SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor

Name: Work Video:
Duration: 3 min 30 s
Mikhail A. Semenov; Keiko Tamai; Xi He
{'id': 'https://openalex.org/W2002725330', 'doi': 'https://doi.org/10.1074/jbc.m504308200', 'title': 'SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor', 'display_name': 'SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor', 'publication_year': 2005, 'publication_date': '2005-05-21', 'ids': {'openalex': 'https://openalex.org/W2002725330', 'doi': 'https://doi.org/10.1074/jbc.m504308200', 'mag': '2002725330', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15908424'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m504308200', 'pdf_url': 'http://www.jbc.org/article/S0021925820566933/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820566933/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5088020355', 'display_name': 'Mikhail A. Semenov', 'orcid': 'https://orcid.org/0000-0002-1561-7113'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mikhail Semënov', 'raw_affiliation_strings': ["Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA."], 'affiliations': [{'raw_affiliation_string': "Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.", 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103572709', 'display_name': 'Keiko Tamai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I1288882113', 'display_name': "Boston Children's Hospital", 'ror': 'https://ror.org/00dvg7y05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1288882113']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Keiko Tamai', 'raw_affiliation_strings': ["Division of Neuroscience, Children's Hospital-Harvard Medical School, Boston, Massachusetts 02115"], 'affiliations': [{'raw_affiliation_string': "Division of Neuroscience, Children's Hospital-Harvard Medical School, Boston, Massachusetts 02115", 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I1288882113']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5000021060', 'display_name': 'Xi He', 'orcid': 'https://orcid.org/0000-0002-8093-7981'}, 'institutions': [{'id': 'https://openalex.org/I1288882113', 'display_name': "Boston Children's Hospital", 'ror': 'https://ror.org/00dvg7y05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1288882113']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xi He', 'raw_affiliation_strings': ["Division of Neuroscience, Children's Hospital-Harvard Medical School, Boston, Massachusetts 02115"], 'affiliations': [{'raw_affiliation_string': "Division of Neuroscience, Children's Hospital-Harvard Medical School, Boston, Massachusetts 02115", 'institution_ids': ['https://openalex.org/I1288882113', 'https://openalex.org/I136199984']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 10.036, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 746, 'citation_normalized_percentile': {'value': 0.99998, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '280', 'issue': '29', 'first_page': '26770', 'last_page': '26775'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt/β-catenin signaling in development and cancer', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10929', 'display_name': 'Wnt/β-catenin signaling in development and cancer', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11310', 'display_name': 'Connective tissue disorders research', 'score': 0.9908, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13426', 'display_name': 'Kruppel-like factors research', 'score': 0.9735, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lrp5', 'display_name': 'LRP5', 'score': 0.9386821}, {'id': 'https://openalex.org/keywords/lrp6', 'display_name': 'LRP6', 'score': 0.80738163}, {'id': 'https://openalex.org/keywords/sclerostin', 'display_name': 'Sclerostin', 'score': 0.5718488}, {'id': 'https://openalex.org/keywords/wnt3a', 'display_name': 'WNT3A', 'score': 0.55801463}], 'concepts': [{'id': 'https://openalex.org/C182819311', 'wikidata': 'https://www.wikidata.org/wiki/Q18028670', 'display_name': 'LRP5', 'level': 4, 'score': 0.9386821}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.9037398}, {'id': 'https://openalex.org/C107300179', 'wikidata': 'https://www.wikidata.org/wiki/Q41797887', 'display_name': 'Frizzled', 'level': 4, 'score': 0.80925155}, {'id': 'https://openalex.org/C170320316', 'wikidata': 'https://www.wikidata.org/wiki/Q18028667', 'display_name': 'LRP6', 'level': 4, 'score': 0.80738163}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.62742233}, {'id': 'https://openalex.org/C2779277721', 'wikidata': 'https://www.wikidata.org/wiki/Q14887295', 'display_name': 'Sclerostin', 'level': 4, 'score': 0.5718488}, {'id': 'https://openalex.org/C2779131293', 'wikidata': 'https://www.wikidata.org/wiki/Q18048098', 'display_name': 'WNT3A', 'level': 4, 'score': 0.55801463}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5235674}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.34816277}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.32959506}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.31961}], 'mesh': [{'descriptor_ui': 'D019485', 'descriptor_name': 'Bone Morphogenetic Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D005819', 'descriptor_name': 'Genetic Markers', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D036341', 'descriptor_name': 'Intercellular Signaling Peptides and Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D026502', 'descriptor_name': 'LDL-Receptor Related Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011973', 'descriptor_name': 'Receptors, LDL', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019521', 'descriptor_name': 'Body Patterning', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001848', 'descriptor_name': 'Bone Diseases, Developmental', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D001848', 'descriptor_name': 'Bone Diseases, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019485', 'descriptor_name': 'Bone Morphogenetic Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019485', 'descriptor_name': 'Bone Morphogenetic Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004625', 'descriptor_name': 'Embryo, Nonmammalian', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051157', 'descriptor_name': 'Frizzled Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005819', 'descriptor_name': 'Genetic Markers', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005819', 'descriptor_name': 'Genetic Markers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036341', 'descriptor_name': 'Intercellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026502', 'descriptor_name': 'LDL-Receptor Related Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060492', 'descriptor_name': 'Low Density Lipoprotein Receptor-Related Protein-5', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060488', 'descriptor_name': 'Low Density Lipoprotein Receptor-Related Protein-6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011973', 'descriptor_name': 'Receptors, LDL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051153', 'descriptor_name': 'Wnt Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014981', 'descriptor_name': 'Xenopus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m504308200', 'pdf_url': 