Publication Information

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'https://openalex.org/W1519234293'], 'abstract_inverted_index': {'The': [0, 15, 62, 246, 290, 305, 352, 536, 791, 1213, 2083, 2174, 2183, 2223, 2251, 2312, 2332, 2483, 2568, 2613, 2718, 2746, 2842, 2869, 2898, 2935, 3110, 3143, 3156, 3243, 3270, 3329, 3362, 3388, 3403, 3422, 3678, 3986, 4157, 4191, 4226, 4261, 4294, 4326, 4398, 4438, 4466], 'metabotropic': [1, 291, 582, 736], 'glutamate': [2, 292, 583, 732, 737, 743], 'receptors': [3, 16, 293, 306, 733, 738, 744, 810, 861, 887, 1138, 1768, 2315, 3037, 3081, 3691, 3836, 4145], '(mGluRs)': [4, 294], 'belong': [5, 295], 'to': [6, 26, 33, 72, 77, 102, 135, 147, 154, 159, 296, 316, 323, 362, 367, 392, 425, 437, 444, 449, 685, 1218, 1226, 1234, 1237, 1650, 1691, 1720, 1725, 1728, 1772, 1778, 1922, 1928, 2002, 2037, 2072, 2080, 2324, 2474, 2833, 2850, 3063, 3067, 3234, 3251, 3392, 3479, 3536, 3573, 3624, 3634, 3674, 3705, 3957, 3968, 4005, 4021, 4171], 'family': [7, 213, 258, 287, 297, 503, 548, 577, 796, 857, 1140, 1228, 1432, 1657, 1686, 1766], 'C': [8, 214, 259, 298, 504, 549, 797, 1141, 1229, 1658, 1687, 1767, 3169], 'of': [9, 43, 46, 65, 111, 123, 128, 145, 163, 171, 185, 199, 233, 238, 254, 283, 288, 299, 333, 336, 355, 401, 413, 418, 435, 453, 461, 475, 489, 523, 528, 544, 573, 578, 648, 688, 728, 754, 766, 795, 798, 858, 954, 1069, 1102, 1111, 1119, 1129, 1135, 1203, 1433, 1442, 1488, 1490, 1502, 1507, 1510, 1655, 1661, 1679, 1684, 1732, 1738, 1781, 1931, 1947, 2005, 2009, 2031, 2044, 2068, 2085, 2208, 2241, 2253, 2334, 2462, 2563, 2587, 2596, 2611, 2624, 2632, 2720, 2748, 2797, 2821, 2981, 2995, 3002, 3017, 3034, 3046, 3054, 3075, 3098, 3127, 3171, 3216, 3352, 3379, 3507, 3527, 3553, 3587, 3616, 3628, 3637, 3645, 3649, 3699, 3729, 3742, 3777, 3800, 3812, 3815, 3822, 3857, 3867, 3887, 3915, 3918, 3924, 3932, 3939, 4044, 4058, 4139, 4153, 4185, 4199, 4240, 4292, 4314, 4324, 4338, 4361, 4364, 4372, 4379, 4384, 4430, 4459, 4464, 4478], 'the': [10, 44, 85, 99, 116, 136, 143, 149, 161, 164, 179, 183, 200, 205, 219, 234, 242, 252, 263, 300, 334, 375, 389, 406, 426, 433, 439, 451, 454, 469, 473, 490, 495, 509, 524, 532, 542, 553, 630, 635, 686, 730, 735, 741, 757, 799, 952, 1064, 1070, 1100, 1104, 1117, 1120, 1133, 1136, 1227, 1440, 1445, 1485, 1493, 1500, 1508, 1653, 1656, 1673, 1680, 1682, 1685, 1721, 1733, 1736, 1762, 1765, 1917, 1942, 1948, 2006, 2011, 2028, 2032, 2041, 2045, 2066, 2069, 2073, 2076, 2086, 2092, 2097, 2227, 2263, 2319, 2325, 2339, 2350, 2362, 2380, 2464, 2475, 2478, 2487, 2524, 2558, 2573, 2581, 2619, 2733, 2765, 2770, 2789, 2823, 2834, 2837, 2846, 2872, 2969, 2998, 3050, 3079, 3094, 3133, 3165, 3168, 3179, 3191, 3196, 3224, 3235, 3238, 3247, 3273, 3311, 3348, 3375, 3500, 3537, 3551, 3557, 3563, 3567, 3574, 3585, 3591, 3597, 3607, 3646, 3667, 3683, 3695, 3714, 3725, 3730, 3735, 3740, 3752, 3774, 3797, 3804, 3810, 3831, 3855, 3864, 3871, 3883, 3888, 3913, 3921, 3936, 3949, 3958, 4007, 4012, 4015, 4039, 4053, 4056, 4136, 4169, 4177, 4194, 4197, 4299, 4307, 4331, 4336, 4362, 4365, 4368, 4380, 4443, 4451, 4455, 4471, 4476], 'G-protein-coupled': [11, 301, 585, 758, 800], 'receptor': [12, 260, 302, 550, 584, 586, 591, 595, 801, 836, 1230, 1659, 1688, 2370, 3670, 3780, 3817, 3873, 3885, 4017], '(GPCR)': [13, 303, 802], 'superfamily.': [14, 304], 'are': [17, 70, 307, 360, 793, 2025, 2791, 4135, 4179, 4357, 4494], 'characterized': [18, 308], 'by': [19, 97, 309, 387, 1050, 1056, 1063, 1667, 2061, 2345, 2477, 2617, 2639, 2836, 3040, 3237, 3320, 3395, 3463, 3602, 3756, 3760, 3902, 4238, 4244, 4335, 4349, 4382, 4388, 4475, 4488], 'having': [20, 310], 'unusually': [21, 311], 'long': [22, 312], 'amino-terminal': [23, 313, 596, 1210], 'domains': [24, 314, 1211, 1664], '(ATDs),': [25, 315], 'which': [27, 69, 317, 359, 749, 804, 1077, 3132, 3499], 'agonist': [28, 82, 274, 318, 372, 564, 970, 1224, 1776, 1926, 2019, 2048, 2077, 3820, 3889], 'binding': [29, 60, 93, 153, 170, 275, 319, 350, 383, 443, 460, 565, 599, 1225, 1435, 1719, 1777, 1927, 2057, 2078, 2971, 3042, 3066, 3144, 3967, 4513], 'has': [30, 173, 226, 320, 463, 516, 682, 950, 1231, 1919], 'been': [31, 227, 321, 517, 683, 1232, 1516, 1770, 1920, 2268, 3850], 'shown': [32, 322, 1771, 1921], 'take': [34, 324, 1235, 1726], 'place.': [35, 325], 'Previously,': [36, 326], 'we': [37, 88, 167, 327, 378, 457, 2050, 3186], 'have': [38, 89, 328, 379, 1482, 1515, 1769, 2051, 2266, 3706, 3744], 'constructed': [39, 210, 329, 500, 2317], 'a': [40, 50, 57, 78, 91, 103, 108, 175, 186, 192, 212, 222, 230, 239, 330, 340, 347, 368, 381, 393, 398, 465, 476, 482, 502, 512, 520, 529, 645, 834, 856, 1109, 1431, 1497, 1503, 1668, 1700, 1729, 2053, 2081, 2347, 2423, 2452, 2470, 2492, 2589, 2604, 2811, 2829, 2903, 3013, 3044, 3116, 3140, 3206, 3230, 3505, 3700, 3710, 3748, 3853, 3893, 3903, 3980, 4034, 4214, 4220], 'molecular': [41, 331, 1505], 'model': [42, 332, 1506, 2004], 'ATD': [45, 63, 180, 255, 267, 335, 353, 470, 545, 557, 1509, 1654, 1683, 1722, 1739, 2008, 2046, 2093, 2102], 'mGluR1': [47, 337, 1051, 1932, 2060, 3951], 'based': [48, 338, 963], 'on': [49, 115, 339, 405, 964, 1672, 2040, 2374, 2722, 2752, 3384, 3713, 3764, 3779, 3870, 3882, 3994, 4038, 4223], 'weak': [51, 341], 'amino': [52, 342, 966, 1113, 1220, 1422], 'acid': [53, 343, 581, 588, 590, 602, 605, 627, 809, 967, 1114, 1423, 2121, 2135, 3026], 'sequence': [54, 344, 968, 1424], 'similarity': [55, 345], 'with': [56, 119, 346, 409, 1941, 2433, 2459, 2505, 2528, 2545, 2621, 2726, 2755, 2818, 2856, 2961, 2973, 2992, 3023, 3078, 3090, 3122, 3213, 3257, 3431, 3439, 3621, 3641, 3734, 3843, 3852, 3863, 3929, 4258, 4266, 4270, 