DAX-1 Functions as an LXXLL-containing Corepressor for Activated Estrogen Receptors

Name: Work Video:
Duration: 3 min 30 s
Hui Zhang; Jane S. Thomsen; Lotta Johansson; Jan-Ακε Gustafsson; Eckardt Treuter
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3888, 3907, 3999, 4177, 5203, 5344, 5391], 'estrogen': [12, 123, 171, 282, 331, 350, 683, 912, 4189, 4688, 5371], 'receptors': [13, 172, 372, 407, 684, 2440, 3009, 3400, 5063, 5266, 5420, 5448], 'ERα': [14, 173, 689, 1823, 2256, 2262, 2997, 3177, 3379, 3528, 3833, 4089, 4142, 4295, 4317, 4345, 4574], 'and': [15, 24, 27, 75, 89, 134, 174, 183, 186, 234, 248, 293, 365, 405, 508, 513, 516, 690, 698, 779, 908, 1035, 1305, 1316, 1418, 1553, 1555, 1570, 1824, 1921, 1940, 2017, 2031, 2075, 2114, 2219, 2257, 2264, 2269, 2469, 2553, 2575, 2589, 2602, 2641, 2736, 2763, 2775, 2825, 2851, 2854, 2869, 2976, 2998, 3056, 3159, 3268, 3331, 3384, 3406, 3446, 3455, 3472, 3529, 3620, 3748, 3802, 3827, 3909, 3979, 4143, 4165, 4167, 4285, 4296, 4309, 4332, 4350, 4537, 4605, 4609, 4718, 4911, 4920, 5233, 5270, 5287, 5304, 5326, 5340, 5365, 5449, 5528, 5542, 5556, 5566, 5579], 'ERβ.': [16, 175], 'Interaction': [17, 176, 2326], 'occurs': [18, 177], 'ligand-activated': [20, 179, 5381], 'ERs': [21, 111, 180, 270, 975, 1054, 1843, 2604, 2982, 3041, 3052, 3187, 3226, 3428, 3445, 3519, 3589, 3908, 3933, 4007, 4178, 4604, 4698, 4719, 5082, 5269], 'in': [22, 56, 72, 112, 140, 181, 215, 231, 271, 299, 398, 519, 673, 675, 695, 700, 707, 906, 971, 1149, 1236, 1413, 1548, 1810, 2441, 2494, 2497, 2538, 2580, 2618, 2625, 2742, 2773, 2821, 2983, 3202, 3209, 3229, 3243, 3272, 3287, 3431, 3437, 3496, 3503, 3537, 3844, 3945, 3974, 3991, 4008, 4078, 4099, 4117, 4153, 4187, 4303, 4315, 4321, 4341, 4376, 4529, 4571, 4607, 4685, 4699, 4708, 4723, 4752, 4807, 4819, 5024, 5101, 5151, 5285, 5400, 5445], 'solution': [23, 182], 'on': [25, 184, 323, 504, 2564, 2569, 3590, 4087, 5094], 'DNA': [26, 185, 3266, 3407, 5072], 'is': [28, 53, 108, 187, 212, 267, 497, 887, 1119, 1252, 1545, 2845, 3401, 3613, 3736, 4185, 4291, 4338, 4347, 4520, 4693, 5064, 5073, 5215, 5311, 5348, 5408, 5443, 5505], 'mediated': [29, 188, 3068], 'by': [30, 121, 189, 280, 893, 1049, 1844, 1871, 1892, 1911, 1927, 2009, 2067, 2118, 2127, 2178, 2213, 2465, 2471, 2746, 2753, 3069, 3303, 3740, 5199, 5319], 'unique': [32, 151, 191, 310, 1145], 'N-terminal': [34, 193, 1828, 2796, 3016, 3810, 3893], 'repeat': [35, 194, 1147, 1829, 2912, 3017, 3030, 3044, 3204, 3235, 3249, 3894, 4909, 5020], 'domain.': [36, 195, 3026, 3921], 'Each': [37, 196], 'of': [38, 69, 84, 92, 146, 154, 197, 228, 243, 251, 305, 313, 434, 488, 525, 682, 782, 911, 965, 974, 1032, 1053, 1157, 1566, 1572, 1739, 1812, 1841, 1852, 1929, 2135, 2447, 2503, 2522, 2534, 2543, 2621, 2785, 2793, 3019, 3040, 3097, 3214, 3232, 3246, 3290, 3298, 3313, 3342, 3462, 3544, 3583, 3586, 3593, 3867, 3905, 3930, 3996, 4002, 4011, 4081, 4102, 4105, 4123, 4162, 4173, 4307, 4360, 4378, 4525, 4603, 4614, 4687, 4697, 4705, 4726, 4756, 4906, 4926, 4935, 5092, 5206, 5209, 5226, 5281, 5380, 5388, 5498, 5513, 5525, 5570], 'three': [40, 199, 1146, 2782, 2795, 3199, 3248, 3604], 'repeats': [41, 200, 2797], 'contains': [42, 201, 1143, 1832, 2798, 3032, 5023, 5438], 'a': [43, 77, 102, 202, 236, 261, 904, 1045, 1139, 1144, 1154, 1245, 1749, 1845, 2002, 2070, 2180, 2221, 2570, 2659, 2799, 2917, 3033, 3104, 3162, 3180, 3295, 3323, 3365, 3438, 3477, 3504, 3542, 3617, 3621, 3804, 3845, 3902, 3927, 3941, 4137, 4357, 4564, 4678, 4702, 4903, 5029, 5196, 5320, 5349, 5360, 5378, 5389, 5397, 5439, 5499, 5522], 'leucine-rich': [44, 203, 2800], 'receptor-binding': [45, 204, 3025], 'motif,': [46, 51, 205, 210, 3036, 3072], 'known': [47, 206, 538, 3614, 4369, 4521, 4694, 4713], 'as': [48, 66, 101, 207, 225, 260, 381, 539, 704, 706, 1314, 1748, 1861, 2015, 2331, 2509, 2674, 2740, 2751, 2879, 2916, 3003, 3005, 3024, 3237, 3368, 3474, 3476, 3554, 3917, 3936, 4136, 4677, 4749, 4751, 4902, 5268, 5336], 'LXXLL': [50, 209, 540, 1833, 2817, 3035, 3071, 3095, 3217, 3340, 3419, 5302, 5457], 'which': [52, 211, 1029, 1137, 2871, 2914, 3102, 3612, 3735, 4566, 5407], 'usually': [54, 213, 886], 'found': [55, 214, 2992, 4075], 'nuclear': [57, 156, 216, 315, 336, 344, 371, 435, 1116, 3399, 3618, 4899, 4928, 5062, 5152, 5265], 'coactivators.': [59, 218], 'demonstrated': [62, 221, 1817, 2875], 'functions': [65, 224, 2915, 5150], 'an': [67, 226, 962, 1033, 1559, 1862, 1873, 2880, 3452, 3918, 5085, 5306, 5337, 5363, 5506], 'inhibitor': [68, 227], 'ER': [70, 229, 890, 1813, 1863, 2209, 3210, 3270, 3868, 3919, 4682, 5564], 'activation': [71, 230, 531, 891, 2026, 3516, 3981, 5318, 5402], 'mammalian': [73, 232, 1414, 3942, 5019], 'cells': [74, 233, 2730], 'suggest': [76, 235, 1744, 4601], 'mechanism': [78, 237, 5077, 5322], 'involving': [79, 238, 1849, 4809, 4823, 5323], 'two': [80, 239, 2830, 3186, 3432, 4924, 5283, 5292], 'sequential': [81, 240, 1846, 5321], 'events,': [82, 241], 'occupation': [83, 242], 'ligand-induced': [86, 245], 'coactivator-binding': [87, 246], 'surface': [88, 247], 'subsequent': [90, 249, 5327], 'recruitment': [91, 250, 1851, 3929], 'corepressors.': [93, 252, 514, 1853], 'Accordingly,': [94, 253, 1854], 'we': [95, 254, 1023, 1801, 1855, 2872, 2907, 3037, 3073, 3088, 3160, 3274, 3596, 3939, 4074, 5078, 5194, 5567], 'propose': [96, 255, 1856, 5079], 'itself': [99, 258, 1859, 5332], 'acts': [100, 259, 1747, 1860], 'corepressor': [103, 262, 4145, 5328, 5339, 5411], 'for': [104, 152, 263, 311, 430, 1411, 1563, 1751, 2452, 2561, 2577, 2612, 2765, 3183, 3423, 3459, 3926, 3951, 5081, 5088, 5369, 5377, 5410, 5415, 5455, 5545, 5562, 5573, 5576], 'ERs.': [105, 264, 2961], 'Because': [106, 265, 4107, 4779, 5298], 'coexpressed': [109, 268], 'reproductive': [113, 272, 4311], 'tissues,': [114, 273], 'these': [115, 274, 1742, 3065, 4379, 5282, 5291], 'interactions': [116, 275, 1052, 3066, 3413, 3585, 4176, 5220], 'could': [117, 