Publication Information

{'id': 'https://openalex.org/W2002953145', 'doi': 'https://doi.org/10.1371/journal.pcbi.1004062', 'title': 'Cyclin and DNA Distributed Cell Cycle Model for GS-NS0 Cells', 'display_name': 'Cyclin and DNA Distributed Cell Cycle Model for GS-NS0 Cells', 'publication_year': 2015, 'publication_date': '2015-02-27', 'ids': {'openalex': 'https://openalex.org/W2002953145', 'doi': 'https://doi.org/10.1371/journal.pcbi.1004062', 'mag': '2002953145', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25723523', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4344234'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pcbi.1004062', 'pdf_url': 'https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004062&type=printable', 'source': {'id': 'https://openalex.org/S86033158', 'display_name': 'PLoS Computational Biology', 'issn_l': '1553-734X', 'issn': ['1553-734X', '1553-7358'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316756', 'host_organization_name': 'International Society for Computational Biology', 'host_organization_lineage': ['https://openalex.org/P4310316756'], 'host_organization_lineage_names': ['International Society for Computational Biology'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004062&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5042803755', 'display_name': 'David Garcia Munzer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I47508984', 'display_name': 'Imperial College London', 'ror': 'https://ror.org/041kmwe10', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I47508984']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'David G. García Münzer', 'raw_affiliation_strings': ['Biological Systems Engineering Laboratory, Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Biological Systems Engineering Laboratory, Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, London, United Kingdom', 'institution_ids': ['https://openalex.org/I47508984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030892989', 'display_name': 'Margaritis Kostoglou', 'orcid': 'https://orcid.org/0000-0001-7955-0002'}, 'institutions': [{'id': 'https://openalex.org/I21370196', 'display_name': 'Aristotle University of Thessaloniki', 'ror': 'https://ror.org/02j61yw88', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I21370196']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Margaritis Kostoglou', 'raw_affiliation_strings': ['Department of Chemistry, Aristotle University of Thessaloníki, Thessaloníki, Greece'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Aristotle University of Thessaloníki, Thessaloníki, Greece', 'institution_ids': ['https://openalex.org/I21370196']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062286648', 'display_name': 'Michael C. Georgiadis', 'orcid': 'https://orcid.org/0000-0002-2016-5131'}, 'institutions': [{'id': 'https://openalex.org/I21370196', 'display_name': 'Aristotle University of Thessaloniki', 'ror': 'https://ror.org/02j61yw88', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I21370196']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Michael C. Georgiadis', 'raw_affiliation_strings': ['Dept. of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece', 'institution_ids': ['https://openalex.org/I21370196']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005967060', 'display_name': 'Efstratios N. Pistikopoulos', 'orcid': 'https://orcid.org/0000-0001-6220-818X'}, 'institutions': [{'id': 'https://openalex.org/I47508984', 'display_name': 'Imperial College London', 'ror': 'https://ror.org/041kmwe10', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I47508984']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Efstratios N. Pistikopoulos', 'raw_affiliation_strings': ['Biological Systems Engineering Laboratory, Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Biological Systems Engineering Laboratory, Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, London, United Kingdom', 'institution_ids': ['https://openalex.org/I47508984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048473531', 'display_name': 'Athanasios Mantalaris', 'orcid': 'https://orcid.org/0000-0001-6183-0292'}, 'institutions': [{'id': 'https://openalex.org/I47508984', 'display_name': 'Imperial