Title: Hexobarbital (Enhexymalum NFN) Sleeping Times and EEG Threshold Doses as Measurements of Tolerance to Barbiturates in the Rat
Abstract: Acta Pharmacologica et ToxicologicaVolume 26, Issue 1 p. 64-80 Hexobarbital (Enhexymalum NFN) Sleeping Times and EEG Threshold Doses as Measurements of Tolerance to Barbiturates in the Rat Göran Wahlström, Göran Wahlström From the Department of Pharmacology, University of Uppsala, Sweden. (Professor Ernst Bárány)Search for more papers by this author Göran Wahlström, Göran Wahlström From the Department of Pharmacology, University of Uppsala, Sweden. (Professor Ernst Bárány)Search for more papers by this author First published: December 1967 https://doi.org/10.1111/j.1600-0773.1967.tb00428.xCitations: 30AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References Aston, R.: Latent hypersensitivity to pentobarbital in the rat. Proc. Soc. Exp. Biol. Med. 1966, 121, 623–626. 10.3181/00379727-121-30846 CASPubMedWeb of Science®Google Scholar Burns, J. J., C. Evans & N. Trousof: Stimulatory effect of barbital on urinary excretion of L-ascorbic acid and non-conjugated D-glucuronic acid. J. Biol. Chem. 1957, 227, 785–794. CASPubMedWeb of Science®Google Scholar Collier, H. O. J.: Tolerance, physical dependence and receptors. Advances Drug Res. 1966, 3, 171–188. Google Scholar Conney, A. H. & J. J. Burns: Factors influencing drug metabolism. Advances Pharmacol. 1962, 1, 31–58. 10.1016/S1054-3589(08)60507-4 CASWeb of Science®Google Scholar Deneau, G. A. & M. H. Seevers: Pharmacological aspects of drug dependence. Advances Pharmacol. 1964, 3, 267–283. 10.1016/S1054-3589(08)61114-X CASPubMedWeb of Science®Google Scholar Ebert, A. G., G. K. W. Yim & T. S. Miya: Distribution and metabolism of barbital-14C in tolerant and non-tolerant rats. Biochem. Pharmacol. 1964, 13, 1267–1274. 10.1016/0006-2952(64)90227-8 CASPubMedWeb of Science®Google Scholar Essig, C. F. & H. G. Flanary: Convulsions in cats following withdrawal of barbital sodium. Exp. Neurol. 1959, 1, 529–533. 10.1016/0014-4886(59)90015-9 PubMedWeb of Science®Google Scholar Essig, C. F. & H. G. Flanary: Convulsive aspects of barbital sodium withdrawal in the cat. Exp. Neurol. 1961, 3, 149–159. 10.1016/0014-4886(61)90065-6 Web of Science®Google Scholar Goldschmidt, S. & R. Wehr: Über Barbiturate, III. Mitteilung. Der Metabolismus von Veronal. Z. Physiol. Chem. 1957, 308, 9–19. 10.1515/bchm2.1957.308.1.9 CASPubMedWeb of Science®Google Scholar Gruber, C. M. & G. F. Keyser: A study on the development of tolerance and cross-tolerance to barbiturates in experimental animals. J. Pharmacol. Exp. Ther. 1946, 86, 186–196. CASPubMedWeb of Science®Google Scholar Jaffe, J. H. & S. K. Sharpless: The rapid development of physical dependence on barbiturates. J. Pharmacol. Exp. Ther. 1965, 150, 140–145. CASPubMedWeb of Science®Google Scholar McQuarrie, D. G. & E. Fingl: Effects of single doses and chronic administration of ethanol on experimental seizures in mice. J. Pharmacol. Exp. Ther. 1958, 124, 264–271. CASPubMedWeb of Science®Google Scholar Moir, W. M.: The influence of age and sex on the repeated administration of sodium pentobarbital to albino rats. J. Pharmacol. Exp. Ther. 1937, 59, 68–85. Google Scholar Remmer, H.: Drug tolerance. In: Enzymes and drug action. Ciba Found. Symp. Churchill Ltd. London1962, 276–298. 10.1002/9780470719251.ch17 Google Scholar Remmer, H.: Gewöhnung an Hexobarbital durch beschleunigten Abbau. Arch. Int. Pharmacodyn. 1964, 152, 346–359. CASPubMedWeb of Science®Google Scholar Remmer, H., M. Siegert, H. R. Nitze & I. Kirsten: Die Gewöhnung an langwirkende Barbiturate. Arch. Exp. Pathol. Pharmakol. 1962, 243, 468–478. 10.1007/BF00245541 CASPubMedWeb of Science®Google Scholar Seevers, M. H. & G. A. Deneau: Physiological aspects of tolerance and physical dependence. In: Physiological Pharmacology. Academic Press. New York and London. 1963, 1, 565–640. Google Scholar Wahlström, G.: Estimation of brain sensitivity to hexobarbitone (enhexymal NFN) in rats by an EEG threshold. Acta Pharmacol. Toxicol. 1966a, 24, 404–418. 10.1111/j.1600-0773.1966.tb00402.x CASPubMedWeb of Science®Google Scholar Wahlström, G.: Hexobarbitone sleeping time in rats following doses with similar EEG changes. Acta Pharmacol. Toxicol. 1966b, 24, 419–434. 10.1111/j.1600-0773.1966.tb00403.x CASPubMedWeb of Science®Google Scholar Wahlström, G.: Abstinence symptoms after alcohol treatments in the rat. Acta physiol. scand. 1966c, 68, suppl. 277, 215. Google Scholar Citing Literature Volume26, Issue1December 1967Pages 64-80 ReferencesRelatedInformation
Publication Year: 1967
Publication Date: 1967-12-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 33
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