276, 902, 4093, 4782, 5355, 5515], 'play': [118, 277, 692, 903, 1808], 'significant': [119, 278, 3324], 'roles': [120, 279, 694, 1410, 1809, 4524], 'influencing': [122, 281], 'signaling': [124, 283, 367, 437, 913, 5154], 'pathways.': [125, 284], 'Our': [126, 285], 'results': [127, 286, 4151, 4234, 4897], 'point': [128, 287], 'at': [129, 288, 2455, 2583, 2615, 2667, 2780, 2834], 'functional': [130, 289, 780, 2878, 3581, 4916, 5219], 'similarities': [131, 290, 4917], 'between': [132, 291, 511, 2847, 3527, 4140, 4918, 5067, 5221], 'SHP': [138, 297, 969, 1113, 3553, 4824], '(NROB2)': [139, 298, 970], 'they': [142, 301], 'acquired': [144, 303, 1044, 4933], 'features': [145, 304], 'transcriptional': [147, 306, 374, 680, 1839, 3623, 4936], 'coregulators': [148, 307, 382, 489, 674, 786, 4937], 'are': [150, 309, 377, 425, 3540, 4299, 4712, 5550], 'members': [153, 312, 4925, 5569], 'family.': [158, 317], 'ligand-binding': [318, 494, 5500], 'domain': [319, 343, 495, 532, 1148, 1161, 1830, 2027, 2919, 3250, 3341, 3417, 3517, 3813, 3988, 4910, 5021, 5403], 'DSS-AHC': [320], 'critical': [321, 429, 2822, 5454], 'region': [322, 3018, 3046, 3205], 'X-chromosome': [325], 'gene': [326, 1239, 1574, 4097], '1': [327, 335, 1907, 2448, 2504, 2544, 2622, 2638, 2806, 2839, 2974, 3172, 3220, 3310, 3318, 3484], 'short': [328, 535, 5026], 'heterodimer': [329], 'partner': [330], 'steroidogenic': [333], 'factor': [334, 340], 'receptor-corepressor': [337], 'transcription': [338, 415, 5098], 'intermediary': [339], '2': [341, 2578, 2613, 3001, 3049, 3084, 3330, 3471], 'DNA-binding': [342], 'receptor-box': [345], 'glutathioneS-transferase': [346], 'amino': [347], 'acid(s)': [348], '17β-estradiol': [349], 'response': [351], 'element': [352], 'luciferase': [353, 2737, 2767], 'wild-type': [354, 3447, 3610, 3860], 'polymerase': [355], 'chain': [356], 'reaction': [357, 2556], 'thymidine': [358], 'kinase': [359], 'cyto-': [360], 'megalovirus': [361], 'To': [362, 3259, 3579, 3922], 'transduce': [363], 'hormone': [364], 'metabolic': [366], 'to': [368, 380, 408, 412, 418, 427, 491, 499, 1112, 1310, 1822, 2429, 2559, 2591, 2863, 2876, 2960, 2971, 2980, 2993, 3042, 3062, 3076, 3081, 3322, 3345, 3533, 3615, 3743, 3854, 3880, 3932, 3947, 4004, 4006, 4330, 4352, 4365, 4714, 5061, 5071, 5217, 5276, 5288, 5362, 5418, 5452, 5494, 5552], 'target': [369, 1039, 4190, 5235, 5372], 'genes,': [370], 'require': [373], 'cofactors': [375], 'collectively': [378], 'referred': [379], '(1Glass': [383, 438, 5421], 'C.K.': [384, 439, 583, 630, 4036, 4038, 5422, 5476], 'Rosenfeld': [385, 440, 584, 625, 4039, 5423, 5471], 'M.G.': [386, 441, 550, 585, 626, 4040, 4737, 5424, 5472], 'Genes': [387, 442, 586, 5425], 'Dev.': [388, 443, 587, 4665, 5426], '2000;': [389, 444, 473, 875, 1101, 1227, 1376, 2052, 2318, 2377, 2720, 2898, 2948, 3151, 3571, 3653, 3789, 4246, 4841, 4882, 4981, 5002, 5048, 5427], '14:': [390, 445, 5428], '121-141Crossref': [391, 446, 5429], 'PubMed': [392, 447, 461, 481, 555, 591, 608, 637, 665, 727, 752, 766, 810, 839, 867, 878, 933, 953, 989, 1017, 1081, 1104, 1132, 1174, 1211, 1230, 1289, 1337, 1356, 1384, 1401, 1435, 1478, 1498, 1524, 1541, 1588, 1608, 1632, 1658, 1675, 1699, 1731, 1767, 1793, 1962, 1990, 2055, 2109, 2168, 2199, 2249, 2298, 2321, 2357, 2380, 2416, 2700, 2723, 2901, 2932, 2951, 3131, 3154, 3359, 3574, 3637, 3656, 3680, 3697, 3723, 3769, 3797, 3967, 4053, 4069, 4210, 4227, 4249, 4277, 4414, 4453, 4479, 4511, 4559, 4593, 4643, 4669, 4744, 4774, 4849, 4890, 4961, 4984, 5005, 5051, 5137, 5169, 5186, 5257, 5430, 5483], 'Google': [393, 448, 464, 484, 558, 594, 611, 640, 668, 730, 755, 769, 813, 842, 870, 881, 936, 956, 992, 1020, 1084, 1107, 1135, 1177, 1214, 1233, 1292, 1340, 1359, 1387, 1404, 1438, 1457, 1481, 1501, 1527, 1542, 1591, 1611, 1635, 1661, 1676, 1702, 1734, 1770, 1796, 1965, 1993, 2058, 2112, 2171, 2202, 2252, 2301, 2324, 2360, 2383, 2419, 2703, 2726, 2904, 2935, 2954, 3134, 3157, 3362, 3577, 3640, 3659, 3683, 3700, 3726, 3772, 3800, 3970, 4056, 4072, 4213, 4230, 4252, 4280, 4417, 4436, 4456, 4482, 4514, 4562, 4596, 4646, 4672, 4747, 4777, 4803, 4852, 4893, 4964, 4987, 5008, 5054, 5140, 5172, 5189, 5260, 5431, 5486], 'Scholar).': [394, 485, 669, 770, 882, 957, 1021, 1108, 1234, 1293, 1405, 1543, 1735, 1797, 1994, 2059, 2172, 2325, 2420, 2727, 2905, 3578, 3971, 4231, 4515, 4597, 4673, 4778, 4894, 5009, 5055, 5190, 5432, 5487], 'These': [395, 3391, 5237], 'proteins': [396, 422, 2427, 2462, 3281, 4298], 'exist': [397, 423], 'multiple': [399, 402, 701, 4188], 'complexes,': [400], 'possess': [401], 'enzymatic': [403], 'activities,': [404], 'bridge': [406], 'chromatin': [409], 'components': [410], 'or': [411, 417, 541, 2445, 2501, 2526, 2541, 3251, 3837, 3994, 4121, 4680, 5262, 5296, 5519], 'basal': [414], 'machinery': [416], 'both.': [419], 'Multiple': [420, 1406], 'candidate': [421], 'believed': [426], 'be': [428, 2877, 3207, 3616, 3855, 4180, 4366, 4783, 5240, 5274, 5334, 5453, 5492, 5516], 'proper': [432], 'function': [433, 1048, 1301, 3818, 4166, 4707], 'Scholar,': [449, 465, 559, 595, 612, 641, 731, 756, 814, 843, 871, 937, 993, 1085, 1178, 1215, 1341, 1360, 1388, 1439, 1458, 1482, 1502, 1528, 1592, 1612, 1636, 1662, 1677, 1703, 1771, 1966, 2302, 2361, 2384, 2704, 2936, 3135, 3641, 3660, 3684, 3701, 3773, 4057, 4214, 4253, 4418, 4437, 4457, 4483, 4647, 4853, 4965, 4988, 5173], '2McKenna': [450], 'N.J.': [451], 'Lanz': [452], 'R.B.': [453], "O'Malley": [454, 4062], 'B.W.': [455, 4063, 4220, 5179], 'Endocr.': [456, 761, 1127], 'Rev.': [457, 762, 1128], '1999;': [458, 763, 864, 925, 1009, 1073, 1129, 1696, 1982, 2160, 2290, 2349, 2408, 2692, 4274, 4666, 4741, 4953], '20:': [459, 764, 1102, 1130, 1228, 1433, 1606, 2053, 2319, 2378, 2721, 2899, 2949, 3152, 3572, 3654, 4557, 4982, 5003], '321-344Crossref': [460], 'Scopus': [462, 482, 556, 592, 609, 638, 666, 728, 753, 767, 811, 840, 868, 879, 934, 954, 990, 1018, 