College London', 'ror': 'https://ror.org/041kmwe10', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I47508984']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Athanasios Mantalaris', 'raw_affiliation_strings': ['Biological Systems Engineering Laboratory, Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Biological Systems Engineering Laboratory, Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, London, United Kingdom', 'institution_ids': ['https://openalex.org/I47508984']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2655, 'currency': 'USD', 'value_usd': 2655, 'provenance': 'doaj'}, 'apc_paid': {'value': 2655, 'currency': 'USD', 'value_usd': 2655, 'provenance': 'doaj'}, 'fwci': 1.517, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 25, 'citation_normalized_percentile': {'value': 0.856575, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '11', 'issue': '2', 'first_page': 'e1004062', 'last_page': 'e1004062'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10621', 'display_name': 'Gene Regulatory Network Analysis', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10621', 'display_name': 'Gene Regulatory Network Analysis', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11829', 'display_name': 'Mathematical Biology Tumor Growth', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/2611', 'display_name': 'Modeling and Simulation'}, 'field': {'id': 'https://openalex.org/fields/26', 'display_name': 'Mathematics'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12859', 'display_name': 'Cell Image Analysis Techniques', 'score': 0.9874, 'subfield': {'id': 'https://openalex.org/subfields/1304', 'display_name': 'Biophysics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cyclin-a', 'display_name': 'Cyclin A', 'score': 0.46454644}], 'concepts': [{'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.8630377}, {'id': 'https://openalex.org/C120089663', 'wikidata': 'https://www.wikidata.org/wiki/Q59250999', 'display_name': 'Cyclin', 'level': 4, 'score': 0.69387746}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.6449332}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.60106725}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5753443}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.52588576}, {'id': 'https://openalex.org/C105696609', 'wikidata': 'https://www.wikidata.org/wiki/Q1068809', 'display_name': 'Cell cycle checkpoint', 'level': 4, 'score': 0.49415234}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.4652392}, {'id': 'https://openalex.org/C16438837', 'wikidata': 'https://www.wikidata.org/wiki/Q5198260', 'display_name': 'Cyclin A', 'level': 5, 'score': 0.46454644}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.41850752}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.20814231}], 'mesh': [{'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016213', 'descriptor_name': 'Cyclins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pcbi.1004062', 'pdf_url': 'https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004062&type=printable', 'source': {'id': 'https://openalex.org/S86033158', 'display_name': 'PLoS Computational Biology', 'issn_l': '1553-734X', 'issn': ['1553-734X', '1553-7358'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316756', 'host_organization_name': 'International Society for Computational Biology', 'host_organization_lineage': ['https://openalex.org/P4310316756'], 'host_organization_lineage_names': ['International Society for Computational Biology'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/f52327696484461abaabba4532988838', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4344234', 'pdf_url': 'https://europepmc.org/articles/pmc4344234?