I-TAC/CXCL11 is a natural antagonist for CCR5

Name: Work Video:
Duration: 3 min 30 s
Vibor Petkovic; Christian Moghini; Samantha Paoletti; Mariagrazia Uguccioni; Basil O. Gerber
{'id': 'https://openalex.org/W2003037948', 'doi': 'https://doi.org/10.1189/jlb.1103570', 'title': 'I-TAC/CXCL11 is a natural antagonist for CCR5', 'display_name': 'I-TAC/CXCL11 is a natural antagonist for CCR5', 'publication_year': 2004, 'publication_date': '2004-06-03', 'ids': {'openalex': 'https://openalex.org/W2003037948', 'doi': 'https://doi.org/10.1189/jlb.1103570', 'mag': '2003037948', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15178708'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1189/jlb.1103570', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S199011235', 'display_name': 'Journal of Leukocyte Biology', 'issn_l': '0741-5400', 'issn': ['0741-5400', '1938-3673'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5033285915', 'display_name': 'Vibor Petkovic', 'orcid': None}, 'institutions': [], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Vibor Petkovic', 'raw_affiliation_strings': ['Institute for Research in Biomedicine , Bellinzona, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Institute for Research in Biomedicine , Bellinzona, Switzerland', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067952389', 'display_name': 'Christian Moghini', 'orcid': None}, 'institutions': [], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Christian Moghini', 'raw_affiliation_strings': ['Institute for Research in Biomedicine , Bellinzona, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Institute for Research in Biomedicine , Bellinzona, Switzerland', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046495527', 'display_name': 'Samantha Paoletti', 'orcid': 'https://orcid.org/0000-0001-7982-6478'}, 'institutions': [], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Samantha Paoletti', 'raw_affiliation_strings': ['Institute for Research in Biomedicine , Bellinzona, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Institute for Research in Biomedicine , Bellinzona, Switzerland', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015756254', 'display_name': 'Mariagrazia Uguccioni', 'orcid': 'https://orcid.org/0000-0002-9570-7011'}, 'institutions': [], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Mariagrazia Uguccioni', 'raw_affiliation_strings': ['Institute for Research in Biomedicine , Bellinzona, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Institute for Research in Biomedicine , Bellinzona, Switzerland', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5038235405', 'display_name': 'Basil O. Gerber', 'orcid': None}, 'institutions': [], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Basil Gerber', 'raw_affiliation_strings': ['Institute for Research in Biomedicine , Bellinzona, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Institute for Research in Biomedicine , Bellinzona, Switzerland', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3350, 'currency': 'USD', 'value_usd': 3350, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.509, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 56, 'citation_normalized_percentile': {'value': 0.859373, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '76', 'issue': '3', 'first_page': '701', 'last_page': '708'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11532', 'display_name': 'Chemokine receptors and signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11532', 'display_name': 'Chemokine receptors and signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10371', 'display_name': 'Immune Response and Inflammation', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cxcl14', 'display_name': 'CXCL14', 'score': 0.67836875}, {'id': 'https://openalex.org/keywords/ccl5', 'display_name': 'CCL5', 'score': 0.66847646}, {'id': 'https://openalex.org/keywords/xcl2', 'display_name': 'XCL2', 'score': 0.6513921}, {'id': 'https://openalex.org/keywords/cxcl9', 'display_name': 'CXCL9', 'score': 0.6341847}, {'id': 'https://openalex.org/keywords/ccl17', 'display_name': 'CCL17', 'score': 0.62367123}, {'id': 'https://openalex.org/keywords/cxcl11', 'display_name': 'CXCL11', 'score': 0.6084525}, {'id': 'https://openalex.org/keywords/cxcr3', 