1082, 1105, 1133, 1175, 1212, 1231, 1290, 1338, 1357, 1385, 1402, 1436, 1479, 1499, 1525, 1589, 1609, 1633, 1659, 1700, 1732, 1768, 1794, 1963, 1991, 2056, 2110, 2169, 2200, 2250, 2299, 2322, 2358, 2381, 2417, 2701, 2724, 2902, 2933, 2952, 3132, 3155, 3360, 3575, 3638, 3657, 3681, 3698, 3724, 3770, 3798, 3968, 4054, 4070, 4211, 4228, 4250, 4278, 4415, 4454, 4480, 4512, 4560, 4594, 4644, 4670, 4745, 4775, 4850, 4891, 4962, 4985, 5006, 5052, 5138, 5170, 5187, 5258, 5484], '(1660)': [463], '3Malik': [466], 'S.': [467, 548, 567, 618, 720, 739, 747, 1188, 1266, 1685, 4030, 4048, 4203, 4391, 5114, 5464, 5554], 'Roeder': [468], 'R.G.': [469], 'Trends': [470, 1467, 1621], 'Biochem.': [471], 'Sci.': [472, 745, 4046], '25:': [474], '277-283Abstract': [475], 'Full': [476, 478, 660, 662, 805, 807, 928, 930, 1012, 1014, 1076, 1078, 1379, 1381, 1473, 1475, 1519, 1521, 1627, 1629, 1653, 1655, 1788, 1790, 1985, 1987, 2163, 2165, 2293, 2295, 2352, 2354, 2411, 2413, 2695, 2697, 3126, 3128, 3718, 3720, 3792, 3794, 4474, 4476, 4844, 4846, 4885, 4887, 4956, 4958], 'Text': [477, 479, 661, 663, 806, 808, 929, 931, 1013, 1015, 1077, 1079, 1380, 1382, 1474, 1476, 1520, 1522, 1628, 1630, 1654, 1656, 1789, 1791, 1986, 1988, 2164, 2166, 2294, 2296, 2353, 2355, 2412, 2414, 2696, 2698, 3127, 3129, 3719, 3721, 3793, 3795, 4475, 4477, 4845, 4847, 4886, 4888, 4957, 4959], 'PDF': [480, 664, 809, 932, 1016, 1080, 1383, 1477, 1523, 1631, 1657, 1792, 1989, 2167, 2297, 2356, 2415, 2699, 3130, 3722, 3796, 4478, 4848, 4889, 4960], '(306)': [483], 'The': [486, 1109, 2024, 4150, 4175], 'majority': [487], 'bind': [490, 1038, 3744, 4005], '(LBD),1which': [496], 'able': [498], 'adopt': [500], 'different': [501, 3605], 'conformations': [502], 'depending': [503], 'ligand': [506, 3307], 'status': [507], 'thereby': [509, 4912, 5366], 'discriminate': [510], 'coactivators': [512, 1057, 5232], 'Functional': [515], 'structural': [517, 778, 5489], 'studies': [518, 4600], 'particular': [520, 676], 'elucidated': [521], 'precise': [523], 'mechanisms': [524, 897, 4806, 5208], 'coactivator': [526, 894, 3100, 5324, 5416, 5456], 'interaction': [527, 3224, 3396, 3426, 3536, 3547, 3812, 3904, 3920, 3987], 'ligand-inducible': [530], '(AF-2)': [533], 'via': [534, 1826, 3418, 3934, 5243, 5264], 'leucine': [536, 2861], 'motifs': [537, 2831, 5303], 'NR-Box': [542, 1914, 3078], '(4Heery': [543], 'D.M.': [544, 1167, 1534, 1668, 2925, 3630, 5250], 'Kalkhoven': [545], 'E.': [546, 599, 716, 735, 939, 1005, 1069, 1097, 1163, 1165, 1180, 1192, 1217, 1258, 1270, 1319, 1323, 1447, 1486, 1530, 1664, 1713, 1715, 1953, 1978, 2048, 2091, 2095, 2138, 2185, 2231, 2235, 2286, 2314, 2345, 2373, 2386, 2688, 2716, 2894, 2921, 2923, 2938, 3147, 3350, 3567, 3626, 3628, 3643, 3662, 3666, 3751, 3755, 4199, 4383, 4395, 4426, 4441, 4493, 4495, 4625, 4627, 4793, 4949, 4977, 5106, 5118, 5246, 5248, 5536], 'Hoare': [547], 'Parker': [549, 1724, 4504, 4636], 'Nature.': [551, 633, 835, 1170, 1207, 1285, 2928, 3633, 4410, 5133, 5253, 5479], '1997;': [552, 724, 836, 1171, 1334, 1398, 1585, 2106, 2246, 2929, 3634, 3677, 3694, 3766, 4066, 4207, 4771, 5254], '387:': [553], '733-736Crossref': [554], '(1785)': [557], '5McInerney': [560], 'E.M.': [561, 4576], 'Rose': [562, 4041], 'D.W.': [563, 4042], 'Flynn': [564], 'S.E.': [565], 'Westin': [566, 617, 5463], 'Mullen': [568, 4021], 'T.M.': [569, 628, 1186, 1264, 1327, 2099, 2239, 3670, 3759, 4022, 4389, 4877, 5112, 5474], 'Krones': [570], 'A.': [571, 748, 1089, 1372, 1484, 1488, 1707, 2040, 2144, 2225, 2306, 2365, 2392, 2708, 2886, 3139, 3559, 3785, 4049, 4439, 4443, 4487, 4619, 4969, 5538], 'Inostroza': [572], 'J.': [573, 575, 597, 718, 857, 863, 945, 1006, 1070, 1349, 1373, 1760, 1951, 1979, 2146, 2157, 2191, 2287, 2346, 2394, 2405, 2689, 3348, 3786, 3960, 4020, 4032, 4201, 4243, 4766, 4769, 4836, 4950, 5045, 5162, 5543], 'Torchia': [574, 4019], 'Nolte': [576], 'R.T.': [577, 614, 5460], 'Assa-Munt': [578], 'N.': [579], 'Milburn': [580, 631, 5477], 'M.V.': [581, 632, 5478], 'Glass': [582, 629, 4037, 5475], '1998;': [588, 605, 634, 657, 802, 950, 986, 1353, 1432, 1470, 1516, 1538, 1605, 1624, 1650, 1672, 1764, 1785, 1959, 2196, 3123, 3356, 3715, 3964, 4050, 4471, 4556, 5166, 5480], '12:': [589, 951, 987, 1496, 2197, 4451], '3357-3368Crossref': [590], '(530)': [593], '6Leers': [596], 'Treuter': [598, 1004, 1068, 1096, 1952, 1977, 2047, 2285, 2313, 2344, 2372, 2687, 2715, 2893, 3146, 3349, 3566, 4948, 4976], 'Gustafsson': [600, 721, 740, 831, 858, 946, 1002, 1066, 1094, 1954, 1975, 2045, 2155, 2192, 2283, 2311, 2342, 2370, 2403, 2685, 2713, 2891, 3144, 3351, 3564, 4204, 4269, 4284, 4654, 4946, 4974], 'J.A.': [601, 722, 741, 1003, 1067, 1095, 1955, 1976, 2046, 2156, 2284, 2312, 2343, 2371, 2404, 2686, 2714, 2892, 3145, 3352, 3565, 4205, 4947, 4975], 'Mol.': [602, 948, 984, 1098, 1224, 1332, 1350, 1395, 1452, 1582, 1694, 1726, 1761, 1956, 2049, 2104, 2194, 2244, 2315, 2374, 2717, 2895, 2945, 3148, 3353, 3568, 3650, 3675, 3691, 3764, 3961, 4064, 4244, 4431, 4506, 4638, 4798, 4839, 4880, 4978, 4999, 5046, 5163], 'Cell.': [603, 656, 801, 924, 1099, 1225, 1351, 1396, 1515, 1583, 1649, 1762, 1784, 1957, 2050, 2316, 2375, 2718, 2896, 2946, 3122, 3149, 3354, 3569, 3651, 3692, 3714, 3962, 4470, 4840, 4881, 4979, 5000, 5164], 'Biol.': [604, 1007, 1071, 1100, 1226, 1352, 1374, 1397, 1584, 1763, 1958, 1980, 2051, 2158, 2288, 2317, 2347, 2376, 2406, 2690, 2719, 2897, 2947, 3150, 3355, 3570, 3652, 3693, 3787, 3963, 4951, 4980, 5001, 5165], '18:': [606, 865, 1354, 1765, 1960, 3357, 3965, 5167], '6001-6013Crossref': [607, 1961, 3358], '(93)': [610, 1964, 3361], '7Nolte': [613], 'Wisely': [615, 5461], 'G.B.': [616, 5462], 'Cobb': [619, 5465], 'J.E.': [620, 5466], 'Lambert': [621, 5467], 'M.H.': [622, 1532, 1666, 5468], 'Kurokawa': [623, 5469], 'R.': [624, 1370, 1392, 1490, 1579, 1721, 3688, 3783, 4024, 4445, 4501, 4633, 5470], 'Willson': [627, 5473], '395:': [635, 