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/10044/1/33038', 'pdf_url': 'http://spiral.imperial.ac.uk/bitstream/10044/1/33038/2/Cyclin%20and%20DNA%20distributed%20cell%20cycle%20model%20for%20GS-NS0%20cells.pdf', 'source': {'id': 'https://openalex.org/S4306401396', 'display_name': 'Spiral (Imperial College London)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I47508984', 'host_organization_name': 'Imperial College London', 'host_organization_lineage': ['https://openalex.org/I47508984'], 'host_organization_lineage_names': ['Imperial College London'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344234', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25723523', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pcbi.1004062', 'pdf_url': 'https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004062&type=printable', 'source': {'id': 'https://openalex.org/S86033158', 'display_name': 'PLoS Computational Biology', 'issn_l': '1553-734X', 'issn': ['1553-734X', '1553-7358'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316756', 'host_organization_name': 'International Society for Computational Biology', 'host_organization_lineage': ['https://openalex.org/P4310316756'], 'host_organization_lineage_names': ['International Society for Computational Biology'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/8', 'score': 0.53, 'display_name': 'Decent work and economic growth'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 87, 'referenced_works': ['https://openalex.org/W1487252915', 'https://openalex.org/W1487485549', 'https://openalex.org/W1498699116', 'https://openalex.org/W1516270958', 'https://openalex.org/W1551250150', 'https://openalex.org/W1564970155', 'https://openalex.org/W1583997234', 'https://openalex.org/W1966293504', 'https://openalex.org/W1967757831', 'https://openalex.org/W1968277140', 'https://openalex.org/W1969192942', 'https://openalex.org/W1974391793', 'https://openalex.org/W1976883035', 'https://openalex.org/W1981449476', 'https://openalex.org/W1983555294', 'https://openalex.org/W1985871342', 'https://openalex.org/W1987743933', 'https://openalex.org/W1988540551', 'https://openalex.org/W1989722723', 'https://openalex.org/W1990149904', 'https://openalex.org/W1990925999', 'https://openalex.org/W1991285146', 'https://openalex.org/W1995016972', 'https://openalex.org/W1996759600', 'https://openalex.org/W2001622184', 'https://openalex.org/W2002115571', 'https://openalex.org/W2003209357', 'https://openalex.org/W2004486211', 'https://openalex.org/W2013276474', 'https://openalex.org/W2014618083', 'https://openalex.org/W2015612415', 'https://openalex.org/W2020668111', 'https://openalex.org/W2021785679', 'https://openalex.org/W2027558915', 'https://openalex.org/W2028032839', 'https://openalex.org/W2029640436', 'https://openalex.org/W2031475240', 'https://openalex.org/W2034638137', 'https://openalex.org/W2043070535', 'https://openalex.org/W2044807816', 'https://openalex.org/W2047899422', 'https://openalex.org/W2052355054', 'https://openalex.org/W2054186763', 'https://openalex.org/W2060805800', 'https://openalex.org/W2061302404', 'https://openalex.org/W2061498745', 'https://openalex.org/W2062057385', 'https://openalex.org/W2063372321', 'https://openalex.org/W2064927748', 'https://openalex.org/W2065303540', 'https://openalex.org/W2066499437', 'https://openalex.org/W2066764369', 'https://openalex.org/W2067912936', 'https://openalex.org/W2069825639', 'https://openalex.org/W2071646337', 'https://openalex.org/W2074930902', 'https://openalex.org/W2077779831', 'https://openalex.org/W2080760786', 'https://openalex.org/W2085593164', 'https://openalex.org/W2087783847', 'https://openalex.org/W2098201181', 'https://openalex.org/W2099312222', 'https://openalex.org/W2110128638', 'https://openalex.org/W2117045376', 'https://openalex.org/W2128156756', 'https://openalex.org/W2130873080', 'https://openalex.org/W2132205889', 'https://openalex.org/W2134217080', 'https://openalex.org/W2135461398', 'https://openalex.org/W2142884934', 'https://openalex.org/W2148650601', 'https://openalex.org/W2149943165', 'https://openalex.org/W2155196267', 'https://openalex.org/W2163754616', 'https://openalex.org/W2164441383', 'https://openalex.org/W2169082384', 'https://openalex.org/W2169658509', 'https://openalex.org/W2263017274', 'https://openalex.org/W2323387578', 'https://openalex.org/W2524892032', 'https://openalex.org/W4239403073', 'https://openalex.org/W4247623139', 'https://openalex.org/W4252069185', 'https://openalex.org/W4285719527', 'https://openalex.org/W4301648907', 'https://openalex.org/W641652653', 'https://openalex.org/W993219267'], 'related_works': ['https://openalex.org/W4296270000', 'https://openalex.org/W4293783213', 'https://openalex.org/W4290975420', 'https://openalex.org/W3107603624', 