Title: Effect of propranolol on the factors promoting bacterial translocation in cirrhotic rats with ascites
Abstract: HepatologyVolume 31, Issue 1 p. 43-48 Original ArticleFree Access Effect of propranolol on the factors promoting bacterial translocation in cirrhotic rats with ascites María Pérez-Paramo, María Pérez-Paramo Divisions of Nuclear Medicine Clínica Puerta de Hierro, Madrid, SpainSearch for more papers by this authorJavier Muñoz, Javier Muñoz Divisions of Gastroenterology, Clínica Puerta de Hierro, Madrid, SpainSearch for more papers by this authorAgustín Albillos M.D., Corresponding Author Agustín Albillos M.D. [email protected] Divisions of Division of Gastroenterology, Hospital Ramón y Cajal, Department of Medicine, University of Alcalá, Madrid, SpainDept. de Medicina, Facultad de Medicina-Campus Universitario, Universidad de Alcalá, Ctra. Madrid-Barcelona, km. 33.600. 28871 Alcalá de Henares, Madrid, Spain===Search for more papers by this authorIsabel Freile, Isabel Freile Divisions of Nuclear Medicine Clínica Puerta de Hierro, Madrid, SpainSearch for more papers by this authorFrancisca Portero, Francisca Portero Divisions of Microbiology Clínica Puerta de Hierro, Madrid, SpainSearch for more papers by this authorMartín Santos, Martín Santos Divisions of Experimental Surgery, Clínica Puerta de Hierro, Madrid, SpainSearch for more papers by this authorJosé Ortiz-Berrocal, José Ortiz-Berrocal Divisions of Experimental Surgery, Clínica Puerta de Hierro, Madrid, SpainSearch for more papers by this author María Pérez-Paramo, María Pérez-Paramo Divisions of Nuclear Medicine Clínica Puerta de Hierro, Madrid, SpainSearch for more papers by this authorJavier Muñoz, Javier Muñoz Divisions of Gastroenterology, Clínica Puerta de Hierro, Madrid, SpainSearch for more papers by this authorAgustín Albillos M.D., Corresponding Author Agustín Albillos M.D. [email protected] Divisions of Division of Gastroenterology, Hospital Ramón y Cajal, Department of Medicine, University of Alcalá, Madrid, SpainDept. de Medicina, Facultad de Medicina-Campus Universitario, Universidad de Alcalá, Ctra. Madrid-Barcelona, km. 33.600. 28871 Alcalá de Henares, Madrid, Spain===Search for more papers by this authorIsabel Freile, Isabel Freile Divisions of Nuclear Medicine Clínica Puerta de Hierro, Madrid, SpainSearch for more papers by this authorFrancisca Portero, Francisca Portero Divisions of Microbiology Clínica Puerta de Hierro, Madrid, SpainSearch for more papers by this authorMartín Santos, Martín Santos Divisions of Experimental Surgery, Clínica Puerta de Hierro, Madrid, SpainSearch for more papers by this authorJosé Ortiz-Berrocal, José Ortiz-Berrocal Divisions of Experimental Surgery, Clínica Puerta de Hierro, Madrid, SpainSearch for more papers by this author First published: 30 December 2003 https://doi.org/10.1002/hep.510310109Citations: 185AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Bacterial translocation appears to be an important mechanism in the pathogenesis of spontaneous infections in cirrhosis. Cirrhotic patients are commonly treated with β-adrenoceptor blockers, but the impact of this treatment in the factors promoting bacterial translocation has not been investigated. This study was aimed at investigating in cirrhotic rats with ascites the effect of propranolol on intestinal bacterial load, transit, and permeability of the bowel and on the rate of bacterial translocation. Bacterial translocation to mesenteric lymph nodes and intestinal bacterial overgrowth, permeability (urinary excretion of 99mTc-diethylenetriaminepentaacetic acid [99mTc-DTPA]), and transit (geometric center ratio of 51Cr) were assessed in 29 rats with carbon tetrachloride (CCl4 ) cirrhosis and 20 controls. These variables were then measured in 12 placebo- and in 13 propranolol-treated ascitic cirrhotic rats. Bacterial translocation was present in 48% of the cirrhotic rats and in none of the controls. Cirrhotic rats with intestinal bacterial overgrowth had a significantly higher rate of translocation and slower intestinal transit than those without it. Among the 15 rats with overgrowth and a 99mTc-DTPA excretion greater than 10%, 15 had translocation and 2 had bacterial peritonitis. Only 1 of the 14 rats with either intestinal overgrowth or a 99mTc-DTPA excretion greater than 10% presented translocation. Compared with the placebo group, propranolol-treated animals had significantly lower portal pressure, faster intestinal transit, and lower rates of bacterial overgrowth and translocation. In ascitic cirrhotic rats, bacterial translocation results from intestinal overgrowth and severe damage to gut permeability. In this setting, intestinal overgrowth is associated with intestinal hypomotility. Propranolol accelerates the intestinal transit, decreasing the rates of bacterial overgrowth and translocation. Citing Literature Volume31, Issue1January 2000Pages 43-48 ReferencesRelatedInformation
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 256
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