Title: Development of a One-Pot Asymmetric Azaelectrocyclization Protocol: Synthesis of Chiral 2,4-Disubstituted 1,2,5,6-Tetrahydropyridines
Abstract: [reaction: see text] A one-pot procedure for tetracyclic chiral aminoacetals, the useful precursors for substituted piperidine synthesis, has been established via Stille-Migita coupling, 6pi-azaelectrocyclization, and aminoacetal formation from readily prepared vinylstannanes, vinyliodides, and cis-aminoindanol derivatives. Based on the method, chiral 2,4-disubstituted 1,2,5,6-tetrahydropyridines, bearing a variety of aromatic substituents at the C-2 position, have been prepared.
Publication Year: 2006
Publication Date: 2006-07-21
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 57
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