4277, 4280, 4395, 4403, 4407, 4414, 4417], 'bacterial': [58, 348], 'periplasmic': [59, 349, 598, 1434], 'protein.': [61, 351], 'consists': [64, 354, 1660], 'two': [66, 356, 725, 807, 1662, 1694, 3080, 3660], 'globular': [67, 357, 1663], 'lobes,': [68, 358], 'speculated': [71, 361, 1690], 'contract': [73, 363], 'from': [74, 364, 1676, 2115, 2127, 2141, 2156, 2172, 2179, 2192, 2234, 2258, 2355, 3530, 3566, 4146], 'an': [75, 120, 365, 410, 641, 1696, 1912, 1938, 2035, 2375, 3635, 3642, 3707, 3819, 3880, 4350, 4489], '“openȁ': [76, 197, 366, 487, 1697, 2007], '“closedȁ': [79, 187, 369, 477, 1701], 'conformation': [80, 370], 'following': [81, 371, 2047, 2465, 2824, 2870, 3225, 3271, 3538], 'binding.': [83, 373], 'In': [84, 374, 1099, 2968, 3732, 3809, 3840, 3975, 4027], 'present': [86, 376, 1754], 'study,': [87, 377, 3739], 'created': [90, 228, 380, 518, 2052], 'Zn2+': [92, 146, 152, 382, 436, 442, 2771, 3060, 3568, 3625, 3675, 3703, 3778, 3813, 3858, 3878, 3933, 3962, 3977, 4151], 'site': [94, 209, 225, 384, 499, 515, 2058], 'in': [95, 133, 139, 178, 211, 229, 273, 385, 423, 429, 468, 501, 519, 563, 634, 644, 1080, 1139, 1439, 1447, 1693, 2018, 2027, 2059, 2065, 2422, 2427, 2498, 2542, 2557, 2580, 2732, 2769, 2780, 2786, 2876, 2909, 2939, 2997, 3012, 3049, 3093, 3139, 3148, 3167, 3178, 3195, 3278, 3333, 3347, 3407, 3446, 3467, 3475, 3484, 3504, 3525, 3626, 3724, 3737, 3751, 3782, 3912, 3955, 4010, 4018, 4055, 4168, 4196, 4213, 4253, 4306, 4367, 4390, 4450], 'mGluR1b': [96, 386, 2761, 3623, 3973], 'mutating': [98, 388, 2062], 'residue': [100, 390, 1914], 'Lys260': [101, 391, 2351, 3848], 'histidine.': [104, 394, 2082], 'Zinc': [105, 395], 'acts': [106, 396], 'as': [107, 397, 651, 1073, 1496, 2015, 2469, 2643, 2743, 2768, 2793, 2828, 2965, 3229, 3796, 4162, 4181, 4231, 4359, 4496], 'noncompetitive': [109, 399, 3894, 3950, 3981, 4221], 'antagonist': [110, 400, 3895, 3952, 3960, 3982, 4222], 'agonist-induced': [112, 150, 402, 440, 3638, 4008], 'IP': [113, 403, 2776, 3639, 4155, 4158, 4227, 4241, 4345, 4385, 4484], 'accumulation': [114, 404, 3640, 4242, 4386], 'K260H': [117, 140, 155, 407, 430, 445, 2336, 2357, 2760, 3070, 3193, 3220, 3845, 3925, 3972, 3997, 4224, 4259, 4396], 'mutant': [118, 408, 2335, 2356, 3036, 3192, 3807, 3835, 3844, 3884, 3984, 4016, 4047, 4143], 'IC50': [121, 411, 3643, 3856, 3866], 'value': [122, 412, 3644], '2': [124, 414, 2803, 2945, 2948, 3288, 3875, 4173], 'μm.': [125, 415], 'Alanine': [126, 416], 'mutations': [127, 417], 'three': [129, 419, 883, 961, 2012, 2800, 3154, 3426, 3464, 3689, 4188, 4311], 'potential': [130, 278, 420, 568], '“zinc': [131, 421], 'coligandsȁ': [132, 422], 'proximity': [134, 424], 'introduced': [137, 174, 427, 464], 'histidine': [138, 428], 'knock': [141, 431], 'out': [142, 432, 2638], 'ability': [144, 434], 'antagonize': [148, 438, 4006], 'response.': [151, 441, 3564, 3598], 'does': [156, 446, 3175], 'not': [157, 447, 3176, 3964, 4025, 4099, 4209], 'appear': [158, 448], 'affect': [160, 450], 'dimerization': [162, 452], 'receptor.': [165, 455], 'Instead,': [166, 456], 'propose': [168, 458], 'that': [169, 266, 459, 556, 2737, 3680, 3694], 'zinc': [172, 462, 2056, 3681], 'structural': [176, 466, 2098], 'constraint': [177, 467], 'lobe,': [181, 471], 'preventing': [182, 472], 'formation': [184, 474, 4346, 4485], 'conformation,': [188, 478], 'and': [189, 241, 257, 479, 531, 547, 639, 656, 691, 697, 734, 882, 972, 1052, 1058, 1060, 1223, 1430, 1512, 1521, 1699, 1746, 1764, 1785, 1933, 2023, 2096, 2108, 2123, 2133, 2149, 2187, 2212, 2226, 2246, 2256, 2440, 2457, 2517, 2534, 2552, 2572, 2593, 2608, 2630, 2739, 2750, 2788, 2816, 2863, 2886, 2918, 2952, 2976, 3008, 3052, 3120, 3137, 3190, 3211, 3264, 3280, 3296, 3300, 3316, 3338, 3342, 3416, 3437, 3452, 3473, 3490, 3520, 3560, 3594, 3631, 3666, 3768, 3806, 3833, 3876, 3954, 3990, 3996, 4001, 4014, 4046, 4062, 4141, 4150, 4167, 4174, 4176, 4203, 4249, 4272, 4289, 4298, 4321, 4330, 4370, 4409, 4426, 4442, 4461, 4470], 'thus': [190, 480], 'stabilizing': [191, 481], 'more': [193, 483], 'or': [194, 484, 764, 1750, 2598, 2602, 2728, 2759, 3000, 3069, 3096, 3106, 3150, 3222, 3350, 3358, 3709, 3971, 4318, 4435], 'less': [195, 485], 'inactive': [196, 486], 'form': [198, 488, 745, 1703, 1731], 'ATD.': [201, 491, 2033], 'This': [202, 492, 2930, 3173, 3460, 3898], 'study': [203, 493, 2087], 'presents': [204, 494], 'first': [206, 220, 496, 510], 'metal': [207, 223, 497, 513, 3647, 3987], 'ion': [208, 224, 498, 514, 747, 2640, 3648, 3719, 3869, 4490], 'GPCR.': [215, 505], 'Furthermore,': [216, 262, 506, 552, 1911, 3946], 'it': [217, 507], 'is': [218, 508, 629, 1048, 1689, 1723, 1741, 1752, 3162, 3550, 3556, 3562, 3584, 3590, 3596, 3698, 3785, 4219], 'time': [221, 511], 'region': [231, 521, 623, 1239, 2348, 3174], 'outside': [232, 522], 'seven': [235, 525], 'transmembrane': [236, 526, 622], 'regions': [237, 268, 527, 558], 'GPCR': [240, 530], 'loops': [243, 533], 'connecting': [244, 534], 'these.': [245, 535], 'findings': [247, 264, 537, 554, 3736], 'offer': [248, 538], 'valuable': [249, 539], 'insight': [250, 540], 'into': [251, 541, 960, 1444, 1743, 2262, 2359, 2451, 2491, 2810, 3205, 3282], 'mechanism': [253, 543, 2095], 'closure': [256, 546, 1737, 2094], 'activation.': [261, 551], 'demonstrate': [265, 555], 'other': [269, 559, 1121, 2168, 3035, 3661], 'than': [270, 560], 'those': [271, 561], 'participating': [272, 562], 'could': [276, 566], 'be': [277, 567, 1216, 1773, 1923], 'targets': [279, 569], 'for': [280, 285, 570, 575, 1499, 1518, 1775, 1925, 2110, 2338, 2539, 2577, 2895, 2906, 2927, 2986, 3084, 3308, 3326, 3344, 3366, 3400, 3428, 3457, 3495, 4274, 4303, 4411, 4447], 