'http://www.jbc.org/article/S0021925820566933/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15908424', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m504308200', 'pdf_url': 'http://www.jbc.org/article/S0021925820566933/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1504655784', 'https://openalex.org/W1564357553', 'https://openalex.org/W1611720630', 'https://openalex.org/W1635607892', 'https://openalex.org/W1969717239', 'https://openalex.org/W1982724912', 'https://openalex.org/W1987237521', 'https://openalex.org/W1999921847', 'https://openalex.org/W2002073678', 'https://openalex.org/W2002272803', 'https://openalex.org/W2003457351', 'https://openalex.org/W2015389578', 'https://openalex.org/W2015602170', 'https://openalex.org/W2016395646', 'https://openalex.org/W2034133599', 'https://openalex.org/W2037750372', 'https://openalex.org/W2045678396', 'https://openalex.org/W2047178578', 'https://openalex.org/W2055808176', 'https://openalex.org/W2068221099', 'https://openalex.org/W2070849620', 'https://openalex.org/W2073558178', 'https://openalex.org/W2074597244', 'https://openalex.org/W2084275797', 'https://openalex.org/W2086694435', 'https://openalex.org/W2087560312', 'https://openalex.org/W2091258025', 'https://openalex.org/W2095537830', 'https://openalex.org/W2104490911', 'https://openalex.org/W2108403721', 'https://openalex.org/W2108624125', 'https://openalex.org/W2115686163', 'https://openalex.org/W2117156715', 'https://openalex.org/W2119413986', 'https://openalex.org/W2119934014', 'https://openalex.org/W2135671879', 'https://openalex.org/W2146167376', 'https://openalex.org/W2154455745', 'https://openalex.org/W2155377428', 'https://openalex.org/W2161984225', 'https://openalex.org/W2166720212', 'https://openalex.org/W2170298287'], 'related_works': ['https://openalex.org/W3175429427', 'https://openalex.org/W292087288', 'https://openalex.org/W2143353042', 'https://openalex.org/W2114867213', 'https://openalex.org/W2113934769', 'https://openalex.org/W2054774672', 'https://openalex.org/W2042096006', 'https://openalex.org/W2042013412', 'https://openalex.org/W2041640802', 'https://openalex.org/W1990855183'], 'abstract_inverted_index': {'Sclerosteosis': [0, 27, 119, 146, 238, 343, 1160], 'is': [1, 7, 15, 90, 120, 126, 134, 209, 344, 471, 581, 663, 767, 1220, 1498, 2452, 2751, 2761, 3613, 4190, 4327, 4398, 4504], 'an': [2, 91, 121, 210, 772, 1038, 1183, 2399, 2838, 3088, 3221, 3614, 3625, 4220, 4334, 4483], 'autosomal': [3, 122, 282], 'recessive': [4, 123, 283, 3736], 'disease': [5, 124, 277, 470, 1164, 1572, 2977, 4211, 4248], 'that': [6, 55, 88, 97, 111, 125, 174, 207, 216, 230, 482, 763, 875, 1040, 1143, 1150, 1490, 1505, 1550, 1567, 2425, 2635, 2815, 2984, 3044, 3105, 3190, 3364, 3499, 3599, 3650, 3689, 4313, 4328, 4353, 4514, 4574], 'characterized': [8, 127, 290], 'by': [9, 37, 66, 128, 156, 185, 291, 889, 1087, 1101, 1182, 1585, 1605, 2049, 2369, 2391, 2444, 2481, 2485, 2637, 2753, 2949, 3179, 3195, 3421, 3480, 3515, 3532, 3694, 4087, 4117, 4568], 'overgrowth': [10, 114, 129, 233, 293, 326], 'of': [11, 72, 100, 108, 130, 191, 219, 227, 281, 294, 306, 334, 349, 351, 478, 485, 590, 746, 752, 782, 878, 884, 1034, 1080, 1156, 1185, 1188, 1477, 1577, 1610, 2188, 2220, 2305, 2308, 2313, 2326, 2337, 2397, 2435, 2457, 2563, 2566, 2585, 2608, 2625, 2640, 2684, 2781, 2818, 2842, 2852, 2938, 2972, 3022, 3030, 3106, 3123, 3158, 3200, 3213, 3294, 3303, 3309, 3319, 3415, 3495, 3503, 3509, 3603, 3627, 3646, 3666, 3730, 3885, 4031, 4094, 4115, 4203, 4224, 4231, 4254, 4318, 4388, 4393, 4400, 4501, 4509, 4560, 4777, 4839, 4850, 4941, 4943, 4963, 4973], 'bone': [12, 33, 113, 131, 152, 232, 295, 747, 765, 897, 909, 1172, 3672, 3704, 4098, 4214, 4225, 4938, 4964], 'tissue': [13, 132, 296, 4771], 'and': [14, 63, 77, 79, 96, 133, 182, 196, 198, 215, 256, 302, 337, 660, 668, 749, 756, 1048, 1161, 1190, 1192, 1512, 1556, 1558, 1569, 1601, 1956, 1980, 2045, 2087, 2122, 2217, 2252, 2257, 2276, 2283, 2387, 2402, 2579, 2671, 2760, 2833, 2868, 2903, 2906, 2975, 3001, 3026, 3032, 3040, 3051, 3076, 3083, 3134, 3151, 3197, 3206, 3298, 3313, 3373, 3375, 3382, 3468, 3490, 3569, 3609, 3622, 3624, 3636, 3657, 3671, 3683, 3696, 4195, 4197, 4208, 4233, 4269, 4325, 4342, 4386, 4562, 4576, 4582, 4767, 4772, 4781, 4822, 4841, 4852, 4915, 4931, 4946, 4951, 4980], 'linked': [16, 135, 345, 472, 2978], 'to': [17, 68, 105, 136, 187, 224, 346, 473, 666, 771, 880, 1082, 1483, 1500, 1507, 1553, 1985, 2279, 2437, 2634, 2686, 2763, 2865, 2871, 2890, 2979, 2993, 3081, 3104, 3118, 3219, 3352, 3355, 3527, 3652, 4111, 4121, 4218, 4240, 4266, 4270, 4357, 4402, 4476, 4506, 4516, 4784, 4911], 'mutations': [18, 39, 137, 158, 1224, 3678, 3729, 3884, 4015, 4090, 4244], 'in': [19, 40, 60, 116, 138, 159, 179, 235, 299, 303, 584, 758, 774, 1225, 1519, 2127, 2229, 2335, 2383, 2414, 2418, 2446, 2508, 2575, 2583, 2618, 2677, 2690, 2772, 2789, 2834, 2877, 2952, 3070, 3112, 3161, 3210, 3224, 3472, 3485, 3517, 3563, 3575, 3590, 3607, 3632, 3702, 4025, 4193, 4206, 4250, 4276, 4339, 4482, 4484, 4738], 'the': [20, 23, 41, 69, 73, 98, 106, 139, 142, 160, 188, 192, 217, 225, 304, 332, 352, 479, 585, 588, 778, 876, 1078, 1154, 1170, 1226, 1488, 1508, 1560, 1593, 1597, 1608, 1615, 1619, 1627, 2165, 2230, 2322, 2411, 2433, 2614, 2626, 2638, 2682, 2695, 2798, 2810, 2816, 2819, 2835, 2848, 2878, 2970, 2997, 3019, 3027, 3036, 3092, 3113, 3162, 3211, 3291, 3301, 3307, 3464, 3601, 3604, 3618, 3628, 3644, 3653, 3690, 3735, 4026, 4032, 4092, 4229, 4309, 4315, 4406, 4474, 4492, 4507, 4557, 4836, 4936, 4961, 4974], 'gene': [21, 140, 354, 481, 487, 572, 1228, 3530, 3605], 'encoding': [22, 141], 'secreted': [24, 143, 575, 1503, 2958, 3647], 'protein': [25, 144, 1095, 1504, 2800, 2821, 3127, 4513], 'SOST.': [26, 145, 1599, 4442], 'shares': [28, 147, 4258], 'remarkable': [29, 148, 1167], 'similarities': [30, 149], 'with': [31, 150, 341, 1169, 1222, 1618, 2134, 2185, 2224, 2241, 2405, 2776, 2809, 2831, 2847, 2859, 2969, 3018, 3035, 3049, 3055, 3074, 3170, 3290, 3371, 3521, 3588, 3676, 3734, 3889, 4246, 4261, 4405, 4441, 4833], '“high': [32, 151, 1171], 'mass”': [34, 153, 1173], 'diseases': [35, 154, 288, 1178, 3674, 3891, 4966], 'caused': [36, 155, 1181, 2331, 2580], '“gain-of-function”': [38, 157, 3883], 'LRP5': [42, 76, 161, 195, 1227, 1485, 1494, 1555, 2981, 3002, 3031, 3050, 3082, 3124, 3144, 3150, 3165, 3182, 3196, 3203, 3372, 3484, 3520, 3621, 3656, 3677, 3695, 3731, 3886, 4014, 4033, 4105, 4116, 4125, 4232, 4243, 4255, 4947, 4952], 'gene,': [43, 162], 'which': [44, 163, 1396, 2750, 3015, 3098, 3424, 4088, 4263, 4432], 'encodes': [45, 164, 573, 1397], 'a': [46, 165, 347, 474, 574, 1166, 1398, 1475, 1502, 1520, 1575, 2274, 2327, 2357, 2384, 2403, 2406, 2453, 2631, 2777, 2782, 2790, 3011, 3056, 3100, 3338, 3492, 3699, 4199, 4277, 4350, 4358, 4488, 4511, 4956], 'coreceptor': [47, 166, 1400, 1510], 'for': [48, 93, 167, 212, 2255, 2899, 2909, 2936, 3091, 3617, 3663, 4123, 4336, 4491, 4843, 4928, 4960, 4978], 'Wnt': [49, 58, 74, 94, 109, 168, 177, 193, 213, 228, 1399, 1509, 1517, 1562, 1579, 2281, 2284, 2381, 2416, 2429, 2458, 2642, 2688, 2764, 2787, 2939, 2988, 3159, 3214, 3225, 3366, 3473, 3478, 3504, 3512, 3534, 3565, 3577, 3591, 3619, 3654, 4274, 4390, 4502, 4757, 4930], 'signaling': [50, 59, 95, 110, 169, 178, 214, 229, 1148, 1518, 2382, 2417, 2459, 2574, 2689, 2788, 2982, 2989, 