5481], '137-143Crossref': [636, 5482], '(1707)': [639, 5485], '8Shiau': [642], 'A.K.': [643, 788, 3109], 'Barstad': [644, 789, 3110], 'D.': [645, 790, 921, 1329, 1368, 2101, 2241, 3111, 3672, 3761, 3781], 'Loria': [646, 791, 3112], 'P.M.': [647, 792, 3113], 'Cheng': [648, 793, 3114], 'L.': [649, 794, 828, 943, 995, 1059, 1087, 1443, 1968, 2038, 2140, 2189, 2276, 2304, 2335, 2363, 2388, 2678, 2706, 2884, 3115, 3137, 3557, 4222, 4422, 4789, 4939, 4967, 5181], 'Kushner': [650, 795, 3116], 'P.J.': [651, 796, 3117], 'Agard': [652, 797, 3118], 'D.A.': [653, 798, 3119], 'Greene': [654, 799, 829, 3120], 'G.L.': [655, 800, 830, 3121, 4739], '95:': [658, 803, 3124, 4051], '927-937Abstract': [659, 804, 3125], '(2282)': [667, 812, 3133], 'became': [671], 'interested': [672], 'influence': [678], 'activity': [681, 1840, 3592, 3839, 4098], '(ER).': [685], 'Two': [686], 'related': [687], 'subtypes,': [688], 'ERβ,': [691], 'crucial': [693], 'sex': [696, 1415], 'development': [697, 1565, 4536], 'reproduction': [699], 'physiological': [702], 'processes': [703], 'well': [705, 3004, 3475, 3555, 4750], 'cancer': [708], '(9Kuiper': [709, 4192], 'G.G.': [710, 733, 4193, 4272, 4653], 'Carlsson': [711, 4194], 'B.': [712, 979, 1184, 1262, 1321, 1362, 2093, 2233, 3664, 3753, 3775, 4195, 4264, 4387, 4663, 4855, 5110], 'Grandien': [713, 4196], 'K.': [714, 1219, 1679, 1687, 1693, 2005, 2940, 3645, 4016, 4197, 4832, 5540], 'Enmark': [715, 734, 4198], 'Haggblad': [717, 4200], 'Nilsson': [719, 738, 4202, 5555], 'Endocrinology.': [723, 1537, 1671, 4206, 4223, 4273, 4589, 4740, 5182], '138:': [725, 4208], '863-870Crossref': [726, 4209], '(3678)': [729, 4212], '10Kuiper': [732], 'Pelto-Huikko': [736, 2147, 2395], 'M.': [737, 834, 861, 981, 1093, 1423, 1449, 1464, 1596, 1618, 2044, 2148, 2150, 2310, 2369, 2396, 2398, 2712, 2890, 3143, 3563, 4028, 4286, 4428, 4547, 4795, 4828, 4973, 4996, 5557], 'Proc.': [742, 4043], 'Natl.': [743, 4044], 'Acad.': [744, 4045], 'U.': [746, 1366, 3779, 4047], '1996;': [749, 1454, 1495, 1728, 4224, 4433, 4450, 4508, 4590, 4640, 4800, 5183], '93:': [750, 1517, 1651, 1786, 3716, 4472], '5925-5930Crossref': [751], '(4252)': [754], '11Couse': [757], 'J.C.': [758, 1462, 1616], 'Korach': [759, 4587], 'K.S.': [760, 4588, 5042], '358-417Crossref': [765], '(0)': [768, 955, 991, 2201], 'Previous': [771], 'research': [772], 'has': [773, 960, 1042, 1138, 2086, 2855, 4568], 'provided': [774, 1025, 1803, 2117], 'detailed': [775], 'insights': [776, 4157], 'into': [777, 1881, 2020, 2078, 2131, 2204, 2216, 4158], 'aspects': [781, 4161], 'their': [783, 2978, 3497, 3534], 'interplay': [784], '(8Shiau': [787, 3108], '12Brzozowski': [815], 'A.M.': [816, 847], 'Pike': [817], 'A.C.': [818], 'Dauter': [819], 'Z.': [820, 4061], 'Hubbard': [821, 848], 'R.E.': [822, 849], 'Bonn': [823, 850], 'T.': [824, 851, 941, 1200, 1278, 1681, 1689, 2187, 4018, 4403, 5126], 'Engstrom': [825, 854], 'O.': [826, 855], 'Ohman': [827], 'J.Å.': [832, 947, 2193, 4270, 4655], 'Carlquist': [833, 860, 5558], '389:': [837], '753-758Crossref': [838], '(2980)': [841], '13Pike': [844], 'A.C.W.': [845], 'Brzozowski': [846], 'Thorsell': [852], 'A.G.': [853], 'Ljunggren': [856], 'J.K.': [859], 'EMBO': [862], '4608-4618Crossref': [866], '(917)': [869], '14Klinge': [872], 'C.M.': [873], 'Steroids.': [874], '65:': [876], '227-251Crossref': [877], '(399)': [880], 'Although': [883, 4356, 5346], 'agonist': [884], 'binding': [885, 2555, 2959, 2979, 3039, 3075, 3308, 3408, 4901, 5060, 5070, 5412, 5417, 5458], 'associated': [888, 1056, 1253], 'caused': [892, 3302, 3739, 4541], 'recruitment,': [895], 'regulatory': [896, 4171], 'been': [899, 1947, 2034, 2087, 2272, 3550, 4569, 4721], 'proposed': [900], 'role': [905, 964, 5379], 'modulation': [907, 4686], 'feedback': [909, 4805, 4817], 'control': [910, 3292, 4108], '(15Chen': [914], 'H.W.': [915], 'Lin': [916], 'R.J.': [917], 'Xie': [918], 'W.': [919, 977, 1190, 1268, 4393, 5116], 'Wilpitz': [920], 'Evans': [922], 'R.M.': [923, 4014], '98:': [926], '675-686Abstract': [927], '(563)': [935], '16Treuter': [938], 'Albrektsen': [940, 2186], 'Johansson': [942, 2139, 2188, 2387], 'Leers': [944, 2145, 2190, 2393, 5544], 'Endocrinol.': [949, 985, 1333, 1453, 1468, 1622, 1695, 1727, 2105, 2195, 2245, 3676, 3765, 4065, 4245, 4432, 4507, 4639, 4770, 4799, 5047], '864-881Crossref': [952, 2198], 'Recent': [958], 'work': [959], 'revealed': [961, 2790], 'unexpected': [963], 'inhibiting': [972], 'transactivation': [973], '(17Seol': [976], 'Hanstein': [978], 'Brown': [980], 'Moore': [982, 4864, 4997], 'D.D.': [983, 4863, 4998], '1551-1557Crossref': [988], '18Johansson': [994, 1967], 'Thomsen': [996, 1060, 1090, 1969, 2041, 2141, 2277, 2307, 2336, 2366, 2389, 2679, 2709, 2887, 3140, 3560, 4940, 4970], 'J.S.': [997, 1061, 1091, 1970, 2042, 2142, 2278, 2308, 2337, 2367, 2390, 2680, 2710, 2888, 3141, 3561, 4733, 4941, 4971], 'Damdimopoulos': [998, 1062, 1971, 2279, 2338, 2681, 4942], 'A.E.': [999, 1063, 1972, 2280, 2339, 2682, 4943], 'Spyrou': [1000, 1064, 1973, 2153, 2281, 2340, 2401, 2683, 4944], 'G.': [1001, 1065, 1206, 1284, 1492, 1723, 1974, 2154, 2282, 2341, 2402, 2684, 4409, 4447, 4503, 4635, 4945, 5132], 'Chem.': [1008, 1072, 1375, 1981, 2159, 2289, 2348, 2407, 2691, 3788, 4952], '274:': [1010, 1074, 1983, 2161, 2291, 2350, 2409, 2693, 4954], '345-353Abstract': [1011, 1075, 1984, 2292, 2351, 2694, 4955], '(161)': [1019, 1083, 1992, 2300, 2359, 2702, 4963], 'Particularly,': [1022], 'evidence': [1026, 1407, 1804, 3422, 3925, 5376], 'SHP,': [1028, 4921], 'consists': [1030], 'only': [1031, 2842, 3029, 3489, 4923], 'LBD': [1034, 1141, 1304, 2122, 3890, 3914], 'thus': [1036], 'cannot': [1037, 3915], 'genes': [1040, 5238], 'directly,': [1041], 'instead': [1043, 3410, 4540], 'novel': [1046, 1155, 4904, 5523], 'coregulator': [1047, 4683, 5223, 5529], 'antagonizing': [1050], '(18Johansson': [1058, 2275, 2334, 2677, 4938], '19Johansson': [1086, 2303, 