'https://openalex.org/W2919428694', 'https://openalex.org/W2393344259', 'https://openalex.org/W2073146317', 'https://openalex.org/W1995228374', 'https://openalex.org/W1972085353', 'https://openalex.org/W1686076540'], 'abstract_inverted_index': {'Mammalian': [0], 'cell': [1, 13, 36, 39, 56, 71, 89, 95, 119, 137, 145, 210, 214, 220, 226, 230, 283], 'cultures': [2], 'are': [3, 47], 'intrinsically': [4], 'heterogeneous': [5], 'at': [6, 16, 208], 'different': [7], 'scales': [8], '(molecular': [9], 'to': [10, 51, 54, 107, 127, 203, 245, 264], 'bioreactor).': [11], 'The': [12, 149, 219], 'cycle': [14, 40, 57, 72, 90, 93, 96, 211, 242], 'is': [15, 82, 105, 270], 'the': [17, 29, 116, 131, 158, 182, 204, 209, 235, 238, 278], 'centre': [18], 'of': [19, 34, 87, 188, 196, 223, 237, 253, 261, 281], 'capturing': [20], 'heterogeneity': [21, 222, 248], 'since': [22], 'it': [23], 'plays': [24], 'a': [25, 77, 109, 178, 193], 'critical': [26], 'role': [27], 'in': [28, 130, 250], 'growth,': [30], 'death,': [31], 'and': [32, 49, 59, 98, 111, 212, 228, 257, 267, 285], 'productivity': [33, 141], 'mammalian': [35], 'cultures.': [37], 'Current': [38], 'models': [41, 243], 'use': [42, 160], 'biological': [43], 'variables': [44], '(mass/volume/age)': [45], 'that': [46, 69, 156, 272], 'non-mechanistic,': [48], 'difficult': [50], 'experimentally': [52], 'determine,': [53], 'describe': [55], 'transition': [58], 'capture': [60, 246], 'culture': [61, 132, 262], 'heterogeneity.': [62], 'To': [63], 'address': [64], 'this': [65, 273], 'problem,': [66], 'cyclins—key': [67], 'molecules': [68], 'regulate': [70], 'transition—have': [73], 'been': [74], 'utilized.': [75], 'Herein,': [76], 'novel': [78], 'integrated': [79], 'experimental-modelling': [80], 'platform': [81], 'presented': [83], 'whereby': [84], 'experimental': [85, 205], 'quantification': [86], 'key': [88], 'metrics': [91], '(cell': [92], 'timings,': [94], 'fractions,': [97], 'cyclin': [99, 110], 'expression': [100], 'determined': [101], 'by': [102, 169, 186], 'flow': [103], 'cytometry)': [104], 'used': [106], 'develop': [108], 'DNA': [112], 'distributed': [113], 'model': [114, 183, 201], 'for': [115, 162], 'industrially': [117], 'relevant': [118], 'line,': [120], 'GS-NS0.': [121], 'Cyclins/DNA': [122], 'synthesis': [123], 'rates': [124], 'were': [125], 'linked': [126], 'stimulatory/inhibitory': [128], 'factors': [129], 'medium,': [133], 'which': [134, 174], 'ultimately': [135], 'affect': [136], 'growth.': [138], 'Cell': [139, 241], 'antibody': [140], 'was': [142, 167, 217, 232], 'characterized': [143], 'using': [144], 'cycle-specific': [146], 'production': [147], 'rates.': [148], 'solution': [150], 'method': [151], 'delivered': [152], 'fast': [153], 'computational': [154], 'time': [155], 'renders': [157], "model's": [159], 'suitable': [161], 'model-based': [163, 279], 'applications.': [164], 'Model': [165], 'structure': [166], 'studied': [168], 'global': [170], 'sensitivity': [171], 'analysis': [172], '(GSA),': [173], 'identified': [175], 'parameters': [176, 191], 'with': [177], 'significant': [179, 190], 'effect': [180], 'on': [181], 'output,': [184], 'followed': [185], 're-estimation': [187], 'its': [189], 'from': [192], 'control': [194], 'set': [195], 'batch': [197], 'experiments.': [198], 'A': [199], 'good': [200], 'fit': [202], 'data,': [206], 'both': [207], 'viable': [213], 'density': [215], 'levels,': [216], 'observed.': [218], 'population': [221, 247], 'disturbed': [224], '(after': [225], 'arrest)': [227], 'undisturbed': [229], 'growth': [231, 266], 'captured': [233], 'proving': [234], 'versatility': [236], 'modelling': [239, 274], 'approach.': [240], 'able': [244], 'facilitate': [249], 'depth': [251], 'understanding': [252], 'these': [254], 'complex': [255], 'systems': [256], 'enable': [258], 'systematic': [259], 'formulation': [260], 'strategies': [263], 'improve': [265], 'productivity.': [268], 'It': [269], 'envisaged': [271], 'approach': [275], 'will': [276], 'pave': [277], 'development': [280], 'industrial': [282], 'lines': [284], 'clinical': [286], 'studies.': [287]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2002953145', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-08T21:25:42.828962', 'created_date': '2016-06-24'}