3147, 3160, 3177, 3194, 3226, 3474, 3479, 3513, 3566, 3578, 3592, 3631, 3692, 4096, 4126, 4275, 4338, 4356, 4503], 'proteins.': [51, 170, 4319], 'We': [52, 171, 2500, 2813, 2932, 3042, 3361, 3461, 3476, 4970], 'show': [53, 172, 1549, 4435], 'here': [54, 173], 'SOST': [56, 89, 101, 175, 208, 220, 353, 480, 486, 571, 579, 661, 759, 783, 879, 1026, 1031, 1081, 1089, 1144, 1478, 1491, 1497, 1551, 1581, 1612, 2050, 2342, 2363, 2375, 2392, 2401, 2404, 2426, 2436, 2477, 2489, 2504, 2590, 2609, 2666, 2685, 2783, 2799, 2820, 2828, 2857, 2894, 2934, 2942, 2959, 2973, 2985, 3000, 3017, 3045, 3078, 3141, 3174, 3191, 3326, 3350, 3469, 3496, 3568, 3584, 4189, 4204, 4216, 4252, 4257, 4324, 4330, 4404, 4472, 4494, 4499, 4563, 4575, 4743, 4780, 4821, 4840, 4914, 4944, 4950], 'antagonizes': [57, 176, 2376, 2428, 2961, 3193], 'Xenopus': [61, 180, 917, 2085, 2269, 2329, 2439, 2509, 2577, 2678, 3637, 4343, 4739], 'embryos': [62, 181, 2339, 2510, 2578], 'mammalian': [64, 183, 2691, 3634, 3703, 4340], 'cells': [65, 184, 2124, 2172, 2774, 2807, 2832, 2954, 3487, 3518, 3635, 4341], 'binding': [67, 186, 2992, 2998, 3093, 4837], 'extracellular': [70, 189, 3028, 3292, 4034], 'domain': [71, 190, 3293, 4035, 4312], 'coreceptors': [75, 194, 3620, 3655], 'LRP6': [78, 197, 1511, 1557, 3033, 3052, 3084, 3126, 3146, 3152, 3167, 3186, 3205, 3295, 3314, 3374, 3623, 3658, 3697, 4234, 4268], 'disrupting': [80, 199], 'Wnt-induced': [81, 200, 3357, 3377], 'Frizzled-LRP': [82, 201], 'complex': [83, 202, 2013, 2047, 3330, 3345, 3359, 3378, 4480], 'formation.': [84, 203, 3331, 3360], 'Our': [85, 204, 1564], 'findings': [86, 205, 3640], 'suggest': [87, 206, 762, 874, 1142, 1566, 2983, 4573], 'antagonist': [92, 211, 4335, 4409, 4749, 4830], 'loss': [99, 218, 348, 779, 2971, 4200, 4942], 'function': [102, 221, 350, 1479, 4205, 4348, 4387, 4918, 4925, 4945], 'likely': [103, 222, 769, 3525, 4227], 'leads': [104, 223], 'hyperactivation': [107, 226], 'underlies': [112, 231], 'seen': [115, 234], 'sclerosteosis': [117, 236, 1568, 2967, 3608, 4207], 'patients.': [118, 237], '(1Beighton': [239], 'P.': [240, 314, 366, 378, 388, 441, 447, 507, 541, 551, 729, 813, 819, 1011, 1126, 1326, 1673, 3445, 3783, 3989, 4535, 4677], 'Durr': [241], 'L.': [242, 429, 437, 539, 717, 801, 809, 999, 1114, 1236, 1283, 1295, 1350, 1362, 1408, 1701, 3830, 3899, 3946, 3958, 4038, 4050, 4134, 4172, 4665, 4722, 4891], 'Hamersma': [243, 444, 554, 723, 816, 1005, 1120, 4671], 'H.': [244, 310, 445, 555, 599, 724, 817, 928, 1006, 1121, 1669, 1856, 2516, 2649, 2740, 3441, 3753, 3814, 3836, 4416, 4531, 4594, 4672, 4861], 'Ann.': [245], 'Intern.': [246], 'Med.': [247, 522, 560, 734, 1016, 1131, 1250, 3913, 4148, 4682], '1976;': [248], '84:': [249], '393-397Crossref': [250], 'PubMed': [251, 272, 320, 408, 462, 527, 565, 619, 655, 702, 738, 834, 867, 948, 984, 1020, 1071, 1135, 1214, 1254, 1343, 1391, 1423, 1442, 1469, 1542, 1650, 1684, 1726, 1755, 1784, 1808, 1831, 1867, 1900, 1930, 1951, 1969, 2007, 2037, 2080, 2116, 2212, 2299, 2472, 2527, 2556, 2660, 2718, 2745, 2927, 3250, 3281, 3407, 3456, 3553, 3723, 3877, 3917, 4006, 4079, 4152, 4183, 4298, 4379, 4427, 4467, 4546, 4614, 4650, 4686, 4712, 4732, 4815, 4881, 4901], 'Scopus': [252, 273, 321, 409, 463, 528, 566, 620, 656, 703, 739, 835, 868, 949, 985, 1021, 1072, 1136, 1215, 1255, 1344, 1392, 1424, 1443, 1470, 1543, 1651, 1685, 1727, 1756, 1785, 1809, 1832, 1868, 1901, 1931, 1952, 1970, 2008, 2038, 2081, 2117, 2213, 2300, 2473, 2528, 2557, 2661, 2719, 2746, 2928, 3251, 3282, 3408, 3457, 3554, 3724, 3878, 3918, 4007, 4080, 4153, 4184, 4299, 4380, 4428, 4468, 4547, 4615, 4651, 4687, 4713, 4733, 4816, 4882, 4902], '(100)': [253], 'Google': [254, 275, 323, 411, 465, 530, 568, 622, 658, 705, 741, 837, 870, 951, 987, 1023, 1074, 1138, 1217, 1257, 1346, 1394, 1426, 1445, 1472, 1545, 1653, 1687, 1729, 1758, 1787, 1811, 1834, 1870, 1903, 1933, 1954, 1972, 2010, 2040, 2083, 2119, 2215, 2302, 2475, 2530, 2559, 2663, 2721, 2748, 2930, 3253, 3284, 3410, 3459, 3556, 3726, 3880, 3920, 4009, 4082, 4155, 4186, 4301, 4382, 4430, 4470, 4549, 4617, 4653, 4689, 4715, 4735, 4818, 4884, 4904], 'Scholar)': [255, 276, 1973, 2216], 'Van': [257, 362, 373, 399, 417, 468, 495, 518, 789, 857, 1162, 1204, 1324, 1376, 1570, 3610, 3668, 3713, 3851, 3987, 4064, 4209], 'Buchem': [258, 260, 469, 1163, 1571, 3611, 3669, 4210], '(2van': [259], 'F.S.P.': [261], 'Hadders': [262], 'H.N.': [263], 'Ubbens': [264], 'R.': [265, 1203, 1293, 1454, 1537, 1740, 1850, 2022, 2288, 2461, 2734, 2920, 3235, 3266, 3712, 3863, 3956, 4293, 4374, 4810], 'Acta': [266], 'Radiol.': [267], '(Stockh.).': [268], '1955;': [269], '44:': [270], '109-120Crossref': [271], '(102)': [274], 'are': [278, 289, 1179, 1193, 3732, 3887, 4019, 4554, 4845], 'rare': [279], 'forms': [280], 'severe': [284], 'craniotubular': [285], 'hyperostoses.': [286], 'Both': [287], 'generalized': [292], 'mostly': [297], 'manifested': [298], 'cranial': [300], 'bones': [301, 308], 'diaphysis': [305], 'tubular': [307], '(3Hamersma': [309], 'Gardner': [311, 415, 544, 787], 'J.': [312, 376, 419, 449, 451, 521, 559, 595, 608, 651, 698, 732, 791, 821, 823, 854, 860, 924, 937, 980, 1014, 1129, 1207, 1232, 1234, 1249, 1267, 1332, 1354, 1375, 1380, 1431, 1639, 1663, 1797, 1939, 1996, 2290, 2463, 3435, 3549, 3716, 3765, 3777, 3895, 3897, 3912, 3930, 3995, 4042, 4063, 4068, 4130, 4132, 4147, 4164, 4166, 4170, 4525, 4590, 4603, 4646, 4680, 4696, 4701, 4718, 4857, 4870, 4887], 'Beighton': [313, 446, 550, 818, 3782], 'Clin.': [315, 861], 'Genet.': [316, 404, 453, 523, 561, 825, 1334, 1382, 3997, 4070], '2003;': [317, 611, 652, 699, 864, 940, 981, 1383, 1539, 2204, 2710, 4071, 4295, 4376, 4606, 4647, 4729, 4812, 4873, 4898], '63:': [318], '192-197Crossref': [319], '(174)': [322], 'Scholar).': [324, 569, 742, 871, 1024, 1075, 1139, 1218, 1473, 1546, 1654, 2011, 2084, 2120, 2303, 2476, 2560, 2664, 2931, 3254, 3411, 3460, 3557, 3727, 4010, 4083, 4187, 4302, 4383, 4550, 4736, 4819, 4905], 'Bone': [325, 1208, 3717], 'appears': [327, 3351, 4217], 'as': [328, 330, 1045, 1176, 1195, 1592, 2055, 2091, 2227, 2623, 2845, 3003, 3005, 3337, 3680, 4333, 4349, 4584, 4765, 4919, 4926, 4968], 'early': [329], 'at': [331, 587, 1607, 2356, 2594, 2613, 2901, 2912, 4792, 4825], 'age': [333], '5': [335, 2306], 'years': [336], 'becoming': [338], 'more': [339], 'prominent': [340], 'time.': [342], 'product': [355, 3602], '(4Balemans': [356], 'W.': [357, 372, 401, 490, 499, 520, 848, 859, 1206, 1378, 1659, 2514, 2647, 3431, 3715, 3767, 3846, 3853, 4066, 4414, 4521, 4694], 'Ebeling': [358, 493], 'M.': [359, 368, 384, 494, 503, 597, 601, 639, 645, 686, 692, 722, 844, 926, 930, 968, 974, 1004, 1119, 1269, 1402, 1450, 1665, 1736, 1769, 2018, 2065, 2101, 3231, 3262, 3392, 3437, 3761, 3779, 3824, 3834, 3855, 3857, 3932, 4452, 4527, 4592, 4596, 4634, 4640, 4670, 4859, 4863], 'Patel': [360, 491], 'N.': [361, 492, 593, 607, 922, 936, 1247, 1303, 1525, 1844, 2537, 2545, 2726, 3745, 3910, 3966, 4145, 4281, 4362, 4588, 4602, 4726, 4798, 4855, 4869, 4895], 'Hul': [363, 400, 496, 519, 858, 1205, 1377, 3714, 3852, 4065], 'E.': [364, 497, 720, 1002, 1060, 1117, 1352, 1414, 3826, 3838, 4040, 4668], 'Olson': [365], 'Dioszegi': [367, 502], 'Lacza': [369, 500], 'C.': [370, 392, 501, 631, 678, 846, 850, 960, 1058, 1271, 1299, 1366, 1456, 1675, 