2362, 2705, 3136, 4966], 'Bavner': [1088, 2039, 2305, 2364, 2707, 2885, 3138, 3558, 4968], 'Farnegardh': [1092, 2043, 2309, 2368, 2711, 2889, 3142, 3562, 4972], '1124-1133Crossref': [1103, 2054, 2320, 2379, 2722, 2900, 3153, 3573, 4983], '(133)': [1106, 2057, 2323, 2382, 2725, 2903, 3156, 3576, 4986], 'closest': [1110], 'relative': [1111, 2510, 2766, 5279], 'within': [1114, 1302, 3819], 'family': [1118, 4930], '(20Giguere': [1125], 'V.': [1126, 5036], '689-725Crossref': [1131], '(721)': [1134], 'Scholar),': [1136, 2253, 2955, 3158, 3727, 3801, 4073, 4281, 4563, 4804, 5141], 'homologous': [1140], 'but': [1142, 3239, 3409, 3494, 3520, 3548, 3814, 4539, 5022, 5413], 'N': [1151, 5027], 'terminus': [1152, 5028], 'representing': [1153, 3480], 'type': [1156], 'single': [1158, 5030], 'strand': [1159], 'DNA/RNA-binding': [1160, 2918], '(21Zazopoulos': [1162, 2920, 3625, 5245], 'Lalli': [1164, 1191, 1269, 1446, 1714, 2922, 3627, 4394, 4425, 4494, 4626, 4792, 5117, 5247], 'Stocco': [1166, 1533, 1667, 2924, 3629, 5249], 'Sassone-Corsi': [1168, 1203, 1222, 1281, 1330, 1450, 1535, 1669, 1718, 2102, 2242, 2926, 2943, 3631, 3648, 3673, 3762, 4406, 4429, 4498, 4630, 4796, 5129, 5251], 'P.': [1169, 1204, 1223, 1282, 1331, 1451, 1536, 1670, 1719, 2103, 2119, 2243, 2927, 2944, 3632, 3649, 3674, 3763, 4407, 4430, 4499, 4631, 4797, 5130, 5252, 5534], '390:': [1172, 2930, 3635, 5255], '311-315Crossref': [1173, 2931, 3636, 5256], '(368)': [1176, 2934, 3639, 5259], '22Zanaria': [1179], 'Muscatelli': [1181, 1259, 4384, 5107], 'F.': [1182, 1260, 4242, 4385, 5108], 'Bardoni': [1183, 1261, 1320, 2092, 2232, 3663, 3752, 4386, 5109], 'Strom': [1185, 1263, 1326, 2098, 2238, 3669, 3758, 4388, 5111], 'Guioli': [1187, 1265, 4390, 5113], 'Guo': [1189, 1267, 4392, 5115], 'Moser': [1193, 1271, 4396, 5119], 'C.': [1194, 1221, 1272, 1345, 1756, 2942, 3647, 3956, 4397, 4867, 5120, 5158], 'Walker': [1195, 1273, 4398, 5121], 'A.P.': [1196, 1202, 1274, 1280, 2152, 2400, 4399, 4405, 5122, 5128], 'McCabe': [1197, 1275, 4400, 5123], 'E.R.B.': [1198, 1276, 4401, 5124], 'Meitinger': [1199, 1277, 4402, 5125], 'Monaco': [1201, 1279, 1442, 4404, 4421, 4788, 5127], 'Camerino': [1205, 1283, 1491, 1722, 4408, 4446, 4502, 4634, 5131], '1994;': [1208, 1286, 4411, 5134], '372:': [1209, 1287, 4412, 5135], '635-641Crossref': [1210, 1288, 4413, 5136], '(731)': [1213, 1291, 4416, 5139], '23Lalli': [1216, 2937, 3642], 'Ohe': [1218, 2939, 3644], 'Hindelang': [1220, 2941, 3646], '4910-4921Crossref': [1229, 2950, 3655], '(110)': [1232, 2953, 3658], 'Mutations': [1235], 'human': [1238, 2012, 2061, 2071, 2182, 2255, 2787, 2852], 'encoding': [1240, 1932], 'cause': [1242], 'adrenal': [1243, 2072, 4700, 4716, 5394], 'hypoplasia,': [1244], 'rare': [1246], 'inherited': [1247], 'male': [1248, 4308, 4542], 'disorder': [1249], 'frequently': [1251], 'hypogonadotropic': [1255], 'hypogonadism': [1256], '(22Zanaria': [1257, 4382, 5105], 'Intriguingly,': [1294, 2841, 5075], 'many': [1295], 'mutations': [1296], 'abolish': [1297], 'potent': [1299, 3622], 'silencing': [1300, 5308], 'lost': [1307], 'ability': [1309], 'recruit': [1311], 'corepressors': [1312, 3746, 3931, 5227], 'such': [1313, 5267], 'N-CoR': [1315, 2183, 3747, 3983, 4003, 4146], 'Alien': [1317, 3749], '(24Lalli': [1318, 2090, 2230, 3750], 'Zazopoulos': [1322, 2094, 2234, 3665, 3754], 'Wurtz': [1324, 2096, 2236, 3667, 3756], 'J.M.': [1325, 2097, 2237, 3668, 3757], 'Moras': [1328, 2100, 2240, 3671, 3760], '11:': [1335, 2107, 2247, 3678, 3767, 4067], '1950-1960Crossref': [1336, 2108, 2248, 3679, 3768], '(162)': [1339, 2111, 2251, 3682, 3771], '25Crawford': [1342], 'P.A.': [1343, 1754, 3954, 5156], 'Dorn': [1344, 1755, 3955, 5157], 'Sadovsky': [1346, 1757, 3957, 5159], 'Y.': [1347, 1506, 1640, 1705, 1758, 1775, 3705, 3958, 4461, 4485, 4617, 5160], 'Milbrandt': [1348, 1759, 3959, 5161], '2949-2956Crossref': [1355, 1766, 3966, 5168], '(289)': [1358, 1769, 3969, 5171], '26Altincicek': [1361, 3774], 'Tenbaum': [1363, 3776], 'S.P.': [1364, 3777], 'Dressel': [1365, 3778], 'Thormeyer': [1367, 3780], 'Renkawitz': [1369, 3782], 'Baniahmad': [1371, 3784], '275:': [1377, 3790], '7662-7667Abstract': [1378, 3791], '(92)': [1386, 3799], '27Ito': [1389, 3685], 'M.,': [1390, 1577, 3686], 'Yu,': [1391, 1578, 3687], 'Jameson': [1393, 1428, 1465, 1580, 1601, 1619, 3689, 4552], 'J.L.': [1394, 1429, 1466, 1581, 1602, 1620, 3690, 4553], '17:': [1399, 1586, 3695], '1476-1483Crossref': [1400, 1587, 3696], '(401)': [1403, 1590, 3699], 'suggests': [1408, 4131, 4373, 5058], 'key': [1409], 'development,': [1416, 4717], 'reproduction,': [1417], 'steroidogenesis': [1419, 4808], '(28Yu': [1420, 4544], 'R.N.': [1421, 1460, 1594, 1614, 4545], 'Ito': [1422, 1463, 1595, 1617, 4546], 'Saunders': [1424, 1597, 4548], 'T.L.': [1425, 1598, 4549], 'Camper': [1426, 1599, 4550], 'S.A.': [1427, 1600, 4551, 4857, 4879, 5040], 'Nat.': [1430, 1493, 1603, 4448, 4554], 'Genet.': [1431, 1494, 1604, 4449, 4555], '353-357Crossref': [1434, 1607, 4558], '(394)': [1437, 1610, 4561], '29Tamai': [1440, 4419], 'K.T.': [1441, 1717, 4420, 4497, 4629, 4787], 'Alastalo': [1444, 4423, 4790], 'T.P.': [1445, 4424, 4791], 'Parvinen': [1448, 4427, 4794], '10:': [1455, 1729, 4434, 4509, 4641, 4801], '1561-1569PubMed': [1456, 4435, 4802], '30Yu': [1459, 1613], 'Achermann': [1461, 1615], 'Metab.': [1469, 1623], '9:': [1471, 1625], '169-175Abstract': [1472, 1626], '(40)': [1480, 1634], '31Swain': [1483, 4438], 'Zanaria': [1485, 1712, 4440, 4492, 4624], 'Hacker': [1487, 4442], 'Lovell-Badge': [1489, 1720, 4444, 4500, 4632], '404-409Crossref': [1497, 4452], '(350)': [1500, 4455], '32Nachtigal': [1503, 1637, 1772, 3702, 4458], 'M.W.': [1504, 1638, 1773, 3703, 4459], 'Hirokawa': [1505, 1639, 1774, 3704, 4460], 'Enyeart-VanHouten': [1507, 1641, 1776, 3706, 4462], 'D.L.': [1508, 1642, 1777, 3707, 4463], 'Flanagan': [1509, 1643, 1778, 3708, 4464], 'J.N.': [1510, 1644, 1779, 3709, 4465], 