'new': [281, 571, 4215], 'generations': [282, 572], 'ligands': [284, 574], 'this': [286, 576, 1238, 3718, 3738, 3829, 3868], 'receptors.': [289, 579, 3731], '(S)-glutamic': [580], 'γ-aminobutyric': [587, 589, 808], 'type': [592, 615, 811, 2757], 'B': [593, 812], 'calcium-sensing': [594, 835], 'domain': [597], 'protein': [600, 2953], '[3H]quisqualic': [601], '(S)-4-Carboxyphenylglycine': [603, 2131], '7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylic': [604, 2134], 'ethyl': [606, 2136], 'ester': [607, 2137], 'inositol': [608], 'phosphate': [609], "Hanks'": [610, 2529], 'balanced': [611, 2530], 'saline': [612, 617, 2531, 3409], 'solution': [613, 618, 2532, 3410, 3506], 'wild': [614, 2756], 'phosphate-buffered': [616, 3408], 'Chinese': [619], 'hamster': [620], 'ovary': [621], 'seven-transmembrane': [624], 'moiety': [625], '(S)-Glutamic': [626], '(Glu)1': [628], 'major': [631], 'excitatory': [632], 'neurotransmitter': [633], 'central': [636], 'nervous': [637], 'system': [638], 'plays': [640], 'essential': [642], 'role': [643], 'wide': [646], 'range': [647], 'functions,': [649], 'such': [650], 'brain': [652], 'development,': [653], 'memory': [654], 'formation,': [655], 'neurotoxicity': [657], '(1Bräuner-Osborne': [658, 699, 770, 976], 'H.': [659, 700, 771, 815, 909, 977, 1163, 1245, 1324, 1362, 1454, 1528, 1568, 1598, 1792, 1820, 1858, 1888, 1963, 1989, 2201, 2272, 2298, 2647, 2701], 'Egebjerg': [660, 701, 772, 978], 'J.': [661, 668, 702, 709, 773, 780, 841, 892, 926, 979, 986, 1021, 1146, 1180, 1282, 1325, 1345, 1371, 1394, 1398, 1402, 1569, 1605, 1633, 1829, 1859, 1895, 1964, 1991, 2281, 2671, 2702], 'Nielsen': [662, 703, 774, 980], 'E.Ø.': [663, 704, 775, 981], 'Madsen': [664, 705, 776, 982], 'U.': [665, 706, 777, 983], 'Krogsgaard-Larsen': [666, 707, 778, 910, 984, 1164, 1369, 1827, 1986, 2279, 2301, 2650, 2698], 'P.': [667, 708, 779, 911, 985, 1165, 1368, 1370, 1826, 1828, 1987, 2278, 2280, 2302, 2651, 2699], 'Med.': [669, 710, 781, 842, 987], 'Chem.': [670, 711, 782, 894, 988, 1148, 1284, 1327, 1347, 1373, 1571, 1607, 1635, 1831, 1861, 1897, 1966, 2283, 2673, 2704], '2000;': [671, 712, 783, 913, 940, 989, 1167, 1194, 1993, 2705], '43:': [672, 713, 784, 990], '2609-2645Crossref': [673, 714, 785, 991], 'PubMed': [674, 715, 786, 829, 851, 903, 916, 943, 992, 1006, 1026, 1041, 1094, 1157, 1170, 1197, 1267, 1291, 1308, 1336, 1356, 1382, 1416, 1476, 1550, 1580, 1616, 1644, 1713, 1814, 1840, 1870, 1906, 1975, 1996, 2292, 2307, 2412, 2656, 2682, 2713], 'Scopus': [675, 716, 787, 830, 852, 878, 904, 917, 944, 993, 1007, 1027, 1042, 1095, 1158, 1171, 1198, 1268, 1337, 1357, 1383, 1417, 1477, 1551, 1581, 1617, 1645, 1714, 1815, 1841, 1871, 1907, 1976, 1997, 2293, 2308, 2413, 2657, 2683, 2714], '(533)': [676, 717, 788, 994], 'Google': [677, 718, 789, 832, 854, 880, 906, 919, 946, 995, 1009, 1029, 1044, 1097, 1160, 1173, 1200, 1270, 1292, 1309, 1339, 1359, 1385, 1419, 1479, 1553, 1583, 1619, 1647, 1716, 1817, 1843, 1873, 1909, 1978, 1999, 2295, 2310, 2415, 2659, 2685, 2716], 'Scholar).': [678, 719, 790, 947, 1045, 1098, 1420, 1480, 1648, 1717, 1910, 2000, 2311, 2717], 'Excessive': [679], 'glutamatergic': [680], 'signaling': [681, 753, 761], 'linked': [684], 'pathogenesis': [687], 'certain': [689], 'psychiatric': [690], 'neurological': [692], 'disorders,': [693], 'including': [694], 'schizophrenia,': [695], 'epilepsy,': [696], 'ischemia': [698], 'Glu': [720, 2591, 3005, 3531, 3825, 3907, 3940, 4061, 4147, 4202, 4252, 4315, 4389], 'mediates': [721], 'its': [722, 1204], 'effects': [723, 2747], 'through': [724, 762, 1937], 'distinct': [726], 'types': [727], 'receptors:': [729], 'ionotropic': [731, 742], '(mGluRs).': [739], 'Whereas': [740], 'ligand-gated': [746], 'channels,': [748], 'directly': [750], 'mediate': [751], 'electrical': [752], 'nerve': [755], 'cells,': [756], 'mGluRs': [759, 792, 1918], 'regulate': [760], 'stimulation': [763], 'inhibition': [765, 1751, 3636, 3697, 4152, 4237, 4381], 'intracellular': [767], 'metabolic': [768], 'cascades': [769], 'members': [794, 1205], 'superfamily,': [803], 'also': [805, 3745], 'includes': [806], '(GABABR1–2)': [813], '(2Möhler': [814], 'Fritschy': [816], 'J.-M.': [817], 'Trends': [818, 868], 'Pharmacol.': [819, 1022, 1412, 1992], 'Sci.': [820], '1999;': [821, 843, 870, 1023, 1038, 1091, 1348, 1374, 1413, 1572, 1608, 1636, 1832, 1862, 1898, 1967, 2284, 2304, 2653], '20:': [822, 1711], '87-89Abstract': [823], 'Full': [824, 826, 846, 848, 873, 875, 898, 900, 1003, 1152, 1154, 1264, 1288, 1331, 1333, 1351, 1353, 1377, 1379, 1473, 1547, 1575, 1577, 1611, 1613, 1639, 1641, 1811, 1835, 1837, 1865, 1867, 1901, 1903, 1970, 1972, 2287, 2289, 2677, 2679, 2708, 2710], 'Text': [825, 827, 847, 849, 874, 876, 899, 901, 1004, 1153, 1155, 1265, 1289, 1332, 1334, 1352, 1354, 1378, 1380, 1474, 1548, 1576, 1578, 1612, 1614, 1640, 1642, 1812, 1836, 1838, 1866, 1868, 1902, 1904, 1971, 1973, 2288, 2290, 2678, 2680, 2709, 2711], 'PDF': [828, 850, 877, 902, 1005, 1156, 1266, 1290, 1335, 1355, 1381, 1475, 1549, 1579, 1615, 1643, 1813, 1839, 1869, 1905, 1974, 2291, 2681, 2712], '(85)': [831], 'Scholar),': [833, 855, 881, 1201], '(CaR)': [837], '(3Brown': [838], 'E.M.': [839], 'Am.': [840], '106:': [844], '238-253Abstract': [845], '(199)': [853], 'putative': [859], 'pheromone': [860], '(4Tirindelli': [862], 'R.': [863, 891, 1145, 1303, 1400, 1560, 1596, 1850, 1886, 1955, 2215, 2406], 'Mucignat-Caretta': [864], 'C.': [865, 1015, 1255, 1390, 1404, 1464, 1538, 1566, 1590, 1802, 1856, 1880, 1961], 'Ryba': [866], 'N.J.': [867], 'Neurosci.': [869], '21:': [871], '482-486Abstract': [872], '(95)': [879], 'recently': [884], 'cloned': [885, 