1679, 1695, 1742, 1911, 2024, 2520, 2522, 2653, 2655, 3237, 3268, 3447, 3451, 3791, 3934, 3962, 4054, 4420, 4422, 4537, 4541, 4626], 'Wuyts': [371, 498], 'Den': [374], 'Ende': [375], 'Willems': [377, 508], 'Paes-Alves': [379], 'A.F.': [380], 'Hill': [381], 'S.': [382, 425, 535, 553, 797, 1285, 1309, 1410, 1418, 1433, 1529, 1645, 1771, 1803, 2002, 2067, 2103, 2551, 2922, 3394, 3749, 3769, 3773, 3948, 3972, 4174, 4285, 4366, 4454, 4802], 'Bueno': [383], 'Ramos': [385], 'F.J.': [386], 'Tacconi': [387, 440, 812], 'Dikkers': [389, 504], 'F.G.': [390, 505], 'Stratakis': [391], 'Lindpaintner': [393, 512], 'K.': [394, 513, 533, 643, 690, 842, 972, 1201, 1244, 1287, 1406, 1448, 1697, 1709, 1734, 1765, 1907, 2016, 2061, 2097, 2543, 2916, 3229, 3260, 3388, 3710, 3763, 3818, 3907, 3950, 4142, 4448, 4638], 'Vickery': [395, 514], 'B.': [396, 515, 1279, 1307, 1657, 1711, 2738, 3429, 3797, 3802, 3806, 3840, 3842, 3859, 3942, 3970, 4519], 'Foernzler': [397, 516], 'D.': [398, 443, 517, 547, 637, 684, 815, 966, 1242, 1360, 1412, 1671, 1705, 2731, 3443, 3759, 3822, 3905, 4048, 4140, 4176, 4533, 4632], 'Hum.': [402, 452, 824, 1333, 1381, 3996, 4069], 'Mol.': [403, 1920, 4177], '2001;': [405, 454, 826, 1776, 2072, 2108, 3399, 3869, 4459], '10:': [406], '537-543Crossref': [407], '(924)': [410], 'Scholar,': [412, 531, 623, 706, 838, 952, 988, 1258, 1347, 1427, 1446, 2531, 2722, 3921, 4156, 4618, 4654, 4690, 4716, 4885], '5Brunkow': [413], 'M.E.': [414, 557, 647, 694, 786, 976, 4642], 'J.C.': [416, 545, 629, 676, 788, 958, 1056, 1535, 1633, 1791, 1990, 4291, 4372, 4624, 4808], 'Ness': [418, 790], 'Paeper': [420, 536, 792], 'B.W.': [421, 537, 793], 'Kovacevich': [422, 640, 687, 794, 969, 4635], 'B.R.': [423, 641, 688, 795, 970, 3865, 4636], 'Proll': [424, 534, 796], 'Skonier': [426, 634, 681, 798, 963, 1061, 4629], 'J.E.': [427, 635, 682, 799, 840, 964, 1062, 4630], 'Zhao': [428, 538, 800, 1276, 3939], 'Sabo': [430, 802], 'P.J.': [431, 509, 803, 1838, 1878, 2728], 'Fu': [432, 804], 'Y.': [433, 805, 1289, 1368, 1452, 1458, 1738, 1744, 1848, 1915, 2020, 2026, 3233, 3239, 3264, 3270, 3741, 3952, 4056, 4158, 4160, 4720, 4889], 'Alisch': [434, 806], 'R.S.': [435, 807, 1817, 2535, 3832], 'Gillett': [436, 808], 'Colbert': [438, 810], 'T.': [439, 633, 680, 811, 962, 1364, 1713, 3755, 3810, 3828, 3861, 4052, 4628], 'Galas': [442, 546, 814], 'Mulligan': [448, 820], 'Am.': [450, 558, 822, 1331, 1379, 3994, 4067], '68:': [455, 827], '577-589Abstract': [456, 828], 'Full': [457, 459, 614, 616, 829, 831, 943, 945, 1338, 1340, 1386, 1388, 1779, 1781, 1828, 1925, 1927, 1966, 2075, 2077, 2111, 2113, 2207, 2209, 2713, 2715, 3402, 3404, 3872, 3874, 4001, 4003, 4074, 4076, 4462, 4464, 4609, 4611, 4707, 4709, 4876, 4878], 'Text': [458, 460, 615, 617, 830, 832, 944, 946, 1339, 1341, 1387, 1389, 1780, 1782, 1829, 1926, 1928, 1967, 2076, 2078, 2112, 2114, 2208, 2210, 2714, 2716, 3403, 3405, 3873, 3875, 4002, 4004, 4075, 4077, 4463, 4465, 4610, 4612, 4708, 4710, 4877, 4879], 'PDF': [461, 618, 833, 947, 1342, 1390, 1783, 1830, 1929, 1968, 2079, 2115, 2211, 2717, 3406, 3876, 4005, 4078, 4466, 4613, 4711, 4880], '(806)': [464, 836], 'Scholar),': [466, 659, 1395, 1688, 1730, 1759, 1788, 1812, 1835, 1871, 1904, 1934, 1955, 2041, 2749, 3285, 3881, 4431, 4471], 'whereas': [467, 3882, 4329, 4760], '52-kb': [475], 'deletion': [476], 'downstream': [477, 2455], 'causes': [483], 'down-regulation': [484, 4202], 'expression': [488, 580, 662, 784, 2497, 2784], '(6Balemans': [489], 'Hildering': [506], 'Verheij': [510], 'J.B.': [511], '2002;': [524, 562, 1251, 1335, 1681, 3453, 3914, 3998, 4149, 4543], '39:': [525], '91-97Crossref': [526], '(582)': [529], '7Staehling-Hampton': [532], 'Charmley': [540], 'Brown': [542, 1702, 1845], 'A.': [543, 603, 713, 932, 995, 1110, 1238, 1301, 1305, 1317, 1416, 1531, 1635, 1646, 1677, 1793, 1804, 1992, 2003, 2197, 2512, 2533, 2552, 2645, 2703, 2918, 3449, 3541, 3800, 3812, 3820, 3844, 3901, 3964, 3968, 3980, 4136, 4287, 4368, 4412, 4539, 4598, 4661, 4804, 4865], 'Schatzman': [548], 'R.C.': [549, 1840, 1876, 3808], 'Papapoulos': [552, 725, 1007, 1122, 4673], 'Brunkow': [556, 646, 693, 975, 4641], '110:': [563], '144-152Crossref': [564], '(248)': [567], 'The': [570, 743, 2766, 2826, 3317, 3412, 4084, 4384], 'protein.': [576], 'During': [577], 'embryogenesis': [578], 'first': [582, 4027], 'detected': [583, 2876], 'mesenchyme': [586], 'sites': [589, 2898], 'osteogenesis': [591], '(8Kusu': [592, 921, 4587, 4854], 'Laurikkala': [594, 923, 4589, 4856], 'Imanishi': [596, 925, 4591, 4858], 'Usui': [598, 927, 4593, 4860], 'Konishi': [600, 929, 4595, 4862], 'Miyake': [602, 931, 4597, 4864], 'Thesleff': [604, 933, 4599, 4723, 4866, 4892], 'I.': [605, 934, 4600, 4724, 4867, 4893], 'Itoh': [606, 935, 4601, 4725, 4868, 4894], 'Biol.': [609, 938, 1775, 2071, 2107, 2203, 2295, 2468, 2709, 3398, 4179, 4458, 4604, 4728, 4871, 4897], 'Chem.': [610, 939, 4605, 4872], '278:': [612, 941, 4607, 4874], '24113-24117Abstract': [613, 942, 4608, 4875], '(210)': [621, 950, 4616, 4734, 4883, 4903], '9Winkler': [624, 953, 4619], 'D.G.': [625, 672, 954, 1064, 4620], 'Sutherland': [626, 673, 955, 4621], 'M.K.': [627, 674, 956, 1054, 4622], 'Geoghegan': [628, 675, 957, 1055, 4623], 'Yu': [630, 677, 959, 1057, 4625], 'Hayes': [632, 679, 961, 4627], 'Shpektor': [636, 683, 965, 4631], 'Jonas': [638, 685, 967, 4633], 'Staehling-Hampton': [642, 689, 971, 4637], 'Appleby': [644, 691, 973, 4639], 'Latham': [648, 695, 977, 1065, 4643], 'J.A.': [649, 696, 978, 1066, 1860, 1890, 3781, 4644], 'EMBO': [650, 697, 979, 3548, 4645], '22:': [653, 700, 982, 4648], '6267-6276Crossref': [654, 701, 983, 4649], '(876)': [657, 704, 986, 4652], 'confined': [664], 'specifically': [665, 3079], 'osteoblasts': [667, 885, 1189, 4194], 'osteocytes': [669, 1191], 'postnatally': [670], '(9Winkler': [671], '10van': [707, 989, 4655], 'Bezooijen': [708, 990, 1105, 4656], 'R.L.': [709, 991, 1106, 4657], 'Roelen': [710, 992, 1107, 4658], 'B.A.': [711, 993, 1108, 4659], 'Visser': [712, 994, 1109, 4660], 'van': [714, 996, 1111, 2729, 3847, 4662], 'der': [715, 997, 1112, 4663], 'Wee-Pals': [716, 998, 1113, 4664], 'de': [718, 1000, 1115, 2732, 4666], 'Wilt': [719, 1001, 1116, 4667], 'Karperien': [721, 1003, 1118, 4669], 'S.E.': [726, 1008, 1123, 4674], 'ten': [727, 1009, 1124, 4675], 'Dijke': [728, 1010, 1125, 4676], 'Lowik': [730, 1012, 1127, 4678], 'C.W.': [731, 1013, 1128, 4679], 'Exp.': [733, 1015, 1130, 4681], '2004;': [735, 1017, 1068, 1132, 1211, 1922, 3720, 4180, 4683, 4704], '199:': [736, 1018, 1133, 4684], '805-814Crossref': [737, 1019, 1134, 4685], '(693)': [740, 1022, 1137, 4688], 'increased': [744, 4124, 4213], 'rate': [745], 'formation': [748, 2014, 2334, 2352, 3308, 3346, 3379, 4481, 4774], 'elevated': [750], 'levels': [751, 4794], 'serum': [753], 'alkaline': [754, 3334], 'phosphatase': [755], 'osteocalcin': [757], 'mutation': [760], 'carriers': [761], 'excessive': [764, 1484], 'accumulation': [766, 2947], 'most': [768], 'due': [770, 3526], 'increase': [773, 1184, 4093], 'osteoblast': [775, 1084], 'activity': [776, 883, 920, 1039, 1187, 2413, 2507, 2670, 2676, 2963, 3414, 3514, 4392], 'upon': [777], 'or': [780, 1097, 1152, 1515, 1626, 2051, 2310, 3125, 3145, 3166, 3183, 3204, 3324, 3470, 3497, 4201, 4272, 4922], 'decrease': [781, 