Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2003260510', 'doi': 'https://doi.org/10.1074/jbc.m109.021832', 'title': 'Naturally Occurring Mutations Alter the Stability of Polycystin-1 Polycystic Kidney Disease (PKD) Domains', 'display_name': 'Naturally Occurring Mutations Alter the Stability of Polycystin-1 Polycystic Kidney Disease (PKD) Domains', 'publication_year': 2009, 'publication_date': '2009-09-17', 'ids': {'openalex': 'https://openalex.org/W2003260510', 'doi': 'https://doi.org/10.1074/jbc.m109.021832', 'mag': '2003260510', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19759016', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2781709'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m109.021832', 'pdf_url': 'http://www.jbc.org/article/S0021925820378868/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820378868/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102783696', 'display_name': 'Liang Ma', 'orcid': 'https://orcid.org/0000-0002-0509-4937'}, 'institutions': [{'id': 'https://openalex.org/I4210093127', 'display_name': 'MRC Laboratory for Molecular Cell Biology', 'ror': 'https://ror.org/00fv61j67', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I4210087105', 'https://openalex.org/I4210093127', 'https://openalex.org/I45129253', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Liang Ma', 'raw_affiliation_strings': ['Department of Neuroscience and Cell Biology, MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience and Cell Biology, MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW, United Kingdom', 'institution_ids': ['https://openalex.org/I4210093127']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110128282', 'display_name': 'Meixiang Xu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210093127', 'display_name': 'MRC Laboratory for Molecular Cell Biology', 'ror': 'https://ror.org/00fv61j67', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I4210087105', 'https://openalex.org/I4210093127', 'https://openalex.org/I45129253', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Meixiang Xu', 'raw_affiliation_strings': ['Department of Neuroscience and Cell Biology, MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience and Cell Biology, MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW, United Kingdom', 'institution_ids': ['https://openalex.org/I4210093127']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109390398', 'display_name': 'Julia Forman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Julia R. Forman', 'raw_affiliation_strings': ['Cambridge University Chemical Laboratory, MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Cambridge University Chemical Laboratory, MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW, United Kingdom', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020633703', 'display_name': 'Jane Clarke', 'orcid': 'https://orcid.org/0000-0002-7921-900X'}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Jane Clarke', 'raw_affiliation_strings': ['Cambridge University Chemical Laboratory, MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Cambridge University Chemical Laboratory, MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW, United Kingdom', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5008627573', 'display_name': 'Andrés F. Oberhauser', 'orcid': 'https://orcid.org/0000-0001-7375-7109'}, 'institutions': [{'id': 'https://openalex.org/I55302922', 'display_name': 'The University of Texas Medical Branch at Galveston', 'ror': 'https://ror.org/016tfm930', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55302922']}, {'id': 'https://openalex.org/I4210093127', 'display_name': 'MRC Laboratory for Molecular Cell Biology', 'ror': 'https://ror.org/00fv61j67', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I4210087105', 'https://openalex.org/I4210093127', 'https://openalex.org/I45129253', 'https://openalex.org/I90344618']}], 'countries': ['GB', 'US'], 'is_corresponding': True, 'raw_author_name': 'Andres F. Oberhauser', 'raw_affiliation_strings': ['Department of Neuroscience and Cell Biology, MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW, United Kingdom', 'Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas 77555'], 'affiliations': [{'raw_affiliation_string': 'Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas 77555', 