3688], 'Thus': [3689], 'support': [3692, 4465], 'importance': [3700], 'residues': [3702, 3717, 3885, 3902], 'α4′.': [3711], 'They': [3712], 'important': [3730], 'binding.DNA': [3733], 'Site': [3741], 'Half-Sites—The': [3745], 'halves': [3753, 3816, 3945], 'iteron.': [3756, 4292], 'shows': [3760], 'makes': [3769, 3784], 'stronger': [3770], 'referred': [3821], '"first"': [3824], '"second"': [3826], 'before': [3827], 'half-site': [3843, 3852, 4120, 4171, 4179, 4327, 4358, 4372, 4387, 4419, 4440, 4459, 4477], 'α4,': [3882], 'directly': [3893], 'while': [3894], 'four': [3901], 'higher': [3955, 4144], 'second.': [3966], 'oligonucleotides': [3974, 4165, 4172], 'site,': [3982, 3988, 4232, 4482], '4).': [3999], '50%': [4014], 'retardation': [4015], '80': [4019], 'nm': [4020, 4024], '125': [4023], 'fragment': [4026], '5A).': [4028], 'iteron,': [4040, 4088, 4315], 'bound,': [4045], 'apparent': [4048], '60-fold': [4052], 'full': [4058, 4102, 4229, 4396, 4409], '5B).': [4061], 'specific': [4065], 'ClpA.': [4070], 'contrast': [4072], 'detect': [4077], 'least': [4095], '300-fold': [4096], '5C).': [4105], 'detected': [4111, 4257, 4526, 4545], 'plus': [4121], 'T': [4123], 'middle': [4129], '19': [4132], 'bp': [4133], '(data': [4135, 4553], 'shown).': [4137], 'RepA.Fig.': [4162], '4Double-stranded': [4163], 'used.': [4166], 'replacing': [4176], 'random': [4183], 'bp.View': [4187], '(PPT)Fig.': [4195], '5RepA': [4196], 'half-site.': [4208], 'indicated': [4213], 'ATP.': [4221, 4506], 'Then': [4222], '(A),': [4233], '(B),': [4241], '(C),': [4250], 'added,': [4252, 4521], 'complexes': [4255], 'Procedures."View': [4266], 'interacts': [4285], 'reasoned': [4297], 'way.': [4301], 'Since': [4302], 'binds,': [4304], 'affinity,': [4308, 4362], '6).': [4349, 4461], 'relative': [4361], 'Moreover': [4381], '3),': [4399], 'defect': [4403, 4413], 'reflects': [4411], 'interaction': [4415], 'addition,': [4427], 'would': [4433], 'weaker': [4435], 'tested,': [4448], 'no': [4451, 4541], 'detectable': [4452], 'model.Fig.': [4471], '6RepA(R130A)': [4472], 'not.': [4486], 'squares),': [4489], 'triangles),': [4492], 'diamonds)': [4497], 'shown).View': [4555]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2003371514', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2025-01-09T14:58:51.979152', 'created_date': '2016-06-24'}
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