881], '(5Brunkow': [785], '11Wergedal': [839], 'Veskovic': [841], 'Hellan': [843], 'Nyght': [845], 'Balemans': [847], 'Libanati': [849], 'Vanhoenacker': [851], 'F.M.': [852], 'Tan': [853], 'Baylink': [855], 'D.J.': [856], 'Endocrinol.': [862], 'Metab.': [863], '88:': [865], '5778-5783Crossref': [866], '(77)': [869], 'Some': [872, 4571], 'studies': [873, 4572, 4907], 'ability': [877, 1079, 2434, 2683, 4475], 'osteogenic': [882, 1186], 'may': [886, 1145, 1492, 1573, 2887, 2986, 4824, 4954], 'be': [887, 1574, 2888, 3220, 3353, 3418, 4219, 4238, 4565, 4909, 4955], 'explained': [888], 'its': [890], 'anti-BMP': [891, 2506, 2675], '1The': [892], 'abbreviations': [893], 'used': [894, 3096, 3336, 3491], 'are:': [895], 'BMP,': [896, 1088, 4752], 'morphogenetic': [898], 'protein;': [899, 915], 'CM,': [900, 3114], 'conditioned': [901, 2140], 'medium;': [902], 'DKK,': [903], 'Dickkopf;': [904], 'Fz,': [905], 'Frizzled;': [906], 'HBM,': [907], 'high': [908, 2128, 2358, 4793], 'mass;': [910], 'LRP,': [911], 'low-density': [912, 3059], 'lipoprotein': [913, 3060], 'receptor-related': [914], 'Xnr3,': [916], 'nodal-related': [918, 2440], '3.': [919], 'However,': [1025, 2362, 4496, 4737], 'clearly': [1027], 'has': [1028, 2895, 3099, 3216, 3686, 4473], 'additional': [1029, 3089], 'activities.': [1030, 3148, 4831], 'induces': [1032], 'apoptosis': [1033], 'human': [1035], 'osteoblastic': [1036], 'cells,': [1037, 2692], 'other': [1041, 1147, 2225, 2641, 4569], 'BMP': [1042, 1157, 2568, 2573, 4580, 4585, 4762, 4778, 4829, 4932], 'antagonists': [1043, 2643, 4586, 4763, 4921, 4927], 'such': [1044, 2622, 3329, 3679, 4764, 4967], 'Noggin,': [1046], 'Chordin,': [1047], 'Gremlin': [1049], 'do': [1050, 4785], 'not': [1051, 1091, 2348, 2389, 2484, 2494, 2598, 2673, 3054, 3572, 3586, 3641, 4434], 'possess': [1052], '(12Sutherland': [1053], 'Turcott': [1059], 'Winkler': [1063], 'Bone.': [1067], '35:': [1069], '828-835Crossref': [1070], '(188)': [1073], 'Furthermore,': [1076, 2605, 3065], 'despite': [1077], 'antagonize': [1083, 1493, 2987], 'differentiation': [1085], 'induced': [1086, 2948, 3306], 'does': [1090, 2672, 3585, 4433], 'inhibit': [1092, 2438, 2687, 3143, 4273], 'BMP-induced': [1093], 'SMAD': [1094], 'phosphorylation': [1096], 'luciferase': [1098, 2259, 2262], 'reporters': [1099], 'driven': [1100, 2752], 'BMP-responsive': [1102], 'elements': [1103, 2759], '(10van': [1104], 'These': [1140, 2882, 3639, 4303], 'data': [1141], 'affect': [1146, 4756], 'pathways': [1149], 'complement': [1151], 'mediate': [1153], 'effect': [1155, 3343, 3505], 'on': [1158, 3344], 'osteoblasts.': [1159], 'share': [1165, 4308], 'similarity': [1168, 4440], '(HBM)': [1174], 'phenotype,': [1175], 'these': [1177, 4089], 'all': [1180, 4012], 'classified': [1194], '“craniotubular': [1196], 'hyperostoses”': [1197], '(13Johnson': [1198, 3707], 'M.L.': [1199, 1330, 1370, 1858, 1886, 3708, 3804, 3867, 3993, 4058], 'Harnish': [1200, 3709], 'Nusse': [1202, 3711], 'Miner.': [1209, 3718], 'Res.': [1210, 1895, 3719], '19:': [1212, 3721], '1749-1757Crossref': [1213, 3722], '(183)': [1216, 3725], 'HBM': [1219, 2976, 3681, 3890, 4017, 4247], 'associated': [1221, 2830, 3675, 3733, 3888, 4245], '“activating”': [1223], '(14Boyden': [1229, 3892, 4127], 'L.M.': [1230, 3789, 3893, 4128], 'Mao': [1231, 3894, 4129, 4165], 'Belsky': [1233, 3896, 4131], 'Mitzner': [1235, 3898, 4133], 'Farhi': [1237, 3900, 4135], 'Mitnick': [1239, 3902, 4137], 'M.A.': [1240, 3903, 4138], 'Wu': [1241, 1658, 2513, 2646, 3430, 3904, 4139, 4175, 4413, 4520], 'Insogna': [1243, 3906, 4141], 'Lifton': [1245, 3908, 4143], 'R.P.': [1246, 3909, 4144], 'Engl.': [1248, 3911, 4146], '346:': [1252, 3915, 4150], '1513-1521Crossref': [1253, 3916, 4151], '(1345)': [1256, 3919, 4154], '15Little': [1259, 3922], 'R.D.': [1260, 1880, 3923], 'Carulli': [1261, 3924], 'J.P.': [1262, 1462, 1748, 2030, 3243, 3274, 3925], 'Del': [1263, 3926], 'Mastro': [1264, 3927], 'R.G.': [1265, 3787, 3928], 'Dupuis': [1266, 3929], 'Osborne': [1268, 3931], 'Folz': [1270, 3933], 'Manning': [1272, 3935], 'S.P.': [1273, 3936], 'Swain': [1274, 3937], 'P.M.': [1275, 1533, 1637, 1795, 1994, 3938, 4289, 4370, 4806], 'S.C.': [1277, 3940], 'Eustace': [1278, 3941], 'Lappe': [1280, 3943], 'M.M.': [1281, 3944], 'Spitzer': [1282, 3945], 'Zweier': [1284, 3947], 'Braunschweiger': [1286, 3949], 'Benchekroun': [1288, 3951], 'Hu': [1290, 3953], 'X.': [1291, 1311, 1464, 1750, 1773, 1852, 1909, 1913, 1919, 2032, 2069, 2105, 3245, 3276, 3396, 3954, 3974, 4162, 4456], 'Adair': [1292, 3955], 'Chee': [1294, 3957], 'FitzGerald': [1296, 3959], 'M.G.': [1297, 3960], 'Tulig': [1298, 3961], 'Caruso': [1300, 3963], 'Tzellas': [1302, 3965], 'Bawa': [1304, 3967], 'Franklin': [1306, 3969], 'McGuire': [1308, 3971], 'Nogues': [1310, 3973], 'Gong': [1312, 1367, 3975, 4055], 'G.': [1313, 1661, 1707, 3433, 3747, 3771, 3976, 4523], 'Allen': [1314, 3977], 'K.M.': [1315, 3978], 'Anisowicz': [1316, 3979], 'Morales': [1318, 3981], 'A.J.': [1319, 1821, 3982], 'Lomedico': [1320, 3983], 'P.T.': [1321, 3984], 'Recker': [1322, 1327, 3985, 3990], 'S.M.': [1323, 3986], 'Eerdewegh': [1325, 3988], 'R.R.': [1328, 3991], 'Johnson': [1329, 3992], '70:': [1336, 3999], '11-19Abstract': [1337, 4000], '(1096)': [1345, 4008], '16Van': [1348], 'Wesenbeeck': [1349, 4037], 'Cleiren': [1351, 4039], 'Gram': [1353, 4041], 'Beals': [1355, 4043], 'R.K.': [1356, 4044], 'Benichou': [1357, 4045], 'O.': [1358, 4046], 'Scopelliti': [1359, 4047], 'Key': [1361, 4049], 'Renton': [1363, 4051], 'Bartels': [1365, 4053], 'Warman': [1369, 3866, 4057], 'De': [1371, 3798, 4059], 'Vernejoul': [1372, 4060], 'M.C.': [1373, 4061], 'Bollerslev': [1374, 4062], '72:': [1384, 4072], '763-771Abstract': [1385, 4073], '(486)': [1393, 4081], '(17Wehrli': [1401], 'Dougan': [1403], 'S.T.': [1404], 'Caldwell': [1405], "O'Keefe": [1407], 'Schwartz': [1409, 3538], 'Vaizel-Ohayon': [1411], 'Schejter': [1413], 'Tomlinson': [1415], 'DiNardo': [1417], 'Nature.': [1419, 1438, 1465, 1680, 1751, 2033, 2523, 2656, 3246, 3277, 3452, 4423, 4542], '2000;': [1420, 1439, 1466, 1752, 2034, 3247, 3278], '407:': [1421, 1440, 1467, 1753, 2035, 3248, 3279], '527-530Crossref': [1422], '(727)': [1425], '18Pinson': [1428], 'K.I.': [1429], 'Brennan': [1430], 'Monkley': [1432], 'Avery': [1434], 'B.J.': [1435], 'Skarnes': [1436], 'W.C.': [1437], '535-538Crossref': [1441], '(904)': [1444], '19Tamai': [1447], 'Semenov': [1449, 1735, 2017, 3230, 3261], 'Kato': [1451, 1737, 2019, 3232, 3263], 'Spokony': [1453, 1739, 2021, 3234, 3265], 'Liu': [1455, 1741, 1910, 2023, 3236, 3267], 'Katsuyama': [1457, 1743, 2025, 3238, 3269], 'Hess': [1459, 1745, 1861, 1891, 2027, 3240, 3271], 'F.': [1460, 1746, 2028, 3241, 3272], 'Saint-Jeannet': [1461, 1747, 2029, 3242, 3273], 'He': [1463, 1749, 1772, 1918, 2031, 2068, 2104, 3244, 3275, 3395, 4455, 4976], '530-535Crossref': [1468, 1754, 2036, 3249, 3280], '(1103)': [1471, 1757, 2039, 3252, 3283], 'Thus,': [1474, 2374, 2665, 2957, 3349, 3581, 4551, 4820], 'lack': [1476], 'exhibits': [1480, 4212, 4746], 'phenotypes': [1481, 4940], 'related': [1482, 1499, 4306], 'function,': [1486], 'implying': [1487], 'possibility': [1489], 'function.': [1495, 4235, 4256], 'Interestingly,': [1496], 'WISE,': [1501, 4262], 'binds': [1506, 1552, 4515], 'modulates': [1513], '(activates': [1514], 'inhibits)': [1516], 'cell': [1521, 