1124], 'orphan': [886, 1137], '(5Cheng': [888, 1142], 'V.': [889, 1143, 1251, 1460, 1534, 1562, 1798, 1852, 1957, 2238], 'Lotan': [890, 1144], 'Biol.': [893, 1147, 1283, 1326, 1346, 1372, 1570, 1606, 1634, 1830, 1860, 1896, 1965, 2282, 2672, 2703], '1998;': [895, 1149, 1328], '273:': [896, 1150, 1329], '35008-35015Abstract': [897, 1151], '(124)': [905, 1159], 'Scholar,': [907, 920, 996, 1010, 1030, 1161, 1174, 1271, 1293, 1310, 1340, 1360, 1386, 1554, 1584, 1620, 1818, 1844, 1874, 1979, 2296, 2660], '6Bräuner-Osborne': [908, 1162], 'Genomics.': [912, 939, 1166, 1193], '65:': [914, 1168], '121-128Crossref': [915, 1169], '(65)': [918, 1172], '7Robbins': [921, 1175], 'M.J.': [922, 1176], 'Michalovich': [923, 1177], 'D.': [924, 1178, 1247, 1456, 1530, 1794], 'Hill': [925, 1179, 3558, 3592], 'Calver': [927, 1181], 'A.R.': [928, 1182], 'Medhurst': [929, 1183], 'A.D.': [930, 1184], 'Gloger': [931, 1185], 'I.': [932, 1186], 'Sims': [933, 1187], 'M.': [934, 1188, 1279, 1316, 1392, 2399, 2666, 2668], 'Middlemiss': [935, 1189], 'D.N.': [936, 1190], 'Pangalos': [937, 1191], 'M.N.': [938, 1192], '67:': [941, 1195], '8-18Crossref': [942, 1196], '(104)': [945, 1199], 'Molecular': [948], 'cloning': [949], 'revealed': [951], 'existence': [953], 'eight': [955], 'different': [956, 3690, 4312, 4428, 4457], 'mGluR': [957], 'subtypes,': [958], 'subdivided': [959], 'subgroups': [962], 'their': [965, 1081, 2259], 'similarities,': [969], 'pharmacology,': [971], 'signal': [973, 3726], 'transduction': [974, 3727], 'pathways': [975], '8Nakanishi': [997], 'S.': [998, 1281, 1322, 2237], 'Neuron.': [999, 1260, 1469, 1543, 1807], '1994;': [1000, 2409], '13:': [1001], '1031-1037Abstract': [1002], '(648)': [1008], '9Pin': [1011], 'J-P.': [1012, 1604, 1894], 'de': [1013], 'Colle': [1014], 'Bessis': [1016], 'A.S.': [1017], 'Acher': [1018], 'F.': [1019], 'Eur.': [1020, 1990], '375:': [1024], '277-294Crossref': [1025], '(146)': [1028], '10Schoepp': [1031], 'D.D.': [1032, 1085], 'Jane': [1033, 1086], 'D.E.': [1034, 1087], 'Monn': [1035, 1088], 'J.A.': [1036, 1089], 'Neuropharmacology.': [1037, 1090], '38:': [1039, 1092], '1431-1476Crossref': [1040, 1093], '(1016)': [1043, 1096], 'Group': [1046], 'I': [1047], 'constituted': [1049], 'mGluR5,': [1053], 'group': [1054, 1061, 1946, 3741], 'II': [1055], 'mGluR2': [1057], 'mGluR3,': [1059], 'III': [1062], 'remaining': [1065], 'four': [1066, 4427, 4456], 'subtypes.': [1067], 'Some': [1068], 'subtypes': [1071], 'exist': [1072, 1426, 1692, 3177], 'multiple': [1074], 'splice': [1075, 1105, 1122, 3182], 'variants,': [1076], 'only': [1078, 1127, 3746], 'differ': [1079], 'carboxyl': [1082], 'termini': [1083, 1118], '(10Schoepp': [1084], 'case': [1101], 'mGluR1,': [1103, 1511, 1782, 2010], 'variant': [1106, 3183], 'mGluR1a': [1107, 3189, 3194], 'possesses': [1108], 'C-terminal': [1110], '359': [1112], 'residues,': [1115, 2079], 'whereas': [1116, 3935], 'variants': [1123], 'so': [1125], 'far': [1126], 'consist': [1128], '50–60': [1130], 'residues.': [1131], 'With': [1132], 'exception': [1134], 'all': [1202, 2267, 2775, 3526, 3834], 'contain': [1206], 'remarkably': [1207], 'large': [1208], 'extracellular': [1209], '(ATDs).': [1212], 'ATDs': [1214, 1429], 'can': [1215], 'up': [1217, 4020], '600': [1219], 'acids': [1221], 'long,': [1222], 'demonstrated': [1233], 'place': [1236, 1727], "(11O'Hara": [1240, 1449, 1523, 1787], 'P.J.': [1241, 1299, 1450, 1524, 1626, 1788, 1985, 2695], 'Sheppard': [1242, 1365, 1451, 1525, 1789, 1823, 1982, 2275, 2692], 'P.O.': [1243, 1366, 1452, 1526, 1790, 1824, 1983, 2276, 2693], 'Thøgersen': [1244, 1453, 1527, 1567, 1791, 1857, 1962], 'Venezia': [1246, 1455, 1529, 1793], 'Haldeman': [1248, 1457, 1531, 1795], 'B.A.': [1249, 1458, 1532, 1796], 'McGrane': [1250, 1459, 1533, 1797], 'Houamed': [1252, 1461, 1535, 1799], 'K.H.': [1253, 1462, 1536, 1800], 'Thomsen': [1254, 1463, 1537, 1565, 1801, 1855, 1960], 'Gilbert': [1256, 1465, 1539, 1803], 'T.L.': [1257, 1466, 1540, 1804], 'Mulvihill': [1258, 1467, 1541, 1805], 'E.R.': [1259, 1468, 1542, 1806], '1993;': [1261, 1285, 1470, 1544, 1808], '11:': [1262, 1471, 1545, 1809], '41-52Abstract': [1263, 1472, 1546, 1810], '(621)': [1269, 1478, 1552, 1816], '12Takahishi': [1272], 'K.': [1273, 1275, 1408, 1594, 1622, 1884], 'Tsuchida': [1274], 'Tanabe': [1276], 'Y.': [1277, 1318], 'Masayuki': [1278], 'Nakanishi': [1280, 1321, 2195], '268:': [1286], '19341-19345Abstract': [1287], '13Tones': [1294], 'M.A.': [1295], 'Bendali': [1296], 'N.': [1297, 1314], 'Flor': [1298], 'Knöpfel': [1300], 'T.': [1301, 1312, 1586, 1876, 2662], 'Kuhn': [1302, 1399, 1595, 1885], 'Neuroreport.': [1304, 2303, 2652], '1995;': [1305], '7:': [1306], '117-120Crossref': [1307], '14Okamoto': [1311], 'Sekiyama': [1313], 'Otsu': [1315], 'Shimada': [1317], 'Sato': [1319], 'A.': [1320], 'Jingami': [1323], '13089-13096Abstract': [1330], '(141)': [1338], '15Han': [1341], 'G.': [1342, 1564, 1854, 1959], 'Hampson': [1343], 'D.R.': [1344, 1556, 1846, 1951], '274:': [1349, 1375, 1573, 1609, 1637, 1833, 1863, 1899, 1968, 2285], '10008-10013Abstract': [1350], '(74)': [1358], '16Bräuner-Osborne': [1361, 1819], 'Jensen': [1363, 1821, 2273, 2299, 2648], 'A.A.': [1364, 1822, 1981, 2274, 2300, 2649, 2687], "O'Hara": [1367, 1825, 1984, 2277, 2694], '18382-18386Abstract': [1376, 1834, 2286], '(158)': [1384, 1842, 2294], '17Malitschek': [1387], 'B.': [1388, 1410, 1592, 1602, 1882, 1892], 'Schweizer': [1389], 'Keir': [1391], 'Heid': [1393], 'Froestl': [1395, 1599, 1889], 'W.': [1396, 1600, 1890], 'Mosbacher': [1397], 'Henley': [1401], 'Joly': [1403, 1589, 1879], 'Pin': [1405, 1603, 1893, 3743], 'J.