'institution_ids': ['https://openalex.org/I55302922']}, {'raw_affiliation_string': 'Department of Neuroscience and Cell Biology, MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW, United Kingdom', 'institution_ids': ['https://openalex.org/I4210093127']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5008627573'], 'corresponding_institution_ids': ['https://openalex.org/I55302922', 'https://openalex.org/I4210093127'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 1.854, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 23, 'citation_normalized_percentile': {'value': 0.765932, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '284', 'issue': '47', 'first_page': '32942', 'last_page': '32949'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11412', 'display_name': 'Genetic and Kidney Cyst Diseases', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11412', 'display_name': 'Genetic and Kidney Cyst Diseases', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12140', 'display_name': 'Renal and related cancers', 'score': 0.9872, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pkd1', 'display_name': 'PKD1', 'score': 0.8075324}, {'id': 'https://openalex.org/keywords/ectodomain', 'display_name': 'Ectodomain', 'score': 0.49622446}], 'concepts': [{'id': 'https://openalex.org/C2776266639', 'wikidata': 'https://www.wikidata.org/wiki/Q2732398', 'display_name': 'Autosomal dominant polycystic kidney disease', 'level': 3, 'score': 0.88773483}, {'id': 'https://openalex.org/C2780145431', 'wikidata': 'https://www.wikidata.org/wiki/Q15443105', 'display_name': 'Polycystic kidney disease', 'level': 3, 'score': 0.82233185}, {'id': 'https://openalex.org/C100773827', 'wikidata': 'https://www.wikidata.org/wiki/Q82302467', 'display_name': 'PKD1', 'level': 4, 'score': 0.8075324}, {'id': 'https://openalex.org/C100094513', 'wikidata': 'https://www.wikidata.org/wiki/Q180436', 'display_name': 'Cilium', 'level': 2, 'score': 0.8008455}, {'id': 'https://openalex.org/C75563809', 'wikidata': 'https://www.wikidata.org/wiki/Q2656896', 'display_name': 'Missense mutation', 'level': 4, 'score': 0.7905375}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5520874}, {'id': 'https://openalex.org/C1009742', 'wikidata': 'https://www.wikidata.org/wiki/Q5333998', 'display_name': 'Ectodomain', 'level': 3, 'score': 0.49622446}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.47245649}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.45454735}, {'id': 'https://openalex.org/C28406088', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Extracellular', 'level': 2, 'score': 0.44527325}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.43112314}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.41247168}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.39405203}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.22583964}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16513437}], 'mesh': [{'descriptor_ui': 'D020125', 'descriptor_name': 'Mutation, Missense', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D050396', 'descriptor_name': 'TRPP Cation Channels', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001105', 'descriptor_name': 'Archaea', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018625', 'descriptor_name': 'Microscopy, Atomic Force', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D018625', 'descriptor_name': 'Microscopy, Atomic Force', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050396', 'descriptor_name': 'TRPP Cation Channels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050396', 'descriptor_name': 'TRPP Cation Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013816', 'descriptor_name': 'Thermodynamics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m109.021832', 'pdf_url': 'http://www.jbc.org/article/S0021925820378868/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2781709', 'pdf_url': 'https://europepmc.org/articles/pmc2781709?