2755], 'context-dependent': [1522, 4278], 'manner': [1523, 2386, 2792, 4279], '(20Itasaki': [1524, 4280, 4361, 4797], 'Jones': [1526, 4282, 4363, 4799], 'C.M.': [1527, 4283, 4364, 4800], 'Mercurio': [1528, 4284, 4365, 4801], 'Rowe': [1530, 4286, 4367, 4803], 'Domingos': [1532, 4288, 4369, 4805], 'Smith': [1534, 4290, 4371, 4807], 'Krumlauf': [1536, 4292, 4373, 4809], 'Development.': [1538, 4294, 4375, 4811], '130:': [1540, 4296, 4377, 4813], '4295-4305Crossref': [1541, 4297, 4378, 4814], '(273)': [1544, 4300, 4381, 4817], 'Here': [1547], 'we': [1548, 2431, 2693, 2802, 3007, 3095, 3138, 3256, 3597], 'both': [1554, 3633, 4553, 4754, 4929], 'inhibits': [1559], 'canonical': [1561, 3629], 'pathway.': [1563], 'results': [1565], 'result': [1576, 4249], 'hyperactive': [1578, 2980], 'signaling.': [1580, 2765, 2940, 4758, 4933], 'cDNA': [1582, 1589, 1613], 'was': [1583, 2143, 2388, 2769, 3068, 3116, 3524, 4119, 4264], 'cloned': [1584], 'PCR': [1586], 'using': [1587, 2164, 2233], 'IMAGE': [1588], 'clone': [1590], '2380708': [1591], 'template.': [1594], 'SOST/pcDNA3.1+': [1595], 'contains': [1596], 'full-length': [1598, 1611], 'SOST-Myc/pcDNA3': [1600], 'SOST-IgG/pcDNA3.1+': [1602], 'were': [1603, 1982, 2053, 2089, 2125, 2152, 2162, 2173, 2183, 2239, 2246, 2264, 2874, 4790], 'generated': [1604, 2803], 'fusion': [1606, 3013], '5′-end': [1609], 'without': [1614], 'stop': [1616], 'codon': [1617], '6×': [1620], 'Myc': [1621, 2408, 3037], 'epitope': [1622, 3038], 'tag': [1623, 1629], 'from': [1624, 1630, 2145, 2154, 2805, 2863, 2869, 4016], 'CS2+MT': [1625], 'IgG': [1628], 'IgG/pRK5': [1631], '(21Hsieh': [1632, 1790, 1989], 'Rattner': [1634, 1792, 1991], 'Smallwood': [1636, 1794, 1993], 'Nathans': [1638, 1796, 1995], 'Proc.': [1640, 1798, 1997, 2546], 'Natl.': [1641, 1799, 1998, 2547], 'Acad.': [1642, 1800, 1999, 2548], 'Sci.': [1643, 1801, 2000, 2549], 'U.': [1644, 1802, 2001, 2550], '1999;': [1647, 1723, 1805, 2004], '96:': [1648, 1806, 2005], '3546-3551Crossref': [1649, 1807, 2006], '(292)': [1652, 1810, 2009], 'Kremen2/pCS': [1655], '(22Mao': [1656, 3428, 4518], 'Davidson': [1660, 3432, 4522], 'Marhold': [1662, 3434, 4524], 'Li': [1664, 3436, 4161, 4167, 4171, 4526], 'Mechler': [1666, 3438, 4528], 'B.M.': [1667, 3439, 4529], 'Delius': [1668, 2515, 2648, 3440, 4415, 4530], 'Hoppe': [1670, 3442, 4532], 'Stannek': [1672, 3444, 4534], 'Walter': [1674, 3446, 4536], 'Glinka': [1676, 3448, 4538], 'Niehrs': [1678, 2521, 2654, 3450, 4421, 4540], '417:': [1682, 3454, 4544], '664-667Crossref': [1683, 3455, 4545], '(873)': [1686, 3458, 4548], 'DKK1-FLAG/CS2+': [1689], '(23Krupnik': [1690], 'V.E.': [1691], 'Sharp': [1692], 'J.D.': [1693], 'Jiang': [1694], 'Robison': [1696], 'Chickering': [1698], 'T.W.': [1699], 'Amaravadi': [1700], 'D.E.': [1703], 'Guyot': [1704], 'Mays': [1706], 'Leiby': [1708], 'Chang': [1710, 1916], 'Duong': [1712], 'Goodearl': [1714], 'A.D.': [1715], 'Gearing': [1716], 'D.P.': [1717], 'Sokol': [1718, 1770, 2066, 2102, 3393, 4453], 'S.Y.': [1719], 'McCarthy': [1720], 'S.A.': [1721], 'Gene.': [1722, 1863], '238:': [1724], '301-313Crossref': [1725], '(421)': [1728], 'LRP6N-Myc/pcDNA3,': [1731], 'Xwnt8/CS2+': [1732], '(19Tamai': [1733, 2015, 3228, 3259], 'LRP5N-Myc/pcDNA3,': [1760], 'LDLRN-Myc/pcDNA3': [1761], '(24Semenov': [1762, 2058, 2094, 3385, 4445], 'M.V.': [1763, 2059, 2095, 3386, 4446], 'Tamai': [1764, 2060, 2096, 3387, 4447], 'Brott': [1766, 2062, 2098, 3389, 4449], 'B.K.': [1767, 2063, 2099, 3390, 4450], 'Kuhl': [1768, 2064, 2100, 3391, 4451], 'Curr.': [1774, 2070, 2106, 2202, 2708, 3397, 4457], '11:': [1777, 2073, 2109, 3400, 4460], '951-961Abstract': [1778, 2074, 2110, 3401, 4461], '(602)': [1786, 2082, 2118, 3409, 4469], 'Fz8CRD-IgG': [1789, 3115, 3286], 'tBR/pSP64T+': [1813], '(25Graff': [1814], 'J.M.': [1815, 2541], 'Thies': [1816, 2534], 'Song': [1818, 2538], 'J.J.': [1819, 2539], 'Celeste': [1820], 'Melton': [1822], 'D.A.': [1823, 1941], 'Cell.': [1824, 1921, 1962, 3868, 4178], '1994;': [1825, 1963, 2553], '79:': [1826, 1964], '169-179Abstract': [1827], '(430)': [1833], 'LRP5/pcDNA3': [1836], '(26Hey': [1837], 'Twells': [1839, 1875], 'Phillips': [1841], 'M.S.': [1842], 'Yusuke': [1843], 'S.D.': [1846, 1874], 'Kawaguchi': [1847], 'Cox': [1849, 1879], 'Guochun': [1851], 'Dugan': [1853], 'V.': [1854, 2724], 'Hammond': [1855], 'Metzker': [1857, 1885], 'Todd': [1859, 1889], 'J.F.': [1862, 1892], '1998;': [1864, 1897, 2524, 2657, 4424], '216:': [1865], '103-111Crossref': [1866], '(192)': [1869], 'LRP6/pcDNA3.1': [1872], '(27Brown': [1873], 'Hey': [1877], 'Levy': [1881], 'E.R.': [1882], 'Soderman': [1883], 'A.R.': [1884], 'Caskey': [1887], 'C.T.': [1888], 'Biochem.': [1893], 'Biophys.': [1894], 'Commun.': [1896], '248:': [1898], '879-888Crossref': [1899], '(177)': [1902], 'LRP6ΔN/CS2+': [1905], '(28Tamai': [1906], 'Zeng': [1908], 'Zhang': [1912, 4163], 'Harada': [1914], 'Z.': [1917, 4168], '13:': [1923, 2205, 2297, 2470, 2711], '149-156Abstract': [1924], '(452)': [1932], 'Wnt1/LNCX': [1935], '(29Munsterberg': [1936], 'A.E.': [1937], 'Kitajewski': [1938], 'Bumcrot': [1940], 'McMahon': [1942], 'A.P.': [1943, 2518, 2651, 4418], 'Lassar': [1944], 'A.B.': [1945], 'Genes': [1946], 'Dev.': [1947, 2294, 2467, 4727, 4896], '1995;': [1948], '9:': [1949], '2911-2922Crossref': [1950], '(444)': [1953], 'PSecAP-MH': [1957], '(30Cheng': [1958], 'H.J.': [1959], 'Flanagan': [1960], 'J.G.': [1961], '157-168Abstract': [1965], '(328)': [1971], 'constructions': [1974], 'have': [1975, 3362, 3661, 4827], 'been': [1976, 3217], 'described': [1977, 2056, 2092], 'previously.': [1978], 'Precipitation': [1979], 'immunoblotting': [1981], 'done': [1983], 'similarly': [1984, 3057], 'Hsieh': [1986], 'et': [1987], 'al.': [1988], 'Fz-LRP6': [2012, 3358], 'cytosolic': [2042, 2945], 'β-catenin': [2043, 2946, 4355], 'assay,': [2044, 3164, 4486], 'LRP6N-Fz8': [2046], 'disruption': [2048], 'DKK1': [2052, 3416, 3427, 3471, 3498, 3529, 3559, 4118, 4410, 4444, 4517, 4561], 'performed': [2054, 2090, 2163], 'previously': [2057, 2093, 3258], 'injection': [2086, 2345, 2491, 2592, 2607, 2639], 'RT-PCR': [2088], 'Rat2': [2121, 2148, 2953], 'HEK293T': [2123, 2157, 2171, 2773, 2806, 3486], 'maintained': [2126], 'glucose': [2129], "Dulbecco's": [2130], 'modified': [2131], "Eagle's": [2132], 'medium': [2133, 2141], '10%': [2135], 'newborn': [2136], 'calf': [2137], 'serum.': [2138], 'Wnt1': [2139, 2962, 3171, 3180, 3184, 3304, 3482, 3522], '(CM)': [2142], 'collected': [2144, 2153], 'retrovirally': [2146], 'infected': [2147], 'cells.': [2149, 2158], 'Other': [2150], 'CMs': [2151], 'transiently': [2155], 'transfected': [2156, 2184, 2775, 2808], 'TOPflash': [2159], 'reporter': [2160, 2167, 2190, 2697, 2768], 'assays': [2161], 'Dual-Luciferase': [2166], 'assay': [2168, 2272, 2420], 'system': [2169], '(Promega).': [2170], 'seeded': [2174], 'into': [2175, 2321], '24-well': [2176], 'plates': [2177], '1': [2178], 'day': [2179], 'before': [2180], 'transfection.': [2181], 'Cells': [2182], '100': [2186], 'ng': [2187, 2219], 'SuperTOPflash': [2189, 2696, 2767, 3163], 'plasmid': [2191, 2222, 2785], '(31Veeman': [2192, 2698], 'M.T.': [2193, 2699], 'Slusarski': [2194, 2700], 'D.C.': [2195, 2701], 'Kaykas': [2196, 2702], 'Louie': [2198, 2704], 'S.H.': [2199, 2705], 'Moon': [2200, 2706], 'R.T.': [2201, 