-P.': [1406, 3769], 'Kaupmann': [1407, 1593, 1883], 'Bettler': [1409, 1601, 1891], 'Mol.': [1411, 1708], '56:': [1414], '448-454Crossref': [1415], '(98)': [1418], 'Weak': [1421], 'similarities': [1425], 'between': [1427, 4052, 4193], 'these': [1428, 1491, 1651], 'proteins': [1436, 3389], '(PBPs)': [1437], 'involved': [1438], 'transfer': [1441], 'nutrients': [1443], 'cytoplasm': [1446], 'bacteria': [1448], 'We': [1481], 'previously': [1483, 2270, 2645], 'applied': [1484], 'crystal': [1486, 1677], 'structure': [1487], 'one': [1489], 'PBPs,': [1492, 1681], 'leucine/isoleucine/valine-binding': [1494], 'protein,': [1495], 'template': [1498], 'construction': [1501, 2333], 'tertiary': [1504], 'similar': [1513, 3521, 3654], 'models': [1514], 'published': [1517], 'mGluR4,': [1519, 1783, 1934], 'GABABR1,': [1520, 1784], 'CaR': [1522, 1786, 2257, 3665], '18Hampson': [1555, 1845], 'Huang': [1557, 1847, 1952], 'X-P.': [1558, 1848, 1953], 'Pekhletski': [1559, 1849, 1954], 'Peltekova': [1561, 1851, 1956], 'Hornby': [1563, 1853, 1958], '33488-33495Abstract': [1574, 1864, 1969], '(68)': [1582, 1872, 1977], '19Galvez': [1585, 1875], 'Parmentier': [1587, 1877], 'M-L.': [1588, 1878], 'Malitschek': [1591, 1881], 'Bittiger': [1597, 1887], '13362-13369Abstract': [1610, 1900], '(188)': [1618, 1908], '20Ray': [1621], 'Hauschild': [1623], 'B.C.': [1624], 'Steinbach': [1625], 'Goldsmith': [1627], 'P.K.': [1628], 'Hauache': [1629], 'O.': [1630], 'Spiegel': [1631], 'A.M.': [1632], '27642-27650Abstract': [1638], '(173)': [1646], 'According': [1649, 2001], 'models,': [1652], '(“lobesȁ)': [1665], 'connected': [1666], 'hinge': [1669], 'region.': [1670, 1734], 'Based': [1671], 'information': [1674, 2090], 'obtained': [1675, 2114, 2171, 2178, 3524], 'structures': [1678], 'conformations:': [1695], 'inactivated': [1698], 'activated': [1702], '(21Quiocho': [1704], 'F.A.': [1705], 'Ledvina': [1706], 'P.S.': [1707], 'Microbiol.': [1709], '1996;': [1710, 2674], '17-25Crossref': [1712], '(456)': [1715], 'Agonist': [1718], 'believed': [1724], 'closed': [1730], 'How': [1735], 'subsequently': [1740], 'translated': [1742], 'G-protein': [1744], 'coupling': [1745], 'effector': [1747], 'enzyme': [1748], 'activation': [1749, 1780, 1930], 'at': [1753, 2419, 2536, 2798, 2888, 2892, 2920, 2924, 2989, 3027, 3043, 3087, 3152, 3304, 3322, 3369, 3397, 3688, 3787, 3983, 4186], 'poorly': [1755], 'understood.': [1756], 'Two': [1757], 'conserved': [1758, 1915], 'serine/threonine': [1759], 'residues': [1760, 2013], 'throughout': [1761], 'PBPs': [1763], 'important': [1774], 'and/or': [1779, 1929], 'arginine': [1913], 'within': [1916, 2100], 'crucial': [1924], 'most': [1935], 'likely': [1936], 'ionic': [1939], 'interaction': [1940], 'distal': [1943], 'negatively': [1944], 'charged': [1945], 'agonists': [1949], '(18Hampson': [1950], '22Jensen': [1980], 'Bräuner-Osborne': [1988, 2700], '397:': [1994], '247-253Crossref': [1995], '(28)': [1998], 'our': [2003, 3783], 'identified': [2014], 'key': [2016], 'participants': [2017], 'binding,': [2020, 2049, 3010], 'Arg78,': [2021], 'Ser165,': [2022], 'Thr188,': [2024], 'located': [2026, 2064], 'same': [2029, 2582, 2734, 2766, 3684, 4308, 4452], 'lobe': [2030, 2070, 2074], 'As': [2034], 'attempt': [2036], 'shed': [2038], 'light': [2039], 'contraction': [2042], 'process': [2043], 'high': [2054], 'affinity': [2055, 3881], 'Lys260,': [2063], 'top': [2067], 'opposite': [2071], 'containing': [2075, 2349, 2584, 2603, 3290, 3335, 3412, 3433, 3448, 3469, 3486, 4310, 4454], 'results': [2084, 2790, 3522], 'provide': [2088], 'interesting': [2089], 'regarding': [2091], 'flexibility': [2099], 'each': [2101], 'lobe.': [2103], 'Culture': [2104], 'media,': [2105], 'serum,': [2106, 2516], 'antibiotics,': [2107], 'buffers': [2109], 'cell': [2111, 2229, 2396], 'culture': [2112, 2455, 2496, 2814, 3209], 'were': [2113, 2125, 2139, 2154, 2170, 2189, 2231, 2316, 2343, 2372, 2417, 2449, 2489, 2526, 2575, 2615, 2741, 2762, 2778, 2784, 2808, 2874, 2937, 2955, 2984, 3038, 3082, 3135, 3146, 3203, 3275, 3318, 3331, 3364, 3382, 3390, 3405, 3424, 3502, 3518, 3523, 3534, 3571, 3600, 3657, 3672, 3837, 3910, 3941, 3992, 4003, 4160, 4229, 4263, 4301, 4333, 4400, 4445, 4473], 'Life': [2116, 2388], 'Technologies': [2117], '(Paisley,': [2118], 'UK).': [2119, 2144], '[3H]Quisqualic': [2120], '([3H]Quis)': [2122], 'myo-[2-3H]inositol': [2124], 'purchased': [2126, 2140, 2155], 'Amersham': [2128], 'Pharmacia': [2129], 'Biotech.': [2130], '((S)-4CPG)': [2132], '(CPCCOEt)': [2138], 'Tocris': [2142], '(Bristol,': [2143], 'Rabbit': [2145], 'anti-mGluR1a': [2146, 3158, 3441], 'polyclonal': [2147, 3159, 3442], 'antibody': [2148, 3160, 3443], 'horseradish': [2150, 3480], 'peroxidase-goat': [2151], 'anti-rabbit': [2152], 'IgG': [2153, 3477], 'Chemicon': [2157], '(Temecula,': [2158], 'CA)': [2159, 2245], 'andZymed': [2160], 'Laboratories': [2161], 'Inc.': [2162], '(San': [2163], 'Francisco,': [2164], 'CA),': [2165, 2221], 'respectively.': [2166, 2222, 2250, 2745], 'All': [2167, 2368], 'chemicals': [2169], 'Sigma.': [2173], 'pSI': [2175, 2264], 'vector': [2176, 2265], 'was': [2177, 2570, 2636, 2730, 2848, 2900, 2932, 3021, 3061, 3113, 3249, 3314, 3461, 3794, 3826, 3859, 3900, 3926, 3978, 4296, 4328, 4347, 4440, 4468, 4486], 'Promega': [2180], '(Madison,': [2181], 'WI).': [2182], 'plasmids': [2184], 'pmGluR1a,': [2185], 'rCaR-pRK5,': [2186], 'm5-pCD': [2188, 2729], 'generous': [2190, 2232], 'gifts': [2191, 2233], 'Professor': [2193, 2199], 'Shigetada': [2194, 2248], '(Kyoto': [2196], 'University,': [2197], 'Japan),': [2198], 'Solomon': [2200], 'Snyder': [2202], '(The': [2203], 'John': [2204], 'Hopkins': [2205], 'University': [2206], 'School': [2207], 'Medicine,': [2209], 