'Hammer': [1511, 1645, 1780, 3710, 4466], 'G.D.': [1512, 1646, 1781, 3711, 4467], 'Ingraham': [1513, 1647, 1782, 3712, 4468], 'H.A.': [1514, 1648, 1783, 3713, 4469], '445-454Abstract': [1518, 1652, 1787, 3717, 4473], '(499)': [1526, 1660, 1795, 3725, 4481], '33Lalli': [1529, 1663], 'Melner': [1531, 1665], '139:': [1539, 1673], '4237-4243Crossref': [1540, 1674], 'predominantly': [1546, 4319], 'expressed': [1547, 4186, 4302, 4320, 4340], 'adrenal,': [1549], 'ovary,': [1550, 4336], 'testes,': [1551], 'hypothalamus,': [1552], 'pituitary': [1554], 'functionally': [1556], 'antagonizes': [1557], 'SF-1,': [1558], 'essential': [1560], 'hypothalamic-pituitary-gonadal': [1568], 'axis': [1569], 'regulator': [1571], 'male-specific': [1573], 'expression': [1575, 1916, 2259, 2735, 2762, 3607, 3869, 4327, 4346, 4363, 4371, 4696, 4781], '(27Ito': [1576], '28Yu': [1593], '34Kawabe': [1678], 'Shikayama': [1680], 'Tsuboi': [1682], 'H.': [1683, 1691, 4992], 'Oka': [1684], 'Oba': [1686], 'Yanase': [1688], 'Nawata': [1690], 'Morohashi': [1692], '13:': [1697], '1267-1284Crossref': [1698], '(109)': [1701], '35Ikeda': [1704, 4484], 'Swain': [1706, 4486, 4618], 'Weber': [1708, 4488, 4620], 'T.J.': [1709, 4489, 4621], 'Hentges': [1710, 4490, 4622], 'K.E.': [1711, 4491, 4623], 'Tamai': [1716, 4496, 4628], 'K.L.': [1725, 4505, 4637], '1261-1272Crossref': [1730, 4510, 4642], '(278)': [1733, 4513, 4645], 'Together': [1736], 'demonstration': [1738], 'direct': [1740, 3903], 'interaction,': [1741], 'findings': [1743, 5202], 'specifically': [1746, 3487], 'cofactor': [1750], 'SF-1': [1752, 3387, 3952], '(25Crawford': [1753, 3953, 5155], 'In': [1798, 4335, 5191, 5211], 'this': [1799, 4129, 4154, 5212, 5342], 'study': [1800, 4155, 5104], 'may': [1807, 2956, 3022, 3206, 3878, 4134, 4179, 4811, 5083, 5147, 5239, 5315, 5333, 5491], 'regulation': [1811], 'transactivation.': [1814], 'directly': [1820, 5242], 'binds': [1821], 'ERβ': [1825, 2258, 2536, 2999, 3530, 3838, 4297, 4326, 4337], 'motifs.': [1834, 3420], 'Functionally,': [1835], 'inhibits': [1837], 'liganded': [1842, 3176, 3269, 4141, 5419], 'mechanism,': [1847], 'possibly': [1848, 3197, 3479, 3738, 5057, 5356, 5367], 'corepressor.': [1864], 'GST·DAX-1': [1865, 1886, 1899, 2425, 2524, 2989, 3314], 'DBD': [1866, 1878, 1999, 2990], '(aa': [1867, 1888, 1919, 1923, 1938, 1944, 2000, 2063, 2123, 2174], '1–253)': [1868], 'was': [1869, 1890, 1909, 2007, 2018, 2065, 2076, 2115, 2125, 2176, 2550, 2557, 2656, 2991, 3375, 3429, 5450], 'made': [1870, 1926, 2008, 2177, 2212, 2963], 'recloning': [1872, 2179], 'EcoRI/SalI': [1874], 'fragment': [1875], 'from': [1876, 2004, 2069, 2224, 4235, 5359, 5384], 'pGAL4·DAX-1': [1877], '(see': [1879, 1905, 3170, 3316, 4147], 'below)': [1880], 'pGEX4T-1': [1882], '(Amersham': [1883, 2432], 'Pharmacia': [1884, 2433], 'Biotech).': [1885], 'R3': [1887, 2525, 3315], '115–199)': [1889], 'cloned': [1891, 2019, 2066], 'inserting': [1893, 2128], 'PCR-generated': [1894], 'fragments': [1895, 2130, 2969], 'intoEcoRI/SalI': [1896], 'cut': [1897, 1935, 2081], 'pGEX4T-1.': [1898, 1936], 'mut': [1900], 'carrying': [1901, 5396], 'AXXAL': [1903], 'mutation': [1904, 3213, 5399], 'Fig.': [1906, 3171, 3317, 3975, 4148, 5192], 'B)': [1908, 2975, 3319], 'generated': [1910, 2126], 'PCR': [1912, 2010, 2068, 2129, 2214], 'mutagenesis.': [1913], 'peptide': [1915, 1943, 3090, 3164], 'constructs': [1917, 2029, 2267, 2965, 3091], 'pGEX-DAX-1-Box1': [1918], '8–21)': [1920], 'pGEX-DAX-1-Box3': [1922], '141–154)': [1924], 'were': [1925, 2211, 2220, 2328, 2435, 2463, 2482, 2492, 2507, 2529, 2567, 2587, 2605, 2645, 2672, 2731, 2758, 2771, 2778, 3067, 3449, 3486, 3492, 3989], 'insertion': [1928], 'double-stranded': [1930], 'oligonucleotides': [1931], '14-mer': [1933, 3077], 'peptidesEcoRI/SalI': [1934], 'pGEX-TIF2': [1937, 1941], '594–766)': [1939], 'Box2': [1942], '687–700)': [1945], 'described': [1948, 2035, 2088, 2273, 2332, 2675, 3950], 'previously': [1949, 2036, 2089, 2274, 2333, 2676, 2874, 4159], '(6Leers': [1950, 3347], 'Yeast': [1995], 'two-hybrid': [1996, 2475, 3506, 3538, 3943], 'plasmids,': [1997, 2260], 'pGAL4·DAX1': [1998], '1–253),': [2001], 'gift': [2003, 2223], 'Dahlman-Wright,': [2006, 5541], 'using': [2011, 2648, 2658, 2747, 3279, 3864], 'testis': [2013, 4316, 4608], 'cDNA': [2014, 2073], 'template': [2016], 'BamHI-digested': [2021], 'pGBT9': [2022], '(CLONTECH).': [2023], 'GAL4': [2025, 2477], 'fusion': [2028, 2426, 3806], 'pGAD·ERα': [2030], 'pGAD·ERβ': [2032], '(19Johansson': [2037, 2883, 3556], 'Full-length': [2060], '1–470)': [2064], '(CLONTECH)': [2074], 'inserted': [2077], 'pSG5': [2079, 2227], '(Stratagene)': [2080], 'EcoRI.': [2083], 'pSG5-DAX-1': [2084], 'R267P': [2085, 2229, 3733, 3831], 'Scholar)': [2113, 2203, 3363, 4748, 5261], 'generously': [2116], 'Sassone-Corsi.': [2120], 'pSG5-GAL4-DAX-1': [2121], '201–470)': [2124], 'EcoRI': [2133], 'site': [2134, 4704], 'pSG5-GAL4': [2136, 2261], '(36Treuter': [2137], 'Warnmark': [2143, 2391], 'Sjoberg': [2149, 2397], 'Wright': [2151, 2399], '6667-6677Abstract': [2162, 2410], '(76)': [2170, 2418], 'VP16·N-CoR': [2173, 4077, 4092, 4124], '1689–2453)': [2175], 'partial': [2181], '(16Treuter': [2184], 'EcoRI-cut': [2205], 'pBK-CMV-VP16.': [2206], 'FLAG': [2207], 'epitope-tagged': [2208], 'variants': [2210], 'subcloning': [2215], 'pcDNA3': [2217], '(Invitrogen)': [2218], 'generous': [2222], 'Ström.': [2226], 'pSG5-based': [2254], 'LBD,': [2263], 'reporter': [2266, 2738, 4096], '3×ERE-TATA-luc': [2268], 'UAS-tk-luc': [2270], 'assays': [2327, 2985, 3539], 'performed': [2329, 2657, 2673, 2772, 3275, 3597, 3940], 'essentially': [2330], '36Treuter': [2385], 'For': [2421, 2473, 2513, 2594, 3086, 3337, 4313], 'GST': [2422, 2972, 3082, 3291, 3346], 'pull-down': [2423, 2984], 'assays,': [2424, 2476], 'bound': [2428, 2461, 3053, 3267], 'Sepharose': [2430], 'beads': [2431], 'Biotech)': [2434], 'incubated': [2436, 2530, 2606, 