Title: Muscle abnormalities in juvenile dermatomyositis patients: P-31 magnetic resonance spectroscopy studies
Abstract: Arthritis & RheumatismVolume 43, Issue 10 p. 2359-2367 Clinical ScienceFree to Read Muscle abnormalities in juvenile dermatomyositis patients: P-31 magnetic resonance spectroscopy studies Jane H. Park, Jane H. Park Vanderbilt University Medical School, Nashville, TennesseeSearch for more papers by this authorKenneth J. Niermann, Kenneth J. Niermann Vanderbilt University Medical School, Nashville, TennesseeSearch for more papers by this authorNova M. Ryder, Nova M. Ryder Vanderbilt University Medical School, Nashville, TennesseeSearch for more papers by this authorAmanda E. Nelson, Amanda E. Nelson Vanderbilt University Medical School, Nashville, TennesseeSearch for more papers by this authorAmrita Das, Amrita Das Vanderbilt University Medical School, Nashville, TennesseeSearch for more papers by this authorAlexander R. Lawton, Alexander R. Lawton Vanderbilt University Medical School, Nashville, TennesseeSearch for more papers by this authorMarta Hernanz-Schulman, Marta Hernanz-Schulman Vanderbilt University Medical School, Nashville, TennesseeSearch for more papers by this authorNancy J. Olsen, Corresponding Author Nancy J. Olsen Vanderbilt University Medical School, Nashville, TennesseeDepartment of Medicine, T-3219 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232Search for more papers by this author Jane H. Park, Jane H. Park Vanderbilt University Medical School, Nashville, TennesseeSearch for more papers by this authorKenneth J. Niermann, Kenneth J. Niermann Vanderbilt University Medical School, Nashville, TennesseeSearch for more papers by this authorNova M. Ryder, Nova M. Ryder Vanderbilt University Medical School, Nashville, TennesseeSearch for more papers by this authorAmanda E. Nelson, Amanda E. Nelson Vanderbilt University Medical School, Nashville, TennesseeSearch for more papers by this authorAmrita Das, Amrita Das Vanderbilt University Medical School, Nashville, TennesseeSearch for more papers by this authorAlexander R. Lawton, Alexander R. Lawton Vanderbilt University Medical School, Nashville, TennesseeSearch for more papers by this authorMarta Hernanz-Schulman, Marta Hernanz-Schulman Vanderbilt University Medical School, Nashville, TennesseeSearch for more papers by this authorNancy J. Olsen, Corresponding Author Nancy J. Olsen Vanderbilt University Medical School, Nashville, TennesseeDepartment of Medicine, T-3219 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232Search for more papers by this author First published: 26 March 2001 https://doi.org/10.1002/1529-0131(200010)43:10<2359::AID-ANR25>3.0.CO;2-DCitations: 61AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Objective To characterize metabolic abnormalities in the muscles of children with the juvenile variant of dermatomyositis (JDM) by the use of noninvasive P-31 magnetic resonance spectroscopy (MRS). Methods Thirteen patients with JDM (ages 4–16 years) were studied. Biochemical status was evaluated with P-31 MRS by determining the concentrations of the high-energy phosphate compounds, ATP and phosphocreatine (PCr), ratios of inorganic phosphate (Pi) to PCr (Pi:PCr ratio), levels of free cytosolic ADP, and phosphorylation potentials (PPs) during rest, exercise, and recovery. Results Significant metabolic abnormalities were observed in the thigh muscles of 10 severely affected patients during rest, 2 graded levels of exercise, and recovery. Mean ATP and PCr levels in the muscles of JDM patients were 35–40% below the normal control values (P < 0.003). These data, along with elevated Pi:PCr ratios, higher ADP levels, and abnormal values for PPs, indicated defective oxidative phosphorylation in the mitochondria of diseased JDM muscles. MRS findings were normal in 2 additional patients who had improved with prednisone treatment and in 1 patient who had no muscle weakness (amyopathic variant of JDM). Conclusion JDM patients can be monitored with noninvasive P-31 MRS without sedation. Biochemical defects in energy metabolism are concordant with the weakness and fatigue reported by JDM patients. Quantitative MRS data are useful for evaluating patients and optimizing drug treatment regimens. Citing Literature Volume43, Issue10October 2000Pages 2359-2367 RelatedInformation