'display_name': 'CXCR3', 'score': 0.5552009}, {'id': 'https://openalex.org/keywords/chemokine-receptor-ccr5', 'display_name': 'Chemokine receptor CCR5', 'score': 0.53067}, {'id': 'https://openalex.org/keywords/cxc-chemokine-receptors', 'display_name': 'CXC chemokine receptors', 'score': 0.5090737}, {'id': 'https://openalex.org/keywords/cc-chemokine-receptors', 'display_name': 'CC chemokine receptors', 'score': 0.5060691}, {'id': 'https://openalex.org/keywords/cxcl16', 'display_name': 'CXCL16', 'score': 0.4976566}, {'id': 'https://openalex.org/keywords/ccl7', 'display_name': 'CCL7', 'score': 0.43099612}, {'id': 'https://openalex.org/keywords/ccr3', 'display_name': 'CCR3', 'score': 0.42819908}], 'concepts': [{'id': 'https://openalex.org/C45240729', 'wikidata': 'https://www.wikidata.org/wiki/Q21112077', 'display_name': 'CXCL14', 'level': 5, 'score': 0.67836875}, {'id': 'https://openalex.org/C116484652', 'wikidata': 'https://www.wikidata.org/wiki/Q3492926', 'display_name': 'CCL5', 'level': 5, 'score': 0.66847646}, {'id': 'https://openalex.org/C48001867', 'wikidata': 'https://www.wikidata.org/wiki/Q8041712', 'display_name': 'XCL2', 'level': 5, 'score': 0.6513921}, {'id': 'https://openalex.org/C17502307', 'wikidata': 'https://www.wikidata.org/wiki/Q411999', 'display_name': 'CXCL9', 'level': 5, 'score': 0.6341847}, {'id': 'https://openalex.org/C143172330', 'wikidata': 'https://www.wikidata.org/wiki/Q1069599', 'display_name': 'CCL17', 'level': 5, 'score': 0.62367123}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.61425054}, {'id': 'https://openalex.org/C13425408', 'wikidata': 'https://www.wikidata.org/wiki/Q5014882', 'display_name': 'CXCL11', 'level': 5, 'score': 0.6084525}, {'id': 'https://openalex.org/C5858377', 'wikidata': 'https://www.wikidata.org/wiki/Q986112', 'display_name': 'CXCL10', 'level': 4, 'score': 0.6047947}, {'id': 'https://openalex.org/C94205230', 'wikidata': 'https://www.wikidata.org/wiki/Q5005868', 'display_name': 'C-C chemokine receptor type 6', 'level': 5, 'score': 0.5728549}, {'id': 'https://openalex.org/C25532541', 'wikidata': 'https://www.wikidata.org/wiki/Q655541', 'display_name': 'CXCR3', 'level': 5, 'score': 0.5552009}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5329493}, {'id': 'https://openalex.org/C45635710', 'wikidata': 'https://www.wikidata.org/wiki/Q418404', 'display_name': 'Chemokine receptor CCR5', 'level': 5, 'score': 0.53067}, {'id': 'https://openalex.org/C84913492', 'wikidata': 'https://www.wikidata.org/wiki/Q5014892', 'display_name': 'CXC chemokine receptors', 'level': 5, 'score': 0.5090737}, {'id': 'https://openalex.org/C128879288', 'wikidata': 'https://www.wikidata.org/wiki/Q5009764', 'display_name': 'CC chemokine receptors', 'level': 5, 'score': 0.5060691}, {'id': 'https://openalex.org/C135576274', 'wikidata': 'https://www.wikidata.org/wiki/Q21112082', 'display_name': 'CXCL16', 'level': 5, 'score': 0.4976566}, {'id': 'https://openalex.org/C12823836', 'wikidata': 'https://www.wikidata.org/wiki/Q24720618', 'display_name': 'Chemokine receptor', 'level': 4, 'score': 0.4739114}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.4593061}, {'id': 'https://openalex.org/C13164669', 'wikidata': 'https://www.wikidata.org/wiki/Q5009628', 'display_name': 'CCL7', 'level': 5, 'score': 0.43099612}, {'id': 'https://openalex.org/C1423137', 'wikidata': 'https://www.wikidata.org/wiki/Q21113928', 'display_name': 'CCR3', 'level': 5, 'score': 0.42819908}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.3029414}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.28880274}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.10456917}, {'id': 'https://openalex.org/C79484868', 'wikidata': 'https://www.wikidata.org/wiki/Q5971673', 'display_name': 'IL-2 receptor', 'level': 4, 'score': 0.073222965}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D065100', 'descriptor_name': 'CCR5 Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019743', 'descriptor_name': 'Chemokines, CXC', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D002634', 'descriptor_name': 'Chemotaxis, Leukocyte', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D007963', 'descriptor_name': 'Leukocytes, Mononuclear', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D019713', 'descriptor_name': 