3450], '35S': [2438], '-labeled': [2439], 'absence': [2443, 2499, 2540, 3498, 3993, 4080, 4120], '(Me2SO)': [2444, 2500], 'presence': [2446, 2502, 2542, 2620, 3289, 3461, 3995, 4010, 4101, 4122, 5497], 'μm': [2449, 2545, 2623], 'E2': [2450, 2624], '(17β-estradiol)': [2451], '2–3': [2453], 'h': [2454, 2579, 2614], '4': [2456, 2584, 2616, 3328, 3835, 3841, 3976, 4126], '°C.': [2457, 2585], 'After': [2458], 'extensive': [2459, 2856], 'washing,': [2460, 3457], 'analyzed': [2464, 2764, 3089, 3228, 3242, 3458], 'SDS-polyacrylamide': [2466], 'gel': [2467, 2574, 3276], 'electrophoresis': [2468], 'visualized': [2470], 'autoradiography.': [2472], 'yeast': [2474, 3505], 'plasmids': [2478, 2486, 2739], 'transformed': [2479, 2487], 'HF7c': [2480], '(MATα)': [2481], 'mated': [2483], 'GAL4AD': [2485], 'Y187': [2488], '(MATα).': [2489], 'All': [2490], 'cotransformants': [2491], 'grown': [2493], 'selective': [2495], 'media': [2496], 'μmE2.': [2505], 'Interactions': [2506], 'monitored': [2508], 'β-galactosidase': [2511], 'activity.': [2512, 2768, 4090], 'electrophoretic': [2514], 'mobility': [2515], 'shift': [2516, 3277], 'assay': [2517, 3507], 'supershift': [2518, 3367], 'studies,': [2519], '∼200': [2520], 'ng': [2521, 2533], 'purified': [2523, 2535, 3280], 'GST·TIF2,': [2527], 'respectively,': [2528, 3843], '10': [2532], '(Panvera)': [2537], 'E2.': [2546], 'Radiolabeled': [2547], 'ERE': [2548], 'oligonucleotide': [2549], 'added': [2551], 'last,': [2552], 'allowed': [2558], 'proceed': [2560], '20': [2562], 'min': [2563], 'ice.': [2565], 'Reactions': [2566], 'loaded': [2568], '4%': [2571], 'nondenaturing': [2572], 'polyacrylamide': [2573], 'electrophoresed': [2576], '0.5×': [2581], 'Tris-borate-EDTA': [2582], 'Gels': [2586], 'dried': [2588], 'exposed': [2590], 'x-ray': [2592], 'film.': [2593], 'coimmunoprecipitation,': [2595], 'COS-7': [2596, 2729], 'whole': [2597], 'cell': [2598, 4305, 4380, 4754], 'extracts': [2599, 2757, 3442], 'expressing': [2600, 2966, 3092, 3443], 'FLAG-tagged': [2603, 3444], 'FLAG-M2': [2608], 'affinity': [2609, 3182], 'matrix': [2610, 3454], '(Sigma)': [2611], '°C': [2617], 'IP': [2626, 2649], 'buffer': [2627, 2650], '(50': [2628], 'mmTris-HCl,': [2629], 'pH': [2630], '7.4,': [2631], '150': [2632], 'mm': [2633, 2639], 'NaCl,': [2634], '0.2%': [2635], 'Nonidet': [2636, 2652], 'P-40,': [2637], 'EDTA,': [2640], '10%': [2642], 'glycerol).': [2643], 'Beads': [2644], 'subsequently': [2646], 'washed': [2647], 'lacking': [2651, 3808, 3891, 4573], 'P-40.': [2653], 'Western': [2654, 4109, 5037], 'analysis': [2655, 4111, 4359], 'rabbit': [2660], 'polyclonal': [2661], 'anti-DAX-1': [2662], 'serum': [2663], '(Santa': [2664], 'Cruz': [2665], 'Biotechnology)': [2666], '1:1000': [2668], 'dilution.': [2669], 'Transient': [2670], 'transfections': [2671, 2770, 3599], 'Briefly,': [2728], 'transfected': [2732], 'appropriate': [2734], 'indicated': [2741], 'figure': [2744], 'legends': [2745], 'Lipofectin': [2748], '(Life': [2749], 'Technologies)': [2750], 'instructed': [2752], 'manufacturer.': [2755], 'Cell': [2756], 'prepared': [2759], 'after': [2760, 3456], '24-h': [2761], 'Individual': [2769], 'triplicate,': [2774], 'all': [2776, 3190, 3198, 4377, 4753, 5446], 'experiments': [2777, 3278, 3949], 'repeated': [2779], 'least': [2781], 'times.': [2783], 'Inspection': [2784], 'sequence': [2789, 3168], 'each': [2792], 'motif': [2801, 2811, 2882, 3096, 3107, 3218, 5032], 'resembling': [2802], 'NR-box': [2804], '(Fig.': [2805, 2838, 2866, 2973, 2986, 3000, 3048, 3083, 3219, 3282, 3465, 3508, 3600, 3834, 3840, 4125], 'A).': [2807, 3284], 'Whereas': [2808, 3285], 'third': [2810, 3216], '(Box': [2812], '3)': [2813, 3332], 'matches': [2814], 'consensus': [2816], 'core': [2818, 3167], 'leucines': [2820], '+1,': [2823], '+4,': [2824], '+5': [2826], 'positions,': [2827], 'other': [2829, 3008, 3398], 'contain': [2832], 'methionine': [2833], '+4': [2836], 'position': [2837], 'C).': [2840, 3085, 3173], 'Box': [2843], '3': [2844, 3031, 3045, 3236, 3283, 3466, 3509], 'conserved': [2846, 5066, 5444], 'species': [2848, 5068], '(e.g.': [2849], 'mouse': [2850], 'DAX-1)': [2853], 'homology': [2857], '(i.e.': [2858], 'outside': [2859], 'core)': [2862], 'SHP-Box1': [2865], '1,': [2867], 'A': [2868], 'C),': [2870, 3510], 'ER-binding': [2881, 3106], 'Therefore,': [2906, 5330], 'reasoned': [2908], 'region,': [2913], 'additionally': [2957], 'mediate': [2958, 5218], 'several': [2964], 'NR-Box-containing': [2967], 'fused': [2970, 3080, 3344], 'assessed': [2977, 3038, 3074], 'radiolabeled': [2981], '2).': [2987], 'First,': [2988, 3436], 'interact': [2994, 3264], 'estradiol-bound': [2996], 'A)': [3002, 3836], 'various': [3007], '(data': [3010, 3256, 3388, 3871], 'not': [3011, 3240, 3257, 3389, 3402, 3495, 3521, 3541, 3872, 3886, 4533], 'shown),': [3012, 3873], 'indicating': [3013, 3333, 3874, 3896], 'indeed': [3021], 'serve': [3023, 3916, 4135, 5148], 'Second,': [3027, 3502], 'because': [3028, 4183], 'perfect': [3034], 'alone': [3047], 'B).': [3050, 3467], 'Both': [3051], 'equally': [3054], 'well,': [3055], 'estradiol': [3057, 3286], 'enhanced': [3058], 'interactions.': [3060], 'Third,': [3061], 'see': [3063], 'whether': [3064, 3261, 5290], 'peptides': [3079, 3191], 'comparison,': [3087, 3338], 'second': [3094], 'p160': [3099], 'TIF2,': [3101], 'represents': [3103], 'high-affinity': [3105], 'included': [3161], 'DAX-1-Box1': [3163], 'LXXML': [3169], 'Interestingly,': [3174, 5010], 'although': [3175], 'apparently': [3178, 4300, 5015], 'displayed': [3179], 'higher': [3181, 3865], 'DAX-1-Box3,': [3184], 'interacted': [3188, 3513], 'including': [3192], 'DAX-1-Box1.': [3193], 'This': [3194, 5056], 'indicates': [3195], 'NR': [3200], 'Boxes': [3201], 'involved': [3208, 4684], 'binding.': [3211], 'Consistently,': [3212], 'B,': [3221], 'R3mut)': [3222], 'abolished': [3223], 'when': [3227, 3241, 3490, 3863], 'context': [3231, 3245], 'isolated': [3234], 'expected': [3238, 