2707], '680-685Abstract': [2206, 2712], '(733)': [2214, 2720], '10': [2218], 'pRL-TK': [2221], '(Promega)': [2223], 'plasmids': [2226], 'indicated': [2228], 'experiment': [2231], 'descriptions': [2232], 'Lipofectamine': [2234], 'reagent': [2235], '(Invitrogen).': [2236], 'DNA': [2237], 'amounts': [2238], 'balanced': [2240], 'pcDNA3.1+': [2242], 'plasmid.': [2243, 2779, 2812], 'Cell': [2244, 2293, 2466], 'extracts': [2245], 'prepared': [2247], '36': [2248], 'h': [2249], 'after': [2250], 'transfection': [2251], 'assayed': [2253], 'sequentially': [2254], 'firefly': [2256], 'Renilla': [2258, 2267], 'activity.': [2260, 2378], 'Firefly': [2261], 'readings': [2263], 'normalized': [2265], 'against': [2266], 'luciferase.': [2268], 'axis': [2270, 2333, 2351, 2367, 2601], 'duplication': [2271, 2368, 2582, 2602], 'provides': [2273], 'sensitive': [2275], 'reliable': [2277], 'way': [2278], 'test': [2280, 2681, 2996], 'stimulatory': [2282], 'inhibitory': [2285], 'activities': [2286, 4559, 4750], '(32Harland': [2287, 2460], 'Gerhart': [2289, 2462], 'Annu.': [2291, 2464], 'Rev.': [2292, 2465], '1997;': [2296, 2469, 2742], '611-667Crossref': [2298, 2471], '(683)': [2301, 2474], 'Injection': [2304, 2561], 'pg': [2307, 2312, 2565, 2596], 'Xwnt8': [2309, 2370, 2377, 2482], '50': [2311, 2866], 'LRP6ΔN': [2314, 2379, 2486], 'mRNA': [2315, 2343, 2364, 2371, 2490, 2570, 2591, 2610], '(an': [2316], 'constitutively': [2317], 'active': [2318], 'mutant': [2319], 'LRP6)': [2320], 'ventral': [2323, 2344], 'marginal': [2324], 'zone': [2325], 'four-cell': [2328, 2615], 'embryo': [2330, 4740], 'ectopic': [2332, 2350], '>80%': [2336, 2584], 'injected': [2338, 2355, 2586], '(Fig.': [2340, 2372, 2393, 2421, 2487, 2498, 2603, 2793, 2824, 2880, 2955, 3063, 3085, 3128, 3172, 3187, 3315, 3347, 3488, 3506, 3579, 4795], '1A).': [2341, 2373, 2394, 2422], 'alone': [2346, 2492, 3154, 4346], 'did': [2347, 2493, 3571], 'induce': [2349, 2495, 2599, 4769], 'even': [2353, 2593, 4787], 'when': [2354, 3066, 4788], 'dose': [2359], '(2000': [2360, 2611], 'pg/embryo).': [2361], 'efficiently': [2365, 2571, 3175, 3327], 'blocked': [2366, 2478, 2572, 3328], 'activated': [2380, 2771, 3178, 3477, 3533], 'Wnt-independent': [2385], 'inhibited': [2390, 2786, 2944, 3176], 'Two': [2395], 'versions': [2396], 'SOST,': [2398, 3600], 'untagged': [2400, 3323], 'carboxyl-terminal': [2407], 'tag,': [2409], 'showed': [2410, 3046, 3155, 3257, 3287], 'same': [2412], 'antagonizing': [2415, 3576], 'this': [2419, 3595, 4389, 4834], 'To': [2423, 2680, 2795, 2995, 3130], 'ensure': [2424], 'directly': [2427, 2454, 2960], 'signaling,': [2430], 'examined': [2432, 2502, 3139], '3': [2441], '(Xnr3)': [2442], 'induction': [2443, 3531], 'Wnt8': [2445], 'animal': [2447], 'pole': [2448], 'explants,': [2449], 'because': [2450, 2893, 4198], 'Xnr3': [2451, 2479, 2496], 'target': [2456], 'activation': [2480, 3157, 3227], 'but': [2483, 3053, 3300, 3659], '1B).': [2488, 2499], 'also': [2501, 2875, 3369, 3425, 3660, 4399], 'whether': [2503, 3140, 4242, 4913, 4923], 'possesses': [2505], '(33Glinka': [2511, 2644, 4411], 'Monaghan': [2517, 2650, 4417], 'Blumenstock': [2519, 2652, 4419], '391:': [2525, 2658, 4425], '357-362Crossref': [2526, 2659, 4426], '(1362)': [2529, 2662, 4429], '34Suzuki': [2532], 'Yamaji': [2536], 'Wozney': [2540], 'Murakami': [2542], 'Ueno': [2544], '91:': [2554], '10255-10259Crossref': [2555], '(417)': [2558], 'ventrally': [2562], '250': [2564], 'truncated': [2567], 'receptor': [2569, 3061], 'developing': [2576], 'trunk': [2581, 2600, 4773], 'embryos.': [2587, 2679, 3638], 'By': [2588], 'contrast,': [2589], '2000': [2595], 'could': [2597, 3142], '1C).': [2604], 'dorsal': [2606], 'pg/embryo)': [2612], 'stage': [2616], 'resulted': [2617, 3562], 'exaggerated': [2619], 'anterior': [2620], 'development': [2621], 'enlargement': [2624], 'cement': [2627], 'gland': [2628], '(not': [2629], 'shown),': [2630], 'phenotype': [2632], 'similar': [2633, 3101], 'observed': [2636, 4493], 'shows': [2667], 'potent': [2668], 'anti-Wnt': [2669, 3413, 4558], 'exhibit': [2674, 3573], 'employed': [2694], '35Korinek': [2723], 'Barker': [2725], 'Morin': [2727], 'Wichen': [2730], 'Weger': [2733], 'Kinzler': [2735], 'K.W.': [2736], 'Vogelstein': [2737], 'Clevers': [2739], 'Science.': [2741], '275:': [2743], '1784-1787Crossref': [2744], '(2950)': [2747], 'T': [2754], 'factor/lymphoid': [2756], 'enhancer': [2757], 'factor-binding': [2758], 'responsive': [2762], 'readily': [2770], 'Wnt1-expressing': [2778], 'Co-expression': [2780], 'dose-dependent': [2791], '2A).': [2794], 'further': [2796, 3131], 'study': [2797, 3596], 'biochemically,': [2801], 'CM': [2804, 2836, 2879, 2935, 2943, 2951, 3009, 3305, 3320, 3332], 'SOST-Myc': [2811], 'found': [2814, 3043], 'majority': [2817], 'remains': [2822, 4100, 4395], 'cell-associated': [2823], '2B).': [2825, 2881], 'major': [2827], 'isoform': [2829], 'had': [2837, 3341], 'apparent': [2839, 2860], 'molecular': [2840, 2850, 2861, 2884, 3102, 4085], 'mass': [2841, 2851, 2885, 3103], '40': [2843, 2864], 'kDa': [2844, 2867, 2873], 'compared': [2846, 3463], 'calculated': [2849], '33': [2853], 'kDa.': [2854], 'In': [2855, 3594], 'addition,': [2856], 'isoforms': [2858, 2886], 'masses': [2862], '70': [2870], '110': [2872], 'higher': [2883, 3110], 'attributed': [2889], 'post-translational': [2891], 'modifications,': [2892], 'two': [2896, 4304], 'predicted': [2897], 'N-glycosylation': [2900], 'Asn-53': [2902], 'Asn-175': [2904], '(www.w.cbs.dtu.dk/services/NetNGlyc/)': [2905], 'one': [2907, 4103], 'site': [2908], 'O-linked': [2910], 'glycosylation': [2911], 'Thr-55': [2913], '(www.cbs.dtu.dk/services/NetOGlyc/)': [2914], '(36Julenius': [2915], 'Molgaard': [2917], 'Gupta': [2919], 'Brunak': [2921], 'Glycobiology.': [2923], '2005;': [2924, 3550], '15:': [2925], '153-164Crossref': [2926], '(779)': [2929], 'tested': [2933], 'inhibition': [2937, 3502, 4114, 4230, 4253, 4500, 4776], 'Indeed,': [2941, 4759], 'Wnt-1': [2950], '2C).': [2956], 'extracellularly.': [2964], 'Similarities': [2965], 'between': [2966, 2999, 3202, 3311, 3380, 3466, 4323], '(associated': [2968], 'function)': [2974], 'via': [2990], 'direct': [2991], 'LRP5.': [2994], 'well': [3004], 'LRP6,': [3006], 'produced': [3008], 'containing': [3010, 3321, 3333], 'SOST-IgG': [3012], 'protein,': [3014], 'tags': [3016], 'constant': [3020], 'region': [3021], 'immunoglobulin': [3023], 'heavy': [3024], 'chain,': [3025], 'portion': [3029], 'tagged': [3034, 3058], '(LRP5N-Myc': [3039], 'LRP6N-Myc).': [3041], 'specific': [3047, 4937], 'interactions': [3048], '(LDLRN-Myc)': [3062], '3A).': [3064, 3086, 3129], 'LDLRN-Myc': [3067], 'mixed': [3069], 'large': [3071], 'excess': [3072], 'together': [3073], 'LRP5N-Myc': [3075], 'LRP6N-Myc,': [3077], 'bound': [3080], 'As': [3087, 3255], 'control': [3090], 'specificity,': [3094], 'Fz8CRD-IgG,': [3097], 'SOST-IgG.': [3107], 'Despite': [3108], 'much': [3109], 'abundance': [3111], 'unable': [3117], 'precipitate': [3119], 'any': [3120, 4436, 4747], 'detectable': [3121, 4748], 'amount': [3122, 3494], 'demonstrate': [3132], 'SOST-LRP5': [3133], 'SOST-LRP6': [3135], 'interaction': [3136, 3289, 4953], 'functionally,': [3137], 'Although': [3149, 3558], 'overexpression': [3153], 'little': [3156], 'synergized': [3168], 'robustly': [3169], '3B).': [3173], 'plus': [3181, 3185, 