'Receptors, CCR5', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D020013', 'descriptor_name': 'Calcium Signaling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020013', 'descriptor_name': 'Calcium Signaling', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D020013', 'descriptor_name': 'Calcium Signaling', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054405', 'descriptor_name': 'Chemokine CCL3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054407', 'descriptor_name': 'Chemokine CCL4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018946', 'descriptor_name': 'Chemokine CCL5', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018946', 'descriptor_name': 'Chemokine CCL5', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018946', 'descriptor_name': 'Chemokine CCL5', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D054371', 'descriptor_name': 'Chemokine CXCL11', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019743', 'descriptor_name': 'Chemokines, CXC', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019743', 'descriptor_name': 'Chemokines, CXC', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019743', 'descriptor_name': 'Chemokines, CXC', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002634', 'descriptor_name': 'Chemotaxis, Leukocyte', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002634', 'descriptor_name': 'Chemotaxis, Leukocyte', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007963', 'descriptor_name': 'Leukocytes, Mononuclear', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007963', 'descriptor_name': 'Leukocytes, Mononuclear', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D019402', 'descriptor_name': 'Macrophage Inflammatory Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019402', 'descriptor_name': 'Macrophage Inflammatory Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D019402', 'descriptor_name': 'Macrophage Inflammatory Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D054397', 'descriptor_name': 'Receptors, CCR3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019713', 'descriptor_name': 'Receptors, CCR5', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019713', 'descriptor_name': 'Receptors, CCR5', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019707', 'descriptor_name': 'Receptors, Chemokine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019707', 'descriptor_name': 'Receptors, Chemokine', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1189/jlb.1103570', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S199011235', 'display_name': 'Journal of Leukocyte Biology', 'issn_l': '0741-5400', 'issn': ['0741-5400', '1938-3673'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15178708', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320328148', 'funder_display_name': 'Helmut Horten Stiftung', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 64, 'referenced_works': ['https://openalex.org/W1542488102', 'https://openalex.org/W1593511384', 'https://openalex.org/W1596576376', 'https://openalex.org/W1607601839', 'https://openalex.org/W1622920648', 'https://openalex.org/W1648671938', 'https://openalex.org/W1675573039', 'https://openalex.org/W1844442355', 'https://openalex.org/W1924532031', 'https://openalex.org/W1971468252', 'https://openalex.org/W1973190148', 'https://openalex.org/W1975991970', 'https://openalex.org/W1978887381', 'https://openalex.org/W1994387916', 'https://openalex.org/W1996183144', 'https://openalex.org/W1997444277', 'https://openalex.org/W1998279017', 'https://openalex.org/W1998605540', 'https://openalex.org/W2007481273', 'https://openalex.org/W2015642465', 'https://openalex.org/W2017560362', 'https://openalex.org/W2017958811', 'https://openalex.org/W2023088800', 'https://openalex.org/W2026578487', 'https://openalex.org/W2029262446', 'https://openalex.org/W2031414871', 'https://openalex.org/W2043219898', 'https://openalex.org/W2045281561', 'https://openalex.org/W2046842929', 'https://openalex.org/W2051836311', 'https://openalex.org/W2058132087', 'https://openalex.org/W2072451218', 'https://openalex.org/W2081596482', 'https://openalex.org/W2086196933', 'https://openalex.org/W2091040274', 'https://openalex.org/W2102497491', 'https://openalex.org/W2105594104', 'https://openalex.org/W2106042276', 