'Baltimore,': [2210], 'MD),': [2211], 'Dr.': [2213, 2235], 'Mark': [2214], 'Brann': [2216, 2696], '(ACADIA': [2217], 'Pharmaceuticals,': [2218], 'San': [2219, 2243], 'Diego,': [2220, 2244], 'tsA': [2224, 2390, 2447, 2723, 2806, 3201, 3617, 3715, 4040, 4254, 4391], 'cells': [2225, 2391, 2448, 2488, 2525, 2574, 2724, 2753, 2807, 2873, 3076, 3202, 3274, 3618, 3841, 4255, 4262, 4300, 4392, 4399, 4444], 'mGluR1a-CHO': [2228], 'line': [2230, 2397], 'Penelope': [2236], 'Jones': [2239], '(University': [2240], 'California,': [2242], 'professor': [2247], 'Nakanishi,': [2249], 'subcloning': [2252, 2346], 'mGluR1b,': [2254, 2978, 3071, 3846], 'mGluR1a,': [2255], 'respective': [2260], 'vectors': [2261], 'described': [2269, 2644, 4163, 4232], '(16Bräuner-Osborne': [2271], '23Bräuner-Osborne': [2297], '10:': [2305, 2654], '3923-3925Crossref': [2306, 2655], '(29)': [2309, 2658], 'point-mutated': [2313], 'mGlu1b': [2314, 4144], 'using': [2318, 2361, 2379, 2467, 2764, 2826, 2957, 3227, 3606], 'QuickChange': [2320], 'mutagenesis': [2321], 'kit': [2322, 2386], 'according': [2323, 2473, 2832, 3233], "manufacturer's": [2326], 'instructions': [2327], '(Stratagene,': [2328], 'La': [2329], 'Jolla,': [2330], 'CA).': [2331], 'mGluR1a-pSI': [2337, 2360], 'Western': [2340, 3515], 'blot': [2341, 3516], 'experiments': [2342, 2777, 2972, 3145, 3517, 3533, 3570, 3811, 3909, 4149], 'done': [2344], '→': [2352], 'His': [2353], 'mutation': [2354], 'mGluR1b-pSI': [2358], 'unique': [2363], 'restriction': [2364], 'enzymes': [2365], 'XhoI': [2366], 'andApaI.': [2367], 'amplified': [2369], 'DNAs': [2371], 'sequenced': [2373], 'ABI': [2376], '310': [2377], 'sequencer': [2378], 'Big': [2381], 'Dye': [2382], 'Terminator': [2383], 'Cycle': [2384], 'Sequencing': [2385], '(PerkinElmer': [2387], 'Sciences).': [2389], '(a': [2392, 2782], 'transformed': [2393], 'HEK': [2394], '293': [2395], '(24Chahine': [2398], 'Bennett': [2400], 'P.B.': [2401], 'George': [2402], 'Jr.,': [2403], 'A.L.': [2404], 'Horn': [2405], 'Pflügers': [2407], 'Arch.': [2408], '427:': [2410], '136-142Crossref': [2411], '(110)': [2414], 'Scholar))': [2416], 'maintained': [2418], '37': [2420, 2537], '°C': [2421, 2538, 2894, 2926, 3371], 'humidified': [2424], '5%': [2425], 'CO2incubator': [2426], "Dulbecco's": [2428, 2500, 2851, 3252], 'modified': [2429, 2501, 2852, 3253], "Eagle's": [2430, 2502, 2853, 3254], 'medium': [2431, 2847, 2854, 3248, 3255], 'supplemented': [2432, 2504, 2544, 2855, 3256, 4279, 4416], 'penicillin': [2434, 2506, 2857, 3258], '(100': [2435, 2438, 2507, 2510, 2858, 2861, 3259, 3262], 'units/ml),': [2436, 2508, 2859, 3260], 'streptomycin': [2437, 2509, 2860, 3261], 'μg/ml),': [2439, 2511, 2862, 3263], '10%': [2441, 2512, 2864, 3265], 'calf': [2442, 2515, 2867, 3268], 'serum.': [2443, 2868, 3269], '1': [2444, 2518, 2987, 3003, 3055, 3085, 3099, 3198, 3401, 3458, 3496, 3757, 3823, 4059, 4200, 4267, 4404], '×': [2445, 2804, 2890, 2922, 3124, 3199, 3306, 3324], '106': [2446, 2805, 3200], 'split': [2450, 2490, 2809, 3204], '10-cm': [2453, 3207], 'tissue': [2454, 2495, 2813, 3208], 'plate': [2456, 2497, 2815, 3210], 'transfected': [2458, 2725, 2754, 2817, 3077, 3212, 3620, 3842, 4257, 4394], '5': [2460, 3125, 3214, 3309, 3367], 'μg': [2461, 2820, 2980, 3215, 3378], 'plasmid': [2463, 2822, 3217], 'day': [2466, 2484, 2825, 2843, 3226, 3244], 'Superfect': [2468, 2827, 3228], 'DNA': [2471, 2830, 3231], 'carrier': [2472, 2831, 3232], 'protocol': [2476, 2767, 2835, 3236], 'manufacturer': [2479, 2838, 3239], '(Qiagen,': [2480, 2839, 3240], 'Hilden,': [2481, 2840, 3241], 'Germany).': [2482, 2841, 3242], 'after': [2485, 2844, 3131, 3245, 3498], 'transfection,': [2486, 2845, 3246], 'poly-d-lysine-coated': [2493], '24-well': [2494], 'inositol-free': [2499], 'medium,': [2503], 'dialyzed': [2513, 2865, 3266], 'fetal': [2514, 2866, 3267], 'μCi/ml': [2519], 'myo-[2-3H]inositol.': [2520], '16–24': [2521], 'h': [2522, 2988, 3086], 'later,': [2523], 'washed': [2527, 3121, 3276, 3425, 4269, 4406], '(HBSS)': [2533], 'incubated': [2535, 2576, 2985, 3083, 3343, 3406, 3438, 4273, 4302, 4410, 4446], '10': [2540, 2553, 2819, 2881, 2907, 3359, 4275, 4286, 4373, 4412, 4423], 'min': [2541, 2579, 3346, 3368, 3430, 4276, 4305, 4413, 4449], 'HBSS': [2543, 3279, 3334, 4278, 4415], '0.9': [2546, 4281, 4418], 'mm': [2547, 2550, 2554, 2627, 2879, 2882, 2912, 2943, 2946, 2949, 3004, 3286, 3298, 3340, 3356, 3360, 3651, 3824, 4060, 4201, 4284, 4287, 4341, 4374, 4421, 4424], 'CaCl2,': [2548], '1.05': [2549, 4283, 4420], 'MgCl2,': [2551, 2947, 4285, 4422], 'LiCl': [2555], '(and': [2556], 'antagonism': [2559, 2772, 3569, 3814], 'experiments,': [2560], 'various': [2561, 2585, 2594, 2609, 2993, 4290, 4322, 4462], 'concentrations': [2562, 2586, 2595, 2610, 2954, 2994, 3028, 3627, 3788, 3917, 3931, 4019, 4028, 4291, 4313, 4323, 4429, 4458, 4463], 'ZnCl2or': [2564], '100': [2565, 2599, 3018, 3101, 3104, 3107, 3297, 3339, 3355, 3761, 3792, 4022, 4030, 4063, 4204], 'μm': [2566, 2600, 3102, 3108, 3630, 3762, 3793, 4023, 4049, 4064, 4205, 4251], 'CPCCOEt).': [2567], 'buffer': [2569, 2583, 2620, 3284, 4295, 4309, 4327, 4439, 4453, 4467], 'removed,': [2571, 4297, 4441], '40': [2578, 4304, 4448], 'Glu,': [2588], 'fixed': [2590, 2605], 'concentration': [2592, 2607, 3045, 3552, 3586, 3799, 3821, 3890], 'ZnCl2': [2597, 2606, 2721, 3763, 4239, 4383, 4431, 4460], 'CPCCOEt,': [2601, 4065, 4206], 'Glu.': [2612, 4465], 'reactions': [2614, 4332, 4472], 'stopped': [2616, 4334, 4474], 'exchanging': [2618], '500': [2622], 'μl': [2623], 'ice-cold': [2625, 2877, 2910, 3128, 4339, 4479], '20': [2626, 2878, 2896, 2911, 2928, 2942, 3415, 3436, 3451, 3472, 3489, 4340, 4480], 