3483, 3560], '3B),': [3188], 'showing': [3189], 'functionally': [3192], 'LRP6.': [3198], 'Formation': [3199], 'complexes': [3201, 3310], 'Frizzled': [3207], '(Fz)': [3208], 'proteins': [3209, 3215, 3384, 4307, 4581], 'presence': [3212, 4508], 'proposed': [3218], 'initial': [3222], 'step': [3223], 'no': [3288, 3342], '(Figs.': [3296], '3A': [3297], '4A),': [3299], 'addition': [3302, 3318], 'Fz8': [3312], '4A).': [3316, 3348], 'either': [3322], 'Myc-tagged': [3325], 'phosphatase,': [3335], 'negative': [3339, 4222], 'control,': [3340], 'able': [3354], 'disrupt': [3356, 4477], 'shown': [3363, 4265], 'another': [3365], 'antagonist,': [3367], 'DKK1,': [3368, 3583, 4498], 'interacts': [3370], 'prevents': [3376], 'LRP5/6': [3381, 4408, 4555], 'Fz': [3383], 'can': [3417, 4347, 4564, 4578], 'greatly': [3419], 'enhanced': [3420], 'Kremen': [3422, 3467], 'proteins,': [3423], 'bind': [3426, 3651, 4267, 4579], 'thus': [3462], 'relationship': [3465], 'inhibition.': [3475, 3593], 'co-transfecting': [3481], '4B)': [3489], 'suboptimal': [3493], 'exhibited': [3500], 'slight': [3501], '4B).': [3507, 3580], 'Expression': [3508], 'Kremen2': [3510, 3561, 3570, 3589], 'down-regulated': [3511], '∼40%': [3516], 'expressing': [3519], '(this': [3523], 'endogenous': [3528, 4221], 'signaling)': [3535], '(37Chamorro': [3536], 'M.N.': [3537], 'D.R.': [3539], 'Vonica': [3540], 'Brivanlou': [3542], 'A.H.': [3543], 'Cho': [3544], 'K.R.': [3545], 'Varmus': [3546], 'H.E.': [3547], '24:': [3551, 4181], '73-84Crossref': [3552], '(268)': [3555], 'strong': [3564], 'inhibition,': [3567], 'synergy': [3574], 'unlike': [3582, 4497], 'cooperate': [3587], 'demonstrated': [3598], 'mutated': [3606, 4110], 'disease,': [3612, 3670], 'antagonistic': [3615, 3648], 'ligand': [3616], 'inhibitor': [3626], 'Wnt/β-catenin': [3630, 3691], 'only': [3642, 4917], 'expand': [3643], 'repertoire': [3645], 'ligands': [3649], 'implications': [3662], 'our': [3664], 'understanding': [3665], 'sclerosteosis,': [3667], 'density': [3673, 3705, 4965], 'syndrome': [3682, 3739], 'osteoporosis.': [3684, 4969], 'It': [3685, 4236, 4397], 'become': [3687], 'evident': [3688], 'mediated': [3693], 'plays': [3698], 'central': [3700, 4316], 'role': [3701], 'regulation': [3706], 'Loss-of-function': [3728], 'familial': [3737], 'osteoporosis-pseudoglioma': [3738], '(38Gong': [3740], 'Slee': [3742], 'R.B.': [3743], 'Fukai': [3744], 'Rawadi': [3746], 'Roman-Roman': [3748], 'Reginato': [3750], 'A.M.': [3751, 4700], 'Wang': [3752, 4159], 'Cundy': [3754], 'Glorieux': [3756], 'F.H.': [3757], 'Lev': [3758], 'Zacharin': [3760], 'Oexle': [3762], 'Marcelino': [3764], 'Suwairi': [3766], 'Heeger': [3768], 'Sabatakos': [3770], 'Apte': [3772], 'Adkins': [3774], 'W.N.': [3775], 'Allgrove': [3776], 'Arslan-Kirchner': [3778], 'Batch': [3780], 'Black': [3784], 'G.C.': [3785], 'Boles': [3786], 'Boon': [3788], 'Borrone': [3790], 'Brunner': [3792], 'H.G.': [3793], 'Carle': [3794], 'G.F.': [3795], 'Dallapiccola': [3796], 'Paepe': [3799], 'Floege': [3801], 'Halfhide': [3803], 'Hall': [3805], 'Hennekam': [3807], 'Hirose': [3809], 'Jans': [3811], 'Juppner': [3813], 'Kim': [3815], 'C.A.': [3816, 4698], 'Keppler-Noreuil': [3817], 'Kohlschuetter': [3819], 'LaCombe': [3821], 'Lambert': [3823], 'Lemyre': [3825], 'Letteboer': [3827], 'Peltonen': [3829], 'Ramesar': [3831], 'Romanengo': [3833], 'Somer': [3835], 'Steichen-Gersdorf': [3837], 'Steinmann': [3839], 'Sullivan': [3841], 'Superti-Furga': [3843], 'Swoboda': [3845], 'den': [3848], 'Boogaard': [3849], 'M.J.': [3850], 'Vikkula': [3854], 'Votruba': [3856], 'Zabel': [3858], 'Garcia': [3860], 'Baron': [3862], 'Olsen': [3864], '107:': [3870], '513-523Abstract': [3871], '(1873)': [3879], 'Intriguingly,': [4011], 'known': [4013], 'families': [4018], 'single': [4020], 'amino': [4021, 4437], 'acid': [4022, 4438], 'substitutions': [4023], 'clustered': [4024], 'so-called': [4028], 'YWTD': [4029], 'β-propeller': [4030], '(16Van': [4036], 'mechanism': [4086, 4385, 4490], 'cause': [4091], 'LRP5/β-catenin': [4095], 'during': [4097], 'growth': [4099, 4939], 'unclear.': [4101, 4396], 'For': [4102], 'particular': [4104], 'mutation,': [4106], 'G171V': [4107], '(glycine': [4108], '171': [4109], 'valine),': [4112], 'decreased': [4113], 'suggested': [4120], 'account': [4122], '39Zhang': [4157], 'Zheng': [4169], 'Harris': [4173], '4677-4684Crossref': [4182], '(142)': [4185], 'Because': [4188], 'highly': [4191], 'expressed': [4192, 4791], 'osteocytes,': [4196], 'growth,': [4215, 4226], 'regulator': [4223], 'through': [4228], 'will': [4237, 4908], 'interesting': [4239], 'examine': [4241], 'compromised': [4251], '36%': [4259], 'identity': [4260], 'activate': [4271], 'closely': [4305], '“cysteine': [4310], 'knot”': [4311], 'occupies': [4314], 'part': [4317], 'One': [4320], 'noticeable': [4321], 'difference': [4322], 'WISE': [4326, 4345, 4394, 4577, 4745, 4782, 4823, 4842, 4916], 'behaves': [4331], 'exclusively': [4332], 'Wnt/LRP5/6': [4337, 4920], 'embryos,': [4344], 'weak': [4351, 4828], 'agonist': [4352, 4391], 'activates': [4354], 'limited': [4359], 'extent': [4360], 'interest': [4401], 'compare': [4403], 'prototypic': [4407, 4761], 'sequence': [4439], 'Like': [4443], 'Wnt1-induced': [4478], 'Fz8-LRP6': [4479], 'vitro': [4485], 'suggesting': [4487], 'potential': [4489, 4957], 'action.': [4495], 'insensitive': [4505], 'Kremen2,': [4510], 'transmembrane': [4512], 'although': [4552, 4753], 'ligands,': [4556], 'differently': [4566], 'modulated': [4567], 'co-factors.': [4570], 'act': [4583], "40O'Shaughnessy": [4691], 'R.F.': [4692], 'Yeo': [4693], 'Gautier': [4695], 'Jahoda': [4697], 'Christiano': [4699], 'Investig.': [4702], 'Dermatol.': [4703], '123:': [4705], '613-621Abstract': [4706], '(35)': [4714], '41Laurikkala': [4717, 4886], 'Kassai': [4719, 4888], 'Pakkasjarvi': [4721, 4890], '264:': [4730, 4899], '91-105Crossref': [4731, 4900], 'experiments': [4741], 'neither': [4742], 'nor': [4744], 'toward': [4751], 'strongly': [4755], 'Noggin': [4766, 4851], 'Chordin': [4768, 4853], 'neural': [4770], '(via': [4775], 'signaling),': [4779], 'failed': [4783], 'so': [4786], 'they': [4789, 4924], '1C)': [4796], 'best': [4826], 'Consistent': [4832], 'notion,': [4835], 'affinities': [4838], 'BMPs': [4844], 'significantly': [4846], 'weaker': [4847], 'than': [4848], 'those': [4849], 'Further': [4906], 'required': [4910], 'clarify': [4912], 'Nonetheless,': [4934], 'given': [4935], 'mutations,': [4948], 'modulating': [4949], 'therapeutic': [4958], 'strategy': [4959], 'treatment': [4962], 'thank': [4971], 'members': [4972], 'Xi': [4975], 'laboratory': [4977], 'suggestions': [4979], 'help.': [4981]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2002725330', 'counts_by_year': [{'year': 2024, 'cited_by_count': 21}, {'year': 2023, 'cited_by_count': 33}, {'year': 2022, 'cited_by_count': 32}, {'year': 2021, 'cited_by_count': 35}, {'year': 2020, 'cited_by_count': 40}, {'year': 2019, 'cited_by_count': 29}, {'year': 2018, 'cited_by_count': 34}, {'year': 2017, 'cited_by_count': 44}, {'year': 2016, 'cited_by_count': 51}, {'year': 2015, 'cited_by_count': 53}, {'year': 2014, 'cited_by_count': 51}, {'year': 2013, 'cited_by_count': 50}, {'year': 2012, 'cited_by_count': 50}], 'updated_date': '2024-12-28T03:56:45.834775', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