3369], 'entire': [3253, 5018], 'protein': [3255, 3293, 3320, 3464, 3478, 3619, 3807, 4115, 4139, 4362], 'shown).': [3258, 3390], 'investigate': [3260, 3580, 5289], 'can': [3263], 'dimers': [3271], 'vitro,': [3273], 'induced': [3294], 'characteristic': [3296], 'downshift': [3297], 'ERβ·DNA': [3300], 'complex': [3301, 3335, 3373], 'conformational': [3304], 'changes': [3305], 'upon': [3306], '(lanes': [3309, 3470, 3483, 3499], 'and2),': [3311], 'addition': [3312], 'led': [3321], 'upshift': [3325], '(compare': [3326], 'lane': [3327], 'withlanes': [3329], 'ternary': [3334], 'formation.': [3336], 'TIF2': [3343], 'promoted': [3364], 'ligand-dependent': [3366], '(lane': [3370], '6).': [3371], 'Ternary': [3372], 'formation': [3374], 'similarly': [3376], 'observed': [3377, 3430, 3551, 3823, 4570], 'homodimers,': [3380], 'RXR': [3382], 'heterodimers': [3383], 'monomeric': [3386], 'data': [3392], 'indicate': [3393, 4898], 'interfering': [3403], 'dimerization': [3405], 'resembles': [3411], 'coactivator-type': [3412], 'AF-2': [3416], 'Further': [3421], 'additional': [3433, 4915], 'experimental': [3434], 'settings.': [3435], 'coimmunoprecipitation': [3439], 'assay,': [3440], 'whole-cell': [3441], 'αFLAG-affinity': [3453], 'Overexpressed': [3468], '4)': [3473], 'endogenous': [3481, 5353], 'and3)': [3485], 'coprecipitated': [3488], 'FLAG·ERs': [3491], 'present': [3493], '5': [3500, 5193], 'and6).': [3501], 'GAL4·DAX-1': [3511, 3805, 3889], 'strongly': [3512], 'both': [3515, 4118, 5526], '(GAD)-tagged': [3518], 'GAD': [3523], 'alone.': [3524], 'Apparent': [3525], 'differences': [3526], 'regard': [3532], 'ligand-independent': [3535], 'peculiarity': [3543], 'consequences': [3582], 'estrogen-responsive': [3594], 'promoters,': [3595], 'transient': [3598], '4).': [3601], 'compared': [3603], 'constructs:': [3608], '(i)': [3609], 'DAX-1,': [3611, 3861], 'repressor': [3624, 3817, 5361], '24Lalli': [3661], '(ii)': [3728], 'naturally': [3730], 'occurring': [3731], 'mutation,': [3734], 'nonrepressing': [3737], 'its': [3741, 5025], 'inability': [3742, 4001], '(iii)': [3803], 'containing': [3815], 'LBD.': [3821], 'WT': [3826], 'surprisingly': [3828, 4531], 'also': [3829], 'inhibited': [3832], 'B),': [3842], 'dose-dependent': [3846], 'manner.': [3847], 'However,': [3848, 4091, 4710], 'repression-defective': [3850], 'variant': [3852], 'appeared': [3853], 'less': [3856, 4692], 'effective': [3857], 'than': [3858], 'particularly': [3862], 'amounts': [3866, 4104], 'plasmid': [3870], 'active': [3876], 'repression': [3877], 'contribute': [3879], 'inhibitory': [3882, 3899, 4103, 5090], 'effects.': [3883], 'Inhibition': [3884], 'did': [3885, 4532], 'occur': [3887, 5294], 'domain,': [3895], 'effect': [3900, 4086], 'requires': [3901], 'furthermore': [3910], 'obtain': [3923], 'further': [3924], 'possible': [3928], 'bridging': [3937, 4138], 'protein,': [3938, 5565], 'experiment': [3944], 'analogy': [3946], 'As': [3972], 'seen': [3973], 'C,': [3977, 4127], 'GAL4·ERα': [3978], 'VP16': [3980], 'domain-tagged': [3982], 'encompassing': [3984], 'cotransfected': [3990, 4082], 'DAX-1.': [3997, 4106, 4526], 'Consistent': [3998], 'agonists': [4012], '(37Lavinsky': [4013], 'Jepsen': [4015], 'Heinzel': [4017], 'Schiff': [4023], 'Del-Rio': [4025], 'A.L.': [4026], 'Ricote': [4027], 'Ngo': [4029], 'Gemsch': [4031], 'Hilsenbeck': [4033], 'S.G.': [4034], 'Osborne': [4035], '2920-2925Crossref': [4052], '(587)': [4055], '38Smith': [4058], 'C.L.': [4059], 'Nawaz': [4060], '657-666Crossref': [4068], '(556)': [4071], 'had': [4084], 'no': [4085], 'estradiol-induced': [4088], 'partially': [4094], 'restore': [4095], 'blot': [4110], 'shows': [4112], 'equal': [4113], 'levels': [4116], 'lower),': [4128], 'result': [4130], '5).': [4149], 'presented': [4152], 'provide': [4156, 5084, 5195], 'uncovered': [4160], 'structure': [4164], 'substantially': [4168], 'expand': [4169], 'potential': [4172, 5512], 'DAX1.': [4174], 'physiologically': [4181], 'relevant': [4182], 'tissues': [4191], '39Bae': [4215, 5174], 'D.S.': [4216, 5175], 'Schaefer': [4217, 5176], 'M.L.': [4218, 5177], 'Partan': [4219, 5178], 'Muglia': [4221, 5180], '137:': [4225, 4591, 5184], '3921-3927Crossref': [4226, 5185], '(47)': [4229, 5188], 'Summarizing': [4232], 'independent': [4236], 'immunohistochemical': [4237], 'analyses': [4238], '(40Taylor': [4239], 'A.H.': [4240, 5044], 'Al-Azzawi': [4241], '24:': [4247, 5049], '145-155Crossref': [4248], '(458)': [4251], '41Van': [4254], 'der': [4255, 4262, 4266, 4657, 4661], 'Pelt': [4256], 'A.M.M.': [4257], 'De': [4258], 'Rooij': [4259], 'D.G.': [4260], 'Van': [4261, 4265], 'Burg': [4263, 4662], 'Saag': [4267, 4658], 'P.T.': [4268, 4659], 'Kuiper': [4271, 4652], '140:': [4275, 4742], '478-483Crossref': [4276], '(221)': [4279], '2J.': [4282], 'Å.': [4283], 'Warner,': [4287], 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[4565], 'intriguingly': [4567], '(42Eddy': [4575], 'Washburn': [4577], 'T.F.': [4578], 'Bunch': [4579], 'D.O.': [4580], 'Goulding': [4581], 'E.H.': [4582], 'Gladen': [4583], 'B.C.': [4584], 'Lubahn': [4585], 'D.B.': [4586], '4796-4805Crossref': [4592], '(666)': [4595], 'Moreover,': [4598], 'developmental': [4599], 'ovary': [4610], 'during': [4611], 'certain': [4612], 'stages': [4613], 'embryogenesis': [4615], '(35Ikeda': [4616], '43Lemmen': [4648], 'J.G.': [4649, 4869], 'Broekhof': [4650], 'J.L.M.': [4651], 'van': [4656, 4660], 'Mech.': [4664], '81:': [4667], '163-167Crossref': [4668], '(127)': [4671], 'Possibly,': [4674], 'serves': [4676], 'tissue-': [4679], 'stage-specific': [4681], 'signaling.': [4689], 'Comparatively,': [4690], 'gland,': [4701], 'major': [4703], 'steroidogenesis.': [4709], 'estrogens': [4711], 'detected': [4722], 'cortex': [4725], 'fetal': [4727], 'primate': [4728], 'glands': [4729], '(44Albrecht': [4730], 'E.D.': [4731], 'Babischkin': [4732], 'Davies': [4734], 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