'formic': [2628, 4342], 'acid,': [2629], 'separation': [2631], 'total': [2633, 3007, 3014], '[3H]inositol': [2634], 'phosphates': [2635], 'carried': [2637], 'exchange': [2641, 4491], 'chromatography': [2642], '(23Bräuner-Osborne': [2646], '25Nanevicz': [2661], 'Wang': [2663], 'L.': [2664], 'Chen': [2665], 'Ishii': [2667], 'Coughlin': [2669], 'S.R.': [2670], '271:': [2675], '702-706Abstract': [2676], '(101)': [2684], 'Scholar,26Jensen': [2686], 'Spalding': [2688], 'T.A.': [2689], 'Burstein': [2690], 'E.S.': [2691], 'M.R.': [2697], '275:': [2706], '29547-29555Abstract': [2707], '(56)': [2715], 'effect': [2719, 3687, 3712, 3776, 3896, 4037], 'CaR-pSI': [2727], 'studied': [2731, 2763], 'manner,': [2735], 'except': [2736], 'CaCl2': [2738], 'acetylcholine': [2740, 3669], 'used': [2742, 3161, 3187, 3795], 'agonists,': [2744], 'CuCl2': [2749, 4000, 4032], 'CoCl2': [2751, 4002], '(WT)': [2758], 'experiments.': [2773, 2802, 3197], 'Almost': [2774], 'performed': [2779, 2785, 2933, 3147, 3911, 4161, 4230], 'triplicate': [2781, 3151], 'few': [2783], 'duplicate),': [2787], 'given': [2792, 4180, 4358, 4495], 'mean': [2794, 4182], '±': [2795, 4067, 4069, 4071, 4073, 4075, 4077, 4079, 4081, 4083, 4085, 4087, 4089, 4091, 4093, 4095, 4097, 4101, 4103, 4105, 4107, 4109, 4111, 4113, 4115, 4117, 4119, 4121, 4123, 4125, 4127, 4129, 4131, 4133, 4183, 4355, 4502], 'S.E.': [2796, 4184], 'least': [2799, 3153, 4187], 'independent': [2801, 3514, 3886, 4189], '15-cm': [2812], 'changed': [2849, 3250], 'day,': [2871, 3272], 'suspended': [2875], 'HEPES-NaOH,': [2880, 2913, 2944], 'EDTA': [2883], '(pH': [2884, 2916], '7.4)': [2885, 2917], 'centrifuged': [2887, 2919], '50,000': [2889, 2921], 'g': [2891, 2923, 3307, 3325], '4': [2893, 2925], 'min.': [2897, 2929, 3328], 'pellet': [2899, 3313], 'homogenized': [2901, 2938, 3332], '(using': [2902], 'Polytron': [2904], 'homogenizer': [2905], 's)': [2908], '0.1': [2914], 'mmEDTA': [2915], 'step': [2931], 'twice.': [2934], 'membranes': [2936, 3317, 3330, 3394, 3501], 'assay': [2940, 3015, 3111, 3129, 3784], 'buffer,': [2941, 3130], 'CaCl2(pH': [2950], '7.4),': [2951], 'measured': [2956], 'Bradford': [2958], 'Protein': [2959], 'Assay': [2960], 'bovine': [2962], 'serum': [2963], 'albumin': [2964], 'standard': [2966], '(Bio-Rad).': [2967], 'saturation': [2970], 'WT,': [2974], 'K260H,': [2975], 'K260H/H231A/E233A/E238A': [2977], '5–15': [2979], 'membrane': [2982, 3073, 3380], 'fractions': [2983, 3074], 'room': [2990, 3088], 'temperature': [2991, 3089], '[3H]Quis': [2996, 3020, 3065, 3966], 'absence': [2999, 3051, 3095, 3351, 4369], 'presence': [3001, 3053, 3097, 3349, 3914, 4057, 4198, 4371], '(representing': [3006], 'nonspecific': [3009, 3701, 3775], 'respectively)': [3011], 'volume': [3016], 'μl.': [3019], 'diluted': [3022], 'unlabeled': [3024], '(S)-quisqualic': [3025], 'above': [3029, 3632, 4029], '250': [3030, 3047], 'nm.': [3031], 'Expression': [3032], 'levels': [3033], 'estimated': [3039], 'measuring': [3041], 'nm[3H]Quis': [3048, 3092], 'mmGlu.': [3056], 'To': [3057], 'investigate': [3058], 'whether': [3059], 'able': [3062], 'displace': [3064], 'WT': [3068, 3188, 3622, 3805, 3832, 3872, 3970, 3995, 4013, 4045, 4140], '50–100-μg': [3072], '30': [3091, 3327, 3345, 3429], 'mmGlu,': [3100], '(S)-4CPG,': [3103, 3961], 'μmCPCCOEt,': [3105], 'ZnCl2.': [3109, 3361, 4293, 4325, 4375], 'mixture': [3112], 'aspirated': [3114], 'onto': [3115], 'GF/C': [3117], 'filter': [3118], '(Whatman)': [3119], '3': [3123, 4245], 'ml': [3126], 'filters': [3134], 'dried': [3136], 'counted': [3138], 'scintillation': [3141], 'counter.': [3142], 'duplicate': [3149], 'times.': [3155], 'rabbit': [3157, 3440], 'directed': [3163], 'toward': [3164], 'Glu1116–Leu1130peptide': [3166], 'terminus': [3170], 'mGluR1a.': [3172], '“short': [3180], 'tailedȁ': [3181], 'mGluR1b.': [3184, 3998, 4225], 'Hence,': [3185], '(WT': [3218], 'mGluR1a-pSI,': [3219, 3221], 'pSI)': [3223], 'twice': [3277], 'scraped': [3281], 'lysis': [3283], '(2': [3285], 'HEPES,': [3287], 'mmEDTA,': [3289], 'protease': [3291], 'inhibitors': [3292], '(Complete™,': [3293], 'Roche,': [3294], 'Switzerland)': [3295], 'iodoacetamide)': [3299], 'homogenized.': [3301], 'After': [3302], 'centrifugation': [3303, 3321], '1000': [3305, 4250, 4319], 'min,': [3310], 'nuclear': [3312], 'discarded,': [3315], 'harvested': [3319], '35,000': [3323], '1%': [3336], 'SDS': [3337], 'iodoacetamide': [3341], '300': [3353, 3629, 3790], 'mmβ-mercaptoethanol,': [3354], 'dithiothreitol,': [3357], 'samples': [3363, 3376], 'heated': [3365], '65': [3370], 'before': [3372], 'electrophoresis,': [3373], 'where': [3374, 3548, 3582, 3847, 3906], '(5–15': [3377], 'protein/well)': [3381], 'separated': [3383], '7.5%': [3385], 'polyacrylamide': [3386], 'gels.': [3387], 'transferred': [3391], 'nitrocellulose': [3393], 'transblotting': [3396], '200': [3398], 'mA': [3399], 'h.': [3402, 3459], 'blots': [3404, 3423], '(PBS)': [3411], '0.05%': [3413, 3434, 3449, 3470, 3487], 'Tween': [3414, 3435, 3450, 3471, 3488], '2%': [3417, 3453, 3491], 'powdered': [3418, 3454, 3492], 'skim': [3419, 3455, 3493], 'milk': [3420], 'overnight.': [3421], 'times': [3427], 'PBS': [3432, 3447, 3468, 3485], '(diluted': [3444, 3482], '1:2000': [3445], 'milk)': [3456, 3494], 'followed': [3462], '30-min': [3465], 'washes': [3466], 'incubation': [3474], 'anti-Rabbit': [3476], 'conjugated': [3478], 'peroxidase': [3481], '1:1500': [3483], 'h,': [3497], 'developed': [3503], '3,3-diaminobenzidine': [3508], '(Kem-En-Tec': [3509], 'A/S,': [3510], 'Copenhagen,': [3511], 'Denmark).': [3512], 'Three': [3513], 'performed,': [3519], 'them.': [3528], 'Data': [3529, 3565, 4353, 4493], 