'https://openalex.org/W2106607972', 'https://openalex.org/W2119261083', 'https://openalex.org/W2122715437', 'https://openalex.org/W2131859877', 'https://openalex.org/W2139775324', 'https://openalex.org/W2140527770', 'https://openalex.org/W2143584481', 'https://openalex.org/W2144240179', 'https://openalex.org/W2145561586', 'https://openalex.org/W2146822492', 'https://openalex.org/W2151889582', 'https://openalex.org/W2153748057', 'https://openalex.org/W2159520551', 'https://openalex.org/W2159543436', 'https://openalex.org/W2160129587', 'https://openalex.org/W2160272188', 'https://openalex.org/W2165049218', 'https://openalex.org/W2316311853', 'https://openalex.org/W2402533012', 'https://openalex.org/W4239153744', 'https://openalex.org/W4243387284', 'https://openalex.org/W4313347795', 'https://openalex.org/W4313376938', 'https://openalex.org/W4313422358', 'https://openalex.org/W58852549', 'https://openalex.org/W97158386'], 'related_works': ['https://openalex.org/W4237625436', 'https://openalex.org/W2380294475', 'https://openalex.org/W2341885578', 'https://openalex.org/W2269066669', 'https://openalex.org/W2153630912', 'https://openalex.org/W2124328573', 'https://openalex.org/W2098785486', 'https://openalex.org/W2068244606', 'https://openalex.org/W2035635341', 'https://openalex.org/W177323295'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'selective': [2, 116], 'CXC': [3], 'chemokine': [4, 15, 52, 87], 'receptor': [5, 53], '3': [6, 54, 89], '(CXCR3)': [7], 'agonists,': [8], 'monokine': [9], 'induced': [10], 'by': [11, 103, 194], 'interferon-γ': [12], '(IFN-': [13], 'γ)/CXC': [14], 'ligand': [16, 88], '9': [17], '(CXCL9),': [18], 'IFN-inducible': [19, 23], 'protein': [20], '10/CXCL10,': [21], 'and': [22, 39, 56, 96, 110, 113, 125, 140, 151, 161, 184], 'T': [24, 35, 108], 'cell': [25, 100], 'α': [26], 'chemoattractant': [27], '(I-TAC)/CXCL11,': [28], 'attract': [29], 'CXCR3+': [30], 'cells': [31, 92, 124], 'such': [32], 'as': [33, 74, 177, 186, 208], 'CD45RO+': [34], 'lymphocytes,': [36], 'B': [37], 'cells,': [38], 'natural': [40, 49], 'killer': [41], 'cells.': [42], 'Further,': [43], 'all': [44], 'three': [45], 'chemokines': [46, 198], 'are': [47], 'potent,': [48], 'antagonists': [50], 'for': [51, 77, 158], '(CCR3)': [55], 'feature': [57], 'defensin-like,': [58], 'antimirobial': [59], 'activities.': [60], 'In': [61, 128], 'this': [62], 'study,': [63], 'we': [64], 'show': [65], 'that': [66, 199], 'I-TAC,': [67], 'in': [68, 122, 165, 181], 'addition': [69], 'to': [70, 91, 97, 147], 'these': [71], 'effects,': [72], 'acts': [73], 'an': [75], 'antagonist': [76], 'CCR5.': [78], 'I-TAC': [79, 143, 164, 176, 187], 'inhibited': [80, 121], 'the': [81, 115, 134, 172, 191], 'binding': [82], 'of': [83, 118, 136, 163, 175], 'macrophage-inflammatory': [84], 'protein-1α': [85], '(MIP-1α)/CC': [86], '(CCL3)': [90], 'transfected': [93, 123], 'with': [94], 'CCR5': [95, 145, 166, 207], 'monocytes.': [98], 'Furthermore,': [99], 'migration': [101, 183], 'evoked': [102], 'regulated': [104], 'on': [105, 171], 'activation,': [106, 185], 'normal': [107], 'expressed': [109], 'secreted': [111], '(RANTES)/CCL5': [112], 'MIP-1β/CCL4,': [114], 'agonist': [117], 'CCR5,': [119], 'was': [120], 'monocytes,': [126], 'respectively.': [127], 'two': [129], 'other': [130], 'functional': [131], 'assays,': [132], 'namely': [133], 'release': [135], 'free': [137], 'intracellular': [138], 'calcium': [139], 'actin': [141], 'polymerization,': [142], 'reduced': [144], 'activities': [146], 'minimal': [148], 'levels.': [149], 'Sequence': [150], 'structure': [152], 'analyses': [153], 'indicate': [154], 'a': [155, 178], 'potential': [156, 173], 'role': [157, 174], 'K17,': [159], 'K49,': [160], 'Q51': [162], 'binding.': [167], 'Our': [168], 'results': [169], 'expand': [170], 'negative': [179], 'modulator': [180], 'leukocyte': [182], 'would': [188], 'specifically': [189], 'counteract': [190], 'responses': [192], 'mediated': [193], 'many': [195], '“classical,”': [196], 'inflammatory': [197], 'act': [200], 'not': [201], 'only': [202], 'via': [203, 206], 'CCR3': [204], 'but': [205], 'well.': [209]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2003037948', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-24T18:59:26.578289', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