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781709', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19759016', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m109.021832', 'pdf_url': 'http://www.jbc.org/article/S0021925820378868/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.48, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1491509569', 'https://openalex.org/W1519478518', 'https://openalex.org/W1579363245', 'https://openalex.org/W1966359454', 'https://openalex.org/W1969604134', 'https://openalex.org/W1982566418', 'https://openalex.org/W1999560996', 'https://openalex.org/W2007690061', 'https://openalex.org/W2013681980', 'https://openalex.org/W2016388018', 'https://openalex.org/W2029085436', 'https://openalex.org/W2031122845', 'https://openalex.org/W2034000608', 'https://openalex.org/W2037720334', 'https://openalex.org/W2044124409', 'https://openalex.org/W2049817931', 'https://openalex.org/W2049902088', 'https://openalex.org/W2053961215', 'https://openalex.org/W2058912578', 'https://openalex.org/W2068596760', 'https://openalex.org/W2075591864', 'https://openalex.org/W2075799243', 'https://openalex.org/W2080581150', 'https://openalex.org/W2084514383', 'https://openalex.org/W2085458671', 'https://openalex.org/W2091488105', 'https://openalex.org/W2092284139', 'https://openalex.org/W2095869636', 'https://openalex.org/W2096728209', 'https://openalex.org/W2099346627', 'https://openalex.org/W2101368598', 'https://openalex.org/W2101712645', 'https://openalex.org/W2104559182', 'https://openalex.org/W2105739868', 'https://openalex.org/W2116076986', 'https://openalex.org/W2117852779', 'https://openalex.org/W2120553422', 'https://openalex.org/W2128551110', 'https://openalex.org/W2135100794', 'https://openalex.org/W2139617491', 'https://openalex.org/W2164423083', 'https://openalex.org/W2164628127', 'https://openalex.org/W2166882617', 'https://openalex.org/W2168133891', 'https://openalex.org/W3166298713', 'https://openalex.org/W81558796'], 'related_works': ['https://openalex.org/W4205509293', 'https://openalex.org/W3031223194', 'https://openalex.org/W2970655201', 'https://openalex.org/W2917227981', 'https://openalex.org/W2117399753', 'https://openalex.org/W2103377139', 'https://openalex.org/W2055891993', 'https://openalex.org/W2038470235', 'https://openalex.org/W2020202102', 'https://openalex.org/W1969327256'], 'abstract_inverted_index': {'Mutations': [0], 'in': [1, 131], 'polycystin-1': [2], '(PC1)': [3], 'can': [4], 'cause': [5, 15, 163], 'autosomal': [6, 164], 'dominant': [7, 165], 'polycystic': [8, 64, 166], 'kidney': [9, 65, 167], 'disease,': [10], 'which': [11, 69], 'is': [12, 41, 79], 'a': [13, 27, 42, 48, 58, 147], 'leading': [14], 'of': [16, 84, 91, 99, 108, 113, 128, 146, 173], 'renal': [17], 'failure.': [18], 'The': [19], 'available': [20], 'evidence': [21], 'suggests': [22], 'that': [23, 46, 119, 138, 159], 'PC1': [24, 40, 115, 175], 'acts': [25], 'as': [26], 'mechanosensor,': [28], 'receiving': [29], 'signals': [30], 'from': [31], 'the': [32, 82, 88, 97, 105, 109, 124, 143, 171, 174], 'primary': [33], 'cilia,': [34], 'neighboring': [35], 'cells,': [36], 'and': [37], 'extracellular': [38, 51], 'matrix.': [39], 'large': [43], 'membrane': [44], 'protein': [45], 'has': [47], 'long': [49], 'N-terminal': [50], 'region': [52], '(about': [53], '3000': [54], 'amino': [55], 'acids)': [56], 'with': [57], 'multimodular': [59], 'structure': [60], 'including': [61], '16': [62], 'Ig-like': [63], 'disease': [66, 168], '(PKD)': [67], 'domains,': [68], 'are': [70], 'targeted': [71], 'by': [72, 169], 'many': [73], 'naturally': [74, 101], 'occurring': [75, 102], 'missense': [76, 121, 160], 'mutations.': [77], 'Nothing': [78], 'known': [80], 'about': [81], 'effects': [83, 98], 'these': [85, 139, 155], 'mutations': [86, 103, 122, 140, 161], 'on': [87, 104, 154], 'biophysical': [89], 'properties': [90], 'PKD': [92, 111, 151], 'domains.': [93], 'Here': [94], 'we': [95, 136, 157], 'investigate': [96], 'several': [100, 120], 'mechanical': [106, 125, 133, 183], 'stability': [107, 145, 172], 'first': [110], 'domain': [112], 'human': [114], '(HuPKDd1).': [116], 'We': [117], 'found': [118, 137], 'alter': [123, 142], 'unfolding': [126], 'pathways': [127], 'HuPKDd1,': [129], 'resulting': [130], 'distinct': [132], 'phenotypes.': [134], 'Moreover,': [135], 'also': [141], 'thermodynamic': [144], 'structurally': [148], 'homologous': [149], 'archaeal': [150], 'domain.': [152], 'Based': [153], 'findings,': [156], 'hypothesize': [158], 'may': [162], 'altering': [170], 'ectodomain,': [176], 'thereby': [177], 'perturbing': [178], 'its': [179], 'ability': [180], 'to': [181], 'sense': [182], 'signals.': [184]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2003260510', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-11T11:56:57.018051', 'created_date': '2016-06-24'}