'concentration-response': [3532, 3908, 4148], 'fitted': [3535, 3572], 'simple': [3539], 'mass': [3540], 'equation:R': [3541], '=': [3542, 3576], 'Rbasal': [3543], '+': [3544, 3546, 3580], '(Rmax/(1': [3545, 3579], '(EC50/[A]n))),': [3547], '[A]': [3549, 3583], 'agonist,': [3554], 'n': [3555, 3589], 'coefficient,': [3559, 3593], 'R': [3561, 3595], 'following:R': [3575], 'Rmax': [3577], '−': [3578], '(IC50/[A]n))),': [3581], 'antagonist,': [3588], 'Curves': [3599], 'generated': [3601], 'nonweighted': [3603], 'least-squares': [3604], 'fits': [3605], 'program': [3608], 'KaleidaGraph': [3609], '3.08': [3610], '(Synergy': [3611], 'Software,': [3612], 'Reading,': [3613], 'PA).': [3614], 'Exposure': [3615], 'transiently': [3619, 4256, 4393], 'led': [3633], '∼1': [3650], '(Fig.1).': [3652], 'However,': [3653, 3999], 'pharmacological': [3655, 4137], 'profiles': [3656], 'observed': [3658, 3696, 3747], 'when': [3659, 3802], 'phosholipase': [3662], 'C-coupled': [3663], 'receptors,': [3664], 'muscarinic': [3668], 'm5,': [3671], 'exposed': [3673], '(Fig.': [3676, 3874, 3944], '1).': [3677], 'observation': [3679], 'displays': [3682], 'apparent': [3685], 'antagonistic': [3686], 'strongly': [3692], 'suggests': [3693], 'nature.': [3702], 'appears': [3704], 'inhibitory': [3708], 'toxic': [3711, 4036], 'cells.': [3716], 'Alternatively,': [3717], 'may': [3720], 'inhibit': [3721], 'events': [3722], 'downstream': [3723], 'pathway': [3728], 'agreement': [3733], 'minute': [3749], 'decrease': [3750], 'maximal': [3753, 3798, 3922], 'response': [3754, 3923, 4009, 4366], '(induced': [3755], 'mmGlu)': [3758], 'exerted': [3759], 'mGluR1.': [3765], '2L.': [3766], 'Prézeau': [3767], 'Pin,': [3770], 'personal': [3771], 'communication.': [3772], 'Since': [3773], 'functionality': [3781], 'negligible': [3786], 'below': [3789], 'μm,': [3791, 4031, 4246, 4248], 'Zn2+,': [3801], 'testing': [3803], 'mGlu1breceptors.': [3808], 'Glu-induced': [3816, 4154], 'activation,': [3818], 'used.': [3827], 'At': [3828], 'concentration,': [3830], 'fully': [3838], 'activated.': [3839], 'had': [3849, 4033], 'substituted': [3851], 'histidine,': [3854], 'decreased': [3860], '500-fold': [3861], 'compared': [3862], '“apparentȁ': [3865], 'TableI).': [3877], 'showed': [3879], 'used,': [3891], 'indicating': [3892], '(Fig.3A).': [3897], 'proposal': [3899], 'supported': [3901], 'Schild': [3904, 4377], 'analysis,': [3905], 'increasing': [3916, 3930], 'Zn2+.': [3919], 'Here,': [3920], 'markedly': [3927], 'reduced': [3928], 'present,': [3934], 'EC50': [3937], 'values': [3938], 'relatively': [3942], 'unaltered': [3943], '3B).': [3945], 'much': [3947], 'like': [3948], 'CPCCOEt': [3953], 'contrast': [3956], 'competitive': [3959], 'did': [3963], 'influence': [3965], 'either': [3969], '(Fig.4A).': [3974], 'conclusion,': [3976], 'clearly': [3979], 'K260H.': [3985], 'ions': [3988], 'Cu2+': [3989], 'Co2+': [3991], 'tested': [3993], 'unable': [4004], 'both': [4011], '(data': [4024], 'shown).': [4026], 'marked': [4035], 'cells.Table': [4041], 'IPharmacological': [4042], 'characterization': [4043], 'mGlu1breceptorsReceptorGluZn2+EC50Rmax/R100': [4048], 'CPCCOEt1-aThe': [4050], 'ratio': [4051, 4192], 'responses': [4054, 4195], 'respectively.IC50μmμmWT4.1': [4066], '0.623.3': [4068], '0.19>100K260A5.9': [4070], '0.333.5': [4072, 4118], '0.33>100K260H5.5': [4074], '0.433.9': [4076], '0.371.8': [4078], '0.24K260H/H231A6.04': [4080], '1.43.5': [4082], '0.445.9': [4084], '2.5K260H/E233A2.2': [4086], '0.563.7': [4088], '0.472.3': [4090], '0.52K260H/E238A2.9': [4092], '1.13.9': [4094], '0.233.2': [4096], '0.24K260H/H257AND1-bND,': [4098], 'determined.3.6': [4100], '0.393.8': [4102], '1.2K260H/D259AND3.1': [4104], '0.270.94': [4106], '0.25K260H/H231A/E233AND3.6': [4108], '0.191.9': [4110], '0.33K260H/H231A/E238AND4.1': [4112], '0.135.8': [4114], '0.45K260H/E233A/E238AND3.9': [4116], '0.56K260H/H231A/E233A/E238A2.4': [4120], '0.233.3': [4122], '0.14>100K260H/H231E/E233H/E238HND3.9': [4124], '0.230.31': [4126], '0.092K260H/E238H3.1': [4128], '1.93.5': [4130], '0.191.5': [4132], '0.34Shown': [4134], 'parameters': [4138], 'selected': [4142], 'accumulation.': [4156], 'assays': [4159, 4228], 'under': [4164, 4233], '“Experimental': [4165, 4234], 'Proceduresȁ': [4166], 'legends': [4170], 'Figs.': [4172], '6,': [4175], 'data': [4178], 'experiments.1-a': [4190], 'respectively.1-b': [4207], 'ND,': [4208], 'determined.': [4210], 'Open': [4211], 'table': [4212], 'tab': [4216], 'Figure': [4217, 4506], '3Zn2+': [4218], 'Procedures.ȁ': [4235], 'A,': [4236], 'induced': [4243, 4387], '50': [4247], 'mGluR1b-pSI.': [4260, 4397], 'prelabeled': [4264, 4401], 'overnight': [4265, 4402], 'μCi/mlmyo-[2-3H]inositol,': [4268, 4405], 'HBSS,': [4271, 4408], 'mmCaCl2,': [4282, 4419], 'LiCl,': [4288, 4425], '(3,': [4316], '50,': [4317], 'μm)': [4320], 'aspirated,': [4329, 4469], 'addition': [4337, 4477], 'acid.': [4343, 4482], 'Total': [4344, 4483], 'determined': [4348, 4487], 'ion-exchange': [4351], 'assay.': [4352, 4492], '(mean': [4354, 4501], 'S.D.)': [4356], 'percentage': [4360], 'difference': [4363], 'B,': [4376], 'analysis': [4378], '(0,': [4432], '1,': [4433], '4,': [4434], '16': [4436], 'μm).': [4437], 'mmformic': [4481], 'disintegrations/min': [4497], '(DPM)': [4498], 'per': [4499], 'well': [4500], 'S.D).View': [4503], 'Large': [4504], 'Image': [4505], 'ViewerDownload': [4507], 'Hi-res': [4508], 'image': [4509], 'Download': [4510], '(PPT)Figure': [4511], '4[3H]Quis': [4512]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2002561196', 'counts_by_year': [{'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-12T13:02:03.183790', 'created_date': '2016-06-24'}